Aliases for RCOR3 Gene

Aliases for RCOR3 Gene

  • REST Corepressor 3 2 3 4 5
  • FLJ10876 2
  • KIAA1343 4
  • RCOR3 5

External Ids for RCOR3 Gene

Previous GeneCards Identifiers for RCOR3 Gene

  • GC01P208513
  • GC01P207821
  • GC01P209499
  • GC01P211433
  • GC01P182109

Summaries for RCOR3 Gene

GeneCards Summary for RCOR3 Gene

RCOR3 (REST Corepressor 3) is a Protein Coding gene. Diseases associated with RCOR3 include Cone-Rod Dystrophy 6. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is RCOR2.

UniProtKB/Swiss-Prot Summary for RCOR3 Gene

  • May act as a component of a corepressor complex that represses transcription.

Additional gene information for RCOR3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RCOR3 Gene

Genomics for RCOR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RCOR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J211256 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 631.1 +0.9 934 5.4 ARHGAP35 SP1 HNRNPL GATAD2A CTCF PRDM10 ZNF629 TFE3 ZNF512 LEF1 RCOR3 LOC105372902 lnc-KCNH1-2 LINC00467 DTL HHAT RPL21P28 MN309046 TRAF5
GH01J211313 Promoter/Enhancer 0.5 EPDnew dbSUPER 600.2 +53.9 53864 0.1 RCOR3 SLC30A1 MN296921 lnc-RD3-7 TRAF5
GH01J212033 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 57.7 +778.0 778024 5.2 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PRDM10 REST ZNF629 TFE3 DTL INTS7 RCOR3 RPL21P28 ANGEL2 ENSG00000231057 NEK2 ENSG00000229832 LPGAT1-AS1 LPGAT1
GH01J211326 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 27.5 +70.1 70056 4.5 PRDM10 KDM1A POLR2A ZNF692 FOXA1 LARP7 PRDM1 MTA2 ZIC2 ZNF24 TRAF5 RCOR3 LINC00467 SNX25P1 PPP2R5A lnc-RD3-1 RD3
GH01J211674 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 29.2 +417.1 417123 2.6 SP1 CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 RFX1 LEF1 SOX13 ENSG00000231057 LOC91548 NEK2 lnc-LPGAT1-3 RCOR3 SNX25P1 RPL21P28 DTL INTS7 SLC30A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RCOR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RCOR3

Genomic Locations for RCOR3 Gene

Genomic Locations for RCOR3 Gene
chr1:211,258,377-211,316,385
(GRCh38/hg38)
Size:
58,009 bases
Orientation:
Plus strand
chr1:211,431,719-211,489,727
(GRCh37/hg19)
Size:
58,009 bases
Orientation:
Plus strand

Genomic View for RCOR3 Gene

Genes around RCOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR3 Gene

Proteins for RCOR3 Gene

  • Protein details for RCOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2K3-RCOR3_HUMAN
    Recommended name:
    REST corepressor 3
    Protein Accession:
    Q9P2K3
    Secondary Accessions:
    • B3KYA2
    • B4DYY7
    • Q5VT47
    • Q7L9I5
    • Q8N5U3
    • Q9NV83

    Protein attributes for RCOR3 Gene

    Size:
    495 amino acids
    Molecular mass:
    55581 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RCOR3 Gene

    Alternative splice isoforms for RCOR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RCOR3 Gene

Post-translational modifications for RCOR3 Gene

  • Ubiquitination at Lys20 and Lys325
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RCOR3 Gene

Domains & Families for RCOR3 Gene

Gene Families for RCOR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RCOR3 Gene

Suggested Antigen Peptide Sequences for RCOR3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59439, highly similar to REST corepressor 3 (B4DV59_HUMAN)
  • REST corepressor 3 (RCOR3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P2K3

UniProtKB/Swiss-Prot:

RCOR3_HUMAN :
  • Belongs to the CoREST family.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR3: view

Function for RCOR3 Gene

Molecular function for RCOR3 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Phenotypes From GWAS Catalog for RCOR3 Gene

Gene Ontology (GO) - Molecular Function for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0003714 transcription corepressor activity IBA 21873635
genes like me logo Genes that share ontologies with RCOR3: view
genes like me logo Genes that share phenotypes with RCOR3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RCOR3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR3 Gene

Localization for RCOR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCOR3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0017053 transcriptional repressor complex IBA 21873635
genes like me logo Genes that share ontologies with RCOR3: view

Pathways & Interactions for RCOR3 Gene

PathCards logo

SuperPathways for RCOR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with RCOR3: view

No data available for Pathways by source and SIGNOR curated interactions for RCOR3 Gene

Drugs & Compounds for RCOR3 Gene

No Compound Related Data Available

Transcripts for RCOR3 Gene

mRNA/cDNA for RCOR3 Gene

6 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RCOR3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -
SP12:

ExUns: 15c · 15d ^ 16a · 16b · 16c
SP1:
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10: - -
SP11:
SP12: - -

Relevant External Links for RCOR3 Gene

GeneLoc Exon Structure for
RCOR3

Expression for RCOR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RCOR3 Gene

Protein differential expression in normal tissues from HIPED for RCOR3 Gene

This gene is overexpressed in Urine (23.3), Breast (16.5), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RCOR3 Gene



Protein tissue co-expression partners for RCOR3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RCOR3

SOURCE GeneReport for Unigene cluster for RCOR3 Gene:

Hs.356399

Evidence on tissue expression from TISSUES for RCOR3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with RCOR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCOR3 Gene

Orthologs for RCOR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RCOR3 30 31
  • 99.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RCOR3 30 31
  • 97.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RCOR3 30 31
  • 96.36 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rcor3 30
  • 91.76 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RCOR3 31
  • 90 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RCOR3 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rcor3 31
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RCOR3 31
  • 93 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RCOR3 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rcor3 30
  • 78.4 (n)
Zebrafish
(Danio rerio)
Actinopterygii rcor3 30 31
  • 70.72 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CoRest 31
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rcor-1 31
  • 15 (a)
ManyToMany
spr-1 31
  • 13 (a)
ManyToMany
Species where no ortholog for RCOR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RCOR3 Gene

ENSEMBL:
Gene Tree for RCOR3 (if available)
TreeFam:
Gene Tree for RCOR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RCOR3: view image

Paralogs for RCOR3 Gene

Paralogs for RCOR3 Gene

(4) SIMAP similar genes for RCOR3 Gene using alignment to 8 proteins:

  • RCOR3_HUMAN
  • B4DV59_HUMAN
  • E9PPC5_HUMAN
  • E9PQE5_HUMAN
  • E9PR63_HUMAN
  • H0YDD7_HUMAN
  • H0YDR8_HUMAN
  • H0YF22_HUMAN
genes like me logo Genes that share paralogs with RCOR3: view

Variants for RCOR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RCOR3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17856928 - p.Lys42Arg

Additional dbSNP identifiers (rs#s) for RCOR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RCOR3 Gene

Variant ID Type Subtype PubMed ID
esv3546011 CNV deletion 23714750
esv6409 CNV gain 19470904
nsv1068848 CNV deletion 25765185
nsv159013 CNV deletion 16902084
nsv952066 CNV deletion 24416366

Variation tolerance for RCOR3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RCOR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCOR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR3 Gene

Disorders for RCOR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RCOR3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cone-rod dystrophy 6
  • retinitis pigmentosa 6
- elite association - COSMIC cancer census association via MalaCards
Search RCOR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RCOR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RCOR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RCOR3 Gene

Publications for RCOR3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RCOR3 Gene

Sources for RCOR3 Gene