Aliases for RCOR2 Gene
External Ids for RCOR2 Gene
- HGNC: 27455
- Entrez Gene: 283248
- Ensembl: ENSG00000167771
- OMIM: 616019
- UniProtKB: Q8IZ40
Previous GeneCards Identifiers for RCOR2 Gene
- GC11M063455
- GC11M063435
- GC11M063678
- GC11M060007
Summaries for RCOR2 Gene
GeneCards Summary for RCOR2 Gene
RCOR2 (REST Corepressor 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is RCOR3.
UniProtKB/Swiss-Prot for RCOR2 Gene
-
May act as a component of a corepressor complex that represses transcription.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR2 Gene
Genomics for RCOR2 Gene
Regulatory Elements for RCOR2 Gene
Enhancers for RCOR2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RCOR2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for RCOR2 Gene
- Chromosome:
- 11
- Start:
- 63,911,221 bp from pter
- End:
- 63,916,844 bp from pter
- Size:
- 5,624 bases
- Orientation:
- Minus strand
Genomic View for RCOR2 Gene
Genes around RCOR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
RCOR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RCOR2 Gene
Proteins for RCOR2 Gene
-
Protein details for RCOR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IZ40-RCOR2_HUMAN
- Recommended name:
- REST corepressor 2
- Protein Accession:
- Q8IZ40
- Q96FP3
Protein attributes for RCOR2 Gene
- Size:
- 523 amino acids
- Molecular mass:
- 58012 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};
Protein Expression for RCOR2 Gene
Post-translational modifications for RCOR2 Gene
Other Protein References for RCOR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RCOR2
- Novus Biologicals Antibodies for RCOR2
-
Abcam antibodies for RCOR2
- Invitrogen Antibodies for RCOR2
- antibodies-online Antibodies for RCOR2: See all 24
- Search GeneTex for Antibodies for RCOR2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RCOR2
- Origene Custom Protein Services for RCOR2
- Novus Biologicals proteins for RCOR2
- antibodies-online Proteins for RCOR2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RCOR2
No data available for DME Specific Peptides for RCOR2 Gene
Domains & Families for RCOR2 Gene
Gene Families for RCOR2 Gene
Protein Domains for RCOR2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RCOR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IZ40- Family:
-
- Belongs to the CoREST family.
Function for RCOR2 Gene
Molecular function for RCOR2 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a component of a corepressor complex that represses transcription.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003714 | transcription corepressor activity | IBA | -- |
| GO:0008134 | transcription factor binding | IBA | -- |
| GO:0019899 | enzyme binding | IEA | -- |
Phenotypes for RCOR2 Gene
- GenomeRNAi human phenotypes for RCOR2:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for RCOR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RCOR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RCOR2 gene
- Search ViGene Biosciences for RCOR2
CRISPR Products
-
OriGene CRISPR knockouts for RCOR2
-
Applied Biological Materials CRISPR for RCOR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RCOR2
- GenScript: Design CRISPR guide RNA sequences for RCOR2
miRNA for RCOR2 Gene
- miRTarBase miRNAs that target RCOR2
miRNA Products
- Search ViGene Biosciences for RCOR2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RCOR2
- Browse OriGene Inhibitory RNA Products For RCOR2
-
ViGene Biosciences ready-to-package AAV shRNAs for RCOR2 gene
Clone Products
-
OriGene ORF clones in human for RCOR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RCOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RCOR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RCOR2
-
ViGene Biosciences adenoviral particle packaged cDNA for RCOR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RCOR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RCOR2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR2 Gene
Localization for RCOR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RCOR2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0005667 | transcription factor complex | IBA | -- |
| GO:0017053 | transcriptional repressor complex | IBA | -- |
Pathways & Interactions for RCOR2 Gene
No Data Available
Interacting Proteins for RCOR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RCOR2 Gene
Transcripts for RCOR2 Gene
mRNA/cDNA for RCOR2 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for RCOR2
-
Applied Biological Materials CRISPR for RCOR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RCOR2
- GenScript: Design CRISPR guide RNA sequences for RCOR2
miRNA Products
- Search ViGene Biosciences for RCOR2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RCOR2
- Browse OriGene Inhibitory RNA Products For RCOR2
-
ViGene Biosciences ready-to-package AAV shRNAs for RCOR2 gene
Clone Products
-
OriGene ORF clones in human for RCOR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RCOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RCOR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||
| SP6: |
Expression for RCOR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
This gene is overexpressed in Heart (32.3) and Fetal Brain (31.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCOR2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RCOR2 Gene:
RCOR2SOURCE GeneReport for Unigene cluster for RCOR2 Gene:
Hs.98788Evidence on tissue expression from TISSUES for RCOR2 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for RCOR2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCOR2 Gene
Orthologs for RCOR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RCOR2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | RCOR2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RCOR2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Rcor2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rcor2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RCOR2 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RCOR2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rcor2 34 |
|
||
| Str.20516 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7678 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rcor2 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CoRest 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | rcor-1 35 |
|
ManyToMany | |
| spr-1 35 |
|
ManyToMany |
- Species where no ortholog for RCOR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RCOR2 Gene
(2) SIMAP similar genes for RCOR2 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for RCOR2 Gene
Variants for RCOR2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000242364 | -- | 63,912,822(+) | CTGCC(A/T)CCAGA | intron-variant | |
| rs1001502456 | -- | 63,917,440(+) | CCCAC(A/G)CGCAC | upstream-variant-2KB | |
| rs1002156863 | -- | 63,912,405(+) | CTCCC(-/A)ATTCC | intron-variant, reference, frameshift-variant | |
| rs1002598884 | -- | 63,917,151(+) | CGCTC(C/T)TCGCG | upstream-variant-2KB | |
| rs1002656561 | -- | 63,915,871(+) | GCCAA(A/G)CAGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660413 | CNV | deletion | 23128226 |
| nsv1070465 | CNV | deletion | 25765185 |
| nsv555180 | CNV | loss | 21841781 |
| nsv555181 | CNV | loss | 21841781 |
| nsv951009 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.15;
23.23% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RCOR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RCOR2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR2 Gene
Disorders for RCOR2 Gene
Relevant External Links for RCOR2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RCOR2
No disorders were found for RCOR2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR2 Gene
Publications for RCOR2 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3 64
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
Products for RCOR2 Gene
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- GenScript: Design CRISPR guide RNA sequences for RCOR2
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- Novus Biologicals Antibodies for RCOR2
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- Novus Biologicals
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- Invitrogen Antibodies for RCOR2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for RCOR2: See all 24
- Search antibodies-online for kits
- antibodies-online Proteins for RCOR2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for RCOR2
- Search GeneTex for Proteins for RCOR2
- ViGene Biosciences adenoviral particle packaged cDNA for RCOR2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RCOR2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RCOR2 gene
- Search ViGene Biosciences for RCOR2
- Horizon Cell Lines for RCOR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for RCOR2
- VectorBuilder custom plasmid, inducible vectors for RCOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RCOR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RCOR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio