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RCOR2 (REST Corepressor 2) is a Protein Coding gene. Diseases associated with RCOR2 include Duane-Radial Ray Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RCOR3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO:0003714 | transcription corepressor activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0017053 | transcriptional repressor complex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RCOR2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RCOR2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RCOR2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rcor2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rcor2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RCOR2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RCOR2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rcor2 30 |
|
||
Str.20516 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7678 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rcor2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CoRest 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | spr-1 31 |
|
ManyToMany | |
rcor-1 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660413 | CNV | deletion | 23128226 |
nsv1070465 | CNV | deletion | 25765185 |
nsv555180 | CNV | loss | 21841781 |
nsv555181 | CNV | loss | 21841781 |
nsv951009 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
duane-radial ray syndrome |
|
|