Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RCOR2 Gene

Aliases for RCOR2 Gene

  • REST Corepressor 2 2 3 4 5

External Ids for RCOR2 Gene

Previous GeneCards Identifiers for RCOR2 Gene

  • GC11M063455
  • GC11M063435
  • GC11M063678
  • GC11M060007

Summaries for RCOR2 Gene

GeneCards Summary for RCOR2 Gene

RCOR2 (REST Corepressor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RCOR3.

UniProtKB/Swiss-Prot for RCOR2 Gene

  • May act as a component of a corepressor complex that represses transcription.

Additional gene information for RCOR2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR2 Gene

Genomics for RCOR2 Gene

GeneHancer (GH) Regulatory Elements for RCOR2 Gene

Promoters and enhancers for RCOR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J063915 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 604.1 -1.3 -1293 6.1 HDGF SP1 ZFX ELF3 CTCF ZKSCAN8 MNT ZNF148 NCOA6 ZBTB7A RCOR2 OTUB1 LGALS12 GC11M063921 GC11P063911 GC11P063909
GH11J064267 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.1 -353.5 -353536 7.2 HDGF SP1 ZFX CC2D1A ZNF652 ELF3 SIX5 ZNF148 NKRF POLR2A GPR137 SF1 ZFPL1 POLA2 PLCB3 ENSG00000257086 DNAJC4 SYVN1 ENSG00000236935 TRPT1
GH11J063937 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.1 -22.3 -22293 3.9 SP1 ELF3 ZFX MNT CBFA2T2 NKRF MLLT1 POLR2A CSDE1 MYC NAA40 SF1 RCOR2 RTN3 GC11P063909 GC11P063911 GC11P063971
GH11J064372 Enhancer 1.1 FANTOM5 ENCODE 4.5 -456.0 -456008 0.8 SP1 CBFA2T2 GLIS2 POLR2A IKZF1 PRDM10 REST RFX1 ZNF341 SP2 ENSG00000236935 NRXN2 RCOR2 KCNK4 NAA40 GPR137 CDC42BPG MIR1237 GC11M064381
GH11J063908 Enhancer 0.7 ENCODE dbSUPER 0.4 +7.4 7394 3 EGR1 ZBTB8A CTCF POLR2A SP2 HIC1 EGR2 GC11P063909 PIR50128 PIR46613 GC11P063911 MARK2 RNU6-1306P NAA40 SPINDOC MACROD1 ENSG00000256341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RCOR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RCOR2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Egr-4
  • GATA-2
  • HEN1
  • NF-1/L

Genomic Locations for RCOR2 Gene

Genomic Locations for RCOR2 Gene
chr11:63,911,221-63,917,164
(GRCh38/hg38)
Size:
5,944 bases
Orientation:
Minus strand
chr11:63,678,693-63,684,316
(GRCh37/hg19)
Size:
5,624 bases
Orientation:
Minus strand

Genomic View for RCOR2 Gene

Genes around RCOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RCOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RCOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RCOR2 Gene

Proteins for RCOR2 Gene

  • Protein details for RCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ40-RCOR2_HUMAN
    Recommended name:
    REST corepressor 2
    Protein Accession:
    Q8IZ40
    Secondary Accessions:
    • Q96FP3

    Protein attributes for RCOR2 Gene

    Size:
    523 amino acids
    Molecular mass:
    58012 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

neXtProt entry for RCOR2 Gene

Post-translational modifications for RCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RCOR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RCOR2 Gene

Domains & Families for RCOR2 Gene

Gene Families for RCOR2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RCOR2 Gene

Suggested Antigen Peptide Sequences for RCOR2 Gene

GenScript: Design optimal peptide antigens:
  • REST corepressor 2 (F1T0J8_HUMAN)
  • REST corepressor 2 (RCOR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZ40

UniProtKB/Swiss-Prot:

RCOR2_HUMAN :
  • Belongs to the CoREST family.
Family:
  • Belongs to the CoREST family.
genes like me logo Genes that share domains with RCOR2: view

Function for RCOR2 Gene

Molecular function for RCOR2 Gene

UniProtKB/Swiss-Prot Function:
May act as a component of a corepressor complex that represses transcription.

Phenotypes From GWAS Catalog for RCOR2 Gene

Gene Ontology (GO) - Molecular Function for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA,IEA 21873635
GO:0003714 transcription corepressor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 24726434
genes like me logo Genes that share ontologies with RCOR2: view
genes like me logo Genes that share phenotypes with RCOR2: view

Animal Model Products

CRISPR Products

miRNA for RCOR2 Gene

miRTarBase miRNAs that target RCOR2

Clone Products

  • Applied Biological Materials (abm): Clones for RCOR2 - Now 50% OFF >
  • * RCOR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * RCOR2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR2 Gene

Localization for RCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RCOR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RCOR2 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Midbody (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005667 transcription factor complex IBA,IEA 21873635
GO:0017053 transcriptional repressor complex IBA 21873635
genes like me logo Genes that share ontologies with RCOR2: view

Pathways & Interactions for RCOR2 Gene

PathCards logo

SuperPathways for RCOR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RCOR2: view

No data available for Pathways by source and SIGNOR curated interactions for RCOR2 Gene

Drugs & Compounds for RCOR2 Gene

No Compound Related Data Available

Transcripts for RCOR2 Gene

mRNA/cDNA for RCOR2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(52) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for RCOR2 Gene

REST corepressor 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for RCOR2 - Now 50% OFF >
  • * RCOR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * RCOR2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for RCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for RCOR2 Gene

GeneLoc Exon Structure for
RCOR2
ECgene alternative splicing isoforms for
RCOR2

Expression for RCOR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RCOR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RCOR2 Gene

This gene is overexpressed in Heart (32.3) and Fetal Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RCOR2 Gene



Protein tissue co-expression partners for RCOR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RCOR2 Gene:

RCOR2

SOURCE GeneReport for Unigene cluster for RCOR2 Gene:

Hs.98788

Evidence on tissue expression from TISSUES for RCOR2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RCOR2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCOR2 Gene

Orthologs for RCOR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RCOR2 35 34
  • 97.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RCOR2 35 34
  • 92.48 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RCOR2 35 34
  • 92.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rcor2 17 35 34
  • 89 (n)
rat
(Rattus norvegicus)
Mammalia Rcor2 34
  • 88.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RCOR2 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RCOR2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rcor2 34
  • 66.12 (n)
Str.20516 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7678 34
zebrafish
(Danio rerio)
Actinopterygii rcor2 35 34
  • 63.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CoRest 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-1 35
  • 14 (a)
ManyToMany
rcor-1 35
  • 14 (a)
ManyToMany
Species where no ortholog for RCOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RCOR2 Gene

ENSEMBL:
Gene Tree for RCOR2 (if available)
TreeFam:
Gene Tree for RCOR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RCOR2: view image

Paralogs for RCOR2 Gene

Paralogs for RCOR2 Gene

(2) SIMAP similar genes for RCOR2 Gene using alignment to 2 proteins:

  • RCOR2_HUMAN
  • F1T0J8_HUMAN

Pseudogenes.org Pseudogenes for RCOR2 Gene

genes like me logo Genes that share paralogs with RCOR2: view

Variants for RCOR2 Gene

Sequence variations from dbSNP and Humsavar for RCOR2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000242364 -- 63,912,822(-) T/A intron_variant
rs1001502456 -- 63,917,440(-) G/A upstream_transcript_variant
rs1002156863 -- 63,912,406(-) A/AA coding_sequence_variant, frameshift, intron_variant
rs1002598884 -- 63,917,151(-) C/T upstream_transcript_variant
rs1002656561 -- 63,915,871(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RCOR2 Gene

Variant ID Type Subtype PubMed ID
esv2660413 CNV deletion 23128226
nsv1070465 CNV deletion 25765185
nsv555180 CNV loss 21841781
nsv555181 CNV loss 21841781
nsv951009 CNV deletion 24416366

Variation tolerance for RCOR2 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RCOR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RCOR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR2 Gene

Disorders for RCOR2 Gene

Additional Disease Information for RCOR2

No disorders were found for RCOR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR2 Gene

Publications for RCOR2 Gene

  1. REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. (PMID: 28049845) Monaghan CE … Mandel G (Proceedings of the National Academy of Sciences of the United States of America 2017) 2 3 58
  2. RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency. (PMID: 21433225) Yang P … Gao S (Stem cells (Dayton, Ohio) 2011) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells. (PMID: 28420882) Hiramatsu H … Iba H (Scientific reports 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RCOR2 Gene

Sources for RCOR2 Gene

Content
Loading form....