Aliases for RCOR2 Gene
External Ids for RCOR2 Gene
- HGNC: 27455
- Entrez Gene: 283248
- Ensembl: ENSG00000167771
- OMIM: 616019
- UniProtKB: Q8IZ40
Previous GeneCards Identifiers for RCOR2 Gene
- GC11M063455
- GC11M063435
- GC11M063678
- GC11M060007
Summaries for RCOR2 Gene
GeneCards Summary for RCOR2 Gene
RCOR2 (REST Corepressor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is RCOR3.
UniProtKB/Swiss-Prot for RCOR2 Gene
-
May act as a component of a corepressor complex that represses transcription.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCOR2 Gene
Genomics for RCOR2 Gene
GeneHancer (GH) Regulatory Elements for RCOR2 Gene
Promoters and enhancers for RCOR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RCOR2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RCOR2 gene promoter:
-
- E2F-2
- Egr-4
- E2F
- E2F-1
- E2F-3a
- E2F-4
- GATA-2
- E2F-5
- HEN1
- NF-1/L
Regulatory Element Products
Genomic Locations for RCOR2 Gene
Genomic Locations for RCOR2 Gene
- chr11:63,911,221-63,916,844
- (GRCh38/hg38)
- Size:
- 5,624 bases
- Orientation:
- Minus strand
- chr11:63,678,693-63,684,316
- (GRCh37/hg19)
- Size:
- 5,624 bases
- Orientation:
- Minus strand
Genomic View for RCOR2 Gene
Genes around RCOR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
RCOR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RCOR2 Gene
Proteins for RCOR2 Gene
-
Protein details for RCOR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IZ40-RCOR2_HUMAN
- Recommended name:
- REST corepressor 2
- Protein Accession:
- Q8IZ40
- Q96FP3
Protein attributes for RCOR2 Gene
- Size:
- 523 amino acids
- Molecular mass:
- 58012 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH10608.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};
Protein Expression for RCOR2 Gene
Post-translational modifications for RCOR2 Gene
Other Protein References for RCOR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RCOR2
- Invitrogen Antibodies for RCOR2
- Search GeneTex for Antibodies for RCOR2
-
Boster Bio Antibodies for RCOR2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RCOR2
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- Search GeneTex for Proteins for RCOR2
Assay Products
No data available for DME Specific Peptides for RCOR2 Gene
Domains & Families for RCOR2 Gene
Gene Families for RCOR2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RCOR2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RCOR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IZ40- Family:
-
- Belongs to the CoREST family.
Function for RCOR2 Gene
Molecular function for RCOR2 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a component of a corepressor complex that represses transcription.
Phenotypes From GWAS Catalog for RCOR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IBA,IEA | -- |
| GO:0003714 | transcription corepressor activity | IBA,IEA | -- |
| GO:0008134 | transcription factor binding | IBA | -- |
Phenotypes for RCOR2 Gene
- MGI mutant phenotypes for RCOR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RCOR2:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for RCOR2
-
CRISPR Products
-
OriGene CRISPR knockouts for RCOR2
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- Overview of 86 available Rcor2 gene related products
- Applied Biological Materials CRISPR for RCOR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RCOR2
- GenScript: Design CRISPR guide RNA sequences for RCOR2
miRNA for RCOR2 Gene
- miRTarBase miRNAs that target RCOR2
miRNA Products
Inhibitory RNA Products
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- Overview of 86 available Rcor2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RCOR2
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RCOR2
- Applied Biological Materials Clones for RCOR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RCOR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCOR2 Gene
Localization for RCOR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RCOR2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Midbody (2)
- Nucleus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005667 | transcription factor complex | IBA,IEA | -- |
| GO:0017053 | transcriptional repressor complex | IBA | -- |
Pathways & Interactions for RCOR2 Gene
No Data Available
Interacting Proteins for RCOR2 Gene
Selected Interacting proteins:
Q8IZ40-RCOR2_HUMAN
ENSP00000301459
for RCOR2 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for RCOR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RCOR2 Gene
Transcripts for RCOR2 Gene
mRNA/cDNA for RCOR2 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000301459 2604 bps (uc001nyc.3)
- ENST00000473926 276 bps (uc058csi.1)
- ENST00000489217 792 bps (uc058csh.1)
Unigene Clusters for RCOR2 Gene
- REST corepressor 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RCOR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RCOR2
- genomics-online: gRNA clones - Search results for 86 available Rcor2 gene related products
- Overview of 86 available Rcor2 gene related products
- Applied Biological Materials CRISPR for RCOR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RCOR2
- GenScript: Design CRISPR guide RNA sequences for RCOR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RCOR2
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RCOR2
- genomics-online: shRNA clones - Search results for 86 available Rcor2 gene related products
- Overview of 86 available Rcor2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RCOR2
- VectorBuilder custom plasmid, inducible vectors for RCOR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RCOR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RCOR2
- Applied Biological Materials Clones for RCOR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||
| SP6: |
Expression for RCOR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Adipose (Muscoskeletal System)
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Neural Tube (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
This gene is overexpressed in Heart (32.3) and Fetal Brain (31.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RCOR2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RCOR2 Gene:
RCOR2SOURCE GeneReport for Unigene cluster for RCOR2 Gene:
Hs.98788Evidence on tissue expression from TISSUES for RCOR2 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for RCOR2
- genomics-online: primer clones - Search results for 86 available Rcor2 gene related products
- Overview of 86 available Rcor2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCOR2 Gene
Orthologs for RCOR2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RCOR2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RCOR2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RCOR2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rcor2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rcor2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RCOR2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RCOR2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rcor2 33 |
|
||
| Str.20516 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7678 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rcor2 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CoRest 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | spr-1 34 |
|
ManyToMany | |
| rcor-1 34 |
|
ManyToMany |
- Species where no ortholog for RCOR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RCOR2 Gene
- ENSEMBL:
- Gene Tree for RCOR2 (if available)
- TreeFam:
- Gene Tree for RCOR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RCOR2: view image
Paralogs for RCOR2 Gene
Variants for RCOR2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000242364 | -- | 63,912,822(-) | T/A | intron_variant | |
| rs1001502456 | -- | 63,917,440(-) | G/A | upstream_transcript_variant | |
| rs1002156863 | -- | 63,912,406(-) | A/AA | coding_sequence_variant, frameshift, intron_variant | |
| rs1002598884 | -- | 63,917,151(-) | C/T | upstream_transcript_variant | |
| rs1002656561 | -- | 63,915,871(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv951009 | CNV | deletion | 24416366 |
| nsv555181 | CNV | loss | 21841781 |
| nsv555180 | CNV | loss | 21841781 |
| nsv1070465 | CNV | deletion | 25765185 |
| esv2660413 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.15;
23.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RCOR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RCOR2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCOR2 Gene
Disorders for RCOR2 Gene
Additional Disease Information for RCOR2
No disorders were found for RCOR2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCOR2 Gene
Publications for RCOR2 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
Products for RCOR2 Gene
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- VectorBuilder custom plasmid, inducible vectors for RCOR2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 30 available Rcor2 Antibodies ranked by validation data
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- antibodies-online: Search results for 3 available Rcor2 Proteins ranked by validation data
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- Overview of 86 available Rcor2 gene related products
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- Overview of 86 available Rcor2 gene related products
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Sources for RCOR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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