Aliases for RCOR1 Gene
External Ids for RCOR1 Gene
Previous HGNC Symbols for RCOR1 Gene
Previous GeneCards Identifiers for RCOR1 Gene
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
GeneCards Summary for RCOR1 Gene
RCOR1 (REST Corepressor 1) is a Protein Coding gene. Diseases associated with RCOR1 include Loeys-Dietz Syndrome 1 and Huntington Disease. Among its related pathways are Chromatin organization and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include chromatin binding and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is RCOR3.
UniProtKB/Swiss-Prot Summary for RCOR1 Gene
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.