Aliases for RCN3 Gene
External Ids for RCN3 Gene
Previous GeneCards Identifiers for RCN3 Gene
GeneCards Summary for RCN3 Gene
RCN3 (Reticulocalbin 3) is a Protein Coding gene. Diseases associated with RCN3 include Neonatal Respiratory Failure and Myopathy, Distal, 3. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN1.
UniProtKB/Swiss-Prot Summary for RCN3 Gene
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634).