Aliases for RCN3 Gene
Aliases for RCN3 Gene
External Ids for RCN3 Gene
- HGNC: 21145
- Entrez Gene: 57333
- Ensembl: ENSG00000142552
- UniProtKB: Q96D15
Previous GeneCards Identifiers for RCN3 Gene
- GC19P054706
- GC19P054722
- GC19P050030
- GC19P046407
Summaries for RCN3 Gene
GeneCards Summary for RCN3 Gene
RCN3 (Reticulocalbin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RCN3 Gene
Genomics for RCN3 Gene
GeneHancer (GH) Regulatory Elements for RCN3 Gene
Promoters and enhancers for RCN3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RCN3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RCN3 Gene
Genomic Locations for RCN3 Gene
- chr19:49,527,579-49,546,962
- (GRCh38/hg38)
- Size:
- 19,384 bases
- Orientation:
- Plus strand
- chr19:50,030,875-50,050,219
- (GRCh37/hg19)
Genomic View for RCN3 Gene
Genes around RCN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Ensembl
- 19q13.33 by Entrez Gene
- 19q13.33 by HGNC
RCN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RCN3 Gene
Proteins for RCN3 Gene
-
Protein details for RCN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96D15-RCN3_HUMAN
- Recommended name:
- Reticulocalbin-3
- Protein Accession:
- Q96D15
- Q9HBZ8
Protein attributes for RCN3 Gene
- Size:
- 328 amino acids
- Molecular mass:
- 37493 Da
- Quaternary structure:
- No Data Available
Protein Expression for RCN3 Gene
Post-translational modifications for RCN3 Gene
Other Protein References for RCN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RCN3
- Novus Biologicals Antibodies for RCN3
- Invitrogen Antibodies for RCN3
- antibodies-online: Search results for available RCN3 related products ranked by validation data
- Search GeneTex for Antibodies for RCN3
Protein Products
-
OriGene Purified Proteins for RCN3
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- Sino Biological Cell Lysates for RCN3
- Sino Biological Recombinant Proteins for RCN3
- ProSpec Recombinant Proteins for RCN3
- antibodies-online: Search results for available RCN3 related products ranked by validation data
- Search GeneTex for Proteins for RCN3
-
ProSci Proteins for RCN3
Assay Products
- antibodies-online: Search results for available RCN3 related products ranked by validation data
No data available for DME Specific Peptides for RCN3 Gene
Domains & Families for RCN3 Gene
Gene Families for RCN3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for RCN3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RCN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96D15- Family:
-
- Belongs to the CREC family.
Function for RCN3 Gene
Phenotypes From GWAS Catalog for RCN3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RCN3 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for RCN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RCN3 gene
- Search ViGene Biosciences for RCN3
CRISPR Products
-
OriGene CRISPR knockouts for RCN3
- genomics-online: gRNA clones - Search results for 136 available RCN3 gene related products
- Overview of 136 available RCN3 gene related products
- Applied Biological Materials CRISPR for RCN3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RCN3
miRNA for RCN3 Gene
- miRTarBase miRNAs that target RCN3
miRNA Products
- Search ViGene Biosciences for RCN3
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RCN3
- Browse OriGene Inhibitory RNA Products For RCN3
- genomics-online: shRNA clones - Search results for 136 available RCN3 gene related products
- Overview of 136 available RCN3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RCN3 gene
Clone Products
- Sino Biological Human cDNA Clone for RCN3
- VectorBuilder custom plasmid, inducible vectors for RCN3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RCN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RCN3
-
ViGene Biosciences adenoviral particle packaged cDNA for RCN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RCN3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RCN3 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RCN3 Gene
Localization for RCN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RCN3 Gene
- Endoplasmic reticulum lumen.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | IEA | -- |
Pathways & Interactions for RCN3 Gene
No Data Available
Interacting Proteins for RCN3 Gene
Selected Interacting proteins:
Q96D15-RCN3_HUMAN
ENSP00000270645
for RCN3 Gene via
IID
STRING
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for RCN3 Gene
Transcripts for RCN3 Gene
mRNA/cDNA for RCN3 Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RCN3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RCN3
- genomics-online: gRNA clones - Search results for 136 available RCN3 gene related products
- Overview of 136 available RCN3 gene related products
- Applied Biological Materials CRISPR for RCN3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RCN3
miRNA Products
- Search ViGene Biosciences for RCN3
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RCN3
- Browse OriGene Inhibitory RNA Products For RCN3
- genomics-online: shRNA clones - Search results for 136 available RCN3 gene related products
- Overview of 136 available RCN3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RCN3 gene
Clone Products
- Sino Biological Human cDNA Clone for RCN3
- VectorBuilder custom plasmid, inducible vectors for RCN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RCN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RCN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - |
Expression for RCN3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Smooth Muscle (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
This gene is overexpressed in Bone marrow stromal cell (56.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RCN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of RCN3 Gene:
RCN3SOURCE GeneReport for Unigene cluster for RCN3 Gene:
Hs.567550Evidence on tissue expression from TISSUES for RCN3 Gene
- Lung(4.2)
- Liver(4.1)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for RCN3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RCN3 Gene
Orthologs for RCN3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RCN3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RCN3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RCN3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rcn3 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RCN3 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rcn3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RCN3 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RCN3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rcn3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rcn3 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | scf 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | calu-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| CSA.6945 34 |
|
ManyToMany |
- Species where no ortholog for RCN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RCN3 Gene
(3) SIMAP similar genes for RCN3 Gene using alignment to 4 proteins:
Variants for RCN3 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000196721 | -- | 49,532,378(+) | T/G | intron_variant | |
| rs1000248030 | -- | 49,529,403(+) | A/G | intron_variant | |
| rs1000356116 | -- | 49,540,893(+) | G/A/T | intron_variant | |
| rs1000376443 | -- | 49,535,002(+) | C/T | intron_variant | |
| rs1000930793 | -- | 49,539,382(+) | A/C | intron_variant |
Residual Variation Intolerance Score:
85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.71;
78.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RCN3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RCN3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RCN3 Gene
Disorders for RCN3 Gene
Additional Disease Information for RCN3
No disorders were found for RCN3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RCN3 Gene
Publications for RCN3 Gene
- A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. (PMID: 16433634) Tsuji A … Matsuda Y (The Biochemical journal 2006) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
- Circulating Reticulocalbin 1 and Reticulocalbin 3 in Systemic Sclerosis Patients: Results of a Case Control Study. (PMID: 27468573) Bălănescu P … Dan GA (Clinical laboratory 2016) 3 58
Products for RCN3 Gene
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- Custom Antibody ServicesOriGene Antibodies for RCN3
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- OriGene qPCR primer pairs for RCN3
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for RCN3
- VectorBuilder custom plasmid, inducible vectors for RCN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RCN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available RCN3 related products ranked by validation data
- antibodies-online: Search results for available RCN3 related products ranked by validation data
- antibodies-online: Search results for available RCN3 related products ranked by validation data
- Search GeneTex for Antibodies for RCN3
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- ViGene Biosciences adenoviral particle packaged cDNA for RCN3 gene
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- Search ViGene Biosciences for RCN3
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- genomics-online: cdna clones - Search results for 136 available RCN3 gene related products
- Overview of 136 available RCN3 gene related products
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- Overview of 136 available RCN3 gene related products
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- Overview of 136 available RCN3 gene related products
Sources for RCN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems