Aliases for RCE1 Gene
External Ids for RCE1 Gene
Previous HGNC Symbols for RCE1 Gene
Previous GeneCards Identifiers for RCE1 Gene
This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for RCE1 Gene
RCE1 (Ras Converting CAAX Endopeptidase 1) is a Protein Coding gene. Diseases associated with RCE1 include Tolosa-Hunt Syndrome and Restrictive Dermopathy, Lethal. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and cysteine-type endopeptidase activity.
UniProtKB/Swiss-Prot Summary for RCE1 Gene
Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).