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Aliases for RBPMS2 Gene

Aliases for RBPMS2 Gene

  • RNA Binding Protein, MRNA Processing Factor 2 2 3
  • RNA Binding Protein With Multiple Splicing 2 2 5

External Ids for RBPMS2 Gene

Previous GeneCards Identifiers for RBPMS2 Gene

  • GC15M062612
  • GC15U900325
  • GC15M062747
  • GC15M062819
  • GC15M065032
  • GC15M041857

Summaries for RBPMS2 Gene

Entrez Gene Summary for RBPMS2 Gene

  • The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]

GeneCards Summary for RBPMS2 Gene

RBPMS2 (RNA Binding Protein, MRNA Processing Factor 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS.

UniProtKB/Swiss-Prot for RBPMS2 Gene

  • Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation.

Additional gene information for RBPMS2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBPMS2 Gene

Genomics for RBPMS2 Gene

GeneHancer (GH) Regulatory Elements for RBPMS2 Gene

Promoters and enhancers for RBPMS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I064772 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 589.6 +0.9 873 5 GTF2E2 TEAD4 SIN3A ZNF335 E2F1 ZFHX2 CTBP1 EGR1 POLR2A ZBTB48 RBPMS2 TRIP4 MIR1272
GH15I064697 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 29.9 +74.6 74638 6.4 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF143 SP3 SP5 ENSG00000259635 TRIP4 RBPMS2 RNU6-549P PLEKHO2 ENSG00000249240 OAZ2 ENSG00000264937
GH15I064805 Enhancer 1.3 Ensembl ENCODE dbSUPER 38.1 -33.7 -33703 6.7 RB1 ARNT ZSCAN4 SIN3A BATF IRF4 ZNF48 RAD21 ETS1 ZNF143 RBPMS2 TRIP4 ANKDD1A PIF1
GH15I064632 Enhancer 1.3 Ensembl ENCODE dbSUPER 34.6 +140.5 140452 5 PKNOX1 FOXA2 SMAD1 SIN3A DMAP1 YBX1 IRF4 ZNF280A ZNF121 ZNF207 RBPMS2 TRIP4 SLC24A1 RNU6-549P ZNF609 ENSG00000249240 PLEKHO2 SNX1 ENSG00000239465 LOC101930091
GH15I064801 Enhancer 0.9 Ensembl ENCODE 49.6 -26.7 -26722 1.5 MEIS2 PKNOX1 ATF1 ZNF121 TCF12 POLR2A RCOR1 ZNF600 ATF7 CREM RBPMS2 TRIP4 PIF1 MIR1272
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBPMS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBPMS2 gene promoter:

Genomic Locations for RBPMS2 Gene

Genomic Locations for RBPMS2 Gene
chr15:64,739,892-64,775,587
(GRCh38/hg38)
Size:
35,696 bases
Orientation:
Minus strand
chr15:65,032,091-65,067,786
(GRCh37/hg19)

Genomic View for RBPMS2 Gene

Genes around RBPMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBPMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBPMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBPMS2 Gene

Proteins for RBPMS2 Gene

  • Protein details for RBPMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRY4-RBPS2_HUMAN
    Recommended name:
    RNA-binding protein with multiple splicing 2
    Protein Accession:
    Q6ZRY4
    Secondary Accessions:
    • A2RRG0

    Protein attributes for RBPMS2 Gene

    Size:
    209 amino acids
    Molecular mass:
    22497 Da
    Quaternary structure:
    • Homodimer. Interacts with EEF2.

    Three dimensional structures from OCA and Proteopedia for RBPMS2 Gene

    Alternative splice isoforms for RBPMS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBPMS2 Gene

Post-translational modifications for RBPMS2 Gene

Other Protein References for RBPMS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBPMS2 Gene

Domains & Families for RBPMS2 Gene

Gene Families for RBPMS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBPMS2 Gene

Suggested Antigen Peptide Sequences for RBPMS2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBPMS2: view

No data available for UniProtKB/Swiss-Prot for RBPMS2 Gene

Function for RBPMS2 Gene

Molecular function for RBPMS2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation.

Phenotypes From GWAS Catalog for RBPMS2 Gene

Gene Ontology (GO) - Molecular Function for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IDA 25064856
GO:0005515 protein binding IPI 25064856
GO:0042803 protein homodimerization activity IEA,IPI 25064856
genes like me logo Genes that share ontologies with RBPMS2: view
genes like me logo Genes that share phenotypes with RBPMS2: view

Animal Model Products

miRNA for RBPMS2 Gene

miRTarBase miRNAs that target RBPMS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBPMS2 Gene

Localization for RBPMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBPMS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBPMS2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25064856
genes like me logo Genes that share ontologies with RBPMS2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RBPMS2 Gene

Pathways & Interactions for RBPMS2 Gene

SuperPathways for RBPMS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBPMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030514 negative regulation of BMP signaling pathway ISS --
GO:0048557 embryonic digestive tract morphogenesis ISS --
GO:0048661 positive regulation of smooth muscle cell proliferation ISS --
GO:0051151 negative regulation of smooth muscle cell differentiation ISS --
genes like me logo Genes that share ontologies with RBPMS2: view

No data available for Pathways by source and SIGNOR curated interactions for RBPMS2 Gene

Drugs & Compounds for RBPMS2 Gene

No Compound Related Data Available

Transcripts for RBPMS2 Gene

mRNA/cDNA for RBPMS2 Gene

Unigene Clusters for RBPMS2 Gene

RNA binding protein with multiple splicing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBPMS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for RBPMS2 Gene

GeneLoc Exon Structure for
RBPMS2
ECgene alternative splicing isoforms for
RBPMS2

Expression for RBPMS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBPMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBPMS2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x8.7), Heart - Left Ventricle (x8.1), Colon - Sigmoid (x4.7), Esophagus - Gastroesophageal Junction (x4.2), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for RBPMS2 Gene

This gene is overexpressed in Fetal heart (12.1), Peripheral blood mononuclear cells (10.4), Platelet (9.3), Colon (8.8), Urinary Bladder (8.1), Rectum (6.7), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBPMS2 Gene



Protein tissue co-expression partners for RBPMS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBPMS2 Gene:

RBPMS2

SOURCE GeneReport for Unigene cluster for RBPMS2 Gene:

Hs.436518

Evidence on tissue expression from TISSUES for RBPMS2 Gene

  • Muscle(2.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with RBPMS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBPMS2 Gene

Orthologs for RBPMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBPMS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBPMS2 33 34
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia RBPMS2 33 34
  • 89.63 (n)
oppossum
(Monodelphis domestica)
Mammalia RBPMS2 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbpms2 33 16 34
  • 88.01 (n)
rat
(Rattus norvegicus)
Mammalia Rbpms2 33
  • 87.72 (n)
cow
(Bos Taurus)
Mammalia RBPMS2 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBPMS2 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBPMS 34
  • 86 (a)
OneToOne
RBPMS2 33
  • 81.67 (n)
lizard
(Anolis carolinensis)
Reptilia RBPMS2 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbpms2 33
  • 75.59 (n)
Str.11196 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6280 33
zebrafish
(Danio rerio)
Actinopterygii rbpms2b 34
  • 80 (a)
OneToMany
rbpms2a 33 34
  • 76.63 (n)
zgc55559 33
fruit fly
(Drosophila melanogaster)
Insecta cpo 34
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mec-8 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9310 34
  • 24 (a)
OneToMany
Species where no ortholog for RBPMS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBPMS2 Gene

ENSEMBL:
Gene Tree for RBPMS2 (if available)
TreeFam:
Gene Tree for RBPMS2 (if available)

Paralogs for RBPMS2 Gene

Paralogs for RBPMS2 Gene

(1) SIMAP similar genes for RBPMS2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RBPMS2 Gene

genes like me logo Genes that share paralogs with RBPMS2: view

Variants for RBPMS2 Gene

Sequence variations from dbSNP and Humsavar for RBPMS2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000117598 -- 64,762,421(-) C/T intron_variant
rs1000196643 -- 64,746,131(-) A/G intron_variant
rs1000327835 -- 64,766,203(-) G/A intron_variant
rs1000392342 -- 64,751,116(-) C/T intron_variant
rs1000402998 -- 64,742,648(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBPMS2 Gene

Variant ID Type Subtype PubMed ID
nsv569703 CNV loss 21841781
nsv528510 CNV loss 19592680
nsv1071215 CNV deletion 25765185
dgv31n68 CNV loss 17160897
dgv1226n106 CNV deletion 24896259

Variation tolerance for RBPMS2 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBPMS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBPMS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPMS2 Gene

Disorders for RBPMS2 Gene

Additional Disease Information for RBPMS2

No disorders were found for RBPMS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBPMS2 Gene

Publications for RBPMS2 Gene

  1. Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity. (PMID: 25064856) Sagnol S … de Santa Barbara P (Nucleic acids research 2014) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors. (PMID: 23295309) Hapkova I … de Santa Barbara P (Experimental and molecular pathology 2013) 3 58

Products for RBPMS2 Gene

Sources for RBPMS2 Gene

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