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This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
RBPMS (RNA Binding Protein, MRNA Processing Factor) is a Protein Coding gene. Diseases associated with RBPMS include Hordeolum and Optic Nerve Hypoplasia, Bilateral. Among its related pathways are Diurnally Regulated Genes with Circadian Orthologs. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBPMS2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003713 | transcription coactivator activity | IDA | 17099224 |
GO:0003723 | RNA binding | IEA,IDA | 26347403 |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Diurnally Regulated Genes with Circadian Orthologs |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006396 | RNA processing | TAS | 8855282 |
GO:0006979 | response to oxidative stress | IMP | 26347403 |
GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IDA | 17099224 |
GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
GO:0060391 | positive regulation of SMAD protein signal transduction | IDA | 17099224 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RBPMS 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RBPMS 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RBPMS 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rbpms 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rbpms 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RBPMS 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RBPMS 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RBPMS 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rbpms 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | RBPMS 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | cpo 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | mec-8 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9310 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3802n106 | CNV | deletion | 24896259 |
esv1086519 | CNV | deletion | 17803354 |
esv2367432 | CNV | deletion | 18987734 |
esv2585826 | CNV | deletion | 19546169 |
esv2657168 | CNV | deletion | 23128226 |
esv2736831 | CNV | deletion | 23290073 |
esv3272940 | CNV | deletion | 24192839 |
esv3543294 | CNV | deletion | 23714750 |
esv3572665 | CNV | loss | 25503493 |
esv3616785 | CNV | loss | 21293372 |
esv3616786 | CNV | loss | 21293372 |
esv3616787 | CNV | loss | 21293372 |
esv3616788 | CNV | loss | 21293372 |
esv4813 | CNV | loss | 18987735 |
esv6638 | CNV | loss | 19470904 |
esv988355 | CNV | deletion | 20482838 |
nsv1076077 | CNV | deletion | 25765185 |
nsv396470 | CNV | deletion | 16902084 |
nsv509260 | CNV | insertion | 20534489 |
nsv526509 | CNV | gain | 19592680 |
nsv528908 | CNV | loss | 19592680 |
nsv957675 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hordeolum |
|
|
optic nerve hypoplasia, bilateral |
|
|
ocular hypertension |
|
|
retinal ischemia |
|
|
optic nerve disease |
|
|