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The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pat... See more...
Aliases for RBPJ Gene
Aliases for RBPJ Gene
- CBF1 2 3
- KBF2 2 3
- SUH 2 3
- Immunoglobulin Kappa J Region Recombination Signal Binding Protein 1 3
- Recombining Binding Protein Suppressor Of Hairless (Drosophila) 2
- J Kappa-Recombination Signal-Binding Protein 4
- Suppressor Of Hairless Homolog (Drosophila) 2
- Suppressor Of Hairless Homolog 3
- H-2K Binding Factor-2 3
- AOS3 3
- RBPJ 5
- Csl 3
External Ids for RBPJ Gene
- HGNC: 5724
- Entrez Gene: 3516
- Ensembl: ENSG00000168214
- OMIM: 147183
- UniProtKB: Q06330
Previous HGNC Symbols for RBPJ Gene
- IGKJRB1
- RBPSUH
Previous GeneCards Identifiers for RBPJ Gene
- GC04P025930
- GC04P026321
- GC04P025659
Summaries for RBPJ Gene
-
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
GeneCards Summary for RBPJ Gene
RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a Protein Coding gene. Diseases associated with RBPJ include Adams-Oliver Syndrome 3 and Adams-Oliver Syndrome. Among its related pathways are Signaling by GPCR and Development NOTCH1-mediated pathway for NF-KB activity modulation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is RBPJL.
UniProtKB/Swiss-Prot Summary for RBPJ Gene
-
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
Additional gene information for RBPJ Gene
- HGNC(5724)
- Entrez Gene(3516)
- Ensembl(ENSG00000168214)
- OMIM(147183)
- UniProtKB(Q06330)
- Open Targets Platform(ENSG00000168214)
- Monarch Initiative
- Search for RBPJ at DataMed
- Search for RBPJ at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBPJ Gene
Genomics for RBPJ Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RBPJ Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J026318 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.1 | +157.8 | 157846 | 6.2 | BRCA1 ARHGAP35 SP1 CREB1 GATAD2A TEAD4 PRDM10 ZNF629 IKZF1 NFKBIZ | lnc-CCKAR-10 RBPJ CCKAR HSALNG0033476 | |
| GH04J026362 | Promoter/Enhancer | 0.5 | EPDnew dbSUPER | 600.1 | +199.0 | 198966 | 0.1 | RBPJ lnc-CCKAR-10 HSALNG0033476 CCKAR | ||
| GH04J026162 | Enhancer | 0.3 | Ensembl | 600.7 | -0.6 | -554 | 0.2 | CREB1 ATF2 | RBPJ HSALNG0033465 LOC105374541 SEL1L3 | |
| GH04J026163 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -16 | 0.1 | RBPJ HSALNG0033465 LOC105374541 SEL1L3 | ||
| GH04J026164 | Enhancer | 0.2 | Ensembl | 600.7 | +0.7 | 746 | 0.8 | RBPJ piR-57176-493 LOC105374541 CCKAR |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RBPJ on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBPJ
- Top Transcription factor binding sites by QIAGEN in the RBPJ gene promoter:
-
- AP-1
- MyoD
Genomic Locations for RBPJ Gene
Genomic Locations for RBPJ Gene
- chr4:26,163,455-26,435,131
- (GRCh38/hg38)
- Size:
- 271,677 bases
- Orientation:
- Plus strand
- chr4:26,165,077-26,436,541
- (GRCh37/hg19)
- Size:
- 271,465 bases
- Orientation:
- Plus strand
Genomic View for RBPJ Gene
Genes around RBPJ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.2 by HGNC
- 4p15.2 by Entrez Gene
- 4p15.2 by Ensembl
RBPJ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBPJ Gene
Proteins for RBPJ Gene
-
Protein details for RBPJ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06330-SUH_HUMAN
- Recommended name:
- Recombining binding protein suppressor of hairless
- Protein Accession:
- Q06330
- B4DY22
- Q5XKH9
- Q6P1N3
Protein attributes for RBPJ Gene
- Size:
- 500 amino acids
- Molecular mass:
- 55637 Da
- Quaternary structure:
-
- Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA1/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Interacts with SNW1. Interacts with CHCHD2 and CXXC5 (PubMed:23303788). Interacts with BEND6 (via BEN domain). Interacts with NKAPL (By similarity). Interacts with ZMIZ1. Interacts with RBM15 (By similarity).
- SequenceCaution:
-
- Sequence=AAA16254.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for RBPJ Gene
Protein Expression for RBPJ Gene
Post-translational modifications for RBPJ Gene
Other Protein References for RBPJ Gene
- ENSEMBL proteins:
-
- ENSP00000424789
- ENSP00000427170
- ENSP00000425750
- ENSP00000423644
- ENSP00000305815
- ENSP00000354528
- ENSP00000424989
- ENSP00000339699
- ENSP00000424804
- ENSP00000427344
- ENSP00000426872
- ENSP00000423907
- ENSP00000425061
- ENSP00000422617
- ENSP00000423575
- ENSP00000423406
- ENSP00000422838
- ENSP00000423703
- ENSP00000340124
- ENSP00000424459
- ENSP00000421804
- ENSP00000347659
- ENSP00000345206
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences RBPJ Antibody
- G Biosciences Immunotag™ RBPJ Antibody
- NSJ Bioreagents RBPJ Antibody
- Novus Biologicals Antibodies for RBPJ
-
Abcam antibodies for RBPJ
- Invitrogen Antibodies for RBPJ (AFLGC-RBPJ)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RBPJ
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RBPJ
- Origene Custom Protein Services for RBPJ
-
Abcam proteins for RBPJ
No data available for DME Specific Peptides for RBPJ Gene
Domains & Families for RBPJ Gene
Gene Families for RBPJ Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for RBPJ Gene
- InterPro:
- Blocks:
-
- Cell surface receptor IPT/TIG
- ProtoNet:
Suggested Antigen Peptide Sequences for RBPJ Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50914, highly similar to Recombining binding protein suppressor of hairless (B4DY22_HUMAN)
- H-2K binding factor-2 (Q14663_HUMAN)
- Renal carcinoma antigen NY-REN-30 (SUH_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q06330- Family:
-
- Belongs to the Su(H) family.
Function for RBPJ Gene
Molecular function for RBPJ Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).
Phenotypes From GWAS Catalog for RBPJ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 16691198 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IBA,IPI | 16287852 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 18663143 |
| GO:0003677 | DNA binding | TAS | 9874765 |
Phenotypes for RBPJ Gene
- MGI mutant phenotypes for RBPJ:
-
inferred from 7 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- GenomeRNAi human phenotypes for RBPJ:
Animal Models for RBPJ Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RBPJ - Select products 50% OFF >
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-
OriGene CRISPR knockouts for RBPJ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBPJ
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBPJ
miRNA for RBPJ Gene
- miRTarBase miRNAs that target RBPJ
-
- hsa-miR-375 (MIRT019785)
- hsa-miR-155-5p (MIRT020670)
- hsa-miR-124-3p (MIRT022527)
- hsa-miR-18a-5p (MIRT050652)
- hsa-let-7b-5p (MIRT052218)
- hsa-miR-15a-5p (MIRT212604)
- hsa-miR-16-5p (MIRT212605)
- hsa-miR-32-3p (MIRT212606)
- hsa-miR-15b-5p (MIRT212608)
- hsa-miR-195-5p (MIRT212610)
- hsa-miR-424-5p (MIRT212611)
- hsa-miR-497-5p (MIRT212612)
- hsa-miR-545-3p (MIRT212613)
- hsa-miR-3609 (MIRT212615)
- hsa-miR-548ah-5p (MIRT212617)
- hsa-miR-3064-3p (MIRT212618)
- hsa-miR-6838-5p (MIRT212619)
- hsa-miR-6077 (MIRT309928)
- hsa-miR-4468 (MIRT309949)
- hsa-miR-193b-5p (MIRT356390)
- hsa-miR-561-3p (MIRT356391)
- hsa-miR-619-3p (MIRT356392)
- hsa-miR-4774-5p (MIRT356396)
- hsa-miR-5585-3p (MIRT356398)
- hsa-miR-6765-3p (MIRT356400)
- hsa-miR-490-3p (MIRT356402)
- hsa-miR-548d-3p (MIRT356403)
- hsa-miR-548h-3p (MIRT356404)
- hsa-miR-548z (MIRT356407)
- hsa-miR-548ac (MIRT356409)
- hsa-miR-548bb-3p (MIRT356416)
- hsa-miR-218-5p (MIRT439796)
- hsa-miR-8061 (MIRT492451)
- hsa-miR-4760-5p (MIRT492452)
- hsa-miR-4715-3p (MIRT492453)
- hsa-miR-532-5p (MIRT492454)
- hsa-miR-3923 (MIRT492455)
- hsa-miR-302f (MIRT492456)
- hsa-miR-186-5p (MIRT492457)
- hsa-miR-3133 (MIRT492458)
- hsa-miR-7-5p (MIRT561670)
- hsa-miR-4446-5p (MIRT566102)
- hsa-miR-6814-5p (MIRT566103)
- hsa-miR-3622b-3p (MIRT566104)
- hsa-miR-3622a-3p (MIRT566105)
- gga-miR-21-5p (MIRT731297)
- mmu-miR-133a-5p (MIRT733067)
- hsa-miR-133a-3p (MIRT734973)
- hsa-miR-153-5p (MIRT737887)
- hsa-miR-1910-3p (MIRT738435)
- hsa-miR-208a-5p (MIRT738858)
- hsa-miR-208b-5p (MIRT738864)
- hsa-miR-2467-3p (MIRT739295)
- hsa-miR-25-3p (MIRT739367)
- hsa-miR-3140-3p (MIRT740182)
- hsa-miR-320a (MIRT741194)
- hsa-miR-320b (MIRT741198)
- hsa-miR-320c (MIRT741202)
- hsa-miR-320d (MIRT741206)
- hsa-miR-32-5p (MIRT741260)
- hsa-miR-363-3p (MIRT741812)
- hsa-miR-367-3p (MIRT742128)
- hsa-miR-3680-3p (MIRT742189)
- hsa-miR-3714 (MIRT742568)
- hsa-miR-4429 (MIRT744318)
- hsa-miR-450b-5p (MIRT745600)
- hsa-miR-4708-3p (MIRT747361)
- hsa-miR-4742-5p (MIRT748140)
- hsa-miR-507 (MIRT749605)
- hsa-miR-557 (MIRT750922)
- hsa-miR-6511a-5p (MIRT753160)
- hsa-miR-6511b-5p (MIRT753207)
- hsa-miR-6809-5p (MIRT756635)
- hsa-miR-6811-5p (MIRT756694)
- hsa-miR-92a-3p (MIRT760630)
- hsa-miR-92b-3p (MIRT760658)
- hsa-miR-9-3p (MIRT760788)
- hsa-miR-2681-5p (MIRT784346)
- hsa-miR-4318 (MIRT785751)
- hsa-miR-4474-3p (MIRT785962)
- hsa-miR-4693-5p (MIRT786426)
- hsa-miR-6815-3p (MIRT788913)
- hsa-miR-892a (MIRT789922)
Targeted motifs for RBPJ Gene
HOMER Transcription Factor Regulatory Elements motif RBPJ
- Consensus sequence: HTTTCCCASG Submotif: canonical Cell Type: Panc1 GEO ID: GSE47459
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for RBPJ - Select products 50% OFF >
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- MG207810
- MG226108
- MG226116
- MR207810
- MR207810L3
- MR207810L4
- MR226108
- MR226108L3
- MR226108L4
- MR226116
- MR226116L3
- MR226116L4
- MR230298
- RC204791
- RC204791L1
- RC204791L2
- RC204791L3
- RC204791L4
- RC209094
- RC209094L1
- RC209094L2
- RC209094L3
- RC209094L4
- RC215872
- RC215872L1
- RC215872L2
- RC215872L3
- RC215872L4
- RC218121
- RC218121L1
- RC218121L2
- RC218121L3
- RC218121L4
- RG204791
- RG209094
- RG215872
- RG218121
- RR215087
- RR215087L3
- RR215087L4
- MR207810L3V
- MR207810L4V
- MR226108L3V
- MR226108L4V
- MR226116L3V
- MR226116L4V
- RC204791L1V
- RC204791L2V
- RC204791L3V
- RC204791L4V
- RC209094L1V
- RC209094L2V
- RC209094L3V
- RC209094L4V
- RC215872L1V
- RC215872L2V
- RC215872L3V
- RC215872L4V
- RC218121L1V
- RC218121L2V
- RC218121L3V
- RC218121L4V
- RR215087L3V
- RR215087L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RBPJ
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Cell Line Products
-
Horizon Cell Lines for RBPJ
No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for RBPJ Gene
Localization for RBPJ Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBPJ Gene
- Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 3 |
| cytosol | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| endosome | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex | IBA,IDA | 16510869 |
| GO:0005634 | nucleus | IBA,IDA | 9874765 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IEA,IBA | 21873635 |
Pathways & Interactions for RBPJ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by NOTCH1 | ||
| 2 | Notch Signaling Pathway (WikiPathways) | ||
| 3 | Pre-NOTCH Expression and Processing | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Gene Expression |
.48
|
|
Pathways by source for RBPJ Gene
1 Sino Biological pathway for RBPJ Gene
7 BioSystems pathways for RBPJ Gene
21 Reactome pathways for RBPJ Gene
6 KEGG pathways for RBPJ Gene
2 GeneGo (Thomson Reuters) pathways for RBPJ Gene
- Development Notch Signaling Pathway
- Development NOTCH1-mediated pathway for NF-KB activity modulation
2 R&D Systems pathways for RBPJ Gene
3 Qiagen pathways for RBPJ Gene
- Molecular Mechanisms of Cancer
- Notch Signaling
- Presenilin-Mediated Signaling
1 Cell Signaling Technology pathway for RBPJ Gene
Interacting Proteins for RBPJ Gene
Selected Interacting proteins:
Q06330-SUH_HUMAN
ENSP00000345206
for RBPJ Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RBPJ
SIGNOR curated interactions for RBPJ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,ISS | -- |
| GO:0001525 | angiogenesis | IEA,ISS | -- |
| GO:0001756 | somitogenesis | IEA | -- |
| GO:0001837 | epithelial to mesenchymal transition | IEA,ISS | -- |
| GO:0001974 | blood vessel remodeling | IEA | -- |
Transcripts for RBPJ Gene
mRNA/cDNA for RBPJ Gene
- 13 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 31 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342295 5860 nts (view in UCSC)
- ENST00000342320 5761 nts (view in UCSC)
- ENST00000345843 1682 nts (view in UCSC)
- ENST00000348160 1752 nts (view in UCSC)
- ENST00000355476 5990 nts (view in UCSC)
CRISPR Products
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-
OriGene CRISPR knockouts for RBPJ
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBPJ
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBPJ
miRNA Products
Inhibitory RNA Products
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Clone Products
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-
- MG207810
- MG226108
- MG226116
- MR207810
- MR207810L3
- MR207810L4
- MR226108
- MR226108L3
- MR226108L4
- MR226116
- MR226116L3
- MR226116L4
- MR230298
- RC204791
- RC204791L1
- RC204791L2
- RC204791L3
- RC204791L4
- RC209094
- RC209094L1
- RC209094L2
- RC209094L3
- RC209094L4
- RC215872
- RC215872L1
- RC215872L2
- RC215872L3
- RC215872L4
- RC218121
- RC218121L1
- RC218121L2
- RC218121L3
- RC218121L4
- RG204791
- RG209094
- RG215872
- RG218121
- RR215087
- RR215087L3
- RR215087L4
- MR207810L3V
- MR207810L4V
- MR226108L3V
- MR226108L4V
- MR226116L3V
- MR226116L4V
- RC204791L1V
- RC204791L2V
- RC204791L3V
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- RC209094L1V
- RC209094L2V
- RC209094L3V
- RC209094L4V
- RC215872L1V
- RC215872L2V
- RC215872L3V
- RC215872L4V
- RC218121L1V
- RC218121L2V
- RC218121L3V
- RC218121L4V
- RR215087L3V
- RR215087L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RBPJ
- Addgene plasmids for RBPJ
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| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 18 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: |
Relevant External Links for RBPJ Gene
- GeneLoc Exon Structure for
- RBPJ
Expression for RBPJ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Interstitial Stroma Cells Interstitial Stroma
- Juxtaglomerular Cells Afferent Arteriole
-
Pancreas (Endocrine System)
- Acinar Progenitor Cells Dorsal Pancreatic Bud
-
Epithelial Cells
- Acinar Progenitor Cells Dorsal Pancreatic Bud
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Heart (Cardiovascular System)
- Endocardial Cells Endocardium
This gene is overexpressed in Breast (59.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBPJ Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBPJ
SOURCE GeneReport for Unigene cluster for RBPJ Gene:
Hs.479396Evidence on tissue expression from TISSUES for RBPJ Gene
- Nervous system(4.7)
- Eye(4.6)
- Lung(3.5)
- Liver(3.3)
- Blood(3.2)
- Heart(3.1)
- Bone marrow(3.1)
- Muscle(3.1)
- Skin(3)
- Intestine(3)
- Spleen(3)
- Kidney(2.9)
- Lymph node(2.8)
- Thyroid gland(2.6)
- Pancreas(2.5)
- Stomach(2.3)
- Bone(2.1)
- Gall bladder(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RBPJ Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cerebrospinal fluid
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- meninges
- mouth
- nose
- outer ear
- scalp
- skull
Thorax:
- aorta
- breast
- chest wall
- heart
- heart valve
- lung
- rib
- rib cage
- sternum
Abdomen:
- abdominal wall
Pelvis:
- placenta
- uterus
Limb:
- ankle
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for RBPJ
-
OriGene qPCR primer pairs and template standards for RBPJ
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBPJ Gene
Orthologs for RBPJ Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RBPJ 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RBPJ 31 |
|
OneToOne | |
| LOC479122 30 |
|
||||
| Oppossum (Monodelphis domestica) |
Mammalia | RBPJ 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RBPJ 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RBPJ 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rbpj 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rbpj 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RBPJ 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RBPJ 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100491789 30 |
|
||
| Str.10131 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2907 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rbpjb 30 31 |
|
OneToOne | |
| rbpsuh 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Su(H) 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008935 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | lag-1 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11329 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2779 30 |
|
- Species where no ortholog for RBPJ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RBPJ Gene
- ENSEMBL:
- Gene Tree for RBPJ (if available)
- TreeFam:
- Gene Tree for RBPJ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RBPJ: view image
Paralogs for RBPJ Gene
(2) SIMAP similar genes for RBPJ Gene using alignment to 18 proteins:
- SUH_HUMAN
- D6R927_HUMAN
- D6R946_HUMAN
- D6R9K5_HUMAN
- D6R9X3_HUMAN
- D6RA45_HUMAN
- D6RAT2_HUMAN
- D6RB37_HUMAN
- D6RBQ8_HUMAN
- D6RCM1_HUMAN
- D6RE93_HUMAN
- D6REC2_HUMAN
- D6REP3_HUMAN
- D6RF98_HUMAN
- D6RIV8_HUMAN
- D6RIZ8_HUMAN
- H0Y8R3_HUMAN
- L8E7S3_HUMAN
Pseudogenes.org Pseudogenes for RBPJ Gene
Variants for RBPJ Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBPJ Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 721050 | Likely Benign: not provided | 26,415,577(+) | G/T | SYNONYMOUS_VARIANT | |
| 722717 | Likely Benign: not provided | 26,430,989(+) | A/G | SYNONYMOUS_VARIANT | |
| 727534 | Likely Benign: not provided | 26,430,047(+) | C/T | SYNONYMOUS_VARIANT | |
| 731693 | Likely Benign: not provided | 26,430,954(+) | G/A | MISSENSE_VARIANT | |
| 734121 | Benign: not provided | 26,430,032(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1073315 | CNV | deletion | 25765185 |
| nsv1141985 | OTHER | inversion | 24896259 |
| nsv829889 | CNV | loss | 17160897 |
| nsv950561 | CNV | duplication | 24416366 |
| nsv950562 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.01;
20.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RBPJ Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBPJ Gene
Disorders for RBPJ Gene
(12) MalaCards diseases for RBPJ Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adams-oliver syndrome 3 |
|
|
| adams-oliver syndrome |
|
|
| oliver syndrome |
|
|
| alagille syndrome 1 |
|
|
| hajdu-cheney syndrome |
|
|
Search RBPJ in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SUH_HUMAN- Adams-Oliver syndrome 3 (AOS3) [MIM:614814]: An autosomal dominant form of Adams-Oliver syndrome, a disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. AOS3 patients manifest characteristic vertex scalp defects and terminal limb defects, but without congenital heart defects, other associated defects, or immune defects. {ECO:0000269 PubMed:22883147}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RBPJ
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for RBPJ Gene
Publications for RBPJ Gene
- Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. (PMID: 16530044) Nam Y … Blacklow SC (Cell 2006) 3 4 23
- Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization. (PMID: 9290259) Tang X … Yokoyama KK (The Japanese journal of human genetics 1997) 2 3 23
- Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue. (PMID: 8406481) Amakawa R … Honjo T (Genomics 1993) 2 3 4
- The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia. (PMID: 26522984) Pinnell N … Chiang MY (Immunity 2015) 3 4
- Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. (PMID: 23303788) Aras S … Grossman LI (Nucleic acids research 2013) 3 4
ExternalLinks
Products for RBPJ Gene
- Custom Antibody ServicesOriGene Antibodies for RBPJ
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RBPJ
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- Browse OriGene Inhibitory RNA Products For RBPJ
- OriGene qPCR primer pairs for RBPJ
- OriGene qPCR primer pairs and template standards for RBPJ
- OriGene CRISPR knockouts for RBPJ
- MG207810
- MG226108
- MG226116
- MR207810
- MR207810L3
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- MR226108
- MR226108L3
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- MR230298
- RC204791
- RC204791L1
- RC204791L2
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- RC209094L3
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- RC215872
- RC215872L1
- RC215872L2
- RC215872L3
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- RC218121
- RC218121L1
- RC218121L2
- RC218121L3
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- RG204791
- RG209094
- RG215872
- RG218121
- RR215087
- RR215087L3
- RR215087L4
- MR207810L3V
- MR207810L4V
- MR226108L3V
- MR226108L4V
- MR226116L3V
- MR226116L4V
- RC204791L1V
- RC204791L2V
- RC204791L3V
- RC204791L4V
- RC209094L1V
- RC209094L2V
- RC209094L3V
- RC209094L4V
- RC215872L1V
- RC215872L2V
- RC215872L3V
- RC215872L4V
- RC218121L1V
- RC218121L2V
- RC218121L3V
- RC218121L4V
- RR215087L3V
- RR215087L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RBPJ
- Sino Biological Human cDNA Clone for RBPJ
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RBPJ
- Novus Biologicals proteins and lysates for RBPJ
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for RBPJ
- Abcam proteins for RBPJ
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- Browse Primary Antibodies
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- Invitrogen Antibodies for RBPJ (AFLGC-RBPJ)
- VectorBuilder Custom and pre-made DNA vectors for RBPJ (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RBPJ (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RBPJ (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RBPJ CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RBPJ
- Addgene plasmids for RBPJ
- antibodies-online: Show 38 available RBPJ Antibodies ranked by validation data
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- antibodies-online: Search results for available RBPJ related products ranked by validation data
- antibodies-online: Show 8 available RBPJ Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for RBPJ
- Search Santa Cruz Biotechnology (SCBT) for RBPJ siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RBPJ
- Horizon Cell Lines for RBPJ
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBPJ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBPJ
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RBPJ
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBPJ
Sources for RBPJ Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB