The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016] See more...

Aliases for RBP7 Gene

Aliases for RBP7 Gene

  • Retinol Binding Protein 7 2 3 5
  • Cellular Retinoic Acid-Binding Protein IV 3 4
  • Cellular Retinoic Acid-Binding Protein 4 3 4
  • Retinol Binding Protein 7, Cellular 2 3
  • Cellular Retinol Binding Protein 7 2 3
  • Retinoid-Binding Protein 7 3 4
  • CRABP4 3 4
  • CRBPIV 2 3
  • CRBP4 3 4
  • Putative Cellular Retinol-Binding Protein CRBP IV 3
  • CRABP-IV 4
  • RBP7 5

External Ids for RBP7 Gene

Previous GeneCards Identifiers for RBP7 Gene

  • GC01P010018
  • GC01P009767
  • GC01P009991
  • GC01P009979
  • GC01P010057
  • GC01P009212

Summaries for RBP7 Gene

Entrez Gene Summary for RBP7 Gene

  • The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016]

GeneCards Summary for RBP7 Gene

RBP7 (Retinol Binding Protein 7) is a Protein Coding gene. Among its related pathways are Vitamin A and Carotenoid Metabolism and Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include transporter activity and retinol binding. An important paralog of this gene is RBP2.

UniProtKB/Swiss-Prot Summary for RBP7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBP7 Gene

Genomics for RBP7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBP7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBP7

Top Transcription factor binding sites by QIAGEN in the RBP7 gene promoter:
  • AREB6
  • ATF
  • Elk-1
  • HEN1
  • Msx-1
  • NCX
  • NF-1
  • Pax-5
  • PPAR-alpha
  • YY1

Genomic Locations for RBP7 Gene

Latest Assembly
chr1:9,997,206-10,016,021
(GRCh38/hg38)
Size:
18,816 bases
Orientation:
Plus strand

Previous Assembly
chr1:10,057,286-10,076,079
(GRCh37/hg19 by Entrez Gene)
Size:
18,794 bases
Orientation:
Plus strand

chr1:10,057,264-10,076,078
(GRCh37/hg19 by Ensembl)
Size:
18,815 bases
Orientation:
Plus strand

Genomic View for RBP7 Gene

Genes around RBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP7 Gene

Proteins for RBP7 Gene

  • Protein details for RBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R05-RET7_HUMAN
    Recommended name:
    Retinoid-binding protein 7
    Protein Accession:
    Q96R05
    Secondary Accessions:
    • B2R517
    • Q5SWJ4

    Protein attributes for RBP7 Gene

    Size:
    134 amino acids
    Molecular mass:
    15536 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP7 Gene

neXtProt entry for RBP7 Gene

Post-translational modifications for RBP7 Gene

No Post-translational modifications

Other Protein References for RBP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBP7 Gene

Domains & Families for RBP7 Gene

Gene Families for RBP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBP7 Gene

InterPro:
Blocks:
  • Cytosolic fatty-acid binding protein

Suggested Antigen Peptide Sequences for RBP7 Gene

GenScript: Design optimal peptide antigens:
  • RBP7 protein (Q8N4L3_HUMAN)
  • Cellular retinoic acid-binding protein IV (RET7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96R05

UniProtKB/Swiss-Prot:

RET7_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP7: view

Function for RBP7 Gene

Molecular function for RBP7 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Phenotypes From GWAS Catalog for RBP7 Gene

Gene Ontology (GO) - Molecular Function for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005501 retinoid binding IEA --
GO:0005515 protein binding IPI 25814554
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP7: view
genes like me logo Genes that share phenotypes with RBP7: view

Animal Models for RBP7 Gene

MGI Knock Outs for RBP7:

Animal Models for research

  • Taconic Biosciences Mouse Models for RBP7

miRNA for RBP7 Gene

miRTarBase miRNAs that target RBP7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBP7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBP7 Gene

Localization for RBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBP7 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RBP7: view

Pathways & Interactions for RBP7 Gene

PathCards logo

SuperPathways for RBP7 Gene

SuperPathway Contained pathways
1 Visual Cycle in Retinal Rods
-
2 Vitamin A and Carotenoid Metabolism
genes like me logo Genes that share pathways with RBP7: view

Pathways by source for RBP7 Gene

1 BioSystems pathway for RBP7 Gene
1 Qiagen pathway for RBP7 Gene
  • Visual Cycle in Retinal Rods

Gene Ontology (GO) - Biological Process for RBP7 Gene

None

No data available for SIGNOR curated interactions for RBP7 Gene

Drugs & Compounds for RBP7 Gene

(1) Drugs for RBP7 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Carrier, binder 747
genes like me logo Genes that share compounds with RBP7: view

Transcripts for RBP7 Gene

mRNA/cDNA for RBP7 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBP7

Alternative Splicing Database (ASD) splice patterns (SP) for RBP7 Gene

No ASD Table

Relevant External Links for RBP7 Gene

GeneLoc Exon Structure for
RBP7

Expression for RBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBP7 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.0), Adipose - Subcutaneous (x7.1), and Breast - Mammary Tissue (x6.6).

Protein differential expression in normal tissues from HIPED for RBP7 Gene

This gene is overexpressed in Adrenal (42.6) and Nasopharynx (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBP7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBP7

SOURCE GeneReport for Unigene cluster for RBP7 Gene:

Hs.422688

mRNA Expression by UniProt/SwissProt for RBP7 Gene:

Q96R05-RET7_HUMAN
Tissue specificity: Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.

Evidence on tissue expression from TISSUES for RBP7 Gene

  • Nervous system(4.4)
  • Pancreas(4.1)
  • Heart(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with RBP7: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBP7 Gene

Orthologs for RBP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RBP7 29 30
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RBP7 29 30
  • 90.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RBP7 29 30
  • 90.55 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rbp7 29 16 30
  • 87.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rbp7 29
  • 85.57 (n)
Oppossum
(Monodelphis domestica)
Mammalia RBP7 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RBP7 29 30
  • 75.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RBP7 30
  • 66 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rbp7b 29 30
  • 69.9 (n)
OneToMany
rbp7a 30
  • 59 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9113 29
Species where no ortholog for RBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RBP7 Gene

ENSEMBL:
Gene Tree for RBP7 (if available)
TreeFam:
Gene Tree for RBP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBP7: view image
Alliance of Genome Resources:
Additional Orthologs for RBP7

Paralogs for RBP7 Gene

genes like me logo Genes that share paralogs with RBP7: view

Variants for RBP7 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RBP7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RBP7 Gene

Variant ID Type Subtype PubMed ID
esv2664618 CNV deletion 23128226
esv2667343 CNV deletion 23128226
esv2671412 CNV deletion 23128226
esv3336969 CNV insertion 20981092
esv3585192 CNV loss 21293372
esv3585193 CNV loss 21293372
esv3585194 CNV loss 21293372
nsv1001742 CNV gain 25217958

Variation tolerance for RBP7 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBP7
Leiden Open Variation Database (LOVD)
RBP7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBP7 Gene

Disorders for RBP7 Gene

Additional Disease Information for RBP7

No disorders were found for RBP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBP7 Gene

Publications for RBP7 Gene

  1. Ligand binding and structural analysis of a human putative cellular retinol-binding protein. (PMID: 12177003) Folli C … Berni R (The Journal of biological chemistry 2002) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3

Products for RBP7 Gene

Sources for RBP7 Gene