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Aliases for RBP5 Gene

Aliases for RBP5 Gene

  • Retinol Binding Protein 5 2 3 5
  • Cellular Retinol-Binding Protein III 3 4
  • CRBP-III 3 4
  • HRBPiso 3 4
  • Putative Cellular Retinol-Binding Protein CRBP III 3
  • Retinol-Binding Protein 5, Cellular 2
  • Retinol Binding Protein 5, Cellular 3
  • Retinol-Binding Protein 5 3
  • CRBP3 3

External Ids for RBP5 Gene

Previous GeneCards Identifiers for RBP5 Gene

  • GC12M007234
  • GC12M007403
  • GC12M007176
  • GC12M007167
  • GC12M007089
  • GC12M007276

Summaries for RBP5 Gene

Entrez Gene Summary for RBP5 Gene

  • The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]

GeneCards Summary for RBP5 Gene

RBP5 (Retinol Binding Protein 5) is a Protein Coding gene. Diseases associated with RBP5 include Total Anomalous Pulmonary Venous Return 1 and Hepatocellular Carcinoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and the visual cycle I (vertebrates). Gene Ontology (GO) annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is RBP1.

UniProtKB/Swiss-Prot for RBP5 Gene

  • Intracellular transport of retinol.

Additional gene information for RBP5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP5 Gene

Genomics for RBP5 Gene

GeneHancer (GH) Regulatory Elements for RBP5 Gene

Promoters and enhancers for RBP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I007127 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 557.5 +0.1 131 5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YBX1 YY1 POLR2B FOS SP3 CLSTN3 ENSG00000256967 RBP5 ENSG00000219410 PEX5 ZNF384 NCAPD2 SPSB2 ENSG00000247853 CHD4
GH12I007188 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.7 -59.3 -59264 2.9 HDGF PKNOX1 ATF1 FOXA2 ZNF133 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PEX5 LOC105369639 ZNF384 ENSG00000247853 NOP2 ENSG00000219410 NCAPD2 CHD4 SPSB2 SCARNA12
GH12I006923 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 +203.1 203085 6.8 HDGF SMAD1 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF143 FOS ATN1 ZNF384 LRRC23 CHD4 ENSG00000219410 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5
GH12I007162 Enhancer 0.7 ENCODE 11.6 -32.6 -32594 0.2 CTCF PKNOX1 KLF17 SIN3A REST ELF1 ZEB2 RAD21 RFX5 YY1 RBP5 CLSTN3 ENSG00000256967 RNU6-485P C1RL-AS1 PEX5
GH12I007155 Enhancer 0.6 ENCODE 12.1 -25.1 -25104 0.2 GATA3 CREB1 MAX DPF2 ELF1 FOS CUX1 CHD2 ENSG00000256967 RBP5 CLSTN3 EMG1 PHB2 SCARNA12 PEX5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBP5 gene promoter:

Genomic Locations for RBP5 Gene

Genomic Locations for RBP5 Gene
11,163 bases
Minus strand

Genomic View for RBP5 Gene

Genes around RBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP5 Gene

Proteins for RBP5 Gene

  • Protein details for RBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • Q53FB1

    Protein attributes for RBP5 Gene

    135 amino acids
    Molecular mass:
    15931 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP5 Gene

neXtProt entry for RBP5 Gene

Post-translational modifications for RBP5 Gene

No Post-translational modifications

Other Protein References for RBP5 Gene

No data available for DME Specific Peptides for RBP5 Gene

Domains & Families for RBP5 Gene

Gene Families for RBP5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RBP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP5: view

Function for RBP5 Gene

Molecular function for RBP5 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.

Gene Ontology (GO) - Molecular Function for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005501 retinoid binding TAS 11274389
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP5: view
genes like me logo Genes that share phenotypes with RBP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBP5 Gene

Localization for RBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBP5 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with RBP5: view

Pathways & Interactions for RBP5 Gene

genes like me logo Genes that share pathways with RBP5: view

Interacting Proteins for RBP5 Gene

Gene Ontology (GO) - Biological Process for RBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RBP5: view

No data available for SIGNOR curated interactions for RBP5 Gene

Drugs & Compounds for RBP5 Gene

(1) Drugs for RBP5 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Carrier 529
genes like me logo Genes that share compounds with RBP5: view

Transcripts for RBP5 Gene

Unigene Clusters for RBP5 Gene

Retinol binding protein 5, cellular:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: -

Relevant External Links for RBP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBP5 Gene

mRNA differential expression in normal tissues according to GTEx for RBP5 Gene

This gene is overexpressed in Kidney - Cortex (x22.2), Liver (x13.0), and Spleen (x5.4).

Protein differential expression in normal tissues from HIPED for RBP5 Gene

This gene is overexpressed in Kidney (30.1) and Spleen (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBP5 Gene:


SOURCE GeneReport for Unigene cluster for RBP5 Gene:


mRNA Expression by UniProt/SwissProt for RBP5 Gene:

Tissue specificity: Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level).

Evidence on tissue expression from TISSUES for RBP5 Gene

  • Liver(4.6)
  • Kidney(4.5)
  • Spleen(4.4)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with RBP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBP5 Gene

Orthologs for RBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBP5 33 34
  • 99.01 (n)
(Canis familiaris)
Mammalia RBP5 33 34
  • 89.14 (n)
(Bos Taurus)
Mammalia RBP5 33 34
  • 86.91 (n)
(Gallus gallus)
Aves RBP5 33 34
  • 68.4 (n)
(Anolis carolinensis)
Reptilia RBP5 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp5 33
  • 67.91 (n)
(Danio rerio)
Actinopterygii rbp1a 34
  • 50 (a)
Species where no ortholog for RBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP5 Gene

Gene Tree for RBP5 (if available)
Gene Tree for RBP5 (if available)

Paralogs for RBP5 Gene

Paralogs for RBP5 Gene

(13) SIMAP similar genes for RBP5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBP5: view

Variants for RBP5 Gene

Sequence variations from dbSNP and Humsavar for RBP5 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000269680 -- 7,120,098(-) C/ genic_downstream_transcript_variant, intron_variant
rs1000324504 -- 7,126,381(-) A/G intron_variant
rs1000461829 -- 7,126,598(-) A/G intron_variant
rs1000528676 -- 7,120,359(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000595062 -- 7,121,725(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBP5 Gene

Variant ID Type Subtype PubMed ID
nsv473997 CNV novel sequence insertion 20440878
nsv476400 CNV novel sequence insertion 20440878
nsv479883 CNV novel sequence insertion 20440878
nsv480239 CNV novel sequence insertion 20440878
nsv818882 CNV gain 17921354

Variation tolerance for RBP5 Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.62; 95.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBP5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBP5 Gene

Disorders for RBP5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBP5 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RBP5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBP5

genes like me logo Genes that share disorders with RBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBP5 Gene

Publications for RBP5 Gene

  1. Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. (PMID: 11274389) Folli C … Berni R (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
  2. Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma. (PMID: 17497168) Ho JC … Fan ST (Journal of cancer research and clinical oncology 2007) 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer. (PMID: 24793694) Kim JY … Chakravarti D (Molecular cell 2014) 3 58

Products for RBP5 Gene

Sources for RBP5 Gene

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