Aliases for RBP4 Gene
External Ids for RBP4 Gene
Previous GeneCards Identifiers for RBP4 Gene
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for RBP4 Gene
RBP4 (Retinol Binding Protein 4) is a Protein Coding gene. Diseases associated with RBP4 include Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome and Microphthalmia, Isolated, With Coloboma 10. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and retinol binding.
UniProtKB/Swiss-Prot Summary for RBP4 Gene
Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).