This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial... See more...

Aliases for RBP2 Gene

Aliases for RBP2 Gene

  • Retinol Binding Protein 2 2 3 5
  • CRBP2 2 3 4
  • Cellular Retinol-Binding Protein II 3 4
  • Retinol-Binding Protein 2 3 4
  • CRABP-II 2 3
  • CRBP-II 3 4
  • CRBPII 2 3
  • RBPC2 2 3
  • Retinol-Binding Protein 2, Cellular 2
  • Retinol Binding Protein 2, Cellular 3
  • RBP2 5

External Ids for RBP2 Gene

Previous GeneCards Identifiers for RBP2 Gene

  • GC03M136069
  • GC03M140000
  • GC03M140453
  • GC03M140492
  • GC03M140654
  • GC03M139171
  • GC03M136547

Summaries for RBP2 Gene

Entrez Gene Summary for RBP2 Gene

  • This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]

GeneCards Summary for RBP2 Gene

RBP2 (Retinol Binding Protein 2) is a Protein Coding gene. Diseases associated with RBP2 include Prolapse Of Urethra. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is RBP7.

UniProtKB/Swiss-Prot Summary for RBP2 Gene

Gene Wiki entry for RBP2 Gene

Additional gene information for RBP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBP2 Gene

Genomics for RBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J139471 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.4 +5.6 5595 6.9 JUND NR2C1 ATF7 EP300 ESR1 NFE2 NR2C2 TRIM24 FOSL1 NR2F1 RBP2 ENSG00000272656 ACTG1P1 MRPS22 piR-41696 COPB2 ENSG00000248932 LOC100507291
GH03J139480 Promoter/Enhancer 0.5 EPDnew Ensembl 600.7 -0.3 -254 0.8 RBP2 ACTG1P1 RBP1 ENSG00000248932 LOC100507291
GH03J139531 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.2 -55.9 -55855 10.7 PRDM10 ZNF629 RFX1 ZNF692 ZIC2 PKNOX1 POLR2A PATZ1 SP1 ZNF600 RBP1 COPB2 ENSG00000272656 ENSG00000248932 MRPS22 lnc-RBP1-1 RBP2 LOC100507291
GH03J139519 Enhancer 0.9 Ensembl ENCODE 0.3 -40.2 -40216 2.9 CTCF ATF7 JUND REST MNT MGA CBX3 CTBP1 POLR2A ZBTB17 ENSG00000272656 RBP1 ACTG1P1 lnc-RBP1-1 RBP2 ENSG00000248932 LOC100507291
GH03J139434 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.3 +46.0 46001 2.3 RFX1 CEBPB CTCF MAX CEBPG MAFK SMARCA4 MAFF MNT ZNF83 ENSG00000272656 MRPS22 ACTG1P1 piR-46854 LOC100507291 ENSG00000248932 RBP2 COPB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBP2

Top Transcription factor binding sites by QIAGEN in the RBP2 gene promoter:
  • AML1a
  • GATA-3
  • GCNF
  • GCNF-1
  • GCNF-2
  • GR
  • GR-alpha
  • POU2F1
  • POU2F1a
  • XBP-1

Genomic Locations for RBP2 Gene

Genomic Locations for RBP2 Gene
chr3:139,452,884-139,480,747
(GRCh38/hg38)
Size:
27,864 bases
Orientation:
Minus strand
chr3:139,171,726-139,199,589
(GRCh37/hg19)
Size:
27,864 bases
Orientation:
Minus strand

Genomic View for RBP2 Gene

Genes around RBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP2 Gene

Proteins for RBP2 Gene

  • Protein details for RBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50120-RET2_HUMAN
    Recommended name:
    Retinol-binding protein 2
    Protein Accession:
    P50120
    Secondary Accessions:
    • A8K7G3
    • Q6ISQ9
    • Q6ISS7

    Protein attributes for RBP2 Gene

    Size:
    134 amino acids
    Molecular mass:
    15707 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBP2 Gene

neXtProt entry for RBP2 Gene

Post-translational modifications for RBP2 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for RBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBP2 Gene

Domains & Families for RBP2 Gene

Gene Families for RBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for RBP2 Gene

InterPro:
Blocks:
  • Cytosolic fatty-acid binding protein
ProtoNet:

Suggested Antigen Peptide Sequences for RBP2 Gene

GenScript: Design optimal peptide antigens:
  • RBP2 protein (Q6ISL4_HUMAN)
  • Cellular retinol-binding protein II (RET2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50120

UniProtKB/Swiss-Prot:

RET2_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP2: view

Function for RBP2 Gene

Molecular function for RBP2 Gene

UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol.
GENATLAS Biochemistry:
retinol binding protein 2,cellular (lipocalin family,Kernel group),monomer,involved in the transport of vitamin A in the small intestinal epithelium

Gene Ontology (GO) - Molecular Function for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005501 retinoid binding TAS 7657783
GO:0008289 lipid binding IEA --
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP2: view
genes like me logo Genes that share phenotypes with RBP2: view

Animal Models for RBP2 Gene

MGI Knock Outs for RBP2:

Animal Model Products

CRISPR Products

miRNA for RBP2 Gene

miRTarBase miRNAs that target RBP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBP2 Gene

Localization for RBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBP2 gene
Compartment Confidence
cytosol 5
extracellular 2
peroxisome 2
nucleus 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with RBP2: view

Pathways & Interactions for RBP2 Gene

genes like me logo Genes that share pathways with RBP2: view

Gene Ontology (GO) - Biological Process for RBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006776 vitamin A metabolic process TAS 2992469
GO:0008544 epidermis development TAS 1654334
genes like me logo Genes that share ontologies with RBP2: view

No data available for SIGNOR curated interactions for RBP2 Gene

Drugs & Compounds for RBP2 Gene

(3) Drugs for RBP2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Carrier, binder 685
Beta carotene Approved Nutra Carrier, substrate 72

(8) Additional Compounds for RBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RBP2: view

Transcripts for RBP2 Gene

mRNA/cDNA for RBP2 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBP2

Alternative Splicing Database (ASD) splice patterns (SP) for RBP2 Gene

No ASD Table

Relevant External Links for RBP2 Gene

GeneLoc Exon Structure for
RBP2

Expression for RBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBP2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x51.1).

Protein differential expression in normal tissues from HIPED for RBP2 Gene

This gene is overexpressed in Fetal gut (59.0) and Pancreatic juice (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBP2 Gene



Protein tissue co-expression partners for RBP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBP2

SOURCE GeneReport for Unigene cluster for RBP2 Gene:

Hs.655516

mRNA Expression by UniProt/SwissProt for RBP2 Gene:

P50120-RET2_HUMAN
Tissue specificity: Higher expression in adult small intestine and to a much lesser extent in fetal kidney.

Evidence on tissue expression from TISSUES for RBP2 Gene

  • Intestine(4.7)
  • Liver(2.4)
  • Nervous system(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with RBP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RBP2 Gene

Orthologs for RBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RBP2 30 31
  • 99.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RBP2 30 31
  • 89.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RBP2 30 31
  • 88.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rbp2 30
  • 87.06 (n)
Mouse
(Mus musculus)
Mammalia Rbp2 30 17 31
  • 86.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RBP2 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RBP2 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RBP2 30 31
  • 72.89 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RBP2 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rbp2 30
  • 74.38 (n)
Str.15607 30
Zebrafish
(Danio rerio)
Actinopterygii rbp2a 30 31
  • 74.13 (n)
OneToOne
rbp2 30
Species where no ortholog for RBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RBP2 Gene

ENSEMBL:
Gene Tree for RBP2 (if available)
TreeFam:
Gene Tree for RBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBP2: view image

Paralogs for RBP2 Gene

(14) SIMAP similar genes for RBP2 Gene using alignment to 4 proteins:

  • RET2_HUMAN
  • D6RB89_HUMAN
  • D6RGE6_HUMAN
  • Q6ISL4_HUMAN
genes like me logo Genes that share paralogs with RBP2: view

Variants for RBP2 Gene

Additional dbSNP identifiers (rs#s) for RBP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBP2 Gene

Variant ID Type Subtype PubMed ID
nsv1000519 CNV loss 25217958
nsv1001460 CNV gain 25217958
nsv476594 CNV novel sequence insertion 20440878

Variation tolerance for RBP2 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBP2 Gene

Disorders for RBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prolapse of urethra
  • urethrocele
- elite association - COSMIC cancer census association via MalaCards
Search RBP2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBP2 Gene

Publications for RBP2 Gene

  1. Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution. (PMID: 18076076) Tarter M … Monaco HL (Proteins 2008) 3 4 23
  2. Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization. (PMID: 10072590) De Baere E … Messiaen L (Cytogenetics and cell genetics 1998) 2 3 23
  3. Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. (PMID: 7657783) Loughney AD … Redfern CP (Human reproduction (Oxford, England) 1995) 2 3 4
  4. Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells. (PMID: 19147806) Yamaguchi N … Suruga K (American journal of physiology. Gastrointestinal and liver physiology 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RBP2 Gene

Sources for RBP2 Gene