This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these relate... See more...

Aliases for RBMY1J Gene

Aliases for RBMY1J Gene

  • RNA Binding Motif Protein Y-Linked Family 1 Member J 2 3 5
  • RNA-Binding Motif Protein, Y Chromosome, Family 1 Member F/J 3 4
  • Y Chromosome RNA Recognition Motif 2 3 4
  • RNA Binding Motif Protein, Y-Linked, Family 1, Member J 2
  • RBMY1J 5
  • YRRM2 4

External Ids for RBMY1J Gene

Previous GeneCards Identifiers for RBMY1J Gene

  • GC0YU900273
  • GC0YP022959
  • GC0YP022866
  • GC0YP024456
  • GC0YP022309

Summaries for RBMY1J Gene

Entrez Gene Summary for RBMY1J Gene

  • This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]

GeneCards Summary for RBMY1J Gene

RBMY1J (RNA Binding Motif Protein Y-Linked Family 1 Member J) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMY1F.

UniProtKB/Swiss-Prot Summary for RBMY1J Gene

  • RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Additional gene information for RBMY1J Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBMY1J Gene

Genomics for RBMY1J Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBMY1J Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YJ022441 Promoter 0.3 EPDnew 0.3 +38.1 38102 0.1 TTTY6 ENSG00000235059 LOC101929148 RBMY1J PRY
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBMY1J on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBMY1J

Top Transcription factor binding sites by QIAGEN in the RBMY1J gene promoter:
  • POU2F1
  • POU2F1a

Genomic Locations for RBMY1J Gene

Genomic Locations for RBMY1J Gene
chrY:22,403,410-22,419,317
(GRCh38/hg38)
Size:
15,908 bases
Orientation:
Plus strand
chrY:24,454,970-24,564,028
(GRCh37/hg19)
Size:
109,059 bases
Orientation:
Plus strand

Genomic View for RBMY1J Gene

Genes around RBMY1J on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMY1J Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMY1J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMY1J Gene

Proteins for RBMY1J Gene

  • Protein details for RBMY1J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15415-RBY1F_HUMAN
    Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member F/J
    Protein Accession:
    Q15415
    Secondary Accessions:
    • B2R916

    Protein attributes for RBMY1J Gene

    Size:
    496 amino acids
    Molecular mass:
    55728 Da
    Quaternary structure:
    • Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
    Miscellaneous:
    • The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

    Alternative splice isoforms for RBMY1J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBMY1J Gene

Post-translational modifications for RBMY1J Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMY1J Gene

No data available for DME Specific Peptides for RBMY1J Gene

Domains & Families for RBMY1J Gene

Gene Families for RBMY1J Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBMY1J Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • RBM1CTR
ProtoNet:

Suggested Antigen Peptide Sequences for RBMY1J Gene

GenScript: Design optimal peptide antigens:
  • Y chromosome RNA recognition motif 2 (RBY1F_HUMAN)
genes like me logo Genes that share domains with RBMY1J: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RBMY1J Gene

Function for RBMY1J Gene

Molecular function for RBMY1J Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.

Gene Ontology (GO) - Molecular Function for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,NAS 8269511
GO:0005515 protein binding IPI 21516116
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBMY1J: view
genes like me logo Genes that share phenotypes with RBMY1J: view

Animal Model Products

CRISPR Products

miRNA for RBMY1J Gene

miRTarBase miRNAs that target RBMY1J

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBMY1J

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMY1J Gene

Localization for RBMY1J Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMY1J Gene

Gene Ontology (GO) - Cellular Components for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
GO:0016607 nuclear speck IBA 21873635
genes like me logo Genes that share ontologies with RBMY1J: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for RBMY1J Gene

Pathways & Interactions for RBMY1J Gene

PathCards logo

SuperPathways for RBMY1J Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMY1J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA 21873635
GO:0006397 mRNA processing IEA --
GO:0007283 spermatogenesis NAS 8269511
GO:0008380 RNA splicing IEA --
GO:0045292 mRNA cis splicing, via spliceosome IBA 21873635
genes like me logo Genes that share ontologies with RBMY1J: view

No data available for Pathways by source and SIGNOR curated interactions for RBMY1J Gene

Drugs & Compounds for RBMY1J Gene

No Compound Related Data Available

Transcripts for RBMY1J Gene

mRNA/cDNA for RBMY1J Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBMY1J

Alternative Splicing Database (ASD) splice patterns (SP) for RBMY1J Gene

No ASD Table

Relevant External Links for RBMY1J Gene

GeneLoc Exon Structure for
RBMY1J

Expression for RBMY1J Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBMY1J Gene

mRNA differential expression in normal tissues according to GTEx for RBMY1J Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for RBMY1J Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RBMY1J Gene



Protein tissue co-expression partners for RBMY1J Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBMY1J

mRNA Expression by UniProt/SwissProt for RBMY1J Gene:

Q15415-RBY1F_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with RBMY1J: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMY1J Gene

Orthologs for RBMY1J Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMY1J Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC736145 30
  • 97.24 (n)
-- 31
  • 95 (a)
ManyToMany
-- 31
  • 95 (a)
ManyToMany
-- 31
  • 95 (a)
ManyToMany
-- 31
  • 94 (a)
ManyToMany
-- 31
  • 94 (a)
ManyToMany
-- 31
  • 94 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 56 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia RBMX 31
  • 52 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm3376 31
  • 42 (a)
ManyToMany
Gm21708 31
  • 41 (a)
ManyToMany
Gm21704 31
  • 41 (a)
ManyToMany
Gm21677 31
  • 41 (a)
ManyToMany
Gm21693 31
  • 41 (a)
ManyToMany
Rbmy 31
  • 41 (a)
ManyToMany
Gm10352 31
  • 41 (a)
ManyToMany
Gm10256 31
  • 41 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves RBMX 31
  • 62 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii rbmx 31
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta tra2 31
  • 15 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rsp-8 31
  • 19 (a)
OneToMany
Species where no ortholog for RBMY1J was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RBMY1J Gene

ENSEMBL:
Gene Tree for RBMY1J (if available)
TreeFam:
Gene Tree for RBMY1J (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBMY1J: view image

Paralogs for RBMY1J Gene

(20) SIMAP similar genes for RBMY1J Gene using alignment to 2 proteins:

  • RBY1F_HUMAN
  • J3KQ82_HUMAN
genes like me logo Genes that share paralogs with RBMY1J: view

Variants for RBMY1J Gene

Additional dbSNP identifiers (rs#s) for RBMY1J Gene

Structural Variations from Database of Genomic Variants (DGV) for RBMY1J Gene

Variant ID Type Subtype PubMed ID
esv2758908 CNV gain+loss 17122850
nsv10029 CNV gain 18304495
nsv10031 CNV gain 18304495
nsv1078162 CNV duplication 25765185
nsv1115940 CNV duplication 24896259
nsv1125161 CNV duplication 24896259
nsv1149864 CNV duplication 26484159

Additional Variant Information for RBMY1J Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBMY1J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for RBMY1J Gene

Disorders for RBMY1J Gene

Additional Disease Information for RBMY1J

No disorders were found for RBMY1J Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMY1J Gene

Publications for RBMY1J Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 2 3 4
  2. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (PMID: 8269511) Ma K … Taylor K (Cell 1993) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3

Products for RBMY1J Gene

Sources for RBMY1J Gene