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Aliases for RBMXL3 Gene

Aliases for RBMXL3 Gene

  • RNA Binding Motif Protein, X-Linked Like 3 2 3 5
  • CXorf55 3 4
  • RNA-Binding Motif Protein, X-Linked-Like-3 3
  • Chromosome X Open Reading Frame 55 2

External Ids for RBMXL3 Gene

Previous HGNC Symbols for RBMXL3 Gene

  • CXorf55

Previous GeneCards Identifiers for RBMXL3 Gene

  • GC0XP114330
  • GC0XP114423
  • GC0XP104008

Summaries for RBMXL3 Gene

GeneCards Summary for RBMXL3 Gene

RBMXL3 (RNA Binding Motif Protein, X-Linked Like 3) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMXL2.

Additional gene information for RBMXL3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMXL3 Gene

Genomics for RBMXL3 Gene

GeneHancer (GH) Regulatory Elements for RBMXL3 Gene

Promoters and enhancers for RBMXL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI115189 Promoter 0.7 EPDnew 550.8 0.0 -9 0.1 MAFK ATF2 RBMXL3 GC0XM115147 LRCH2 GC0XM115140 ENSG00000212241
GH0XI114772 Enhancer 0.2 FANTOM5 1.9 -416.3 -416309 0.3 RBMXL3 HSPA8P7 GC0XP114765 LOC105373313 HTR2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBMXL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBMXL3 gene promoter:

Genomic Locations for RBMXL3 Gene

Genomic Locations for RBMXL3 Gene
3,469 bases
Plus strand

Genomic View for RBMXL3 Gene

Genes around RBMXL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMXL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMXL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMXL3 Gene

Proteins for RBMXL3 Gene

  • Protein details for RBMXL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif protein, X-linked-like-3
    Protein Accession:
    Secondary Accessions:
    • B4DXC0

    Protein attributes for RBMXL3 Gene

    1067 amino acids
    Molecular mass:
    114938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBMXL3 Gene

Post-translational modifications for RBMXL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBMXL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBMXL3 Gene

Domains & Families for RBMXL3 Gene

Gene Families for RBMXL3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBMXL3 Gene


Suggested Antigen Peptide Sequences for RBMXL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBMXL3: view

No data available for UniProtKB/Swiss-Prot for RBMXL3 Gene

Function for RBMXL3 Gene

Gene Ontology (GO) - Molecular Function for RBMXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBMXL3: view

Phenotypes for RBMXL3 Gene

GenomeRNAi human phenotypes for RBMXL3:
genes like me logo Genes that share phenotypes with RBMXL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBMXL3 Gene

Localization for RBMXL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMXL3 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RBMXL3 Gene

Pathways & Interactions for RBMXL3 Gene

SuperPathways for RBMXL3 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RBMXL3: view

Pathways by source for RBMXL3 Gene

1 KEGG pathway for RBMXL3 Gene

Interacting Proteins for RBMXL3 Gene

Gene Ontology (GO) - Biological Process for RBMXL3 Gene


No data available for SIGNOR curated interactions for RBMXL3 Gene

Drugs & Compounds for RBMXL3 Gene

No Compound Related Data Available

Transcripts for RBMXL3 Gene

mRNA/cDNA for RBMXL3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMXL3 Gene

RNA binding motif protein, X-linked-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMXL3 Gene

No ASD Table

Relevant External Links for RBMXL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMXL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMXL3 Gene

mRNA differential expression in normal tissues according to GTEx for RBMXL3 Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for RBMXL3 Gene

This gene is overexpressed in Heart (45.1), Adipocyte (11.0), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBMXL3 Gene

Protein tissue co-expression partners for RBMXL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMXL3 Gene:


SOURCE GeneReport for Unigene cluster for RBMXL3 Gene:

genes like me logo Genes that share expression patterns with RBMXL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMXL3 Gene

Orthologs for RBMXL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMXL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBMXL3 34
  • 93 (a)
(Bos Taurus)
Mammalia RBMX 34
  • 64 (a)
(Mus musculus)
Mammalia Rbmxl2 34
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Gallus gallus)
Aves RBMX 34
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
(Danio rerio)
Actinopterygii rbmx 34
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta tra2 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea rsp-8 34
  • 18 (a)
Species where no ortholog for RBMXL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMXL3 Gene

Gene Tree for RBMXL3 (if available)
Gene Tree for RBMXL3 (if available)

Paralogs for RBMXL3 Gene

(7) SIMAP similar genes for RBMXL3 Gene using alignment to 1 proteins: Pseudogenes for RBMXL3 Gene

genes like me logo Genes that share paralogs with RBMXL3: view

Variants for RBMXL3 Gene

Sequence variations from dbSNP and Humsavar for RBMXL3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000843178 -- 115,189,944(+) C/G/T coding_sequence_variant, missense_variant
rs1002469427 -- 115,190,100(+) G/A coding_sequence_variant, missense_variant
rs1002926891 -- 115,191,727(+) G/C/T coding_sequence_variant, synonymous_variant
rs1005511741 -- 115,191,115(+) C/T coding_sequence_variant, synonymous_variant
rs1005667785 -- 115,193,157(+) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RBMXL3 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV gain+loss 17666407
nsv520351 CNV gain 19592680

Variation tolerance for RBMXL3 Gene

Gene Damage Index Score: 5.54; 72.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBMXL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMXL3 Gene

Disorders for RBMXL3 Gene

Additional Disease Information for RBMXL3

No disorders were found for RBMXL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMXL3 Gene

Publications for RBMXL3 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  4. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PMID: 22678362) Stehling O … Lill R (Science (New York, N.Y.) 2012) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for RBMXL3 Gene

Sources for RBMXL3 Gene

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