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Aliases for RBMXL2 Gene

Aliases for RBMXL2 Gene

  • RNA Binding Motif Protein, X-Linked Like 2 2 3 5
  • Testis-Specific Heterogeneous Nuclear Ribonucleoprotein G-T 3 4
  • Heterogeneous Nuclear Ribonucleoprotein G T 2 3
  • HnRNP G-T 3 4
  • HNRNPGT 3 4
  • Testes-Specific Heterogenous Nuclear Ribonucleoprotein G-T 3
  • RNA-Binding Motif Protein, X-Linked-Like-2 3
  • HNRNPG-T 3
  • HNRPGT 3

External Ids for RBMXL2 Gene

Previous GeneCards Identifiers for RBMXL2 Gene

  • GC11P006768

Summaries for RBMXL2 Gene

Entrez Gene Summary for RBMXL2 Gene

  • This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMXL2 Gene

RBMXL2 (RNA Binding Motif Protein, X-Linked Like 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMX.

Additional gene information for RBMXL2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMXL2 Gene

Genomics for RBMXL2 Gene

GeneHancer (GH) Regulatory Elements for RBMXL2 Gene

Promoters and enhancers for RBMXL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I007089 Promoter 0.5 EPDnew 550.8 +0.1 139 0.1 RBMXL2 ENSG00000255179
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBMXL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBMXL2 gene promoter:

Genomic Locations for RBMXL2 Gene

Genomic Locations for RBMXL2 Gene
2,215 bases
Plus strand

Genomic View for RBMXL2 Gene

Genes around RBMXL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMXL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMXL2 Gene

Proteins for RBMXL2 Gene

  • Protein details for RBMXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif protein, X-linked-like-2
    Protein Accession:
    Secondary Accessions:
    • Q6PEZ2
    • Q9NQU0

    Protein attributes for RBMXL2 Gene

    392 amino acids
    Molecular mass:
    42814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBMXL2 Gene

Post-translational modifications for RBMXL2 Gene

No Post-translational modifications

Other Protein References for RBMXL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RBMXL2

No data available for DME Specific Peptides for RBMXL2 Gene

Domains & Families for RBMXL2 Gene

Gene Families for RBMXL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RBMXL2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBMXL2: view

No data available for UniProtKB/Swiss-Prot for RBMXL2 Gene

Function for RBMXL2 Gene

Phenotypes From GWAS Catalog for RBMXL2 Gene

Gene Ontology (GO) - Molecular Function for RBMXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBMXL2: view

Phenotypes for RBMXL2 Gene

genes like me logo Genes that share phenotypes with RBMXL2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RBMXL2 Gene

Localization for RBMXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMXL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMXL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBMXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with RBMXL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RBMXL2 Gene

Pathways & Interactions for RBMXL2 Gene

SuperPathways for RBMXL2 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RBMXL2: view

Pathways by source for RBMXL2 Gene

1 KEGG pathway for RBMXL2 Gene

Gene Ontology (GO) - Biological Process for RBMXL2 Gene


No data available for SIGNOR curated interactions for RBMXL2 Gene

Drugs & Compounds for RBMXL2 Gene

No Compound Related Data Available

Transcripts for RBMXL2 Gene

mRNA/cDNA for RBMXL2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBMXL2 Gene

RNA binding motif protein, X-linked-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMXL2 Gene

No ASD Table

Relevant External Links for RBMXL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMXL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMXL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBMXL2 Gene

This gene is overexpressed in Testis (x50.5).

Protein differential expression in normal tissues from HIPED for RBMXL2 Gene

This gene is overexpressed in Testis (18.4), Monocytes (15.2), Liver, secretome (13.6), Ovary (11.4), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBMXL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMXL2 Gene:


SOURCE GeneReport for Unigene cluster for RBMXL2 Gene:


mRNA Expression by UniProt/SwissProt for RBMXL2 Gene:

Tissue specificity: Expressed predominantly in spermatocytes and less in round spermatids (at protein level). Expressed in germ cells.

Evidence on tissue expression from TISSUES for RBMXL2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RBMXL2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMXL2 Gene

Orthologs for RBMXL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBMXL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBMXL2 33 34
  • 99.06 (n)
(Bos Taurus)
Mammalia RBMX 34
  • 82 (a)
(Mus musculus)
Mammalia Rbmxl2 33 16 34
  • 80.02 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
(Gallus gallus)
Aves RBMX 34
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 71 (a)
(Danio rerio)
Actinopterygii rbmx 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta tra2 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea rsp-8 34
  • 22 (a)
Species where no ortholog for RBMXL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBMXL2 Gene

Gene Tree for RBMXL2 (if available)
Gene Tree for RBMXL2 (if available)

Paralogs for RBMXL2 Gene

(16) SIMAP similar genes for RBMXL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RBMXL2: view

Variants for RBMXL2 Gene

Sequence variations from dbSNP and Humsavar for RBMXL2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001028849 -- 7,090,535(+) G/T 3_prime_UTR_variant
rs1001460031 -- 7,090,983(+) C/A 3_prime_UTR_variant
rs1001837288 -- 7,091,310(+) A/C/T downstream_transcript_variant
rs1003125008 -- 7,088,967(+) C/T 5_prime_UTR_variant
rs1003451031 -- 7,089,084(+) C/T 5_prime_UTR_variant

Variation tolerance for RBMXL2 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBMXL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBMXL2 Gene

Disorders for RBMXL2 Gene

Additional Disease Information for RBMXL2

No disorders were found for RBMXL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMXL2 Gene

Publications for RBMXL2 Gene

  1. An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene. (PMID: 10958650) Elliott DJ … Cooke HJ (Human molecular genetics 2000) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men. (PMID: 12389739) Maymon BB … Yavetz H (Acta histochemica 2002) 3 22 58
  4. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E … Raught B (Molecular & cellular proteomics : MCP 2015) 3 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for RBMXL2 Gene

Sources for RBMXL2 Gene

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