The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicate... See more...

Aliases for RBMS2 Gene

Aliases for RBMS2 Gene

  • RNA Binding Motif Single Stranded Interacting Protein 2 2 3 5
  • SCR3 2 3 4
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 2 3 4
  • Suppressor Of CDC2 With RNA-Binding Motif 3 3 4
  • RBMS2 5

External Ids for RBMS2 Gene

Previous GeneCards Identifiers for RBMS2 Gene

  • GC12P056808
  • GC12P057140
  • GC12P056632
  • GC12P055202
  • GC12P056915
  • GC12P053954
  • GC12P056523
  • GC12P056543
  • GC12P056563

Summaries for RBMS2 Gene

Entrez Gene Summary for RBMS2 Gene

  • The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMS2 Gene

RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2) is a Protein Coding gene. Diseases associated with RBMS2 include Cholesterol Embolism and Hemolytic Uremic Syndrome, Atypical 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBMS3.

Additional gene information for RBMS2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBMS2 Gene

Genomics for RBMS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBMS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J056519 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 635.2 +4.7 4710 11.3 CREB1 PRDM10 ZNF629 ZNF512 IKZF1 KDM1A ZNF692 FOXA1 PRDM1 ZNF143 RBMS2 SPRYD4 piR-32214-127 BAZ2A
GH12J056518 Enhancer 0.4 ENCODE 600.7 -1.8 -1795 1.2 FOXA1 SP1 FOXA2 FOSL2 RBMS2 piR-32285-018 SPRYD4 RPS26 SNORA105C GLS2
GH12J057109 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 48.7 +590.9 590895 4.2 ARHGAP35 CEBPG CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 IKZF1 STAT6 lnc-LRP1-4 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4
GH12J056520 Enhancer 0.2 ENCODE 600.7 -1.1 -1062 0.1 RBMS2 piR-32285-018 SNORA105C GLS2
GH12J056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 32.6 -478.3 -478341 3.5 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 REST ZNF629 TFE3 RPS26 ENSG00000257449 LOC105369780 NONHSAG011344.2 piR-36475-004 BAZ2A STAT2 PAN2 RN7SL809P ZC3H10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBMS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBMS2

Top Transcription factor binding sites by QIAGEN in the RBMS2 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NCX
  • NF-E2
  • Nkx6-1

Genomic Locations for RBMS2 Gene

Genomic Locations for RBMS2 Gene
chr12:56,520,406-56,596,193
(GRCh38/hg38)
Size:
75,788 bases
Orientation:
Plus strand
chr12:56,915,609-56,989,980
(GRCh37/hg19)
Size:
74,372 bases
Orientation:
Plus strand

Genomic View for RBMS2 Gene

Genes around RBMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMS2 Gene

Proteins for RBMS2 Gene

  • Protein details for RBMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15434-RBMS2_HUMAN
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 2
    Protein Accession:
    Q15434

    Protein attributes for RBMS2 Gene

    Size:
    407 amino acids
    Molecular mass:
    43959 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBMS2 Gene

neXtProt entry for RBMS2 Gene

Post-translational modifications for RBMS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBMS2 Gene

Domains & Families for RBMS2 Gene

Gene Families for RBMS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RBMS2 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for RBMS2 Gene

GenScript: Design optimal peptide antigens:
  • Suppressor of CDC2 with RNA-binding motif 3 (RBMS2_HUMAN)
genes like me logo Genes that share domains with RBMS2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RBMS2 Gene

Function for RBMS2 Gene

Phenotypes From GWAS Catalog for RBMS2 Gene

Gene Ontology (GO) - Molecular Function for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IBA 21873635
GO:0003730 mRNA 3'-UTR binding IBA 21873635
GO:0008143 poly(A) binding IBA 21873635
GO:0008266 poly(U) RNA binding IBA 21873635
genes like me logo Genes that share ontologies with RBMS2: view
genes like me logo Genes that share phenotypes with RBMS2: view

Animal Model Products

CRISPR Products

miRNA for RBMS2 Gene

miRTarBase miRNAs that target RBMS2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBMS2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMS2 Gene

Localization for RBMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMS2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:1990904 ribonucleoprotein complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with RBMS2: view

Pathways & Interactions for RBMS2 Gene

PathCards logo

SuperPathways for RBMS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8041632
genes like me logo Genes that share ontologies with RBMS2: view

No data available for Pathways by source and SIGNOR curated interactions for RBMS2 Gene

Drugs & Compounds for RBMS2 Gene

No Compound Related Data Available

Transcripts for RBMS2 Gene

mRNA/cDNA for RBMS2 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBMS2

Alternative Splicing Database (ASD) splice patterns (SP) for RBMS2 Gene

No ASD Table

Relevant External Links for RBMS2 Gene

GeneLoc Exon Structure for
RBMS2

Expression for RBMS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBMS2 Gene

This gene is overexpressed in Lung (40.7) and Islet of Langerhans (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBMS2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBMS2

SOURCE GeneReport for Unigene cluster for RBMS2 Gene:

Hs.505729

Evidence on tissue expression from TISSUES for RBMS2 Gene

  • Lung(4.5)
  • Skin(4.3)
  • Nervous system(2.5)
  • Kidney(2.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with RBMS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMS2 Gene

Orthologs for RBMS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBMS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RBMS2 30 31
  • 98.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RBMS2 30 31
  • 90.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RBMS2 30 31
  • 90.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rbms2 30
  • 87.07 (n)
Mouse
(Mus musculus)
Mammalia Rbms2 30 17 31
  • 86.02 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RBMS2 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RBMS2 31
  • 62 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RBMS2 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rbms2 30
  • 73.52 (n)
Zebrafish
(Danio rerio)
Actinopterygii rbms2b 31
  • 73 (a)
OneToMany
rbms2a 30 31
  • 71.87 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta shep 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea R10E4.2b 32
  • 57 (a)
R10E4.2a 32
  • 53 (a)
sup-26 31
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 31
  • 13 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1122 31
  • 42 (a)
OneToMany
Species where no ortholog for RBMS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RBMS2 Gene

ENSEMBL:
Gene Tree for RBMS2 (if available)
TreeFam:
Gene Tree for RBMS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBMS2: view image

Paralogs for RBMS2 Gene

(38) SIMAP similar genes for RBMS2 Gene using alignment to 6 proteins:

  • RBMS2_HUMAN
  • F5H5C8_HUMAN
  • F8VQS9_HUMAN
  • F8VV01_HUMAN
  • F8VZR4_HUMAN
  • F8W1T6_HUMAN

Pseudogenes.org Pseudogenes for RBMS2 Gene

genes like me logo Genes that share paralogs with RBMS2: view

Variants for RBMS2 Gene

Additional dbSNP identifiers (rs#s) for RBMS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBMS2 Gene

Variant ID Type Subtype PubMed ID
esv1272042 CNV insertion 17803354
esv2662220 CNV deletion 23128226
esv3580280 CNV loss 25503493
nsv1043992 CNV gain 25217958
nsv1052713 CNV gain 25217958
nsv1116501 OTHER inversion 24896259
nsv1143564 CNV deletion 24896259
nsv475589 CNV novel sequence insertion 20440878
nsv476903 CNV novel sequence insertion 20440878
nsv482992 CNV gain+loss 15286789
nsv526706 CNV gain 19592680
nsv820140 CNV loss 19587683

Variation tolerance for RBMS2 Gene

Residual Variation Intolerance Score: 9.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBMS2 Gene

Human Gene Mutation Database (HGMD)
RBMS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBMS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBMS2 Gene

Disorders for RBMS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBMS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cholesterol embolism
  • atheroembolism
hemolytic uremic syndrome, atypical 1
  • hemolytic uremic syndrome, atypical, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search RBMS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBMS2

genes like me logo Genes that share disorders with RBMS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBMS2 Gene

Publications for RBMS2 Gene

  1. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. (PMID: 8041632) Kanaoka Y … Nojima H (Nucleic acids research 1994) 2 3 4
  2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. RBMS2 inhibits the proliferation by stabilizing P21 mRNA in breast cancer. (PMID: 30514345) Sun X … Ding Q (Journal of experimental & clinical cancer research : CR 2018) 3
  5. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3

Products for RBMS2 Gene

  • Signalway Proteins for RBMS2

Sources for RBMS2 Gene