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Aliases for RBMS2 Gene

Aliases for RBMS2 Gene

  • RNA Binding Motif Single Stranded Interacting Protein 2 2 3 5
  • Suppressor Of CDC2 With RNA-Binding Motif 3 3 4
  • SCR3 3 4
  • RNA-Binding Motif, Single-Stranded-Interacting Protein 2 3

External Ids for RBMS2 Gene

Previous GeneCards Identifiers for RBMS2 Gene

  • GC12P056808
  • GC12P057140
  • GC12P056632
  • GC12P055202
  • GC12P056915
  • GC12P053954

Summaries for RBMS2 Gene

Entrez Gene Summary for RBMS2 Gene

  • The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBMS2 Gene

RBMS2 (RNA Binding Motif Single Stranded Interacting Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBMS3.

Additional gene information for RBMS2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBMS2 Gene

Genomics for RBMS2 Gene

GeneHancer (GH) Regulatory Elements for RBMS2 Gene

Promoters and enhancers for RBMS2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I056519 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 585.3 +3.3 3292 11.3 PKNOX1 ATF1 SIN3A FEZF1 GLI4 ZNF121 ZNF213 ZNF143 ATF7 SP3 RBMS2 SPRYD4 GC12P056589
GH12I057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 48.8 +589.4 589430 3.8 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 MCM3 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 ANKRD52 CDK4 CTDSP2
GH12I056040 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.7 -479.8 -479825 3.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 RPS26 LOC105369780 BAZ2A RN7SL809P STAT2 PAN2 ENSG00000258199 ZC3H10 CDK2 ENSG00000257740
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.2 -298.9 -298942 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 NABP2 RNF41 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I056628 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.1 +107.9 107857 3 HDGF FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 IRF4 YY1 BAZ2A RBMS2 RNU6-343P ANKRD52 IKZF4 PTGES3 NEMP1 ENSG00000257740 SMARCC2 R3HDM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBMS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBMS2 gene promoter:

Genomic Locations for RBMS2 Gene

Genomic Locations for RBMS2 Gene
74,373 bases
Plus strand

Genomic View for RBMS2 Gene

Genes around RBMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBMS2 Gene

Proteins for RBMS2 Gene

  • Protein details for RBMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding motif, single-stranded-interacting protein 2
    Protein Accession:

    Protein attributes for RBMS2 Gene

    407 amino acids
    Molecular mass:
    43959 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBMS2 Gene

neXtProt entry for RBMS2 Gene

Post-translational modifications for RBMS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBMS2 Gene

Domains & Families for RBMS2 Gene

Gene Families for RBMS2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RBMS2 Gene

Suggested Antigen Peptide Sequences for RBMS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBMS2: view

No data available for UniProtKB/Swiss-Prot for RBMS2 Gene

Function for RBMS2 Gene

Phenotypes From GWAS Catalog for RBMS2 Gene

Gene Ontology (GO) - Molecular Function for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
genes like me logo Genes that share ontologies with RBMS2: view
genes like me logo Genes that share phenotypes with RBMS2: view

Animal Model Products

CRISPR Products

miRNA for RBMS2 Gene

miRTarBase miRNAs that target RBMS2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBMS2 Gene

Localization for RBMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBMS2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBMS2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RBMS2: view

Pathways & Interactions for RBMS2 Gene

SuperPathways for RBMS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8041632
genes like me logo Genes that share ontologies with RBMS2: view

No data available for Pathways by source and SIGNOR curated interactions for RBMS2 Gene

Drugs & Compounds for RBMS2 Gene

No Compound Related Data Available

Transcripts for RBMS2 Gene

Unigene Clusters for RBMS2 Gene

RNA binding motif, single stranded interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBMS2 Gene

No ASD Table

Relevant External Links for RBMS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBMS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBMS2 Gene

This gene is overexpressed in Lung (40.7) and Islet of Langerhans (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBMS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBMS2 Gene:


SOURCE GeneReport for Unigene cluster for RBMS2 Gene:


Evidence on tissue expression from TISSUES for RBMS2 Gene

  • Lung(4.4)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with RBMS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBMS2 Gene

Orthologs for RBMS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBMS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBMS2 33 34
  • 98.79 (n)
(Canis familiaris)
Mammalia RBMS2 33 34
  • 90.99 (n)
(Bos Taurus)
Mammalia RBMS2 33 34
  • 90.25 (n)
(Rattus norvegicus)
Mammalia Rbms2 33
  • 87.07 (n)
(Mus musculus)
Mammalia Rbms2 33 16 34
  • 86.02 (n)
(Ornithorhynchus anatinus)
Mammalia RBMS2 34
  • 62 (a)
(Gallus gallus)
Aves RBMS2 34
  • 62 (a)
(Anolis carolinensis)
Reptilia RBMS2 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbms2 33
  • 73.52 (n)
(Danio rerio)
Actinopterygii rbms2b 34
  • 73 (a)
rbms2a 33 34
  • 71.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta shep 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea R10E4.2b 35
  • 57 (a)
R10E4.2a 35
  • 53 (a)
sup-26 34
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1122 34
  • 42 (a)
Species where no ortholog for RBMS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBMS2 Gene

Gene Tree for RBMS2 (if available)
Gene Tree for RBMS2 (if available)

Paralogs for RBMS2 Gene

Variants for RBMS2 Gene

Sequence variations from dbSNP and Humsavar for RBMS2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000021585 -- 56,588,463(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000022959 -- 56,544,726(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000062984 -- 56,541,255(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000073017 -- 56,538,190(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000122355 -- 56,571,306(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBMS2 Gene

Variant ID Type Subtype PubMed ID
esv1272042 CNV insertion 17803354
esv2662220 CNV deletion 23128226
esv3580280 CNV loss 25503493
nsv1043992 CNV gain 25217958
nsv1052713 CNV gain 25217958
nsv1116501 OTHER inversion 24896259
nsv1143564 CNV deletion 24896259
nsv475589 CNV novel sequence insertion 20440878
nsv476903 CNV novel sequence insertion 20440878
nsv482992 CNV gain+loss 15286789
nsv526706 CNV gain 19592680
nsv820140 CNV loss 19587683

Variation tolerance for RBMS2 Gene

Residual Variation Intolerance Score: 9.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBMS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBMS2 Gene

Disorders for RBMS2 Gene

Additional Disease Information for RBMS2

No disorders were found for RBMS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBMS2 Gene

Publications for RBMS2 Gene

  1. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. (PMID: 8041632) Kanaoka Y … Nojima H (Nucleic acids research 1994) 2 3 4 58
  2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for RBMS2 Gene

Sources for RBMS2 Gene

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