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Aliases for RBM7 Gene

Aliases for RBM7 Gene

  • RNA Binding Motif Protein 7 2 3 5
  • RNA-Binding Motif Protein 7 4

External Ids for RBM7 Gene

Previous GeneCards Identifiers for RBM7 Gene

  • GC11P116624
  • GC11P115783
  • GC11P114305
  • GC11P113808
  • GC11P113776
  • GC11P110199
  • GC11P114270

Summaries for RBM7 Gene

GeneCards Summary for RBM7 Gene

RBM7 (RNA Binding Motif Protein 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is ENSG00000255663.

UniProtKB/Swiss-Prot for RBM7 Gene

  • Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).

Gene Wiki entry for RBM7 Gene

Additional gene information for RBM7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM7 Gene

Genomics for RBM7 Gene

GeneHancer (GH) Regulatory Elements for RBM7 Gene

Promoters and enhancers for RBM7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I114398 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566.3 +0.4 415 3.8 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RBM7 ENSG00000255663 C11orf71
GH11I113872 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.7 -525.1 -525086 4.5 PKNOX1 SMAD1 MLX ARNT ZFP64 SIN3A FEZF1 DMAP1 ZNF2 YY1 USP28 RBM7 ENSG00000270179 ZW10 NXPE4 LRRC37A13P GC11M113865
GH11I114214 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 22.6 -183.4 -183404 3.6 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 CBX5 GATA2 E2F8 RBM7 ZW10 NNMT NXPE4 NXPE1 TTC12 ENSG00000270179 ZBTB16 PIR38575 PIR57549
GH11I114288 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.5 -104.6 -104576 13.1 FOXA2 PKNOX1 ATF1 SIN3A BRCA1 YY1 TCF12 ATF7 FOS RXRA NNMT LOC101928940 RBM7 C11orf71 ENSG00000255663 ZW10 GC11P114306 GC11M114263 ENSG00000256947
GH11I114353 Enhancer 0.9 FANTOM5 ENCODE 11.2 -45.9 -45887 0.9 ATF1 PKNOX1 NFIB JUN POLR2A NFYB ZNF350 FOSL2 ATF7 FOS LOC101928940 ENSG00000270179 ENSG00000255663 RBM7 C11orf71 ENSG00000256947 GC11P114340
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM7 gene promoter:

Genomic Locations for RBM7 Gene

Genomic Locations for RBM7 Gene
chr11:114,400,030-114,414,203
(GRCh38/hg38)
Size:
14,174 bases
Orientation:
Plus strand
chr11:114,270,752-114,284,925
(GRCh37/hg19)

Genomic View for RBM7 Gene

Genes around RBM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM7 Gene

Proteins for RBM7 Gene

  • Protein details for RBM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y580-RBM7_HUMAN
    Recommended name:
    RNA-binding protein 7
    Protein Accession:
    Q9Y580
    Secondary Accessions:
    • B2R6K8
    • Q9NUT4

    Protein attributes for RBM7 Gene

    Size:
    266 amino acids
    Molecular mass:
    30504 Da
    Quaternary structure:
    • Component of the nuclear exosome targeting (NEXT) complex composed of SKIV2L2/MTR4, ZCCHC8, and RBM7 that directs a subset of non-coding short-lived RNAs for exosomal degradation (PubMed:27905398, PubMed:27871484). Interacts with ZCCHC8 and SF3B2/SAP145 (PubMed:27905398, PubMed:27871484, PubMed:16263084). Binds to SKIV2L2/MTR4 (PubMed:27871484).

    Three dimensional structures from OCA and Proteopedia for RBM7 Gene

neXtProt entry for RBM7 Gene

Post-translational modifications for RBM7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RBM7 Gene

Domains & Families for RBM7 Gene

Gene Families for RBM7 Gene

Protein Domains for RBM7 Gene

Suggested Antigen Peptide Sequences for RBM7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM7: view

No data available for UniProtKB/Swiss-Prot for RBM7 Gene

Function for RBM7 Gene

Molecular function for RBM7 Gene

UniProtKB/Swiss-Prot Function:
Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters (PubMed:27871484). Possible involved in germ cell RNA processing and meiosis (Probable).

Phenotypes From GWAS Catalog for RBM7 Gene

Gene Ontology (GO) - Molecular Function for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003727 single-stranded RNA binding IBA --
GO:0005515 protein binding IPI 16263084
genes like me logo Genes that share ontologies with RBM7: view
genes like me logo Genes that share phenotypes with RBM7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM7 Gene

Localization for RBM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM7 Gene

Nucleus. Note=Excluded from the nucleolus. {ECO:0000269 PubMed:21855801}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM7 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21855801
GO:0005654 nucleoplasm IDA 16263084
GO:0005730 NOT nucleolus IDA 21855801
genes like me logo Genes that share ontologies with RBM7: view

Pathways & Interactions for RBM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with RBM7: view

No data available for Pathways by source and SIGNOR curated interactions for RBM7 Gene

Drugs & Compounds for RBM7 Gene

No Compound Related Data Available

Transcripts for RBM7 Gene

Unigene Clusters for RBM7 Gene

RNA binding motif protein 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for RBM7 Gene

GeneLoc Exon Structure for
RBM7
ECgene alternative splicing isoforms for
RBM7

Expression for RBM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM7 Gene

This gene is overexpressed in Lung (39.4) and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM7 Gene



Protein tissue co-expression partners for RBM7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM7 Gene:

RBM7

SOURCE GeneReport for Unigene cluster for RBM7 Gene:

Hs.7527

mRNA Expression by UniProt/SwissProt for RBM7 Gene:

Q9Y580-RBM7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RBM7 Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RBM7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM7 Gene

Orthologs for RBM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM7 33 34
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia RBM7 33 34
  • 90.46 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
OneToMany
RBM7 33
  • 89.06 (n)
mouse
(Mus musculus)
Mammalia Rbm7 33 16 34
  • 85.16 (n)
rat
(Rattus norvegicus)
Mammalia Rbm7 33
  • 83.42 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves RBM7 33 34
  • 64.57 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735152 33
  • 69.86 (n)
Str.10735 33
African clawed frog
(Xenopus laevis)
Amphibia rbm7-prov 33
zebrafish
(Danio rerio)
Actinopterygii zgc:77304 33
  • 55.04 (n)
RBM7 34
  • 43 (a)
OneToMany
wufa03f03 33
fruit fly
(Drosophila melanogaster)
Insecta CG11454 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y37D8A.21 34
  • 23 (a)
OneToMany
Species where no ortholog for RBM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM7 Gene

ENSEMBL:
Gene Tree for RBM7 (if available)
TreeFam:
Gene Tree for RBM7 (if available)

Paralogs for RBM7 Gene

Paralogs for RBM7 Gene

Pseudogenes.org Pseudogenes for RBM7 Gene

genes like me logo Genes that share paralogs with RBM7: view

Variants for RBM7 Gene

Sequence variations from dbSNP and Humsavar for RBM7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000122162 -- 114,400,453(+) G/A upstream_transcript_variant
rs1000142686 -- 114,399,283(+) G/A upstream_transcript_variant
rs1000345090 -- 114,406,788(+) T/C intron_variant
rs1000352717 -- 114,405,129(+) T/A intron_variant
rs1000794307 -- 114,401,256(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM7 Gene

Variant ID Type Subtype PubMed ID
nsv983063 CNV duplication 23825009

Variation tolerance for RBM7 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM7 Gene

Human Gene Mutation Database (HGMD)
RBM7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM7 Gene

Disorders for RBM7 Gene

Additional Disease Information for RBM7

No disorders were found for RBM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM7 Gene

Publications for RBM7 Gene

  1. Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. (PMID: 27905398) Falk S … Conti E (Nature communications 2016) 3 4 58
  2. Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. (PMID: 27871484) Meola N … Jensen TH (Molecular cell 2016) 3 4 58
  3. RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3'-end extended forms of snRNAs. (PMID: 25852104) Hrossova D … Vanacova S (Nucleic acids research 2015) 2 3 58
  4. Interaction profiling identifies the human nuclear exosome targeting complex. (PMID: 21855801) Lubas M … Jensen TH (Molecular cell 2011) 3 4 58
  5. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. (PMID: 16263084) Gustafson MP … Clurman BE (Biochemical and biophysical research communications 2005) 3 4 58

Products for RBM7 Gene

Sources for RBM7 Gene

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