Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBM45 Gene

Aliases for RBM45 Gene

  • RNA Binding Motif Protein 45 2 3 5
  • DRB1 3 4
  • RB-1 3 4
  • Developmentally Regulated RNA Binding Protein 1 2
  • Developmentally Regulated RNA-Binding Protein 1 3
  • Developmentally-Regulated RNA-Binding Protein 1 4
  • Putative RNA Binding Protein RB-1 3
  • RNA-Binding Motif Protein 45 4
  • RNA-Binding Protein 45 3
  • DRBP1 4

External Ids for RBM45 Gene

Previous GeneCards Identifiers for RBM45 Gene

  • GC02P178686
  • GC02P178977
  • GC02P170847

Summaries for RBM45 Gene

Entrez Gene Summary for RBM45 Gene

  • This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]

GeneCards Summary for RBM45 Gene

RBM45 (RNA Binding Motif Protein 45) is a Protein Coding gene. Diseases associated with RBM45 include Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for RBM45 Gene

  • RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

Additional gene information for RBM45 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM45 Gene

Genomics for RBM45 Gene

GeneHancer (GH) Regulatory Elements for RBM45 Gene

Promoters and enhancers for RBM45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I178111 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 554.5 +0.4 381 2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 RBM45 HNRNPA3 GC02M178126
GH02I177260 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.9 -846.5 -846466 10 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ENSG00000222043 GC02P177265 NFE2L2 HNRNPA3 RBM45 DNAJC19P5 LOC100130691 LOC105373754 ENSG00000271825
GH02I178484 Enhancer 0.9 Ensembl 56.3 +372.3 372289 0.6 SMAD1 NFIB ZNF529 INSM2 MZF1 FEZF1 ZNF213 ZNF366 ZSCAN5C ZNF350 LOC101927027 RBM45 NUDCP2 ENSG00000271401 PJVK PLEKHA3 FKBP7 TTC30A PRKRA TTN-AS1
GH02I177391 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 15 -717.0 -717001 7.2 MLX DMAP1 YY1 SLC30A9 ZNF143 NFYC MEF2D SSRP1 ZNF610 GLIS1 AGPS HNRNPA3 RBM45 LOC100130691 ENSG00000238295 ENSG00000237178 DNAJC19P5 NFE2L2 GC02P177449 GC02M177355
GH02I177164 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 15 -943.8 -943765 9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HNRNPA3 DNAJC19P5 RBM45 NFE2L2 ENSG00000222043 ENSG00000236501 LOC105373760 LOC391465 ENSG00000229337
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM45 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM45 gene promoter:

Genomic Locations for RBM45 Gene

Genomic Locations for RBM45 Gene
chr2:178,112,417-178,139,011
(GRCh38/hg38)
Size:
26,595 bases
Orientation:
Plus strand
chr2:178,977,151-179,003,738
(GRCh37/hg19)

Genomic View for RBM45 Gene

Genes around RBM45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM45 Gene

Proteins for RBM45 Gene

  • Protein details for RBM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH3-RBM45_HUMAN
    Recommended name:
    RNA-binding protein 45
    Protein Accession:
    Q8IUH3
    Secondary Accessions:
    • Q6NYL0
    • Q8NFC9

    Protein attributes for RBM45 Gene

    Size:
    476 amino acids
    Molecular mass:
    53502 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBM45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM45 Gene

Post-translational modifications for RBM45 Gene

No Post-translational modifications

Other Protein References for RBM45 Gene

No data available for DME Specific Peptides for RBM45 Gene

Domains & Families for RBM45 Gene

Gene Families for RBM45 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RBM45 Gene

Suggested Antigen Peptide Sequences for RBM45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM45: view

No data available for UniProtKB/Swiss-Prot for RBM45 Gene

Function for RBM45 Gene

Molecular function for RBM45 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.

Gene Ontology (GO) - Molecular Function for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 12220514
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RBM45: view
genes like me logo Genes that share phenotypes with RBM45: view

Animal Model Products

miRNA for RBM45 Gene

miRTarBase miRNAs that target RBM45

Clone Products

  • Addgene plasmids for RBM45

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM45 Gene

Localization for RBM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM45 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM45 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12220514
GO:0005737 cytoplasm IDA,IEA 12220514
genes like me logo Genes that share ontologies with RBM45: view

Pathways & Interactions for RBM45 Gene

SuperPathways for RBM45 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RBM45: view

No data available for Pathways by source and SIGNOR curated interactions for RBM45 Gene

Drugs & Compounds for RBM45 Gene

No Compound Related Data Available

Transcripts for RBM45 Gene

Unigene Clusters for RBM45 Gene

RNA binding motif protein 45:
Representative Sequences:

Clone Products

  • Addgene plasmids for RBM45

Alternative Splicing Database (ASD) splice patterns (SP) for RBM45 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: -

Relevant External Links for RBM45 Gene

GeneLoc Exon Structure for
RBM45
ECgene alternative splicing isoforms for
RBM45

Expression for RBM45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM45 Gene

Protein differential expression in normal tissues from HIPED for RBM45 Gene

This gene is overexpressed in Plasma (38.9) and Adrenal (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM45 Gene



NURSA nuclear receptor signaling pathways regulating expression of RBM45 Gene:

RBM45

SOURCE GeneReport for Unigene cluster for RBM45 Gene:

Hs.377257
genes like me logo Genes that share expression patterns with RBM45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM45 Gene

Orthologs for RBM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM45 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia RBM45 33 34
  • 93.67 (n)
cow
(Bos Taurus)
Mammalia RBM45 33 34
  • 93.46 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM45 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm45 33 16 34
  • 86.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM45 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm45 33
  • 85.86 (n)
chicken
(Gallus gallus)
Aves RBM45 33 34
  • 74.79 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm45 33
  • 68.34 (n)
Str.2753 33
African clawed frog
(Xenopus laevis)
Amphibia drbp1-pending-prov 33
zebrafish
(Danio rerio)
Actinopterygii rbm45 33 34
  • 62.97 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1796 33
fruit fly
(Drosophila melanogaster)
Insecta CG1316 33 34
  • 49.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005505 33
  • 44.52 (n)
Species where no ortholog for RBM45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBM45 Gene

ENSEMBL:
Gene Tree for RBM45 (if available)
TreeFam:
Gene Tree for RBM45 (if available)

Paralogs for RBM45 Gene

Pseudogenes.org Pseudogenes for RBM45 Gene

genes like me logo Genes that share paralogs with RBM45: view

No data available for Paralogs for RBM45 Gene

Variants for RBM45 Gene

Sequence variations from dbSNP and Humsavar for RBM45 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000027279 -- 178,125,082(+) C/G intron_variant
rs1000119321 -- 178,130,014(+) T/A downstream_transcript_variant
rs1000282348 -- 178,117,749(+) A/G intron_variant
rs1000389593 -- 178,111,169(+) C/T upstream_transcript_variant
rs1000438015 -- 178,116,945(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM45 Gene

Variant ID Type Subtype PubMed ID
nsv583739 CNV loss 21841781
nsv518790 CNV gain 19592680

Variation tolerance for RBM45 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM45 Gene

Disorders for RBM45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RBM45 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search RBM45 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBM45

genes like me logo Genes that share disorders with RBM45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM45 Gene

Publications for RBM45 Gene

  1. cDNA cloning and characterization of Drb1, a new member of RRM-type neural RNA-binding protein. (PMID: 12220514) Tamada H … Endo H (Biochemical and biophysical research communications 2002) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates. (PMID: 27226551) Mashiko T … Endo H (The Journal of biological chemistry 2016) 3 58

Products for RBM45 Gene

Sources for RBM45 Gene

Content
Loading form....