Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBM43 Gene

Aliases for RBM43 Gene

  • RNA Binding Motif Protein 43 2 3 5
  • C2orf38 3 4
  • Chromosome 2 Open Reading Frame 38 2
  • RNA-Binding Motif Protein 43 4
  • RNA-Binding Protein 43 3

External Ids for RBM43 Gene

Previous HGNC Symbols for RBM43 Gene

  • C2orf38

Previous GeneCards Identifiers for RBM43 Gene

  • GC02M151815
  • GC02M152104
  • GC02M144001

Summaries for RBM43 Gene

GeneCards Summary for RBM43 Gene

RBM43 (RNA Binding Motif Protein 43) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

Additional gene information for RBM43 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM43 Gene

Genomics for RBM43 Gene

GeneHancer (GH) Regulatory Elements for RBM43 Gene

Promoters and enhancers for RBM43 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I151260 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569.4 +0.6 598 2.5 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 MXD4 REST RBM43 TNFAIP6 NMI ENSG00000236885
GH02I151408 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -148.0 -148048 3.2 ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GLIS1 NBN RIF1 STAM2 RPL30P2 RBM43 PIR42149
GH02I151238 Enhancer 0.9 Ensembl ENCODE 12 +23.0 23001 0.6 CTCF TFAP4 TAF9B CEBPG RAD21 ZNF7 CC2D1A ARID2 SMC3 ZNF143 RBM43 ENSG00000236885
GH02I151297 Enhancer 0.9 Ensembl ENCODE 11.8 -36.1 -36146 1.3 JUN PYGO2 BATF IRF4 FOSL1 CTBP1 POLR2A NFATC1 ATF7 ETV6 TNFAIP6 NMI STAM2 RPL30P2 RBM43
GH02I151303 Enhancer 0.8 FANTOM5 11.8 -41.2 -41172 0.1 HDAC1 MEIS2 PKNOX1 ATF1 TEAD4 JUN MAX CEBPG FOSL1 NFE2 TNFAIP6 RBM43 NMI
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM43 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM43 gene promoter:

Genomic Locations for RBM43 Gene

Genomic Locations for RBM43 Gene
chr2:151,247,940-151,261,901
(GRCh38/hg38)
Size:
13,962 bases
Orientation:
Minus strand
chr2:152,104,454-152,118,393
(GRCh37/hg19)

Genomic View for RBM43 Gene

Genes around RBM43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM43 Gene

Proteins for RBM43 Gene

  • Protein details for RBM43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSC3-RBM43_HUMAN
    Recommended name:
    RNA-binding protein 43
    Protein Accession:
    Q6ZSC3
    Secondary Accessions:
    • B2RMT5

    Protein attributes for RBM43 Gene

    Size:
    357 amino acids
    Molecular mass:
    40666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM43 Gene

Post-translational modifications for RBM43 Gene

No Post-translational modifications

Other Protein References for RBM43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBM43 Gene

Domains & Families for RBM43 Gene

Gene Families for RBM43 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM43 Gene

Suggested Antigen Peptide Sequences for RBM43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM43: view

No data available for UniProtKB/Swiss-Prot for RBM43 Gene

Function for RBM43 Gene

Phenotypes From GWAS Catalog for RBM43 Gene

Gene Ontology (GO) - Molecular Function for RBM43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with RBM43: view
genes like me logo Genes that share phenotypes with RBM43: view

Animal Model Products

miRNA for RBM43 Gene

miRTarBase miRNAs that target RBM43

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM43 Gene

Localization for RBM43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM43 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM43 Gene

Pathways & Interactions for RBM43 Gene

SuperPathways for RBM43 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM43 Gene

Drugs & Compounds for RBM43 Gene

No Compound Related Data Available

Transcripts for RBM43 Gene

mRNA/cDNA for RBM43 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBM43 Gene

RNA binding motif protein 43:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM43 Gene

No ASD Table

Relevant External Links for RBM43 Gene

GeneLoc Exon Structure for
RBM43
ECgene alternative splicing isoforms for
RBM43

Expression for RBM43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM43 Gene

Protein differential expression in normal tissues from HIPED for RBM43 Gene

This gene is overexpressed in Lung (47.4) and Esophagus (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RBM43 Gene



Protein tissue co-expression partners for RBM43 Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM43 Gene:

RBM43

SOURCE GeneReport for Unigene cluster for RBM43 Gene:

Hs.302442
genes like me logo Genes that share expression patterns with RBM43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM43 Gene

Orthologs for RBM43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBM43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM43 33 34
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia RBM43 33 34
  • 80.02 (n)
mouse
(Mus musculus)
Mammalia Rbm43 33 16 34
  • 72.11 (n)
rat
(Rattus norvegicus)
Mammalia Rbm43 33
  • 71.82 (n)
dog
(Canis familiaris)
Mammalia RBM43 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM43 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM43 33 34
  • 55.39 (n)
lizard
(Anolis carolinensis)
Reptilia RBM43 34
  • 29 (a)
OneToOne
Species where no ortholog for RBM43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RBM43 Gene

ENSEMBL:
Gene Tree for RBM43 (if available)
TreeFam:
Gene Tree for RBM43 (if available)

Paralogs for RBM43 Gene

Pseudogenes.org Pseudogenes for RBM43 Gene

genes like me logo Genes that share paralogs with RBM43: view

No data available for Paralogs for RBM43 Gene

Variants for RBM43 Gene

Sequence variations from dbSNP and Humsavar for RBM43 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000204749 -- 151,259,051(-) G/A intron_variant
rs1000315632 -- 151,252,978(-) A/G intron_variant
rs1000324954 -- 151,259,384(-) G/A intron_variant
rs1000334202 -- 151,252,991(-) A/C intron_variant
rs1000347460 -- 151,259,852(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM43 Gene

Variant ID Type Subtype PubMed ID
nsv834417 CNV gain 17160897
nsv523849 CNV gain 19592680
nsv1014936 CNV gain 25217958
nsv1012891 CNV gain 25217958
esv34659 CNV loss 17911159
dgv744e214 CNV loss 21293372
dgv4094n100 CNV gain 25217958

Variation tolerance for RBM43 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM43 Gene

Human Gene Mutation Database (HGMD)
RBM43
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM43 Gene

Disorders for RBM43 Gene

Additional Disease Information for RBM43

No disorders were found for RBM43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM43 Gene

Publications for RBM43 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genome-wide association study link novel loci to endometriosis. (PMID: 23472165) Albertsen HM … Ward K (PloS one 2013) 3 58
  3. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer ND … Sladek R (PloS one 2012) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for RBM43 Gene

Sources for RBM43 Gene

Content
Loading form....