Aliases for RBM42 Gene

Aliases for RBM42 Gene

  • RNA Binding Motif Protein 42 2 3 5
  • RNA-Binding Protein 42 3 4
  • RNA-Binding Motif Protein 42 4
  • MGC10433 2
  • RBM42 5

External Ids for RBM42 Gene

Previous GeneCards Identifiers for RBM42 Gene

  • GC19P040812
  • GC19P036119
  • GC19P032625
  • GC19P035694
  • GC19P035817
  • GC19P037015
  • GC19P037184
  • GC19P037280
  • GC19P037715
  • GC19P035841
  • GC19P035997
  • GC19P036163
  • GC19P036234
  • GC19P036406
  • GC19P036566
  • GC19P036735
  • GC19P036879

Summaries for RBM42 Gene

GeneCards Summary for RBM42 Gene

RBM42 (RNA Binding Motif Protein 42) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot Summary for RBM42 Gene

  • Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.

Additional gene information for RBM42 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM42 Gene

Genomics for RBM42 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBM42 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM42 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM42

Top Transcription factor binding sites by QIAGEN in the RBM42 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GATA-2
  • Gfi-1
  • IRF-7A
  • ZID

Genomic Locations for RBM42 Gene

Genomic Locations for RBM42 Gene
chr19:35,629,016-35,637,686
(GRCh38/hg38)
Size:
8,671 bases
Orientation:
Plus strand
chr19:36,119,932-36,128,588
(GRCh37/hg19)
Size:
8,657 bases
Orientation:
Plus strand

Genomic View for RBM42 Gene

Genes around RBM42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM42 Gene

Proteins for RBM42 Gene

  • Protein details for RBM42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTD8-RBM42_HUMAN
    Recommended name:
    RNA-binding protein 42
    Protein Accession:
    Q9BTD8
    Secondary Accessions:
    • O00320
    • Q8N5R7
    • Q9BU66

    Protein attributes for RBM42 Gene

    Size:
    480 amino acids
    Molecular mass:
    50414 Da
    Quaternary structure:
    • Interacts with HNRNPK.
    SequenceCaution:
    • Sequence=AAB57629.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM42 Gene

    Alternative splice isoforms for RBM42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM42 Gene

Post-translational modifications for RBM42 Gene

  • Ubiquitination at Lys430
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM42 Gene

No data available for DME Specific Peptides for RBM42 Gene

Domains & Families for RBM42 Gene

Gene Families for RBM42 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM42 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for RBM42 Gene

GenScript: Design optimal peptide antigens:
  • RNA-binding motif protein 42 (RBM42_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BTD8

UniProtKB/Swiss-Prot:

RBM42_HUMAN :
  • Belongs to the RRM RBM42 family.
Family:
  • Belongs to the RRM RBM42 family.
genes like me logo Genes that share domains with RBM42: view

Function for RBM42 Gene

Molecular function for RBM42 Gene

UniProtKB/Swiss-Prot Function:
Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.

Phenotypes From GWAS Catalog for RBM42 Gene

Gene Ontology (GO) - Molecular Function for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IBA 21873635
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RBM42: view
genes like me logo Genes that share phenotypes with RBM42: view

Animal Model Products

CRISPR Products

miRNA for RBM42 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM42

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM42 Gene

Localization for RBM42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM42 Gene

Nucleus. Cytoplasm. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM42 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:1990904 ribonucleoprotein complex IBA 21873635
genes like me logo Genes that share ontologies with RBM42: view

Pathways & Interactions for RBM42 Gene

PathCards logo

SuperPathways for RBM42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048024 regulation of mRNA splicing, via spliceosome IBA 21873635
GO:0048025 negative regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with RBM42: view

No data available for Pathways by source and SIGNOR curated interactions for RBM42 Gene

Drugs & Compounds for RBM42 Gene

No Compound Related Data Available

Transcripts for RBM42 Gene

mRNA/cDNA for RBM42 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM42

Alternative Splicing Database (ASD) splice patterns (SP) for RBM42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for RBM42 Gene

GeneLoc Exon Structure for
RBM42

Expression for RBM42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM42 Gene

Protein differential expression in normal tissues from HIPED for RBM42 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1) and Lung (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM42 Gene



Protein tissue co-expression partners for RBM42 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM42

SOURCE GeneReport for Unigene cluster for RBM42 Gene:

Hs.5086

Evidence on tissue expression from TISSUES for RBM42 Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Muscle(4.4)
  • Skin(3.3)
  • Intestine(2.9)
  • Eye(2.7)
genes like me logo Genes that share expression patterns with RBM42: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM42 Gene

Orthologs for RBM42 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM42 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RBM42 30 31
  • 99.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RBM42 30
  • 92.14 (n)
Cow
(Bos Taurus)
Mammalia RBM42 30 31
  • 91.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rbm42 30 17 31
  • 89.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rbm42 30
  • 89.66 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RBM42 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RBM42 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RBM42 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.6145 30
Zebrafish
(Danio rerio)
Actinopterygii rbm42 31
  • 59 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG2931 31
  • 41 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea tag-262 31
  • 42 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 31
  • 13 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3110 30
Soybean
(Glycine max)
eudicotyledons Gma.2093 30
Barley
(Hordeum vulgare)
Liliopsida Hv.4404 30
Rice
(Oryza sativa)
Liliopsida Os.35508 30
Wheat
(Triticum aestivum)
Liliopsida Ta.4695 30
Corn
(Zea mays)
Liliopsida Zm.15567 30
Species where no ortholog for RBM42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBM42 Gene

ENSEMBL:
Gene Tree for RBM42 (if available)
TreeFam:
Gene Tree for RBM42 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBM42: view image

Paralogs for RBM42 Gene

(3) SIMAP similar genes for RBM42 Gene using alignment to 5 proteins:

  • RBM42_HUMAN
  • K7EML2_HUMAN
  • K7EP90_HUMAN
  • K7EQ03_HUMAN
  • K7ER08_HUMAN
genes like me logo Genes that share paralogs with RBM42: view

No data available for Paralogs for RBM42 Gene

Variants for RBM42 Gene

Additional dbSNP identifiers (rs#s) for RBM42 Gene

Variation tolerance for RBM42 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM42

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for RBM42 Gene

Disorders for RBM42 Gene

No disorders were found for RBM42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM42 Gene

Publications for RBM42 Gene

  1. hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP level during stress conditions. (PMID: 19170760) Fukuda T … Irie K (Genes to cells : devoted to molecular & cellular mechanisms 2009) 2 3 4
  2. Discovery of a splicing regulator required for cell cycle progression. (PMID: 23437009) Suvorova ES … White MW (PLoS genetics 2013) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for RBM42 Gene

Sources for RBM42 Gene