This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] See more...

Aliases for RBM34 Gene

Aliases for RBM34 Gene

  • RNA Binding Motif Protein 34 2 3 5
  • RNA-Binding Protein 34 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • RNA-Binding Motif Protein 34 4
  • KIAA0117 4

External Ids for RBM34 Gene

Previous GeneCards Identifiers for RBM34 Gene

  • GC01M231489
  • GC01M233361
  • GC01M235294
  • GC01M205743

Summaries for RBM34 Gene

Entrez Gene Summary for RBM34 Gene

  • This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

GeneCards Summary for RBM34 Gene

RBM34 (RNA Binding Motif Protein 34) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC3.

Gene Wiki entry for RBM34 Gene

Additional gene information for RBM34 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM34 Gene

Genomics for RBM34 Gene

GeneHancer (GH) Regulatory Elements for RBM34 Gene

Promoters and enhancers for RBM34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J235159 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 441 2.4 FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 RBM34 lnc-GGPS1-13 lnc-TOMM20-6 RPS21P1 GGPS1 IRF2BP2 ARID4B NID1 TBCE
GH01J235135 Promoter 0.5 EPDnew 500.3 +25.9 25923 0.1 FOS PRDM1 RBM34 piR-33735-012 TOMM20 lnc-TOMM20-4 ARID4B
GH01J235131 Promoter 0.5 EPDnew 500.3 +29.7 29653 0.1 ZFP64 POLR2A RBM34 TOMM20 piR-33735-012 lnc-TOMM20-4 ARID4B
GH01J235126 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 9.5 +33.1 33086 5.5 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 POLR2G USF1 SP1 GTF2E2 TOMM20 LOC105379283 SNORA14B lnc-RBM34-3 ARID4B RPS21P1 IRF2BP2 LDHAP2 NID1 TARBP1
GH01J235295 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -135.4 -135395 2.8 FOXK2 HNRNPK ZBTB40 ZNF217 KDM6A TCF7 FOXA1 REST RFX1 CUX1 RPL23AP23 lnc-GGPS1-6 ARID4B GGPS1 TOMM20 RBM34 MG828730-008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM34 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM34

Top Transcription factor binding sites by QIAGEN in the RBM34 gene promoter:
  • FOXJ2 (long isoform)
  • FOXO1
  • FOXO1a
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • POU2F1
  • POU2F1a
  • STAT3

Genomic Locations for RBM34 Gene

Genomic Locations for RBM34 Gene
chr1:235,131,183-235,161,616
(GRCh38/hg38)
Size:
30,434 bases
Orientation:
Minus strand
chr1:235,294,498-235,324,772
(GRCh37/hg19)
Size:
30,275 bases
Orientation:
Minus strand

Genomic View for RBM34 Gene

Genes around RBM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM34 Gene

Proteins for RBM34 Gene

  • Protein details for RBM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42696-RBM34_HUMAN
    Recommended name:
    RNA-binding protein 34
    Protein Accession:
    P42696
    Secondary Accessions:
    • A8K8J7
    • Q8N2Z8
    • Q9H5A1

    Protein attributes for RBM34 Gene

    Size:
    430 amino acids
    Molecular mass:
    48565 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be due to an intron retention.
    SequenceCaution:
    • Sequence=AAH29451.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA07503.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF85051.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM34 Gene

Post-translational modifications for RBM34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM34 Gene

No data available for DME Specific Peptides for RBM34 Gene

Domains & Families for RBM34 Gene

Gene Families for RBM34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM34 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBM34 Gene

GenScript: Design optimal peptide antigens:
  • RNA-binding motif protein 34 (RBM34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42696

UniProtKB/Swiss-Prot:

RBM34_HUMAN :
  • Belongs to the RRM RBM34 family.
Family:
  • Belongs to the RRM RBM34 family.
genes like me logo Genes that share domains with RBM34: view

Function for RBM34 Gene

Phenotypes From GWAS Catalog for RBM34 Gene

Gene Ontology (GO) - Molecular Function for RBM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
genes like me logo Genes that share ontologies with RBM34: view
genes like me logo Genes that share phenotypes with RBM34: view

Animal Model Products

CRISPR Products

miRNA for RBM34 Gene

miRTarBase miRNAs that target RBM34

Clone Products

  • Addgene plasmids for RBM34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM34 Gene

Localization for RBM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM34 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM34 gene
Compartment Confidence
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RBM34: view

Pathways & Interactions for RBM34 Gene

PathCards logo

SuperPathways for RBM34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RBM34 Gene

Drugs & Compounds for RBM34 Gene

No Compound Related Data Available

Transcripts for RBM34 Gene

mRNA/cDNA for RBM34 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for RBM34

Alternative Splicing Database (ASD) splice patterns (SP) for RBM34 Gene

No ASD Table

Relevant External Links for RBM34 Gene

GeneLoc Exon Structure for
RBM34

Expression for RBM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM34 Gene

This gene is overexpressed in Lung (52.7) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM34 Gene



Protein tissue co-expression partners for RBM34 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM34

SOURCE GeneReport for Unigene cluster for RBM34 Gene:

Hs.535224

Evidence on tissue expression from TISSUES for RBM34 Gene

  • Bone marrow(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RBM34: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM34 Gene

Orthologs for RBM34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBM34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM34 31 30
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RBM34 31 30
  • 84.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RBM34 31
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm34 17 31 30
  • 77.28 (n)
rat
(Rattus norvegicus)
Mammalia Rbm34 30
  • 76.91 (n)
oppossum
(Monodelphis domestica)
Mammalia RBM34 31
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM34 31
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM34 31 30
  • 60.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM34 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm34 30
  • 57.39 (n)
zebrafish
(Danio rerio)
Actinopterygii rbm34 31 30
  • 56.4 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12288 31
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11A10.7 31
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP12 31
  • 27 (a)
OneToOne
Species where no ortholog for RBM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM34 Gene

ENSEMBL:
Gene Tree for RBM34 (if available)
TreeFam:
Gene Tree for RBM34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBM34: view image

Paralogs for RBM34 Gene

Variants for RBM34 Gene

Additional dbSNP identifiers (rs#s) for RBM34 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBM34 Gene

Variant ID Type Subtype PubMed ID
esv2670623 CNV deletion 23128226
esv2725296 CNV deletion 23290073
esv275126 CNV loss 21479260
esv3548744 CNV deletion 23714750
esv3578486 CNV loss 25503493
esv3891237 CNV loss 25118596
nsv508699 CNV deletion 20534489

Variation tolerance for RBM34 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBM34 Gene

Disorders for RBM34 Gene

Additional Disease Information for RBM34

No disorders were found for RBM34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM34 Gene

Publications for RBM34 Gene

  1. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T … Kotani H (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. (PMID: 15134903) Kartvelishvili A … Simm M (Immunology letters 2004) 2 3 54

Products for RBM34 Gene

Sources for RBM34 Gene