Aliases for RBM26 Gene

Aliases for RBM26 Gene

  • RNA Binding Motif Protein 26 2 3 5
  • Protein Phosphatase 1, Regulatory 132 2 3
  • Acidic Rich RS Domain Containing 2 2 3
  • CTCL Tumor Antigen Se70-2 3 4
  • RNA-Binding Protein 26 3 4
  • C13orf10 3 4
  • PPP1R132 2 3
  • PRO1777 2 3
  • SE70-2 2 3
  • ZC3H17 2 3
  • ARRS2 2 3
  • Cutaneous T-Cell Lymphoma Tumor Antigen Se70-2 3
  • Chromosome 13 Open Reading Frame 10 2
  • RNA-Binding Motif Protein 26 4
  • FLJ20957 2
  • RBM26 5

External Ids for RBM26 Gene

Previous HGNC Symbols for RBM26 Gene

  • C13orf10

Previous GeneCards Identifiers for RBM26 Gene

  • GC13M078783
  • GC13M079888
  • GC13M060597

Summaries for RBM26 Gene

GeneCards Summary for RBM26 Gene

RBM26 (RNA Binding Motif Protein 26) is a Protein Coding gene. Diseases associated with RBM26 include Cutaneous T Cell Lymphoma and Helsmoortel-Van Der Aa Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM27.

Gene Wiki entry for RBM26 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM26 Gene

Genomics for RBM26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBM26 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J079401 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 283.5 +1.9 1864 6.4 CHD2 ZBTB10 MXD4 FEZF1 NR2C1 MNT IKZF1 BRCA1 SMAD5 MBD2 RBM26-AS1 RBM26 lnc-RBM26-4 NDFIP2 NDFIP2-AS1 RNA5SP33 OBI1
GH13J079481 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.5 -77.6 -77619 7.1 TBP FEZF1 CEBPA IKZF1 SMAD5 ETS1 POLR2A BHLHE40 ZEB1 ELF1 NDFIP2 RBM26-AS1 LINC01068 RBM26 NDFIP2-AS1 piR-47675-031 SPRY2
GH13J078601 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 17.8 +803.4 803376 2.2 CHD2 TBP FEZF1 BRCA1 ZEB1 THAP11 SIN3A SMAD4 SAP130 REST POU4F1 RBM26 LOC780529 EDNRB OBI1-AS1
GH13J080334 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -932.8 -932807 9.1 TBP ZBTB10 FEZF1 CEBPA MNT SMAD5 CTCF ZEB1 ZIC2 ZNF610 SPRY2 lnc-NDFIP2-31 RBM26 RNU6-61P MK280133 lnc-NDFIP2-32 HSALNG0098186 NDFIP2
GH13J078657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +747.5 747477 3.6 CHD2 TBP MXD4 CEBPA MNT SMAD5 POLR2A BHLHE40 ELF1 ZNF610 OBI1 POU4F1 RBM26 LOC780529 piR-30350-018
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM26

Top Transcription factor binding sites by QIAGEN in the RBM26 gene promoter:
  • c-Myc
  • C/EBPalpha
  • ER-alpha
  • HSF1 (long)
  • HSF1short
  • Max
  • STAT5A
  • USF-1
  • USF1
  • ZID

Genomic Locations for RBM26 Gene

Latest Assembly
94,654 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
87,388 bases
Minus strand

(GRCh37/hg19 by Ensembl)
94,651 bases
Minus strand

Genomic View for RBM26 Gene

Genes around RBM26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM26 Gene

Proteins for RBM26 Gene

  • Protein details for RBM26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 26
    Protein Accession:
    Secondary Accessions:
    • B4DZE0
    • Q2NKM2
    • Q2NKQ2
    • Q5CZH8
    • Q5T8P5
    • Q5T8P8
    • Q5U5P5
    • Q5W0G7
    • Q8N3H5
    • Q96K92
    • Q96SZ3
    • Q9H2F8
    • Q9H7F9
    • Q9P1G7

    Protein attributes for RBM26 Gene

    1007 amino acids
    Molecular mass:
    113597 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG34912.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14933.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55125.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM26 Gene

neXtProt entry for RBM26 Gene

Post-translational modifications for RBM26 Gene

  • Ubiquitination at Lys71 and Lys709
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RBM26 Gene

Domains & Families for RBM26 Gene

Gene Families for RBM26 Gene

Protein Domains for RBM26 Gene

  • Zn-finger, C-x8-C-x5-C-x3-H type

Suggested Antigen Peptide Sequences for RBM26 Gene

GenScript: Design optimal peptide antigens:
  • RNA binding motif protein 26 (E2PSN0_HUMAN)
  • RBM26 protein (Q7L643_HUMAN)
  • RNA-binding motif protein 26 (RBM26_HUMAN)
genes like me logo Genes that share domains with RBM26: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RBM26 Gene

Function for RBM26 Gene

Phenotypes From GWAS Catalog for RBM26 Gene

Gene Ontology (GO) - Molecular Function for RBM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IBA 21873635
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 17577209
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RBM26: view
genes like me logo Genes that share phenotypes with RBM26: view

Animal Models for RBM26 Gene

MGI Knock Outs for RBM26:
  • Rbm26 Rbm26<tm1b(KOMP)Mbp>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM26

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBM26 Gene

Localization for RBM26 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM26 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with RBM26: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RBM26 Gene

Pathways & Interactions for RBM26 Gene

PathCards logo

SuperPathways for RBM26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0046833 positive regulation of RNA export from nucleus IBA --
genes like me logo Genes that share ontologies with RBM26: view

No data available for Pathways by source and SIGNOR curated interactions for RBM26 Gene

Drugs & Compounds for RBM26 Gene

No Compound Related Data Available

Transcripts for RBM26 Gene

mRNA/cDNA for RBM26 Gene

20 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM26

Alternative Splicing Database (ASD) splice patterns (SP) for RBM26 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - -
SP2: - -
SP5: -
SP11: -

ExUns: 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP6: -
SP15: - - -
SP16: -

Relevant External Links for RBM26 Gene

GeneLoc Exon Structure for

Expression for RBM26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for RBM26 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5), Heart (8.1), and CD8 Tcells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM26 Gene

Protein tissue co-expression partners for RBM26 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM26

SOURCE GeneReport for Unigene cluster for RBM26 Gene:


Evidence on tissue expression from TISSUES for RBM26 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with RBM26: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM26 Gene

Orthologs for RBM26 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM26 30 31
  • 99.66 (n)
(Canis familiaris)
Mammalia RBM26 30 31
  • 95.44 (n)
(Bos Taurus)
Mammalia RBM26 30 31
  • 95.34 (n)
(Mus musculus)
Mammalia Rbm26 30 17 31
  • 91.63 (n)
(Rattus norvegicus)
Mammalia Rbm26 30
  • 90.71 (n)
(Ornithorhynchus anatinus)
Mammalia RBM26 31
  • 88 (a)
(Monodelphis domestica)
Mammalia RBM26 31
  • 82 (a)
(Gallus gallus)
Aves RBM26 30 31
  • 81.53 (n)
(Anolis carolinensis)
Reptilia RBM26 31
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52868 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.2802 30
(Danio rerio)
Actinopterygii RBM26 31
  • 68 (a)
rbm26 30
  • 65.46 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta swm 31
  • 25 (a)
(Caenorhabditis elegans)
Secernentea B0336.3 31
  • 29 (a)
Species where no ortholog for RBM26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RBM26 Gene

Gene Tree for RBM26 (if available)
Gene Tree for RBM26 (if available)
Evolutionary constrained regions (ECRs) for RBM26: view image

Paralogs for RBM26 Gene

Paralogs for RBM26 Gene

(2) SIMAP similar genes for RBM26 Gene using alignment to 3 proteins:

  • Q7L643_HUMAN
genes like me logo Genes that share paralogs with RBM26: view

Variants for RBM26 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBM26 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs140695915 Benign: not provided 79,358,413(-) T/C
NM_001366735.2(RBM26):c.1550A>G (p.Asn517Ser)
rs140824394 Likely Benign: not provided 79,322,372(-) C/G
NM_001366735.2(RBM26):c.2911G>C (p.Glu971Gln)
rs150357035 Likely Benign: not provided 79,337,300(-) A/C
NM_001366735.2(RBM26):c.2535T>G (p.Ala845=)
rs188958077 Likely Benign: not provided 79,337,132(-) G/A
NM_001366735.2(RBM26):c.2703C>T (p.Ser901=)
rs73564673 Benign: not provided 79,371,937(-) A/T

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RBM26 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RBM26 Gene

Variant ID Type Subtype PubMed ID
esv1133660 CNV deletion 17803354
esv2747705 CNV deletion 23290073
esv3580777 CNV loss 25503493
esv3632814 CNV gain 21293372
esv3632816 CNV gain 21293372
esv3632819 CNV gain 21293372
nsv523979 CNV loss 19592680
nsv64406 CNV deletion 16902084
nsv64617 CNV deletion 16902084
nsv64677 CNV deletion 16902084
nsv832657 CNV gain 17160897
nsv957439 CNV deletion 24416366

Variation tolerance for RBM26 Gene

Residual Variation Intolerance Score: 8.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM26 Gene

Disorders for RBM26 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBM26 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
helsmoortel-van der aa syndrome
  • hvdas
- elite association - COSMIC cancer census association via MalaCards
Search RBM26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBM26

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RBM26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM26 Gene

Publications for RBM26 Gene

  1. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmuller S … Schadendorf D (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  5. A family of RS domain proteins with novel subcellular localization and trafficking. (PMID: 15741184) Kavanagh SJ … Rathjen PD (Nucleic acids research 2005) 2 3

Products for RBM26 Gene

Sources for RBM26 Gene