Aliases for RBM24 Gene

Aliases for RBM24 Gene

  • RNA Binding Motif Protein 24 2 3 5
  • RNA-Binding Region (RNP1, RRM) Containing 6 2 3
  • RNA-Binding Region-Containing Protein 6 3 4
  • RNA-Binding Protein 24 3 4
  • RNPC6 3 4
  • RNA-Binding Motif Protein 24 4
  • DJ259A10.1 3

External Ids for RBM24 Gene

Previous HGNC Symbols for RBM24 Gene

  • RNPC6

Previous GeneCards Identifiers for RBM24 Gene

  • GC06P017390
  • GC06P017391

Summaries for RBM24 Gene

GeneCards Summary for RBM24 Gene

RBM24 (RNA Binding Motif Protein 24) is a Protein Coding gene. Diseases associated with RBM24 include Smallpox and Atrial Septal Defect 2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA 3'-UTR binding. An important paralog of this gene is RBM38.

UniProtKB/Swiss-Prot Summary for RBM24 Gene

  • Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity).

Additional gene information for RBM24 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM24 Gene

Genomics for RBM24 Gene

GeneHancer (GH) Regulatory Elements for RBM24 Gene

Promoters and enhancers for RBM24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM24 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM24

Top Transcription factor binding sites by QIAGEN in the RBM24 gene promoter:
  • CUTL1
  • Evi-1
  • Ik-2
  • NF-AT
  • NF-AT1
  • NF-AT4

Genomic Locations for RBM24 Gene

Genomic Locations for RBM24 Gene
chr6:17,281,361-17,293,875
(GRCh38/hg38)
Size:
12,515 bases
Orientation:
Plus strand
chr6:17,281,577-17,294,106
(GRCh37/hg19)
Size:
12,530 bases
Orientation:
Plus strand

Genomic View for RBM24 Gene

Genes around RBM24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM24 Gene

Proteins for RBM24 Gene

  • Protein details for RBM24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX46-RBM24_HUMAN
    Recommended name:
    RNA-binding protein 24
    Protein Accession:
    Q9BX46
    Secondary Accessions:
    • E9PAY4
    • Q6QDA4
    • Q8N9D3
    • Q96NI3

    Protein attributes for RBM24 Gene

    Size:
    236 amino acids
    Molecular mass:
    24776 Da
    Quaternary structure:
    • Interacts with EIF4E; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex (PubMed:29358667).
    SequenceCaution:
    • Sequence=BAC04474.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM24 Gene

Post-translational modifications for RBM24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RBM24 Gene

Domains & Families for RBM24 Gene

Gene Families for RBM24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM24 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RBM24 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79505, highly similar to RNA-binding region-containing protein 1 (A8KAI7_HUMAN)
  • RNA-binding region-containing protein 6 (RBM24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BX46

UniProtKB/Swiss-Prot:

RBM24_HUMAN :
  • The RRM domain is necessary for mRNA stability and mRNA translation regulation (PubMed:24356969, PubMed:29358667).
Domain:
  • The RRM domain is necessary for mRNA stability and mRNA translation regulation (PubMed:24356969, PubMed:29358667).
genes like me logo Genes that share domains with RBM24: view

Function for RBM24 Gene

Molecular function for RBM24 Gene

UniProtKB/Swiss-Prot Function:
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity).
UniProtKB/Swiss-Prot Induction:
By p53/TP53 following DNA damage (at protein level) (PubMed:24356969). Up-regulated during embryonic stem cell (ESC) differentiation into cardiomyocytes (PubMed:19658189, PubMed:26990106).

Phenotypes From GWAS Catalog for RBM24 Gene

Gene Ontology (GO) - Molecular Function for RBM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003729 mRNA binding IBA 21873635
GO:0003730 mRNA 3'-UTR binding ISS --
GO:0005515 protein binding IPI 29358667
genes like me logo Genes that share ontologies with RBM24: view
genes like me logo Genes that share phenotypes with RBM24: view

Animal Models for RBM24 Gene

MGI Knock Outs for RBM24:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM24

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBM24 Gene

Localization for RBM24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM24 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM24 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IBA --
GO:1990904 ribonucleoprotein complex IBA 21873635
genes like me logo Genes that share ontologies with RBM24: view

Pathways & Interactions for RBM24 Gene

PathCards logo

SuperPathways for RBM24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome ISS --
GO:0003197 endocardial cushion development IEA --
GO:0006397 mRNA processing IBA 21873635
GO:0006417 regulation of translation IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 24356969
genes like me logo Genes that share ontologies with RBM24: view

No data available for Pathways by source and SIGNOR curated interactions for RBM24 Gene

Drugs & Compounds for RBM24 Gene

No Compound Related Data Available

Transcripts for RBM24 Gene

mRNA/cDNA for RBM24 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM24

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM24 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for RBM24 Gene

GeneLoc Exon Structure for
RBM24

Expression for RBM24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM24 Gene

mRNA differential expression in normal tissues according to GTEx for RBM24 Gene

This gene is overexpressed in Muscle - Skeletal (x20.0), Heart - Atrial Appendage (x8.6), and Heart - Left Ventricle (x7.7).

Protein differential expression in normal tissues from HIPED for RBM24 Gene

This gene is overexpressed in Bone (44.8) and Heart (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM24 Gene



Protein tissue co-expression partners for RBM24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM24

SOURCE GeneReport for Unigene cluster for RBM24 Gene:

Hs.519904

mRNA Expression by UniProt/SwissProt for RBM24 Gene:

Q9BX46-RBM24_HUMAN
Tissue specificity: Expressed in fetal and adult heart and skeletal muscles (PubMed:22345307, PubMed:25313962).

Evidence on tissue expression from TISSUES for RBM24 Gene

  • Nervous system(4.2)
  • Muscle(3.4)
  • Heart(3)
genes like me logo Genes that share expression patterns with RBM24: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM24 Gene

Orthologs for RBM24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM24 31 30
  • 99.86 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM24 31
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM24 31 30
  • 92.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RBM24 31 30
  • 90.68 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM24 31
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm24 17 31 30
  • 88.7 (n)
rat
(Rattus norvegicus)
Mammalia Rbm24 30
  • 88.14 (n)
chicken
(Gallus gallus)
Aves RBM24 31
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM24 31
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm24 30
  • 80.24 (n)
MGC75808 30
African clawed frog
(Xenopus laevis)
Amphibia MGC52530 30
zebrafish
(Danio rerio)
Actinopterygii rbm24a 31 30
  • 71.76 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sup-12 31
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10652 31
  • 50 (a)
OneToMany
Species where no ortholog for RBM24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM24 Gene

ENSEMBL:
Gene Tree for RBM24 (if available)
TreeFam:
Gene Tree for RBM24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBM24: view image

Paralogs for RBM24 Gene

(2) SIMAP similar genes for RBM24 Gene using alignment to 4 proteins:

  • RBM24_HUMAN
  • A8KAI7_HUMAN
  • H0Y8S7_HUMAN
  • H0YA61_HUMAN
genes like me logo Genes that share paralogs with RBM24: view

Variants for RBM24 Gene

Additional dbSNP identifiers (rs#s) for RBM24 Gene

Variation tolerance for RBM24 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for RBM24 Gene

Disorders for RBM24 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBM24 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smallpox
  • ordinary smallpox
atrial septal defect 2
  • asd2
- elite association - COSMIC cancer census association via MalaCards
Search RBM24 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RBM24

genes like me logo Genes that share disorders with RBM24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM24 Gene

Publications for RBM24 Gene

  1. Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein. (PMID: 29104163) Lin Y … Xu XQ (The international journal of biochemistry & cell biology 2018) 3 4 54
  2. Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. (PMID: 29358667) Zhang M … Chen X (Cell death and differentiation 2018) 3 4 54
  3. Rbm24 Regulates Alternative Splicing Switch in Embryonic Stem Cell Cardiac Lineage Differentiation. (PMID: 26990106) Zhang T … Xu XQ (Stem cells (Dayton, Ohio) 2016) 3 4 54
  4. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. (PMID: 24356969) Jiang Y … Chen X (The Journal of biological chemistry 2014) 3 4 54
  5. RNA-binding protein RBM24 regulates p63 expression via mRNA stability. (PMID: 24375645) Xu E … Chen X (Molecular cancer research : MCR 2014) 3 4 54

Products for RBM24 Gene

Sources for RBM24 Gene