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Aliases for RBM23 Gene

Aliases for RBM23 Gene

  • RNA Binding Motif Protein 23 2 3 5
  • RNA-Binding Region (RNP1, RRM) Containing 4 2 3
  • RNA-Binding Region-Containing Protein 4 3 4
  • Splicing Factor SF2 3 4
  • RNPC4 3 4
  • Coactivator Of Activating Protein-1 And Estrogen Recep- Tors Beta 3
  • Coactivator Of Activating Protein-1 And Estrogen Receptors Beta 2
  • Probable RNA-Binding Protein 23 3
  • RNA-Binding Motif Protein 23 4
  • CAPERbeta 3
  • PP239 3

External Ids for RBM23 Gene

Previous HGNC Symbols for RBM23 Gene

  • RNPC4

Previous GeneCards Identifiers for RBM23 Gene

  • GC14M021361
  • GC14M022439
  • GC14M023369
  • GC14M003486

Summaries for RBM23 Gene

Entrez Gene Summary for RBM23 Gene

  • This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBM23 Gene

RBM23 (RNA Binding Motif Protein 23) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM39.

UniProtKB/Swiss-Prot for RBM23 Gene

  • Probable RNA-binding protein. May be involved in pre-mRNA splicing process.

Gene Wiki entry for RBM23 Gene

Additional gene information for RBM23 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM23 Gene

Genomics for RBM23 Gene

GeneHancer (GH) Regulatory Elements for RBM23 Gene

Promoters and enhancers for RBM23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I022917 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 568.3 +0.1 85 3.5 HDGF PKNOX1 CLOCK ARNT SIN3A ZNF2 IRF4 YY1 POLR2B ZNF213 RBM23 PRMT5-AS1 HAUS4 ACIN1 PABPN1 CDH24 SLC22A17 PPP1R3E PRMT5
GH14I022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 96.9 -60.7 -60719 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN PRMT5 C14orf93 HAUS4 RBM23 LOC102724814 PABPN1 MMP14
GH14I023005 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 50.7 -89.2 -89151 4.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 C14orf93 ENSG00000280129 ACIN1 RBM23 HAUS4 PRMT5 LOC102724814 C14orf119 PRMT5-AS1 NGDN
GH14I023056 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34 -138.4 -138410 3 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 CDH24 LOC105370705 ACIN1 NGDN RBM23 PRMT5 PABPN1 MMP14 SLC22A17 LOC102724814
GH14I023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 25.7 -151.3 -151275 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 NGDN LOC102724814 RBM23 HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM23 gene promoter:

Genomic Locations for RBM23 Gene

Genomic Locations for RBM23 Gene
chr14:22,893,206-22,919,187
(GRCh38/hg38)
Size:
25,982 bases
Orientation:
Minus strand
chr14:23,369,854-23,388,396
(GRCh37/hg19)

Genomic View for RBM23 Gene

Genes around RBM23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM23 Gene

Proteins for RBM23 Gene

  • Protein details for RBM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U06-RBM23_HUMAN
    Recommended name:
    Probable RNA-binding protein 23
    Protein Accession:
    Q86U06
    Secondary Accessions:
    • D3DS32
    • Q8ND16
    • Q8TB88
    • Q8WY40
    • Q9BUJ1
    • Q9NVV7

    Protein attributes for RBM23 Gene

    Size:
    439 amino acids
    Molecular mass:
    48731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBM23 Gene

    Alternative splice isoforms for RBM23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM23 Gene

Post-translational modifications for RBM23 Gene

No data available for DME Specific Peptides for RBM23 Gene

Domains & Families for RBM23 Gene

Gene Families for RBM23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RBM23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U06

UniProtKB/Swiss-Prot:

RBM23_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with RBM23: view

Function for RBM23 Gene

Molecular function for RBM23 Gene

UniProtKB/Swiss-Prot Function:
Probable RNA-binding protein. May be involved in pre-mRNA splicing process.

Phenotypes From GWAS Catalog for RBM23 Gene

Gene Ontology (GO) - Molecular Function for RBM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with RBM23: view
genes like me logo Genes that share phenotypes with RBM23: view

miRNA for RBM23 Gene

miRTarBase miRNAs that target RBM23

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM23 Gene

Localization for RBM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM23 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with RBM23: view

Pathways & Interactions for RBM23 Gene

SuperPathways for RBM23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with RBM23: view

No data available for Pathways by source and SIGNOR curated interactions for RBM23 Gene

Drugs & Compounds for RBM23 Gene

No Compound Related Data Available

Transcripts for RBM23 Gene

Unigene Clusters for RBM23 Gene

RNA binding motif protein 23:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - -
SP15:
SP16: - - -
SP17: - - - - - - - - - -
SP18: - -
SP19: - - - -
SP20:
SP21:
SP22: -
SP23: - - - - - -

ExUns: 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18
SP1: - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:

Relevant External Links for RBM23 Gene

GeneLoc Exon Structure for
RBM23
ECgene alternative splicing isoforms for
RBM23

Expression for RBM23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM23 Gene

This gene is overexpressed in Liver (56.4) and Lung (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM23 Gene



Protein tissue co-expression partners for RBM23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM23 Gene:

RBM23

SOURCE GeneReport for Unigene cluster for RBM23 Gene:

Hs.4997

Evidence on tissue expression from TISSUES for RBM23 Gene

  • Nervous system(4.9)
  • Muscle(4.3)
  • Lung(2.6)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with RBM23: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM23 Gene

Orthologs for RBM23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBM23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM23 33 34
  • 97.87 (n)
cow
(Bos Taurus)
Mammalia RBM23 33 34
  • 88.38 (n)
dog
(Canis familiaris)
Mammalia RBM23 34 33
  • 87.02 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM23 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM23 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM23 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm23 33
  • 65.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11266 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.3 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP13 34
  • 21 (a)
ManyToMany
RNA15 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
Species where no ortholog for RBM23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RBM23 Gene

ENSEMBL:
Gene Tree for RBM23 (if available)
TreeFam:
Gene Tree for RBM23 (if available)

Paralogs for RBM23 Gene

Variants for RBM23 Gene

Sequence variations from dbSNP and Humsavar for RBM23 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000158477 -- 22,903,679(-) C/T 3_prime_UTR_variant, intron_variant
rs1000454408 -- 22,904,867(-) C/A intron_variant
rs1000533860 -- 22,900,582(-) G/A downstream_transcript_variant
rs1000938717 -- 22,906,603(-) T/C intron_variant
rs1000947209 -- 22,920,194(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM23 Gene

Variant ID Type Subtype PubMed ID
esv3633769 CNV loss 21293372
dgv385e199 CNV deletion 23128226

Variation tolerance for RBM23 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.04; 87.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM23 Gene

Disorders for RBM23 Gene

Additional Disease Information for RBM23

No disorders were found for RBM23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM23 Gene

Publications for RBM23 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. (PMID: 15694343) Dowhan DH … O'Malley BW (Molecular cell 2005) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RBM23 Gene

Sources for RBM23 Gene