This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternativ... See more...

Aliases for RBM23 Gene

Aliases for RBM23 Gene

  • RNA Binding Motif Protein 23 2 3 5
  • CAPERbeta 2 3 4
  • RNA-Binding Region (RNP1, RRM) Containing 4 2 3
  • RNA-Binding Region-Containing Protein 4 3 4
  • Probable RNA-Binding Protein 23 3 4
  • Splicing Factor SF2 3 4
  • CAPER Beta 3 4
  • RNPC4 3 4
  • Coactivator Of Activating Protein-1 And Estrogen Recep- Tors Beta 3
  • Coactivator Of Activating Protein-1 And Estrogen Receptors Beta 2
  • RNA-Binding Motif Protein 23 4
  • FLJ10482 2
  • PP239 3
  • RBM23 5

External Ids for RBM23 Gene

Previous HGNC Symbols for RBM23 Gene

  • RNPC4

Previous GeneCards Identifiers for RBM23 Gene

  • GC14M021361
  • GC14M022439
  • GC14M023369
  • GC14M003486

Summaries for RBM23 Gene

Entrez Gene Summary for RBM23 Gene

  • This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RBM23 Gene

RBM23 (RNA Binding Motif Protein 23) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM39.

UniProtKB/Swiss-Prot Summary for RBM23 Gene

  • RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343).

Gene Wiki entry for RBM23 Gene

Additional gene information for RBM23 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM23 Gene

Genomics for RBM23 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBM23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM23 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM23

Top Transcription factor binding sites by QIAGEN in the RBM23 gene promoter:
  • ATF
  • c-Myb
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • MyoD
  • NRF-2
  • POU3F2

Genomic Locations for RBM23 Gene

Genomic Locations for RBM23 Gene
chr14:22,893,204-22,919,182
(GRCh38/hg38)
Size:
25,979 bases
Orientation:
Minus strand
chr14:23,369,854-23,388,396
(GRCh37/hg19)
Size:
18,543 bases
Orientation:
Minus strand

Genomic View for RBM23 Gene

Genes around RBM23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM23 Gene

Proteins for RBM23 Gene

  • Protein details for RBM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U06-RBM23_HUMAN
    Recommended name:
    Probable RNA-binding protein 23
    Protein Accession:
    Q86U06
    Secondary Accessions:
    • D3DS32
    • Q8ND16
    • Q8TB88
    • Q8WY40
    • Q9BUJ1
    • Q9NVV7

    Protein attributes for RBM23 Gene

    Size:
    439 amino acids
    Molecular mass:
    48731 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RBM23 Gene

    Alternative splice isoforms for RBM23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM23 Gene

Post-translational modifications for RBM23 Gene

  • Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM23 (PubMed:31686031, PubMed:31819272).
  • Ubiquitination at Lys245
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RBM23 Gene

Domains & Families for RBM23 Gene

Gene Families for RBM23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM23 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
ProtoNet:

Suggested Antigen Peptide Sequences for RBM23 Gene

GenScript: Design optimal peptide antigens:
  • RNPC4 protein (Q6IA98_HUMAN)
  • Splicing factor SF2 (RBM23_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86U06

UniProtKB/Swiss-Prot:

RBM23_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with RBM23: view

Function for RBM23 Gene

Molecular function for RBM23 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343).

Phenotypes From GWAS Catalog for RBM23 Gene

Gene Ontology (GO) - Molecular Function for RBM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with RBM23: view
genes like me logo Genes that share phenotypes with RBM23: view

Animal Model Products

CRISPR Products

miRNA for RBM23 Gene

miRTarBase miRNAs that target RBM23

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM23 Gene

Localization for RBM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM23 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016020 membrane HDA 19946888
GO:1990904 ribonucleoprotein complex IBA --
genes like me logo Genes that share ontologies with RBM23: view

Pathways & Interactions for RBM23 Gene

PathCards logo

SuperPathways for RBM23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 15694343
GO:0048024 regulation of mRNA splicing, via spliceosome IDA 15694343
GO:0051252 regulation of RNA metabolic process IBA --
genes like me logo Genes that share ontologies with RBM23: view

No data available for Pathways by source and SIGNOR curated interactions for RBM23 Gene

Drugs & Compounds for RBM23 Gene

No Compound Related Data Available

Transcripts for RBM23 Gene

mRNA/cDNA for RBM23 Gene

9 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM23

Alternative Splicing Database (ASD) splice patterns (SP) for RBM23 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - - - - -
SP15:
SP16: - - -
SP17: - - - - - - - - - -
SP18: - -
SP19: - - - -
SP20:
SP21:
SP22: -
SP23: - - - - - -

ExUns: 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18
SP1: - - -
SP2:
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:

Relevant External Links for RBM23 Gene

GeneLoc Exon Structure for
RBM23

Expression for RBM23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM23 Gene

This gene is overexpressed in Liver (56.4) and Lung (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM23 Gene



Protein tissue co-expression partners for RBM23 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM23

SOURCE GeneReport for Unigene cluster for RBM23 Gene:

Hs.4997

mRNA Expression by UniProt/SwissProt for RBM23 Gene:

Q86U06-RBM23_HUMAN
Tissue specificity: Highly expressed in placenta, liver, skeletal muscle, heart and kidney (PubMed:15694343). Expressed at lower levels in the colon, thymus, spleen, small intestine and lung (PubMed:15694343).

Evidence on tissue expression from TISSUES for RBM23 Gene

  • Nervous system(4.9)
  • Muscle(4.4)
  • Lung(3)
  • Eye(2.8)
  • Blood(2.3)
  • Kidney(2.3)
  • Pancreas(2.2)
  • Skin(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with RBM23: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM23 Gene

Orthologs for RBM23 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RBM23 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RBM23 30 31
  • 97.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RBM23 30 31
  • 88.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RBM23 30 31
  • 87.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RBM23 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RBM23 31
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RBM23 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rbm23 30
  • 65.12 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG11266 31
  • 36 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y55F3AM.3 31
  • 29 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP13 31
  • 21 (a)
ManyToMany
RNA15 31
  • 14 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToMany
Species where no ortholog for RBM23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for RBM23 Gene

ENSEMBL:
Gene Tree for RBM23 (if available)
TreeFam:
Gene Tree for RBM23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBM23: view image

Paralogs for RBM23 Gene

(13) SIMAP similar genes for RBM23 Gene using alignment to 16 proteins:

  • RBM23_HUMAN
  • G3V225_HUMAN
  • G3V2B4_HUMAN
  • G3V2B6_HUMAN
  • G3V2H9_HUMAN
  • G3V3S8_HUMAN
  • G3V3V3_HUMAN
  • G3V546_HUMAN
  • G3V5J5_HUMAN
  • G3V5V1_HUMAN
  • G3V5W6_HUMAN
  • G3V5Y2_HUMAN
  • G3V5Z6_HUMAN
  • G3XAP0_HUMAN
  • H0YJJ3_HUMAN
  • H0YJN4_HUMAN
genes like me logo Genes that share paralogs with RBM23: view

Variants for RBM23 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBM23 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1127066 - p.Phe428Leu
rs34246954 - p.Asp184Asn

Additional dbSNP identifiers (rs#s) for RBM23 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBM23 Gene

Variant ID Type Subtype PubMed ID
dgv385e199 CNV deletion 23128226
esv3633769 CNV loss 21293372

Variation tolerance for RBM23 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.04; 87.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM23 Gene

Disorders for RBM23 Gene

Additional Disease Information for RBM23

No disorders were found for RBM23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM23 Gene

Publications for RBM23 Gene

  1. Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta. (PMID: 15694343) Dowhan DH … O'Malley BW (Molecular cell 2005) 2 3 4
  2. Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. (PMID: 31686031) Faust TB … Fischer ES (Nature chemical biology 2020) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RBM23 Gene

Sources for RBM23 Gene