Aliases for RBM22 Gene
Aliases for RBM22 Gene
External Ids for RBM22 Gene
- HGNC: 25503
- Entrez Gene: 55696
- Ensembl: ENSG00000086589
- OMIM: 612430
- UniProtKB: Q9NW64
Previous GeneCards Identifiers for RBM22 Gene
- GC05M150099
- GC05M150050
- GC05M145216
Summaries for RBM22 Gene
-
This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]
GeneCards Summary for RBM22 Gene
RBM22 (RNA Binding Motif Protein 22) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot for RBM22 Gene
-
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM22 Gene
Genomics for RBM22 Gene
GeneHancer (GH) Regulatory Elements for RBM22 Gene
Promoters and enhancers for RBM22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RBM22 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RBM22 gene promoter:
Regulatory Element Products
Genomic Locations for RBM22 Gene
Genomic Locations for RBM22 Gene
- chr5:150,690,790-150,701,107
- (GRCh38/hg38)
- Size:
- 10,318 bases
- Orientation:
- Minus strand
- chr5:150,070,352-150,080,669
- (GRCh37/hg19)
Genomic View for RBM22 Gene
Genes around RBM22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.1 by Ensembl
- 5q33.1 by Entrez Gene
- 5q33.1 by HGNC
RBM22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBM22 Gene
Proteins for RBM22 Gene
-
Protein details for RBM22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NW64-RBM22_HUMAN
- Recommended name:
- Pre-mRNA-splicing factor RBM22
- Protein Accession:
- Q9NW64
- A6NDM5
- B4DLI9
- O95607
Protein attributes for RBM22 Gene
- Size:
- 420 amino acids
- Molecular mass:
- 46896 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm.
- SequenceCaution:
-
- Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};
Protein Expression for RBM22 Gene
Post-translational modifications for RBM22 Gene
Other Protein References for RBM22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RBM22
- Novus Biologicals Antibodies for RBM22
-
Abcam antibodies for RBM22
- Invitrogen Antibodies for RBM22
- GeneTex RBM22 antibody for RBM22
Protein Products
-
OriGene Purified Proteins for RBM22
- Search Origene for MassSpec and Protein Over-expression Lysates for RBM22
- Origene Custom Protein Services for RBM22
- Search GeneTex for Proteins for RBM22
-
Abcam proteins for RBM22
Assay Products
No data available for DME Specific Peptides for RBM22 Gene
Domains & Families for RBM22 Gene
Gene Families for RBM22 Gene
Protein Domains for RBM22 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RBM22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NW64UniProtKB/Swiss-Prot:
RBM22_HUMAN :- The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
- Belongs to the SLT11 family.
- Domain:
-
- The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
- Family:
-
- Belongs to the SLT11 family.
Function for RBM22 Gene
Molecular function for RBM22 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
Phenotypes From GWAS Catalog for RBM22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | HDA,IEA | 22658674 |
| GO:0005487 | nuclear pore activity | IDA | 21122810 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0017070 | U6 snRNA binding | IDA | 22246180 |
Phenotypes for RBM22 Gene
- GenomeRNAi human phenotypes for RBM22:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Increased HPV18 LCR reporter activity
- Decreased homologous recombination repair frequency
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased Dengue Infection
- Decreased viability with paclitaxel
- Mitotic arrest, spindle defect
Animal Model Products
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-
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ViGene Biosciences lentiviral particle packaged cDNA for RBM22 gene
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CRISPR Products
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OriGene CRISPR knockouts for RBM22
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- Overview of 122 available RBM22 gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBM22
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miRNA for RBM22 Gene
- miRTarBase miRNAs that target RBM22
-
- hsa-mir-155-5p (MIRT020871)
- hsa-let-7b-5p (MIRT052325)
- hsa-mir-297 (MIRT519503)
- hsa-mir-620 (MIRT519504)
- hsa-mir-1270 (MIRT519505)
- hsa-mir-3924 (MIRT519506)
- hsa-mir-223-5p (MIRT519507)
- hsa-mir-7847-3p (MIRT519508)
- hsa-mir-567 (MIRT519509)
- hsa-mir-4683 (MIRT519510)
- hsa-mir-511-3p (MIRT519511)
- hsa-mir-299-3p (MIRT519512)
- hsa-mir-4657 (MIRT519513)
- hsa-mir-4491 (MIRT519514)
- hsa-mir-4495 (MIRT519515)
- hsa-mir-101-5p (MIRT532787)
- hsa-mir-1278 (MIRT532788)
- hsa-mir-3923 (MIRT532789)
- hsa-mir-580-5p (MIRT532790)
- hsa-mir-7703 (MIRT665208)
- hsa-mir-6720-5p (MIRT665209)
- hsa-mir-6512-3p (MIRT665210)
- hsa-mir-1227-3p (MIRT665211)
- hsa-mir-542-3p (MIRT665212)
- hsa-mir-4252 (MIRT665213)
- hsa-mir-4793-3p (MIRT665214)
- hsa-mir-766-3p (MIRT665215)
- hsa-mir-6849-3p (MIRT665216)
- hsa-mir-1273g-3p (MIRT665217)
- hsa-mir-508-5p (MIRT665218)
- hsa-mir-3178 (MIRT671012)
- hsa-mir-24-3p (MIRT671013)
- hsa-mir-4284 (MIRT671014)
- hsa-mir-4743-5p (MIRT671015)
- hsa-mir-5093 (MIRT671016)
- hsa-mir-6499-5p (MIRT671017)
- hsa-mir-486-5p (MIRT671018)
- hsa-mir-483-3p (MIRT671019)
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RBM22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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ViGene Biosciences adenoviral particle packaged cDNA for RBM22 gene
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ViGene Biosciences lentiviral particle packaged cDNA for RBM22 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM22 Gene
Localization for RBM22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBM22 Gene
- Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 1 |
| peroxisome | 1 |
- Nucleus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000974 | Prp19 complex | IBA | -- |
| GO:0005634 | nucleus | IDA | 11278427 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 21122810 |
Pathways & Interactions for RBM22 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for RBM22 Gene
4 Reactome pathways for RBM22 Gene
1 KEGG pathway for RBM22 Gene
Interacting Proteins for RBM22 Gene
Selected Interacting proteins:
ENSP00000199814
Q9NW64-RBM22_HUMAN
for RBM22 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000060 | protein import into nucleus, translocation | IDA | 17045351 |
| GO:0000387 | spliceosomal snRNP assembly | IBA | -- |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006810 | transport | IEA | -- |
No data available for SIGNOR curated interactions for RBM22 Gene
Transcripts for RBM22 Gene
mRNA/cDNA for RBM22 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (239) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RBM22 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RBM22
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- Overview of 122 available RBM22 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBM22
- GenScript: Design CRISPR guide RNA sequences for RBM22
miRNA Products
- Search ViGene Biosciences for RBM22
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RBM22
- Browse OriGene Inhibitory RNA Products For RBM22
- genomics-online: shRNA clones - Search results for 122 available RBM22 gene related products
- Overview of 122 available RBM22 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for RBM22 gene
Clone Products
- Sino Biological Human cDNA Clone for RBM22
- VectorBuilder custom plasmid, inducible vectors for RBM22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RBM22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RBM22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: |
Expression for RBM22 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (27.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM22 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RBM22 Gene:
RBM22SOURCE GeneReport for Unigene cluster for RBM22 Gene:
Hs.713564Evidence on tissue expression from TISSUES for RBM22 Gene
- Nervous system(4.8)
- Blood(4.2)
Primer Products
-
OriGene qPCR primer pairs for RBM22
-
OriGene qPCR primer pairs and template standards for RBM22
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- Overview of 122 available RBM22 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM22 Gene
Orthologs for RBM22 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RBM22 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RBM22 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RBM22 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RBM22 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Rbm22 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rbm22 33 |
|
||
| chicken (Gallus gallus) |
Aves | RBM22 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RBM22 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rbm22 33 |
|
||
| MGC76229 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cg14641-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | RBM22 (3 of 3) 34 |
|
OneToMany | |
| rbm22 33 34 34 |
|
||||
| wufc62e03 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004509 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14641 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | T11G6.8 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ECM2 34 36 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07360 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1512 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0281000 33 |
|
||
| Os.14314 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.2670 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.14515 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.4129 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8471 34 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2969 33 |
|
- Species where no ortholog for RBM22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for RBM22 Gene
Pseudogenes.org Pseudogenes for RBM22 Gene
No data available for Paralogs for RBM22 Gene
Variants for RBM22 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000310509 | -- | 150,694,652(-) | G/C | intron_variant | |
| rs1000705188 | -- | 150,699,633(-) | A/G | intron_variant | |
| rs1000731922 | -- | 150,699,412(-) | C/A | intron_variant | |
| rs1000990844 | -- | 150,696,376(-) | A/G | intron_variant | |
| rs1001221382 | -- | 150,693,522(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RBM22 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RBM22
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM22 Gene
Disorders for RBM22 Gene
Additional Disease Information for RBM22
No disorders were found for RBM22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM22 Gene
Publications for RBM22 Gene
- The influence of calcium signaling on the regulation of alternative splicing. (PMID: 19133299) Krebs J (Biochimica et biophysica acta 2009) 2 3 4 58
- Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. (PMID: 22246180) Rasche N … Lührmann R (The EMBO journal 2012) 3 4 58
- Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. (PMID: 21122810) Janowicz A … Krebs J (Biochimica et biophysica acta 2011) 3 4 58
- RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. (PMID: 20013661) He F … Gou LT (Genetics and molecular research : GMR 2009) 2 3 58
- Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. (PMID: 17045351) Montaville P … Krebs J (Biochimica et biophysica acta 2006) 3 4 58
Products for RBM22 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 39 available RBM22 Antibodies ranked by validation data
- Compare Top RBM22 Antibodies
- antibodies-online: Search results for available RBM22 related products ranked by validation data
- antibodies-online: Search results for 9 available RBM22 Proteins ranked by validation data
- Compare Top RBM22 Proteins
- GeneTex RBM22 antibody for RBM22
- Search GeneTex for Proteins for RBM22
- ViGene Biosciences adenoviral particle packaged cDNA for RBM22 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RBM22 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RBM22 gene
- Search ViGene Biosciences for RBM22
- genomics-online: cdna clones - Search results for 122 available RBM22 gene related products
- Overview of 122 available RBM22 gene related products
- orf clones - Search results for 122 available RBM22 gene related products
- Overview of 122 available RBM22 gene related products
- genomics-online: gRNA clones - Search results for 122 available RBM22 gene related products
- Overview of 122 available RBM22 gene related products
- genomics-online: primer clones - Search results for 122 available RBM22 gene related products
- Overview of 122 available RBM22 gene related products
- genomics-online: shRNA clones - Search results for 122 available RBM22 gene related products
- Overview of 122 available RBM22 gene related products
Sources for RBM22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems