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This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009] See more...
Aliases for RBM22 Gene
Aliases for RBM22 Gene
External Ids for RBM22 Gene
- HGNC: 25503
- Entrez Gene: 55696
- Ensembl: ENSG00000086589
- OMIM: 612430
- UniProtKB: Q9NW64
Previous GeneCards Identifiers for RBM22 Gene
- GC05M150099
- GC05M150050
- GC05M145216
Summaries for RBM22 Gene
-
This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]
GeneCards Summary for RBM22 Gene
RBM22 (RNA Binding Motif Protein 22) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot Summary for RBM22 Gene
-
Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
Additional gene information for RBM22 Gene
- HGNC(25503)
- Entrez Gene(55696)
- Ensembl(ENSG00000086589)
- OMIM(612430)
- UniProtKB(Q9NW64)
- Open Targets Platform(ENSG00000086589)
- Search for RBM22 at DataMed
- Search for RBM22 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM22 Gene
Genomics for RBM22 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RBM22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RBM22 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM22
- Top Transcription factor binding sites by QIAGEN in the RBM22 gene promoter:
-
- AML1a
- E4BP4
- MRF-2
- NF-kappaB
- NF-kappaB1
- PPAR-gamma1
- PPAR-gamma2
- Sp1
- XBP-1
Genomic Locations for RBM22 Gene
Genomic Locations for RBM22 Gene
- chr5:150,690,792-150,701,089
- (GRCh38/hg38)
- Size:
- 10,298 bases
- Orientation:
- Minus strand
- chr5:150,070,352-150,080,669
- (GRCh37/hg19)
- Size:
- 10,318 bases
- Orientation:
- Minus strand
Genomic View for RBM22 Gene
Genes around RBM22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.1 by HGNC
- 5q33.1 by Entrez Gene
- 5q33.1 by Ensembl
RBM22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBM22 Gene
Proteins for RBM22 Gene
-
Protein details for RBM22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NW64-RBM22_HUMAN
- Recommended name:
- Pre-mRNA-splicing factor RBM22
- Protein Accession:
- Q9NW64
- A6NDM5
- B4DLI9
- O95607
Protein attributes for RBM22 Gene
- Size:
- 420 amino acids
- Molecular mass:
- 46896 Da
- Quaternary structure:
-
- Component of the pre-catalytic and catalytic spliceosome complexes (PubMed:11991638, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961). Component of the postcatalytic spliceosome P complex (PubMed:30705154). Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm.
- SequenceCaution:
-
- Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for RBM22 Gene
Protein Expression for RBM22 Gene
Post-translational modifications for RBM22 Gene
Other Protein References for RBM22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences RBM22 Antibody
- Creative Diagnostics Anti-RBM22 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for RBM22
- Novus Biologicals Antibodies for RBM22
-
Abcam antibodies for RBM22
- Invitrogen Antibodies for RBM22 (AFLGC-RBM22)
-
Boster Bio Antibodies for RBM22
Protein Products
-
OriGene Purified Proteins for RBM22
- Search Origene for MassSpec and Protein Over-expression Lysates for RBM22
- Origene Custom Protein Services for RBM22
-
Abcam proteins for RBM22
No data available for DME Specific Peptides for RBM22 Gene
Domains & Families for RBM22 Gene
Gene Families for RBM22 Gene
Protein Domains for RBM22 Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- Zn-finger, C-x8-C-x5-C-x3-H type
- ProtoNet:
Suggested Antigen Peptide Sequences for RBM22 Gene
- GenScript: Design optimal peptide antigens:
-
- Zinc finger CCCH domain-containing protein 16 (RBM22_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NW64UniProtKB/Swiss-Prot:
RBM22_HUMAN :- The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
- Belongs to the SLT11 family.
- Domain:
-
- The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
- Family:
-
- Belongs to the SLT11 family.
Function for RBM22 Gene
Molecular function for RBM22 Gene
- UniProtKB/Swiss-Prot Function:
- Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30705154). Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.
Phenotypes From GWAS Catalog for RBM22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,HDA | 22658674 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0017070 | U6 snRNA binding | IDA | 22246180 |
| GO:0036002 | pre-mRNA binding | IBA,IDA | 22246180 |
Phenotypes for RBM22 Gene
- MGI mutant phenotypes for RBM22:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RBM22:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 25%
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased homologous recombination repair frequency
- Increased HPV18 LCR reporter activity
- Increased hepcidin::fluc mRNA expression
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased Dengue Infection
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability with paclitaxel
- Decreased transferrin (TF) endocytosis
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Mitotic arrest, cytokinesis defect
Animal Models for RBM22 Gene
- MGI Knock Outs for RBM22:
-
- Rbm22 Rbm22<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RBM22 - Select products 50% OFF >
- * RBM22 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for RBM22
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBM22
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBM22
miRNA for RBM22 Gene
- miRTarBase miRNAs that target RBM22
-
- mmu-miR-541-5p (MIRT008144)
- hsa-miR-155-5p (MIRT020871)
- hsa-let-7b-5p (MIRT052325)
- hsa-miR-297 (MIRT519503)
- hsa-miR-620 (MIRT519504)
- hsa-miR-1270 (MIRT519505)
- hsa-miR-3924 (MIRT519506)
- hsa-miR-223-5p (MIRT519507)
- hsa-miR-7847-3p (MIRT519508)
- hsa-miR-567 (MIRT519509)
- hsa-miR-4683 (MIRT519510)
- hsa-miR-511-3p (MIRT519511)
- hsa-miR-299-3p (MIRT519512)
- hsa-miR-4657 (MIRT519513)
- hsa-miR-4491 (MIRT519514)
- hsa-miR-4495 (MIRT519515)
- hsa-miR-101-5p (MIRT532787)
- hsa-miR-1278 (MIRT532788)
- hsa-miR-3923 (MIRT532789)
- hsa-miR-580-5p (MIRT532790)
- hsa-miR-7703 (MIRT665208)
- hsa-miR-6720-5p (MIRT665209)
- hsa-miR-6512-3p (MIRT665210)
- hsa-miR-1227-3p (MIRT665211)
- hsa-miR-542-3p (MIRT665212)
- hsa-miR-4252 (MIRT665213)
- hsa-miR-4793-3p (MIRT665214)
- hsa-miR-766-3p (MIRT665215)
- hsa-miR-6849-3p (MIRT665216)
- hsa-miR-1273g-3p (MIRT665217)
- hsa-miR-508-5p (MIRT665218)
- hsa-miR-3178 (MIRT671012)
- hsa-miR-24-3p (MIRT671013)
- hsa-miR-4284 (MIRT671014)
- hsa-miR-4743-5p (MIRT671015)
- hsa-miR-5093 (MIRT671016)
- hsa-miR-6499-5p (MIRT671017)
- hsa-miR-486-5p (MIRT671018)
- hsa-miR-483-3p (MIRT671019)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBM22
- Browse OriGene Inhibitory RNA Products For RBM22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM22
Clone Products
- Applied Biological Materials (abm): Clones for RBM22 - Select products 50% OFF >
- * RBM22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RBM22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBM22
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBM22 Gene
Localization for RBM22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBM22 Gene
- Nucleus. Cytoplasm. Note=Nearly exclusively nuclear. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol. {ECO:0000269 PubMed:21122810}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endosome | 1 |
| extracellular | 0 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000974 | Prp19 complex | IBA | 21873635 |
| GO:0005634 | nucleus | IEA,IDA | 17045351 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 21122810 |
Pathways & Interactions for RBM22 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for RBM22 Gene
4 Reactome pathways for RBM22 Gene
1 KEGG pathway for RBM22 Gene
Interacting Proteins for RBM22 Gene
Selected Interacting proteins:
Q9NW64-RBM22_HUMAN
ENSP00000199814
for RBM22 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RBM22
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | IEA,TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0033120 | positive regulation of RNA splicing | IDA | 22246180 |
| GO:0035690 | cellular response to drug | IDA | 21122810 |
No data available for SIGNOR curated interactions for RBM22 Gene
Transcripts for RBM22 Gene
mRNA/cDNA for RBM22 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000199814 2299 nts (view in UCSC)
- ENST00000447771 1386 nts (view in UCSC)
- ENST00000518917 566 nts (view in UCSC)
- ENST00000520132 2067 nts (view in UCSC)
- ENST00000521248 660 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RBM22 - Select products 50% OFF >
- * RBM22 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RBM22
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBM22
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBM22
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBM22
- Browse OriGene Inhibitory RNA Products For RBM22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM22
Clone Products
- Applied Biological Materials (abm): Clones for RBM22 - Select products 50% OFF >
- * RBM22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RBM22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBM22
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: |
Relevant External Links for RBM22 Gene
- GeneLoc Exon Structure for
- RBM22
Expression for RBM22 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (27.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM22 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM22
SOURCE GeneReport for Unigene cluster for RBM22 Gene:
Hs.713564Evidence on tissue expression from TISSUES for RBM22 Gene
- Nervous system(4.8)
- Blood(4.3)
- Skin(2.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for RBM22
-
OriGene qPCR primer pairs and template standards for RBM22
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM22 Gene
Orthologs for RBM22 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RBM22 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RBM22 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RBM22 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RBM22 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rbm22 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rbm22 30 |
|
||
| Chicken (Gallus gallus) |
Aves | RBM22 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RBM22 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rbm22 30 |
|
||
| MGC76229 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cg14641-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | RBM22 (3 of 3) 31 |
|
OneToMany | |
| rbm22 30 31 31 |
|
OneToMany | |||
| wufc62e03 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004509 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG14641 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | T11G6.8 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ECM2 31 33 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G07360 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1512 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os07g0281000 30 |
|
||
| Os.14314 30 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.2670 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.14515 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.4129 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8471 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2969 30 |
|
- Species where no ortholog for RBM22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for RBM22 Gene
- ENSEMBL:
- Gene Tree for RBM22 (if available)
- TreeFam:
- Gene Tree for RBM22 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RBM22: view image
Paralogs for RBM22 Gene
Pseudogenes.org Pseudogenes for RBM22 Gene
No data available for Paralogs for RBM22 Gene
Variants for RBM22 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBM22 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 773937 | Benign: not provided | 150,691,844(-) | G/C | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RBM22 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RBM22
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM22 Gene
Disorders for RBM22 Gene
Additional Disease Information for RBM22
No disorders were found for RBM22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM22 Gene
Publications for RBM22 Gene
- The influence of calcium signaling on the regulation of alternative splicing. (PMID: 19133299) Krebs J (Biochimica et biophysica acta 2009) 2 3 4
- Cryo-EM structure of a human spliceosome activated for step 2 of splicing. (PMID: 28076346) Bertram K … Lührmann R (Nature 2017) 3 4
- Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. (PMID: 22246180) Rasche N … Lührmann R (The EMBO journal 2012) 3 4
- Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. (PMID: 21122810) Janowicz A … Krebs J (Biochimica et biophysica acta 2011) 3 4
- RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. (PMID: 20013661) He F … Gou LT (Genetics and molecular research : GMR 2009) 2 3
ExternalLinks
Products for RBM22 Gene
- Custom Antibody ServicesOriGene Antibodies for RBM22
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- OriGene qPCR primer pairs for RBM22
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- Sino Biological Human cDNA Clone for RBM22
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for RBM22
- Novus Biologicals proteins and lysates for RBM22
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- Abcam antibodies for RBM22
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
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- Invitrogen Antibodies for RBM22 (AFLGC-RBM22)
- VectorBuilder Custom and pre-made DNA vectors for RBM22 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RBM22 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for RBM22
- antibodies-online: Show 15 available RBM22 Antibodies ranked by validation data
- Compare Top RBM22 Antibodies
- antibodies-online: Search results for available RBM22 related products ranked by validation data
- antibodies-online: Show 9 available RBM22 Proteins ranked by validation data
- Compare Top RBM22 Proteins
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBM22
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBM22
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RBM22
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM22
- Boster Bio Antibodies for RBM22
- Browse Boster Bio ELISA Kits
Sources for RBM22 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB