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Aliases for RBM15B Gene

Aliases for RBM15B Gene

  • RNA Binding Motif Protein 15B 2 3 5
  • HuOTT3 3 4
  • OTT3 3 4
  • Putative RNA-Binding Protein 15B 3
  • Chromosome 3p21.1 Gene Sequence 3
  • RNA-Binding Motif Protein 15B 4
  • One Twenty Two Protein 3 3
  • One-Twenty Two Protein 3 4

External Ids for RBM15B Gene

Previous GeneCards Identifiers for RBM15B Gene

  • GC03P051405
  • GC03P051428

Summaries for RBM15B Gene

Entrez Gene Summary for RBM15B Gene

  • Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

GeneCards Summary for RBM15B Gene

RBM15B (RNA Binding Motif Protein 15B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM15.

UniProtKB/Swiss-Prot for RBM15B Gene

  • May function in the regulation of alternative or illicit splicing.

Additional gene information for RBM15B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM15B Gene

Genomics for RBM15B Gene

GeneHancer (GH) Regulatory Elements for RBM15B Gene

Promoters and enhancers for RBM15B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I051383 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -3.1 -3067 9.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 MANF PIR60056 RBM15B DCAF1 RRP9 RAD54L2 TEX264 GRM2 CACNA2D2 GPR62
GH03I051668 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 +279.6 279592 4.1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 POLR2B ZNF766 ZNF207 ZNF143 TEX264 DCAF1 RRP9 RNU6ATAC29P RBM15B RAD54L2 DOCK3 GRM2 PIR41340 RNA5SP132
GH03I051990 Enhancer 0.8 ENCODE 3.6 +601.1 601094 3 PKNOX1 NFRKB NFXL1 POLR2B ZNF350 BCLAF1 SMAD5 USF2 NFYC ZFP69B GPR62 DUSP7 RAD54L2 PARP3 RPL29 ABHD14B RBM15B
GH03I051024 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.2 -366.1 -366124 2.1 KLF1 USF1 NFIB MAX MZF1 FEZF1 ZBTB48 PATZ1 SCRT2 ZNF416 RAD54L2 RBM5 DOCK3 SEMA3F-AS1 TEX264 DCAF1 RBM15B ST13P14 GC03M051294
GH03I051394 Enhancer 0.5 dbSUPER 0.8 +4.7 4695 2.1 PAF1 POLR2A SCRT2 MAFG BATF BCLAF1 PIR51350 TEX264 RAD54L2 GRM2 GC03P051392 PIR52841 RBM15B DCAF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RBM15B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM15B gene promoter:

Genomic Locations for RBM15B Gene

Genomic Locations for RBM15B Gene
6,641 bases
Plus strand

Genomic View for RBM15B Gene

Genes around RBM15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM15B Gene

Proteins for RBM15B Gene

  • Protein details for RBM15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA-binding protein 15B
    Protein Accession:
    Secondary Accessions:
    • A4QPG7
    • Q6QE19
    • Q9BV96

    Protein attributes for RBM15B Gene

    890 amino acids
    Molecular mass:
    97205 Da
    Quaternary structure:
    • Interacts (via the SPOC domain) with Epstein-Barr virus BMLF1 (via the N-terminus); the interaction is direct. May interact with NCOR2.
    • Sequence=AAH01367.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAS50153.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=CAD38547.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM15B Gene


neXtProt entry for RBM15B Gene

Post-translational modifications for RBM15B Gene

No Post-translational modifications

Other Protein References for RBM15B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RBM15B Gene

Domains & Families for RBM15B Gene

Gene Families for RBM15B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RBM15B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRM Spen family.
  • Belongs to the RRM Spen family.
genes like me logo Genes that share domains with RBM15B: view

Function for RBM15B Gene

Molecular function for RBM15B Gene

UniProtKB/Swiss-Prot Function:
May function in the regulation of alternative or illicit splicing.

Gene Ontology (GO) - Molecular Function for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0003723 RNA binding NAS 16129689
GO:0005515 protein binding IPI 16129689
genes like me logo Genes that share ontologies with RBM15B: view
genes like me logo Genes that share phenotypes with RBM15B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM15B Gene

Localization for RBM15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM15B Gene

Nucleus, nucleoplasm. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM15B gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,IEA 16129689
GO:0005730 NOT nucleolus IDA 16129689
genes like me logo Genes that share ontologies with RBM15B: view

Pathways & Interactions for RBM15B Gene

SuperPathways for RBM15B Gene

No Data Available

Interacting Proteins for RBM15B Gene

Gene Ontology (GO) - Biological Process for RBM15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 16129689
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006397 mRNA processing IEA --
GO:0006913 NOT nucleocytoplasmic transport IDA 16129689
genes like me logo Genes that share ontologies with RBM15B: view

No data available for Pathways by source and SIGNOR curated interactions for RBM15B Gene

Drugs & Compounds for RBM15B Gene

No Compound Related Data Available

Transcripts for RBM15B Gene

mRNA/cDNA for RBM15B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(310) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RBM15B Gene

RNA binding motif protein 15B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM15B Gene

No ASD Table

Relevant External Links for RBM15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM15B Gene

Protein differential expression in normal tissues from HIPED for RBM15B Gene

This gene is overexpressed in Fetal Brain (15.1), Peripheral blood mononuclear cells (9.7), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM15B Gene

Protein tissue co-expression partners for RBM15B Gene

NURSA nuclear receptor signaling pathways regulating expression of RBM15B Gene:


SOURCE GeneReport for Unigene cluster for RBM15B Gene:


mRNA Expression by UniProt/SwissProt for RBM15B Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for RBM15B Gene

  • Nervous system(4.5)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RBM15B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM15B Gene

Orthologs for RBM15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBM15B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RBM15B 33
  • 99.63 (n)
(Canis familiaris)
Mammalia RBM15B 33
  • 89.64 (n)
(Bos Taurus)
Mammalia RBM15B 33
  • 89.2 (n)
(Mus musculus)
Mammalia Rbm15b 33 16
  • 86.31 (n)
(Rattus norvegicus)
Mammalia Rbm15b 33
  • 86.23 (n)
(Gallus gallus)
Aves MANF 33
  • 76.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm15b 33
  • 64.53 (n)
Str.11287 33
Species where no ortholog for RBM15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RBM15B Gene

Gene Tree for RBM15B (if available)
Gene Tree for RBM15B (if available)

Paralogs for RBM15B Gene

Paralogs for RBM15B Gene

(1) SIMAP similar genes for RBM15B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RBM15B: view

Variants for RBM15B Gene

Sequence variations from dbSNP and Humsavar for RBM15B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000436457 -- 51,390,648(+) C/A upstream_transcript_variant
rs1000542905 -- 51,391,111(+) C/T upstream_transcript_variant
rs1000624451 -- 51,396,109(+) A/C 3_prime_UTR_variant
rs1000678216 -- 51,395,841(+) C/T 3_prime_UTR_variant
rs1001145996 -- 51,389,899(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM15B Gene

Variant ID Type Subtype PubMed ID
dgv8321n54 CNV loss 21841781
nsv475628 CNV novel sequence insertion 20440878
nsv479147 CNV novel sequence insertion 20440878
nsv480643 CNV novel sequence insertion 20440878
nsv590276 CNV loss 21841781
nsv590277 CNV loss 21841781

Variation tolerance for RBM15B Gene

Residual Variation Intolerance Score: 1.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM15B Gene

Disorders for RBM15B Gene

Additional Disease Information for RBM15B

No disorders were found for RBM15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM15B Gene

Publications for RBM15B Gene

  1. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PMID: 16129689) Hiriart E … Manet E (The Journal of biological chemistry 2005) 2 3 4 22 58
  2. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PMID: 19586903) Uranishi H … Felber BK (The Journal of biological chemistry 2009) 3 22 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RBM15B Gene

Sources for RBM15B Gene

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