This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zi... See more...

Aliases for RBM14-RBM4 Gene

Aliases for RBM14-RBM4 Gene

  • RBM14-RBM4 Readthrough 2 3 5 13
  • RRM-Containing Coactivator Activator/Modulator 3
  • Synaptotagmin-Interacting Protein 3
  • Transcriptional Coactivator CoAZ 3
  • RNA-Binding Motif Protein 14 3
  • SYT-Interacting Protein 3
  • RNA-Binding Protein 14 3
  • Paraspeckle Protein 2 3
  • RBM14-RBM4 Protein 3
  • Protein RBM14-RBM4 13
  • RBM14/RBM4 Fusion 3
  • RBM14-RBM4 5
  • RBM14 3
  • COAZ 3
  • PSP2 3
  • SIP 3

External Ids for RBM14-RBM4 Gene

Previous GeneCards Identifiers for RBM14-RBM4 Gene

  • GC11U901759
  • GC11P066388

Summaries for RBM14-RBM4 Gene

Entrez Gene Summary for RBM14-RBM4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RBM14 (RNA binding motif protein 14) and RBM4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This fusion protein contains RRM and zinc finger domains, and it functions to stimulate transcription in a hormone and receptor-dependent manner. [provided by RefSeq, Nov 2010]

GeneCards Summary for RBM14-RBM4 Gene

RBM14-RBM4 (RBM14-RBM4 Readthrough) is a Protein Coding gene. Diseases associated with RBM14-RBM4 include Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy and Farber Lipogranulomatosis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is RBM4.

Additional gene information for RBM14-RBM4 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBM14-RBM4 Gene

Genomics for RBM14-RBM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RBM14-RBM4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM14-RBM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBM14-RBM4

Genomic Locations for RBM14-RBM4 Gene

Genomic Locations for RBM14-RBM4 Gene
chr11:66,616,582-66,646,473
(GRCh38/hg38)
Size:
29,892 bases
Orientation:
Plus strand
chr11:66,384,053-66,413,944
(GRCh37/hg19)
Size:
29,892 bases
Orientation:
Plus strand

Genomic View for RBM14-RBM4 Gene

Genes around RBM14-RBM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM14-RBM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM14-RBM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14-RBM4 Gene

Proteins for RBM14-RBM4 Gene

  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYI9-A0A0A6YYI9_HUMAN
    Recommended name:
    Protein RBM14-RBM4
    Protein Accession:
    A0A0A6YYI9

    Protein attributes for RBM14-RBM4 Gene

    Size:
    118 amino acids
    Molecular mass:
    12894 Da
    Quaternary structure:
    No Data Available
  • Protein details for RBM14-RBM4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A0MSL8-A0A0A0MSL8_HUMAN
    Recommended name:
    RBM14-RBM4 readthrough
    Protein Accession:
    A0A0A0MSL8

    Protein attributes for RBM14-RBM4 Gene

    Size:
    147 amino acids
    Molecular mass:
    15972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RBM14-RBM4 Gene

Post-translational modifications for RBM14-RBM4 Gene

No Post-translational modifications

Other Protein References for RBM14-RBM4 Gene

No data available for DME Specific Peptides for RBM14-RBM4 Gene

Domains & Families for RBM14-RBM4 Gene

Gene Families for RBM14-RBM4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RBM14-RBM4 Gene

genes like me logo Genes that share domains with RBM14-RBM4: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RBM14-RBM4 Gene

Function for RBM14-RBM4 Gene

Phenotypes From GWAS Catalog for RBM14-RBM4 Gene

Gene Ontology (GO) - Molecular Function for RBM14-RBM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RBM14-RBM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM14-RBM4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM14-RBM4 Gene

Localization for RBM14-RBM4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM14-RBM4 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RBM14-RBM4 Gene

Pathways & Interactions for RBM14-RBM4 Gene

PathCards logo

SuperPathways for RBM14-RBM4 Gene

No Data Available

Interacting Proteins for RBM14-RBM4 Gene

Gene Ontology (GO) - Biological Process for RBM14-RBM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with RBM14-RBM4: view

No data available for Pathways by source and SIGNOR curated interactions for RBM14-RBM4 Gene

Drugs & Compounds for RBM14-RBM4 Gene

No Compound Related Data Available

Transcripts for RBM14-RBM4 Gene

mRNA/cDNA for RBM14-RBM4 Gene

2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM14-RBM4

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14-RBM4 Gene

No ASD Table

Relevant External Links for RBM14-RBM4 Gene

GeneLoc Exon Structure for
RBM14-RBM4

Expression for RBM14-RBM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RBM14-RBM4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBM14-RBM4

genes like me logo Genes that share expression patterns with RBM14-RBM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM14-RBM4 Gene

Orthologs for RBM14-RBM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14-RBM4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RBM4 31
  • 75 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 74 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Rbm4 31
  • 73 (a)
ManyToMany
Gm21992 31
  • 55 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia RBM4 31
  • 72 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 69 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 53 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii rbm4.3 31
  • 34 (a)
ManyToMany
rbm4.2 31
  • 34 (a)
ManyToMany
rbm4.1 31
  • 34 (a)
ManyToMany
zgc:77262 31
  • 28 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta lark 31
  • 28 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rnp-1 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToMany
Species where no ortholog for RBM14-RBM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RBM14-RBM4 Gene

ENSEMBL:
Gene Tree for RBM14-RBM4 (if available)
TreeFam:
Gene Tree for RBM14-RBM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBM14-RBM4: view image

Paralogs for RBM14-RBM4 Gene

Variants for RBM14-RBM4 Gene

Additional dbSNP identifiers (rs#s) for RBM14-RBM4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBM14-RBM4 Gene

Variant ID Type Subtype PubMed ID
esv3547919 CNV deletion 23714750
esv990794 OTHER inversion 20482838
nsv363 CNV insertion 18451855
nsv518919 CNV loss 19592680
nsv522277 CNV loss 19592680
nsv975943 CNV duplication 23825009

Variation tolerance for RBM14-RBM4 Gene

Residual Variation Intolerance Score: 9.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM14-RBM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM14-RBM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBM14-RBM4 Gene

Disorders for RBM14-RBM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RBM14-RBM4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RBM14-RBM4

genes like me logo Genes that share disorders with RBM14-RBM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RBM14-RBM4 Gene

Publications for RBM14-RBM4 Gene

  1. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. (PMID: 28977666) Hoffmeister H … Längst G (Nucleic acids research 2017) 3
  4. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (PMID: 28700943) Martin TD … Elledge SJ (Cell reports 2017) 3
  5. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. (PMID: 27545878) Kupka S … Walczak H (Cell reports 2016) 3

Products for RBM14-RBM4 Gene

  • Signalway Proteins for RBM14-RBM4

Sources for RBM14-RBM4 Gene