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Aliases for RBM14 Gene

Aliases for RBM14 Gene

  • RNA Binding Motif Protein 14 2 3 5
  • RRM-Containing Coactivator Activator/Modulator 3 4
  • Synaptotagmin-Interacting Protein 3 4
  • SYT-Interacting Protein 3 4
  • Paraspeckle Protein 2 3 4
  • PSP2 3 4
  • SIP 3 4
  • RNA-Binding Motif Protein 14 4
  • Transmembrane Protein 137 3
  • SYT Interacting Protein 2
  • RNA-Binding Protein 14 3
  • Coactivator Activator 2
  • TMEM137 3
  • SYTIP1 3
  • COAA 3

External Ids for RBM14 Gene

Previous GeneCards Identifiers for RBM14 Gene

  • GC11P068918
  • GC11P068065
  • GC11P066634
  • GC11P066159
  • GC11P066140
  • GC11P066384
  • GC11P062712
  • GC11P066620
  • GC11P066622
  • GC11P066623
  • GC11P066626
  • GC11P066627
  • GC11P066628
  • GC11P066629
  • GC11P066631

Summaries for RBM14 Gene

Entrez Gene Summary for RBM14 Gene

  • This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RBM14 Gene

RBM14 (RNA Binding Motif Protein 14) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBM14-RBM4.

UniProtKB/Swiss-Prot for RBM14 Gene

  • Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Gene Wiki entry for RBM14 Gene

Additional gene information for RBM14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM14 Gene

Genomics for RBM14 Gene

GeneHancer (GH) Regulatory Elements for RBM14 Gene

Promoters and enhancers for RBM14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J066615 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 677 +1.4 1352 4.8 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RBM4 RBM14 PIR40941 RBM14-RBM4 PIR51437 GC11M066616 ACTN3 EIF1AD KDM2A RAD9A
GH11J066624 Promoter 0.7 EPDnew 650.4 +8.2 8234 0.1 POLR2A RBM22 RBM14 RBM14-RBM4 PIR40941 RBM4 GC11P066598
GH11J065886 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 101.1 -721.1 -721124 18.4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 FOSL1 FIBP DRAP1 RBM14 ENSG00000258297 KAT5 MUS81 SART1 SF3B2 RBM4
GH11J065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 99.6 -759.1 -759098 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD ENSG00000258297 POLA2 RBM14 SART1 PCNX3 RBM4 ZFPL1
GH11J067116 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 92.2 +503.1 503121 5.7 PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 ZNF207 SP3 KDM2A ENSG00000258297 RBM14 ENSG00000254461 LOC105369352 RBM4 RAD9A RCE1 ENSG00000245156 BBS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RBM14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RBM14 gene promoter:
  • CUTL1
  • AREB6
  • HOXA5
  • c-Myb
  • NF-1
  • NF-1/L
  • CBF(2)
  • NF-Y
  • FAC1
  • XBP-1

Genomic Locations for RBM14 Gene

Genomic Locations for RBM14 Gene
chr11:66,616,582-66,629,934
(GRCh38/hg38)
Size:
13,353 bases
Orientation:
Plus strand
chr11:66,384,053-66,397,405
(GRCh37/hg19)
Size:
13,353 bases
Orientation:
Plus strand

Genomic View for RBM14 Gene

Genes around RBM14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM14 Gene

Proteins for RBM14 Gene

  • Protein details for RBM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PK6-RBM14_HUMAN
    Recommended name:
    RNA-binding protein 14
    Protein Accession:
    Q96PK6
    Secondary Accessions:
    • B0LM41
    • B3KMN4
    • D6RGD8
    • O75932
    • Q2PYN1
    • Q53GV1
    • Q68DQ9
    • Q96PK5

    Protein attributes for RBM14 Gene

    Size:
    669 amino acids
    Molecular mass:
    69492 Da
    Quaternary structure:
    • Isoform 1: Interacts with NCOA6, CITED1 and XRCC5/KU86 (PubMed:11443112). Isoform 1: Interacts with SS18 isoform 1 (PubMed:15919756). Isoform 1: Interacts with SS18 isoform 2 (PubMed:15919756). Interacts with STIL and interferes with its interaction with CENPJ. Interacts with gamma-tubulin (PubMed:25385835).Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA.

    Three dimensional structures from OCA and Proteopedia for RBM14 Gene

    Alternative splice isoforms for RBM14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM14 Gene

Post-translational modifications for RBM14 Gene

  • Ubiquitination at posLast=135135
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM14 Gene

No data available for DME Specific Peptides for RBM14 Gene

Domains & Families for RBM14 Gene

Gene Families for RBM14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RBM14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RBM14: view

No data available for UniProtKB/Swiss-Prot for RBM14 Gene

Function for RBM14 Gene

Molecular function for RBM14 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Phenotypes From GWAS Catalog for RBM14 Gene

Gene Ontology (GO) - Molecular Function for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 11443112
GO:0005515 protein binding IPI 15919756
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IPI 11443112
GO:0030674 protein binding, bridging NAS 11443112
genes like me logo Genes that share ontologies with RBM14: view
genes like me logo Genes that share phenotypes with RBM14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM14

Clone Products

  • Addgene plasmids for RBM14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM14 Gene

Localization for RBM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM14 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles (PubMed:11790299). Cytoplasmic localization is crucial for its function in suppressing the formation of aberrant centriolar protein complexes (PubMed:25385835). {ECO:0000269 PubMed:11790299, ECO:0000269 PubMed:25385835}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM14 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 25385835
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IPI 11443112
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA 25385835
genes like me logo Genes that share ontologies with RBM14: view

Pathways & Interactions for RBM14 Gene

SuperPathways for RBM14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IDA 28712728
GO:0002376 immune system process IEA --
GO:0006260 DNA replication NAS 11443112
GO:0006281 DNA repair NAS 11443112
GO:0006310 DNA recombination NAS 11443112
genes like me logo Genes that share ontologies with RBM14: view

No data available for Pathways by source and SIGNOR curated interactions for RBM14 Gene

Drugs & Compounds for RBM14 Gene

(3) Drugs for RBM14 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pantothenic acid Approved, Vet_approved Nutra Target 26
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
Coenzyme A Investigational Nutra Target 0
genes like me logo Genes that share compounds with RBM14: view

Transcripts for RBM14 Gene

mRNA/cDNA for RBM14 Gene

Unigene Clusters for RBM14 Gene

RNA binding motif protein 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBM14

Clone Products

  • Addgene plasmids for RBM14

Alternative Splicing Database (ASD) splice patterns (SP) for RBM14 Gene

No ASD Table

Relevant External Links for RBM14 Gene

GeneLoc Exon Structure for
RBM14
ECgene alternative splicing isoforms for
RBM14

Expression for RBM14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.8) and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBM14 Gene



Protein tissue co-expression partners for RBM14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM14 Gene:

RBM14

SOURCE GeneReport for Unigene cluster for RBM14 Gene:

Hs.533712

mRNA Expression by UniProt/SwissProt for RBM14 Gene:

Q96PK6-RBM14_HUMAN
Tissue specificity: Expressed in all tissues tested, including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for RBM14 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Kidney(3.5)
  • Eye(3.3)
  • Pancreas(3)
  • Skin(3)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with RBM14: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM14 Gene

Orthologs for RBM14 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM14 34 33
  • 99.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RBM14 34 33
  • 96.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RBM14 34 33
  • 95.17 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm14 33
  • 94.12 (n)
mouse
(Mus musculus)
Mammalia Rbm14 16 34 33
  • 93.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RBM14 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM14 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RBM14 34 33
  • 64.54 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM14 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm14 33
  • 54.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398498 33
zebrafish
(Danio rerio)
Actinopterygii rbm14b 34
  • 26 (a)
OneToMany
rbm14a 34
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lark 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-1 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for RBM14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM14 Gene

ENSEMBL:
Gene Tree for RBM14 (if available)
TreeFam:
Gene Tree for RBM14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RBM14: view image

Paralogs for RBM14 Gene

Paralogs for RBM14 Gene

(4) SIMAP similar genes for RBM14 Gene using alignment to 3 proteins:

  • RBM14_HUMAN
  • B8ZZ74_HUMAN
  • F8WDX3_HUMAN
genes like me logo Genes that share paralogs with RBM14: view

Variants for RBM14 Gene

Sequence variations from dbSNP and Humsavar for RBM14 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000146641 -- 66,626,189(+) A/G intron_variant
rs1000181826 -- 66,628,323(+) C/T 3_prime_UTR_variant
rs1000260185 -- 66,628,146(+) T/C 3_prime_UTR_variant
rs1000331972 -- 66,614,705(+) C/G/T upstream_transcript_variant
rs1000418099 -- 66,621,992(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RBM14 Gene

Variant ID Type Subtype PubMed ID
nsv363 CNV insertion 18451855
nsv522277 CNV loss 19592680

Variation tolerance for RBM14 Gene

Residual Variation Intolerance Score: 6.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RBM14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM14 Gene

Disorders for RBM14 Gene

Additional Disease Information for RBM14

No disorders were found for RBM14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM14 Gene

Publications for RBM14 Gene

  1. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. (PMID: 15919756) Iwasaki T … Chin WW (Endocrinology 2005) 3 4 22 58
  2. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PMID: 11443112) Iwasaki T … Ko L (The Journal of biological chemistry 2001) 3 4 22 58
  3. HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. (PMID: 28712728) Morchikh M … Benkirane M (Molecular cell 2017) 3 4 58
  4. RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. (PMID: 25385835) Shiratsuchi G … Kitagawa D (The EMBO journal 2015) 3 4 58
  5. Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation. (PMID: 19416963) Brooks YS … Ko L (The Journal of biological chemistry 2009) 3 4 58

Products for RBM14 Gene

Sources for RBM14 Gene

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