Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the pro... See more...
Aliases for RBL1 Gene
Aliases for RBL1 Gene
External Ids for RBL1 Gene
- HGNC: 9893
- Entrez Gene: 5933
- Ensembl: ENSG00000080839
- OMIM: 116957
- UniProtKB: P28749
Previous GeneCards Identifiers for RBL1 Gene
- GC20M035354
- GC20M036264
- GC20M036311
- GC20M035059
- GC20M035624
- GC20M032361
Summaries for RBL1 Gene
-
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RBL1 Gene
RBL1 (RB Transcriptional Corepressor Like 1) is a Protein Coding gene. Diseases associated with RBL1 include Retinoblastoma and Bilateral Retinoblastoma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is RBL2.
UniProtKB/Swiss-Prot Summary for RBL1 Gene
-
Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904).
Additional gene information for RBL1 Gene
- HGNC(9893)
- Entrez Gene(5933)
- Ensembl(ENSG00000080839)
- OMIM(116957)
- UniProtKB(P28749)
- Open Targets Platform(ENSG00000080839)
- Search for RBL1 at DataMed
- Search for RBL1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBL1 Gene
Genomics for RBL1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RBL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RBL1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBL1
- Top Transcription factor binding sites by QIAGEN in the RBL1 gene promoter:
-
- p53
- Sp1
- SRF
- SRF (504 AA)
Genomic Locations for RBL1 Gene
Genomic Locations for RBL1 Gene
- chr20:36,996,349-37,096,029
- (GRCh38/hg38)
- Size:
- 99,681 bases
- Orientation:
- Minus strand
- chr20:35,624,752-35,724,410
- (GRCh37/hg19)
- Size:
- 99,659 bases
- Orientation:
- Minus strand
Genomic View for RBL1 Gene
Genes around RBL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
RBL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBL1 Gene
Proteins for RBL1 Gene
-
Protein details for RBL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P28749-RBL1_HUMAN
- Recommended name:
- Retinoblastoma-like protein 1
- Protein Accession:
- P28749
- A8K2W5
- Q4VXA0
- Q8N5K6
- Q9H1L5
- Q9H1M1
Protein attributes for RBL1 Gene
- Size:
- 1068 amino acids
- Molecular mass:
- 120847 Da
- Quaternary structure:
-
- Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (PubMed:17671431, PubMed:16360038). The complex exists in quiescent cells where it represses cell cycle-dependent genes (PubMed:17671431). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (PubMed:17671431). Interacts with AATF (PubMed:12450794). Interacts with KDM5A (PubMed:7935440). Interacts with KMT5B and KMT5C (By similarity). Interacts with USP4 (By similarity). Interacts with RBBP9 (By similarity).
- (Microbial infection) Interacts with SV40 and JC virus large T antigens. Large T antigen, but not E1A, binds only to the unphosphorylated form.
Three dimensional structures from OCA and Proteopedia for RBL1 Gene
Protein Expression for RBL1 Gene
Post-translational modifications for RBL1 Gene
- Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RBL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ p107 Antibody
- NSJ Bioreagents p107 Antibody
-
Custom Antibody ServicesOriGene Antibodies for RBL1
- Novus Biologicals Antibodies for RBL1
-
Abcam antibodies for RBL1
- Invitrogen Antibodies for RBL1 (AFLGC-RBL1)
- antibodies-online: Show 32 available p107 Antibodies ranked by validation data
- Compare Top p107 Antibodies
-
Recommended
- 76 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for RBL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RBL1
- Sino Biological Antibodies for RBL1
Protein Products
-
OriGene Purified Proteins for RBL1
- Search Origene for MassSpec and Protein Over-expression Lysates for RBL1
- Origene Custom Protein Services for RBL1
-
Signalway Proteins for RBL1
-
Abcam proteins for RBL1
Assay Products
- antibodies-online: Show 6 available p107 Elisa Kits ranked by validation data
- Compare Top p107 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for RBL1
No data available for DME Specific Peptides for RBL1 Gene
Domains & Families for RBL1 Gene
Gene Families for RBL1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for RBL1 Gene
- InterPro:
- Blocks:
-
- Retinoblastoma-associated protein, A-box
- ProtoNet:
Suggested Antigen Peptide Sequences for RBL1 Gene
- GenScript: Design optimal peptide antigens:
-
- RBL1 protein (Q8WVU8_HUMAN)
- pRb1 (RBL1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P28749- Family:
-
- Belongs to the retinoblastoma protein (RB) family.
Function for RBL1 Gene
Molecular function for RBL1 Gene
- UniProtKB/Swiss-Prot Function:
- Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904).
- GENATLAS Biochemistry:
- retinoblastoma product related protein,p107,involved in cell cycle regulation,interacting with transcription factor E2F-4 and with cyclin E/A-CDK2 complexes,may be altered in a limited subset of hematologic malignancies
Phenotypes From GWAS Catalog for RBL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0001012 | RNA polymerase II regulatory region DNA binding | IBA | -- |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 1331501 |
| GO:0008134 | transcription factor binding | IPI | 16360038 |
Phenotypes for RBL1 Gene
- MGI mutant phenotypes for RBL1:
-
inferred from 8 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for RBL1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- Increased circadian period length
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased Aire reporter expression
Animal Models for RBL1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RBL1 - Select products 50% OFF >
- * RBL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RBL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBL1
miRNA for RBL1 Gene
- miRTarBase miRNAs that target RBL1
-
- hsa-miR-17-5p (MIRT005851)
- hsa-miR-20a-5p (MIRT005858)
- hsa-miR-106b-5p (MIRT005866)
- hsa-miR-580-3p (MIRT445708)
- hsa-miR-526b-5p (MIRT445709)
- hsa-miR-3646 (MIRT445710)
- hsa-miR-3662 (MIRT445711)
- hsa-miR-6806-5p (MIRT496131)
- hsa-miR-5685 (MIRT496132)
- hsa-miR-4690-3p (MIRT496133)
- hsa-miR-4717-5p (MIRT496134)
- hsa-miR-449c-5p (MIRT496135)
- hsa-miR-34b-5p (MIRT496136)
- hsa-miR-2682-5p (MIRT496137)
- hsa-miR-940 (MIRT496138)
- hsa-miR-6893-5p (MIRT496139)
- hsa-miR-6808-5p (MIRT496140)
- hsa-miR-6511a-5p (MIRT496141)
- hsa-miR-1910-3p (MIRT496142)
- hsa-miR-6815-3p (MIRT572717)
- hsa-miR-6882-3p (MIRT572718)
- hsa-miR-22-3p (MIRT572719)
- hsa-miR-646 (MIRT572720)
- hsa-miR-892b (MIRT572721)
- hsa-miR-193b-3p (MIRT572722)
- hsa-miR-193a-3p (MIRT572723)
- hsa-miR-5089-5p (MIRT635334)
- hsa-miR-6878-3p (MIRT635335)
- hsa-miR-6783-3p (MIRT635336)
- hsa-miR-1343-3p (MIRT635337)
- hsa-miR-6744-3p (MIRT635338)
- hsa-miR-4757-5p (MIRT635339)
- hsa-miR-6778-3p (MIRT635340)
- hsa-miR-4707-3p (MIRT635341)
- hsa-miR-6506-5p (MIRT635342)
- hsa-miR-619-5p (MIRT635343)
- hsa-miR-212-5p (MIRT635344)
- hsa-miR-6742-3p (MIRT635345)
- hsa-miR-6852-5p (MIRT635346)
- hsa-miR-939-3p (MIRT635347)
- hsa-miR-186-3p (MIRT635348)
- hsa-miR-6838-3p (MIRT635349)
- hsa-miR-6507-3p (MIRT635350)
- hsa-miR-150-5p (MIRT645545)
- hsa-miR-5698 (MIRT666706)
- hsa-miR-8057 (MIRT666707)
- hsa-miR-143-5p (MIRT666708)
- hsa-miR-24-3p (MIRT666709)
- hsa-miR-4284 (MIRT666710)
- hsa-miR-6722-5p (MIRT666711)
- hsa-miR-122-5p (MIRT666712)
- hsa-miR-504-3p (MIRT666713)
- hsa-miR-6499-3p (MIRT666714)
- hsa-miR-5693 (MIRT666715)
- hsa-miR-6813-3p (MIRT666716)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBL1
- Browse OriGene Inhibitory RNA Products For RBL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBL1
Clone Products
- Applied Biological Materials (abm): Clones for RBL1 - Select products 50% OFF >
- * RBL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211567
- MG225589
- MR211567
- MR211567L3
- MR211567L4
- MR225589
- MR225589L3
- MR225589L4
- RC207017
- RC207017L1
- RC207017L2
- RC207017L3
- RC207017L4
- RC215873
- RC215873L1
- RC215873L2
- RC215873L3
- RC215873L4
- RG207017
- RG215873
- RR217437
- MR211567L3V
- MR211567L4V
- MR225589L3V
- MR225589L4V
- RC207017L1V
- RC207017L2V
- RC207017L3V
- RC207017L4V
- RC215873L1V
- RC215873L2V
- RC215873L3V
- RC215873L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RBL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBL1
Cell Line Products
-
Horizon Cell Lines for RBL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBL1 Gene
Localization for RBL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBL1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IBA | 21873635 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005667 | transcription factor complex | IEA,IBA | 21873635 |
Pathways & Interactions for RBL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell cycle Cell cycle (generic schema) |
Cell cycle Cell cycle (generic schema)
.38
Cell cycle Regulation of G1/S transition (part 2)
.38
|
.31
|
| 2 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 3 | Cell cycle |
.58
|
.58
|
| 4 | Cell Cycle, Mitotic |
.83
|
|
| 5 | Cyclins and Cell Cycle Regulation |
.31
|
|
Pathways by source for RBL1 Gene
8 BioSystems pathways for RBL1 Gene
15 Reactome pathways for RBL1 Gene
5 KEGG pathways for RBL1 Gene
2 GeneGo (Thomson Reuters) pathways for RBL1 Gene
- Cell cycle Cell cycle (generic schema)
- Cell cycle Regulation of G1/S transition (part 2)
3 Qiagen pathways for RBL1 Gene
- Estrogen-mediated S-Phase Entry
- Macrophage Differentiation and Growth Inhibition by METS
- Molecular Mechanisms of Cancer
Interacting Proteins for RBL1 Gene
Selected Interacting proteins:
P28749-RBL1_HUMAN
ENSP00000362768
for RBL1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RBL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007346 | regulation of mitotic cell cycle | IBA | 21873635 |
Transcripts for RBL1 Gene
mRNA/cDNA for RBL1 Gene
- 4 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000344359 3225 nts (view in UCSC)
- ENST00000373664 5686 nts (view in UCSC)
- ENST00000525052 763 nts (view in UCSC)
- ENST00000527999 599 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RBL1 - Select products 50% OFF >
- * RBL1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RBL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBL1
- Browse OriGene Inhibitory RNA Products For RBL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBL1
Clone Products
- Applied Biological Materials (abm): Clones for RBL1 - Select products 50% OFF >
- * RBL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211567
- MG225589
- MR211567
- MR211567L3
- MR211567L4
- MR225589
- MR225589L3
- MR225589L4
- RC207017
- RC207017L1
- RC207017L2
- RC207017L3
- RC207017L4
- RC215873
- RC215873L1
- RC215873L2
- RC215873L3
- RC215873L4
- RG207017
- RG215873
- RR217437
- MR211567L3V
- MR211567L4V
- MR225589L3V
- MR225589L4V
- RC207017L1V
- RC207017L2V
- RC207017L3V
- RC207017L4V
- RC215873L1V
- RC215873L2V
- RC215873L3V
- RC215873L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RBL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBL1
Relevant External Links for RBL1 Gene
- GeneLoc Exon Structure for
- RBL1
Expression for RBL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Cerebellum
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
This gene is overexpressed in Serum (39.5) and Monocytes (21.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBL1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBL1
SOURCE GeneReport for Unigene cluster for RBL1 Gene:
Hs.207745Evidence on tissue expression from TISSUES for RBL1 Gene
- Nervous system(2.9)
- Adrenal gland(2.8)
- Muscle(2.6)
- Intestine(2.6)
- Blood(2.5)
- Kidney(2.5)
- Skin(2.4)
- Lung(2.4)
- Thyroid gland(2.3)
- Spleen(2.2)
- Liver(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for RBL1
-
OriGene qPCR primer pairs and template standards for RBL1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBL1 Gene
Orthologs for RBL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RBL1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RBL1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RBL1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rbl1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rbl1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RBL1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | RBL1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RBL1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rbl1 30 |
|
||
| Str.7030 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | rbl1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rbf 31 32 |
|
ManyToMany | |
| Rbf2 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | lin-35 30 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RBR1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os11g0533500 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4619 31 |
|
OneToMany |
- Species where no ortholog for RBL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RBL1 Gene
- ENSEMBL:
- Gene Tree for RBL1 (if available)
- TreeFam:
- Gene Tree for RBL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RBL1: view image
Paralogs for RBL1 Gene
Variants for RBL1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4304n100 | CNV | gain | 25217958 |
| esv3645750 | CNV | gain | 21293372 |
| esv3645751 | CNV | gain | 21293372 |
| nsv1058953 | CNV | gain | 25217958 |
| nsv585951 | CNV | loss | 21841781 |
| nsv585952 | CNV | loss | 21841781 |
| nsv962578 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
8.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.87;
48.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RBL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBL1 Gene
Disorders for RBL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| bilateral retinoblastoma |
|
|
| unilateral retinoblastoma |
|
|
| cecum adenoma |
|
|
| cecal benign neoplasm |
|
|
Search RBL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RBL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RBL1 Gene
Publications for RBL1 Gene
- Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. (PMID: 1833063) Ewen ME … Livingston DM (Cell 1991) 2 3 4 23
- Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. (PMID: 11884610) Leng X … Harper JW (Molecular and cellular biology 2002) 3 4 23
- Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. (PMID: 7791762) Zhu L … Chang LS (Molecular and cellular biology 1995) 3 4 23
- Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. (PMID: 7935440) Kim YW … Kaye FJ (Molecular and cellular biology 1994) 3 4 23
- Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. (PMID: 8319904) Zhu L … Harlow E (Genes & development 1993) 3 4 23
ExternalLinks
Products for RBL1 Gene
- Custom Antibody ServicesOriGene Antibodies for RBL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RBL1
- Search Origene for MassSpec and Protein Over-expression Lysates for RBL1
- Origene Custom Protein Services for RBL1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBL1
- Browse OriGene Inhibitory RNA Products For RBL1
- OriGene qPCR primer pairs for RBL1
- OriGene qPCR primer pairs and template standards for RBL1
- OriGene CRISPR knockouts for RBL1
- MG211567
- MG225589
- MR211567
- MR211567L3
- MR211567L4
- MR225589
- MR225589L3
- MR225589L4
- RC207017
- RC207017L1
- RC207017L2
- RC207017L3
- RC207017L4
- RC215873
- RC215873L1
- RC215873L2
- RC215873L3
- RC215873L4
- RG207017
- RG215873
- RR217437
- MR211567L3V
- MR211567L4V
- MR225589L3V
- MR225589L4V
- RC207017L1V
- RC207017L2V
- RC207017L3V
- RC207017L4V
- RC215873L1V
- RC215873L2V
- RC215873L3V
- RC215873L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RBL1
- Sino Biological Human cDNA Clone for RBL1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for RBL1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RBL1
- Novus Biologicals proteins and lysates for RBL1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RBL1
- Abcam proteins for RBL1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for RBL1 (AFLGC-RBL1)
- VectorBuilder Custom and pre-made DNA vectors for RBL1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RBL1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RBL1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RBL1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RBL1
- antibodies-online: Show 32 available p107 Antibodies ranked by validation data
- Compare Top p107 Antibodies
- Recommended
- 76 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 6 available p107 Elisa Kits ranked by validation data
- Compare Top p107 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available p107 Proteins ranked by validation data
- Compare Top p107 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RBL1
- Search Santa Cruz Biotechnology (SCBT) for RBL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RBL1
- Horizon Cell Lines for RBL1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBL1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RBL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBL1
- Boster Bio Antibodies for RBL1
- Browse Boster Bio ELISA Kits
Sources for RBL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase