Aliases for RBFOX3 Gene
External Ids for RBFOX3 Gene
Previous GeneCards Identifiers for RBFOX3 Gene
This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
GeneCards Summary for RBFOX3 Gene
RBFOX3 (RNA Binding Fox-1 Homolog 3) is a Protein Coding gene. Diseases associated with RBFOX3 include Benign Epilepsy With Centrotemporal Spikes and Sella Turcica Neoplasm. Among its related pathways are Neuroscience. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBFOX1.
UniProtKB/Swiss-Prot for RBFOX3 Gene
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).