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This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein co... See more...
Aliases for RBBP7 Gene
Aliases for RBBP7 Gene
- RB Binding Protein 7, Chromatin Remodeling Factor 2 3 5
- Histone Acetyltransferase Type B Subunit 2 2 3 4
- Retinoblastoma-Binding Protein P46 2 3 4
- Retinoblastoma-Binding Protein 7 2 3 4
- G1/S Transition Control Protein-Binding Protein RbAp46 2 3
- Nucleosome-Remodeling Factor Subunit RBAP46 3 4
- Retinoblastoma-Binding Protein RbAp46 2 3
External Ids for RBBP7 Gene
- HGNC: 9890
- NCBI Entrez Gene: 5931
- Ensembl: ENSG00000102054
- OMIM®: 300825
- UniProtKB/Swiss-Prot: Q16576
Previous GeneCards Identifiers for RBBP7 Gene
- GC0XM016594
- GC0XM015730
- GC0XM016063
- GC0XM016225
- GC0XM016226
- GC0XM016622
- GC0XM016772
- GC0XM014625
Summaries for RBBP7 Gene
-
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for RBBP7 Gene
RBBP7 (RB Binding Protein 7, Chromatin Remodeling Factor) is a Protein Coding gene. Diseases associated with RBBP7 include Retinoblastoma and Wilms Tumor 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is RBBP4.
UniProtKB/Swiss-Prot Summary for RBBP7 Gene
-
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Additional gene information for RBBP7 Gene
- HGNC (9890)
- NCBI Entrez Gene (5931)
- Ensembl (ENSG00000102054)
- OMIM® (300825)
- UniProtKB/Swiss-Prot (Q16576)
- Open Targets Platform(ENSG00000102054)
- Alliance of Genome Resources
- Search for RBBP7 at DataMed
- Search for RBBP7 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RBBP7 Gene
Genomics for RBBP7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RBBP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RBBP7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RBBP7
- Top Transcription factor binding sites by QIAGEN in the RBBP7 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
Genomic Locations for RBBP7 Gene
Latest Assembly
- chrX:16,839,283-16,870,362
- (GRCh38/hg38)
- Size:
- 31,080 bases
- Orientation:
- Minus strand
Previous Assembly
- chrX:16,862,464-16,888,485
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 26,022 bases
- Orientation:
- Minus strand
Genomic View for RBBP7 Gene
Genes around RBBP7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by HGNC
- Xp22.2 by Entrez Gene
- Xp22.2 by Ensembl
RBBP7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBBP7 Gene
Proteins for RBBP7 Gene
-
Protein details for RBBP7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16576-RBBP7_HUMAN
- Recommended name:
- Histone-binding protein RBBP7
- Protein Accession:
- Q16576
- Q5JP00
Protein attributes for RBBP7 Gene
- Size:
- 425 amino acids
- Molecular mass:
- 47820 Da
- Quaternary structure:
-
- Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (PubMed:18571423). Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:12435631). The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10220405). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1. Interacts with CENPA (PubMed:25556658).
Protein Expression for RBBP7 Gene
Post-translational modifications for RBBP7 Gene
Other Protein References for RBBP7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RBBP7 / RbAp46 Antibody (LS-B13992) and RBBP7 / RbAp46 Antibody (LS-B13993)
- G Biosciences Immunotag™ RBBP7 Antibody
- Novus Biologicals Antibodies for RBBP7
-
Abcam antibodies for RBBP7
- Invitrogen Antibodies for RBBP7 (AFLGC-RBBP7)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RBBP7
Protein products for research
-
OriGene Purified Proteins for RBBP7
- Search Origene for MassSpec and Protein Over-expression Lysates for RBBP7
- Origene Custom Protein Services for RBBP7
-
Abcam proteins for RBBP7
Assay products for research
No data available for DME Specific Peptides for RBBP7 Gene
Domains & Families for RBBP7 Gene
Gene Families for RBBP7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RBBP7 Gene
- InterPro:
- Blocks:
-
- G-protein beta WD-40 repeat signature
Suggested Antigen Peptide Sequences for RBBP7 Gene
- GenScript: Design optimal peptide antigens:
-
- Retinoblastoma binding protein 7 (B0R0W4_HUMAN)
- Retinoblastoma binding protein 7 (Q5JNZ6_HUMAN)
- Retinoblastoma binding protein 7 (Q5JNZ9_HUMAN)
- cDNA FLJ34592 fis, clone KIDNE2008987, highly similar to Histone-binding protein RBBP7 (Q5JP00_HUMAN)
- Retinoblastoma binding protein 7 (Q5JP01_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16576- Family:
-
- Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Function for RBBP7 Gene
Molecular function for RBBP7 Gene
- UniProtKB/Swiss-Prot Function:
- Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Phenotypes From GWAS Catalog for RBBP7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 7503932 |
Phenotypes for RBBP7 Gene
- MGI mutant phenotypes for RBBP7:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RBBP7:
-
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Inconclusive
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased cell number in G1, average or increased nuclei size in G1
- Increased G1 length
- Increased G1 length, increased S length
Animal Models for RBBP7 Gene
- MGI Knock Outs for RBBP7:
-
- Rbbp7 Rbbp7<tm1a(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RBBP7 - Starting at $85 >
- * RBBP7 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RBBP7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBBP7
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBBP7
miRNA for RBBP7 Gene
- miRTarBase miRNAs that target RBBP7
-
- hsa-miR-421 (MIRT016133)
- hsa-miR-93-5p (MIRT028061)
- hsa-miR-30e-3p (MIRT044126)
- hsa-miR-30b-5p (MIRT046129)
- hsa-miR-92a-3p (MIRT049160)
- hsa-miR-20a-5p (MIRT439809)
- hsa-miR-106b-5p (MIRT439810)
- hsa-miR-3686 (MIRT546800)
- hsa-miR-3924 (MIRT546801)
- hsa-miR-4742-3p (MIRT546802)
- hsa-miR-4778-5p (MIRT546803)
- hsa-miR-519d-3p (MIRT726779)
- hsa-miR-20b-5p (MIRT726780)
- hsa-miR-17-5p (MIRT726781)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBBP7
- Browse OriGene Inhibitory RNA Products For RBBP7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBBP7
Clone products for research
- Applied Biological Materials (abm): Clones for RBBP7 - Starting at $45 >
- * RBBP7 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RBBP7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBBP7
Cell Lines for research
-
Horizon Cell Lines for RBBP7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBBP7 Gene
Localization for RBBP7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBBP7 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 22720776 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016581 | NuRD complex | IEA,IDA | 19644445 |
| GO:0035098 | ESC/E(Z) complex | IEA,IDA | 20075857 |
Pathways & Interactions for RBBP7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Cellular Senescence (REACTOME) | ||
| 3 | Chromatin organization | ||
| 4 | Chromosome Maintenance | ||
| 5 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Development Notch Signaling Pathway
.55
Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
|
Transcription Sin3 and NuRD in transcription regulation
.31
|
Pathways by source for RBBP7 Gene
6 BioSystems pathways for RBBP7 Gene
29 Reactome pathways for RBBP7 Gene
5 GeneGo (Thomson Reuters) pathways for RBBP7 Gene
- Development Notch Signaling Pathway
- Development NOTCH1-mediated pathway for NF-KB activity modulation
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
- Transcription Sin3 and NuRD in transcription regulation
- Transcription_P53 signaling pathway
1 Qiagen pathway for RBBP7 Gene
- DNA Methylation and Transcriptional Repression
1 Cell Signaling Technology pathway for RBBP7 Gene
1 GeneTex pathway for RBBP7 Gene
Interacting Proteins for RBBP7 Gene
Selected Interacting proteins:
Q16576-RBBP7_HUMAN
ENSP00000369424
for RBBP7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RBBP7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006260 | DNA replication | IEA | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0030308 | negative regulation of cell growth | IDA | 9765217 |
| GO:0034080 | CENP-A containing nucleosome assembly | TAS | -- |
No data available for SIGNOR curated interactions for RBBP7 Gene
Transcripts for RBBP7 Gene
mRNA/cDNA for RBBP7 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330735 858 nts (view in UCSC)
- ENST00000380084 2036 nts (view in UCSC)
- ENST00000380087 2281 nts (view in UCSC)
- ENST00000404022 1904 nts (view in UCSC)
- ENST00000416035 857 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RBBP7 - Starting at $85 >
- * RBBP7 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RBBP7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBBP7
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBBP7
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBBP7
- Browse OriGene Inhibitory RNA Products For RBBP7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBBP7
Clone products for research
- Applied Biological Materials (abm): Clones for RBBP7 - Starting at $45 >
- * RBBP7 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RBBP7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBBP7
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 13b | · | 13c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: |
Relevant External Links for RBBP7 Gene
- GeneLoc Exon Structure for
- RBBP7
Expression for RBBP7 Gene
This gene is overexpressed in Fetal ovary (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBBP7 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RBBP7
SOURCE GeneReport for Unigene cluster for RBBP7 Gene:
Hs.495755Evidence on tissue expression from TISSUES for RBBP7 Gene
- Kidney(4.7)
- Nervous system(4.6)
- Liver(4.6)
- Lung(3.8)
- Intestine(3.6)
- Skin(3.5)
- Muscle(3.4)
- Heart(3.3)
- Bone marrow(3.3)
- Lymph node(3.3)
- Thyroid gland(3.2)
- Pancreas(3.2)
- Spleen(3.1)
- Adrenal gland(2.8)
- Gall bladder(2.8)
- Stomach(2.8)
- Eye(2.8)
- Blood(2.2)
Primer products for research
-
OriGene qPCR primer pairs for RBBP7
-
OriGene qPCR primer pairs and template standards for RBBP7
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBBP7 Gene
Orthologs for RBBP7 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RBBP7 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RBBP7 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RBBP7 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RBBP7 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rbbp7 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rbbp7 29 16 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RBBP7 29 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RBBP7 29 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rbbp7 29 |
|
||
| MGC76124 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rbbp7-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rbb4l 29 30 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Caf1 31 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | lin-53 30 |
|
ManyToMany | |
| rba-1 30 31 |
|
ManyToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HAT2 30 |
|
OneToMany |
- Species where no ortholog for RBBP7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RBBP7 Gene
- ENSEMBL:
- Gene Tree for RBBP7 (if available)
- TreeFam:
- Gene Tree for RBBP7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RBBP7: view image
- Alliance of Genome Resources:
- Additional Orthologs for RBBP7
Paralogs for RBBP7 Gene
(4) SIMAP similar genes for RBBP7 Gene using alignment to 8 proteins:
- RBBP7_HUMAN
- C9J7L0_HUMAN
- C9JAJ9_HUMAN
- E9PC52_HUMAN
- Q5JNZ6_HUMAN
- Q5JP01_HUMAN
- Q5JP02_HUMAN
- Q6FHQ0_HUMAN
Pseudogenes.org Pseudogenes for RBBP7 Gene
Variants for RBBP7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RBBP7 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs72616027 | Benign: not provided | 16,869,171(-) |
G/T NM_002893.4(RBBP7):c.66C>A (p.Ile22=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv29438 | CNV | loss | 19812545 |
| esv3302821 | CNV | tandem duplication | 20981092 |
| nsv1141051 | CNV | deletion | 24896259 |
| nsv511654 | CNV | gain | 21212237 |
Residual Variation Intolerance Score:
15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.27;
76.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RBBP7 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBBP7 Gene
Disorders for RBBP7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| wilms tumor 1 |
|
|
| hemophagocytic lymphohistiocytosis, familial, 1 |
|
|
Search RBBP7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RBBP7
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RBBP7 Gene
Publications for RBBP7 Gene
- Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. (PMID: 10444591) Zhang Y … Reinberg D (Genes & development 1999) 3 4 22
- BRCA1 interacts with components of the histone deacetylase complex. (PMID: 10220405) Yarden RI … Brody LC (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 22
- Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. (PMID: 7503932) Qian YW … Lee EY (The Journal of biological chemistry 1995) 2 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E … Ogryzko V (Proteomics 2009) 3 22
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Products for RBBP7 Gene
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- antibodies-online: Show 39 available RBBP7 Antibodies ranked by validation data
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Sources for RBBP7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (65) Reactome
- (66) GeneGo (Thomson Reuters)
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- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
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- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
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- (95) GTEx
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- (102) diseasecard
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