Aliases for RBBP7 Gene
- RB Binding Protein 7, Chromatin Remodeling Factor 2 3 5
- Histone Acetyltransferase Type B Subunit 2 2 3 4
- Retinoblastoma-Binding Protein P46 2 3 4
- Retinoblastoma-Binding Protein 7 2 3 4
- G1/S Transition Control Protein-Binding Protein RbAp46 2 3
- Nucleosome-Remodeling Factor Subunit RBAP46 3 4
- Retinoblastoma-Binding Protein RbAp46 2 3
External Ids for RBBP7 Gene
Previous GeneCards Identifiers for RBBP7 Gene
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for RBBP7 Gene
RBBP7 (RB Binding Protein 7, Chromatin Remodeling Factor) is a Protein Coding gene. Diseases associated with RBBP7 include Retinoblastoma and Hemophagocytic Lymphohistiocytosis, Familial, 1. Among its related pathways are Regulation of TP53 Activity through Acetylation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is RBBP4.
UniProtKB/Swiss-Prot Summary for RBBP7 Gene
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.