Aliases for RBBP7 Gene
Aliases for RBBP7 Gene
- RB Binding Protein 7, Chromatin Remodeling Factor 2 3 5
- Retinoblastoma-Binding Protein 7 2 2 3 4
- Histone Acetyltransferase Type B Subunit 2 2 3 4
- Retinoblastoma-Binding Protein P46 2 3 4
- G1/S Transition Control Protein-Binding Protein RbAp46 2 3
- Nucleosome-Remodeling Factor Subunit RBAP46 3 4
- Retinoblastoma-Binding Protein RbAp46 2 3
External Ids for RBBP7 Gene
- HGNC: 9890
- Entrez Gene: 5931
- Ensembl: ENSG00000102054
- OMIM: 300825
- UniProtKB: Q16576
Previous GeneCards Identifiers for RBBP7 Gene
- GC0XM016594
- GC0XM015730
- GC0XM016063
- GC0XM016225
- GC0XM016226
- GC0XM016622
- GC0XM014625
Summaries for RBBP7 Gene
-
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for RBBP7 Gene
RBBP7 (RB Binding Protein 7, Chromatin Remodeling Factor) is a Protein Coding gene. Diseases associated with RBBP7 include Retinoblastoma and Retinal Cancer. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is RBBP4.
UniProtKB/Swiss-Prot for RBBP7 Gene
-
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBBP7 Gene
Genomics for RBBP7 Gene
GeneHancer (GH) Regulatory Elements for RBBP7 Gene
Promoters and enhancers for RBBP7 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XJ016868 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 668.7 | +0.1 | 145 | 3.9 | HDGF PKNOX1 ATF1 ARNT SIN3A FEZF1 BRCA1 YY1 POLR2B GLIS2 | RBBP7 PIR41677 | |
| GH0XJ016785 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE | 16.7 | +83.7 | 83690 | 2.7 | HDGF PKNOX1 ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B ZNF213 ZNF207 | TXLNG RBBP7 RPL12P49 | |
| GH0XJ016770 | Enhancer | 1.2 | Ensembl ENCODE | 24 | +98.6 | 98555 | 2.3 | HNRNPUL1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF143 | RBBP7 NHS CTPS2 TXLNG GC0XP016767 | |
| GH0XJ016824 | Enhancer | 1.1 | Ensembl ENCODE | 25.8 | +43.5 | 43453 | 4.8 | FOXA2 ZNF133 ARID4B BRCA1 YY1 RXRA REST MAFF GLIS1 STAT3 | RBBP7 TXLNG ENSG00000201467 CTPS2 GC0XP016842 RPL12P49 | |
| GH0XJ016837 | Enhancer | 1 | Ensembl ENCODE | 27.3 | +31.1 | 31127 | 3.1 | FOXA2 ZNF2 BRCA1 RFX5 ZNF366 EGR1 RCOR1 RXRA CEBPB NR2F2 | RBBP7 ENSG00000201467 GC0XP016842 RPL12P49 TXLNG |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RBBP7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RBBP7 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- E2F-4
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-5
Regulatory Element Products
Genomic Locations for RBBP7 Gene
Genomic Locations for RBBP7 Gene
- chrX:16,839,283-16,870,442
- (GRCh38/hg38)
- Size:
- 31,160 bases
- Orientation:
- Minus strand
- chrX:16,857,406-16,888,537
- (GRCh37/hg19)
- Size:
- 31,132 bases
- Orientation:
- Minus strand
Genomic View for RBBP7 Gene
Genes around RBBP7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by Entrez Gene
- Xp22.2 by HGNC
- Xp22.2 by Ensembl
RBBP7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RBBP7 Gene
Proteins for RBBP7 Gene
-
Protein details for RBBP7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16576-RBBP7_HUMAN
- Recommended name:
- Histone-binding protein RBBP7
- Protein Accession:
- Q16576
- Q5JP00
Protein attributes for RBBP7 Gene
- Size:
- 425 amino acids
- Molecular mass:
- 47820 Da
- Quaternary structure:
-
- Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:12435631). The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10220405). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1. Interacts with CENPA (PubMed:25556658).
Protein Expression for RBBP7 Gene
Post-translational modifications for RBBP7 Gene
Other Protein References for RBBP7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RBBP7
-
Abcam antibodies for RBBP7
- Invitrogen Antibodies for RBBP7 (AFLGC-RBBP7)
- GeneTex RBBP7 Antibody for RBBP7
-
Boster Bio Antibodies for RBBP7
-
Santa Cruz Biotechnology (SCBT) Antibodies for RBBP7
Protein Products
-
OriGene Purified Proteins for RBBP7
- Search Origene for MassSpec and Protein Over-expression Lysates for RBBP7
- Origene Custom Protein Services for RBBP7
- Search GeneTex for Proteins for RBBP7
-
Abcam proteins for RBBP7
Assay Products
No data available for DME Specific Peptides for RBBP7 Gene
Domains & Families for RBBP7 Gene
Gene Families for RBBP7 Gene
Protein Domains for RBBP7 Gene
Suggested Antigen Peptide Sequences for RBBP7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16576- Family:
-
- Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Function for RBBP7 Gene
Molecular function for RBBP7 Gene
- UniProtKB/Swiss-Prot Function:
- Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0004407 | histone deacetylase activity | TAS | -- |
| GO:0005515 | protein binding | IPI,IEA | 7503932 |
Phenotypes for RBBP7 Gene
- MGI mutant phenotypes for RBBP7:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RBBP7:
-
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance
- Increased shRNA abundance (Z-score > 2)
- Increased G1 length, increased G2 length
- Decreased viability
- no effect
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased cell number in S
- shRNA abundance <= 50%
- Increased viability
Animal Models for RBBP7 Gene
- MGI Knock Outs for RBBP7:
-
- Rbbp7 Rbbp7<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RBBP7
-
CRISPR Products
-
OriGene CRISPR knockouts for RBBP7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBBP7
- genomics-online: gRNA clones - Search results for available RBBP7 gene related products
- Applied Biological Materials CRISPR for RBBP7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBBP7
- GenScript: Design CRISPR guide RNA sequences for RBBP7
miRNA for RBBP7 Gene
- miRTarBase miRNAs that target RBBP7
-
- hsa-mir-421 (MIRT016133)
- hsa-mir-93-5p (MIRT028061)
- hsa-mir-30e-3p (MIRT044126)
- hsa-mir-30b-5p (MIRT046129)
- hsa-mir-92a-3p (MIRT049160)
- hsa-mir-20a-5p (MIRT439809)
- hsa-mir-106b-5p (MIRT439810)
- hsa-mir-3686 (MIRT546800)
- hsa-mir-3924 (MIRT546801)
- hsa-mir-4742-3p (MIRT546802)
- hsa-mir-4778-5p (MIRT546803)
- hsa-mir-519d-3p (MIRT726779)
- hsa-mir-20b-5p (MIRT726780)
- hsa-mir-17-5p (MIRT726781)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBBP7
- Browse OriGene Inhibitory RNA Products For RBBP7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBBP7
- genomics-online: shRNA clones - Search results for available RBBP7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RBBP7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBBP7
- genomics-online: cdna clones - Search results for available RBBP7 gene related products
- orf clones - Search results for available RBBP7 gene related products
- Applied Biological Materials Clones for RBBP7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RBBP7 Gene
Localization for RBBP7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RBBP7 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 22720776 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016581 | NuRD complex | IDA,IEA | 19644445 |
| GO:0035098 | ESC/E(Z) complex | IDA | 20075857 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RBBP7 Gene
Pathways & Interactions for RBBP7 Gene
Pathways by source for RBBP7 Gene
1 GeneTex pathway for RBBP7 Gene
6 BioSystems pathways for RBBP7 Gene
5 GeneGo (Thomson Reuters) pathways for RBBP7 Gene
1 Qiagen pathway for RBBP7 Gene
1 Cell Signaling Technology pathway for RBBP7 Gene
Interacting Proteins for RBBP7 Gene
Selected Interacting proteins:
Q16576-RBBP7_HUMAN
ENSP00000369424
for RBBP7 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for RBBP7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006260 | DNA replication | IEA | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for RBBP7 Gene
Transcripts for RBBP7 Gene
mRNA/cDNA for RBBP7 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (745) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000425696 373 bps (uc064ydz.1)
- ENST00000380087 2333 bps (uc004cxt.4)
- ENST00000330735 858 bps (uc064yeb.1)
- ENST00000465244 4031 bps (uc064yec.1)
- ENST00000380084 2036 bps (uc004cxs.3)
Unigene Clusters for RBBP7 Gene
- Retinoblastoma binding protein 7:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RBBP7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBBP7
- genomics-online: gRNA clones - Search results for available RBBP7 gene related products
- Applied Biological Materials CRISPR for RBBP7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RBBP7
- GenScript: Design CRISPR guide RNA sequences for RBBP7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RBBP7
- Browse OriGene Inhibitory RNA Products For RBBP7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RBBP7
- genomics-online: shRNA clones - Search results for available RBBP7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RBBP7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RBBP7
- genomics-online: cdna clones - Search results for available RBBP7 gene related products
- orf clones - Search results for available RBBP7 gene related products
- Applied Biological Materials Clones for RBBP7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 13b | · | 13c |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: |
Expression for RBBP7 Gene
This gene is overexpressed in Fetal ovary (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RBBP7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RBBP7 Gene:
RBBP7SOURCE GeneReport for Unigene cluster for RBBP7 Gene:
Hs.495755Evidence on tissue expression from TISSUES for RBBP7 Gene
- Kidney(4.6)
- Liver(4.4)
- Nervous system(4.4)
- Lung(3.4)
- Intestine(3.1)
- Adrenal gland(2.8)
- Bone marrow(2.8)
- Gall bladder(2.8)
- Heart(2.8)
- Lymph node(2.8)
- Muscle(2.8)
- Pancreas(2.8)
- Skin(2.8)
- Spleen(2.8)
- Stomach(2.8)
- Thyroid gland(2.8)
- Eye(2.5)
Primer Products
-
OriGene qPCR primer pairs for RBBP7
-
OriGene qPCR primer pairs and template standards for RBBP7
- genomics-online: primer clones - Search results for available RBBP7 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBBP7 Gene
Orthologs for RBBP7 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RBBP7 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RBBP7 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RBBP7 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RBBP7 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rbbp7 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Rbbp7 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | RBBP7 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RBBP7 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rbbp7 33 |
|
||
| MGC76124 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rbbp7-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rbb4l 34 33 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Caf1 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | lin-53 34 |
|
ManyToMany | |
| rba-1 34 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HAT2 34 |
|
OneToMany |
- Species where no ortholog for RBBP7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RBBP7 Gene
- ENSEMBL:
- Gene Tree for RBBP7 (if available)
- TreeFam:
- Gene Tree for RBBP7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RBBP7: view image
Paralogs for RBBP7 Gene
(4) SIMAP similar genes for RBBP7 Gene using alignment to 8 proteins:
- RBBP7_HUMAN
- C9J7L0_HUMAN
- C9JAJ9_HUMAN
- E9PC52_HUMAN
- Q5JNZ6_HUMAN
- Q5JP01_HUMAN
- Q5JP02_HUMAN
- Q6FHQ0_HUMAN
Pseudogenes.org Pseudogenes for RBBP7 Gene
Variants for RBBP7 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000078108 | -- | 16,846,144(-) | G/A | intron_variant | |
| rs1000084735 | -- | 16,862,459(-) | C/T | intron_variant | |
| rs1000248276 | -- | 16,858,367(-) | C/T | intron_variant | |
| rs1000306588 | -- | 16,866,163(-) | A/G | intron_variant | |
| rs1000359868 | -- | 16,866,332(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv29438 | CNV | loss | 19812545 |
| esv3302821 | CNV | tandem duplication | 20981092 |
| nsv1141051 | CNV | deletion | 24896259 |
| nsv511654 | CNV | gain | 21212237 |
Residual Variation Intolerance Score:
15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.27;
76.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RBBP7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RBBP7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBBP7 Gene
Disorders for RBBP7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinoblastoma |
|
|
| retinal cancer |
|
|
Search RBBP7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RBBP7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RBBP7 Gene
Publications for RBBP7 Gene
- BRCA1 interacts with components of the histone deacetylase complex. (PMID: 10220405) Yarden RI … Brody LC (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 22 58
- Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. (PMID: 10444591) Zhang Y … Reinberg D (Genes & development 1999) 3 4 22 58
- Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. (PMID: 7503932) Qian YW … Lee EY (The Journal of biological chemistry 1995) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Analysis of interaction partners of H4 histone by a new proteomics approach. (PMID: 19862764) Saade E … Ogryzko V (Proteomics 2009) 3 22 58
Products for RBBP7 Gene
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- Custom Antibody ServicesOriGene Antibodies for RBBP7
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- antibodies-online: Search results for 84 available RBBP7 Antibodies ranked by validation data
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- antibodies-online: Search results for available RBBP7 related products ranked by validation data
- antibodies-online: Search results for 18 available RBBP7 Proteins ranked by validation data
- Compare Top RBBP7 Proteins
- GeneTex RBBP7 Antibody for RBBP7
- Search GeneTex for Proteins for RBBP7
- Santa Cruz Biotechnology (SCBT) Antibodies for RBBP7
- Search Santa Cruz Biotechnology (SCBT) for RBBP7 siRNA/shRNA
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- Horizon Cell Lines for RBBP7
- genomics-online: cdna clones - Search results for available RBBP7 gene related products
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- genomics-online: primer clones - Search results for available RBBP7 gene related products
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RBBP7
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- Boster Bio Antibodies for RBBP7
- Browse Boster Bio ELISA Kits
Sources for RBBP7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
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- (133) ENCODE
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- (148) abm
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- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
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- (158) Applied Biosystems
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- (160) Aminode
- (161) GeneCopoeia
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- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt