Aliases for RBBP4 Gene
- RB Binding Protein 4, Chromatin Remodeling Factor 2 3 5
- Retinoblastoma-Binding Protein 4 2 3 4
- Nucleosome-Remodeling Factor Subunit RBAP48 3 4
- Chromatin Assembly Factor I P48 Subunit 3 4
- Chromatin Assembly Factor 1 Subunit C 3 4
- Retinoblastoma-Binding Protein P48 3 4
- Histone-Binding Protein RBBP4 3 4
- CAF-I 48 KDa Subunit 3 4
External Ids for RBBP4 Gene
Previous GeneCards Identifiers for RBBP4 Gene
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for RBBP4 Gene
RBBP4 (RB Binding Protein 4, Chromatin Remodeling Factor) is a Protein Coding gene. Diseases associated with RBBP4 include Retinoblastoma and Hemophagocytic Lymphohistiocytosis, Familial, 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Hedgehog signaling events mediated by Gli proteins. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is RBBP7.
UniProtKB/Swiss-Prot Summary for RBBP4 Gene
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.