Aliases for RBAK Gene
External Ids for RBAK Gene
Previous GeneCards Identifiers for RBAK Gene
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
GeneCards Summary for RBAK Gene
RBAK (RB Associated KRAB Zinc Finger) is a Protein Coding gene. Diseases associated with RBAK include Familial Hyperaldosteronism. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF12.
UniProtKB/Swiss-Prot for RBAK Gene
May repress E2F-dependent transcription. May promote AR-dependent transcription.