Aliases for RBAK Gene
External Ids for RBAK Gene
Previous GeneCards Identifiers for RBAK Gene
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]
GeneCards Summary for RBAK Gene
RBAK (RB Associated KRAB Zinc Finger) is a Protein Coding gene. Diseases associated with RBAK include Familial Hyperaldosteronism. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF12.
UniProtKB/Swiss-Prot Summary for RBAK Gene
May repress E2F-dependent transcription. May promote AR-dependent transcription.