Aliases for RAVER2 Gene

Aliases for RAVER2 Gene

  • Ribonucleoprotein, PTB Binding 2 2 3 5
  • Ribonucleoprotein PTB-Binding 2 3 4
  • Protein Raver-2 3 4
  • KIAA1579 2 4
  • Ribonucleoprotein, PTB-Binding 2 2
  • FLJ10770 2
  • RAVER2 5

External Ids for RAVER2 Gene

Previous GeneCards Identifiers for RAVER2 Gene

  • GC01P064916
  • GC01P065210
  • GC01P063319

Summaries for RAVER2 Gene

GeneCards Summary for RAVER2 Gene

RAVER2 (Ribonucleoprotein, PTB Binding 2) is a Protein Coding gene. Diseases associated with RAVER2 include Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant and Hypertropia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RAVER1.

UniProtKB/Swiss-Prot Summary for RAVER2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAVER2 Gene

Genomics for RAVER2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAVER2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J064744 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 261.8 +0.7 719 3.4 CHD2 ZBTB10 CTCF NONO ZIC2 SIN3A REST SIN3B VEZF1 SAP130 RAVER2 lnc-JAK1-5 JAK1
GH01J064863 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 9.7 +119.8 119845 2.4 TBP SP1 BCL11A MNT IKZF1 IRF2 HES1 MBD2 POLR2A BHLHE40 JAK1 DNAJC6 RAVER2 lnc-ITGB3BP-13 lnc-ITGB3BP-12 lnc-AK4-1
GH01J064896 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7 +153.2 153159 3.1 CEBPA IKZF1 HES1 ZFP64 ZNF217 ZEB1 ELF1 NONO ZIC2 HOMEZ JAK1 RNU6-1176P AK4 RAVER2 piR-41306-011 lnc-ITGB3BP-13 lnc-AK4-1
GH01J064959 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 6 +218.7 218734 7.8 TBP BCL11A IKZF1 SMAD5 POLR2A ELF1 NONO ZIC2 THAP11 ARNT JAK1 ENSG00000272506 LINC01359 SLC2A3P2 RAVER2 RF00017-236 ENSG00000233877 lnc-AK4-1
GH01J064914 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 7.8 +171.9 171891 3.9 CEBPA FOXA1 MNT IKZF1 ZNF217 NONO HOMEZ KDM6A THAP11 CEBPB ENSG00000234784 LOC100130270 lnc-RAVER2-2 JAK1 RAVER2 piR-41306-011 lnc-AK4-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAVER2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAVER2

Top Transcription factor binding sites by QIAGEN in the RAVER2 gene promoter:
  • C/EBPbeta
  • CUTL1
  • GR
  • GR-alpha
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT3
  • STAT5A
  • STAT5B

Genomic Locations for RAVER2 Gene

Latest Assembly
88,439 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
88,260 bases
Plus strand

(GRCh37/hg19 by Ensembl)
88,138 bases
Plus strand

Genomic View for RAVER2 Gene

Genes around RAVER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAVER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAVER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAVER2 Gene

Proteins for RAVER2 Gene

  • Protein details for RAVER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonucleoprotein PTB-binding 2
    Protein Accession:
    Secondary Accessions:
    • Q6P141
    • Q9NPV7

    Protein attributes for RAVER2 Gene

    691 amino acids
    Molecular mass:
    74339 Da
    Quaternary structure:
    • Interacts with PTBP1 and RAVER1.
    • Sequence=BAB13405.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAVER2 Gene

    Alternative splice isoforms for RAVER2 Gene


neXtProt entry for RAVER2 Gene

Post-translational modifications for RAVER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAVER2 Gene

No data available for DME Specific Peptides for RAVER2 Gene

Domains & Families for RAVER2 Gene

Gene Families for RAVER2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAVER2 Gene

  • RNA-binding region RNP-1 (RNA recognition motif)
  • Beta and gamma crystallin

Suggested Antigen Peptide Sequences for RAVER2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57423, highly similar to Ribonucleoprotein PTB-binding 2 (B4DRE9_HUMAN)
  • Protein raver-2 (RAVR2_HUMAN)
genes like me logo Genes that share domains with RAVER2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RAVER2 Gene

Function for RAVER2 Gene

Molecular function for RAVER2 Gene

UniProtKB/Swiss-Prot Function:
May bind single-stranded nucleic acids.

Phenotypes From GWAS Catalog for RAVER2 Gene

Gene Ontology (GO) - Molecular Function for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA 21873635
GO:0003723 RNA binding IEA,HDA 22658674
genes like me logo Genes that share ontologies with RAVER2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAVER2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAVER2 Gene

Localization for RAVER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAVER2 Gene

Nucleus. Cytoplasm. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAVER2 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RAVER2: view

Pathways & Interactions for RAVER2 Gene

PathCards logo

SuperPathways for RAVER2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA 21873635
genes like me logo Genes that share ontologies with RAVER2: view

No data available for Pathways by source and SIGNOR curated interactions for RAVER2 Gene

Drugs & Compounds for RAVER2 Gene

No Compound Related Data Available

Transcripts for RAVER2 Gene

mRNA/cDNA for RAVER2 Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAVER2

Alternative Splicing Database (ASD) splice patterns (SP) for RAVER2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - -
SP2: - -
SP3: - - -

Relevant External Links for RAVER2 Gene

GeneLoc Exon Structure for

Expression for RAVER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAVER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAVER2 Gene

This gene is overexpressed in Adipocyte (24.0), Pancreas (14.9), Placenta (14.2), and Islet of Langerhans (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAVER2 Gene

Protein tissue co-expression partners for RAVER2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAVER2

SOURCE GeneReport for Unigene cluster for RAVER2 Gene:


Evidence on tissue expression from TISSUES for RAVER2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RAVER2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAVER2 Gene

Orthologs for RAVER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAVER2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAVER2 30 31
  • 99.51 (n)
(Canis familiaris)
Mammalia RAVER2 30 31
  • 91.36 (n)
(Bos Taurus)
Mammalia RAVER2 30 31
  • 91.32 (n)
(Mus musculus)
Mammalia Raver2 30 17 31
  • 81.25 (n)
(Rattus norvegicus)
Mammalia Raver2 30
  • 81.25 (n)
(Monodelphis domestica)
Mammalia RAVER2 31
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia RAVER2 31
  • 68 (a)
(Gallus gallus)
Aves RAVER2 30 31
  • 71.76 (n)
(Anolis carolinensis)
Reptilia RAVER2 31
  • 56 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia raver2 30
  • 64.88 (n)
(Danio rerio)
Actinopterygii raver2 30 31
  • 57.13 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2565 31
  • 32 (a)
Species where no ortholog for RAVER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RAVER2 Gene

Gene Tree for RAVER2 (if available)
Gene Tree for RAVER2 (if available)
Evolutionary constrained regions (ECRs) for RAVER2: view image

Paralogs for RAVER2 Gene

Paralogs for RAVER2 Gene

(1) SIMAP similar genes for RAVER2 Gene using alignment to 3 proteins:

  • E9PE10_HUMAN
genes like me logo Genes that share paralogs with RAVER2: view

Variants for RAVER2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAVER2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAVER2 Gene

Variant ID Type Subtype PubMed ID
esv3577903 CNV loss 25503493

Variation tolerance for RAVER2 Gene

Residual Variation Intolerance Score: 9.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAVER2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAVER2 Gene

Disorders for RAVER2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAVER2 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAVER2

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RAVER2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAVER2 Gene

Publications for RAVER2 Gene

  1. Raver2, a new member of the hnRNP family. (PMID: 16051233) Kleinhenz B … Illenberger S (FEBS letters 2005) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
  4. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. (PMID: 30737378) Tang W … Wang J (Nature communications 2019) 3
  5. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (PMID: 29395067) Youn JY … Gingras AC (Molecular cell 2018) 3

Products for RAVER2 Gene

Sources for RAVER2 Gene