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Aliases for RAVER2 Gene

Aliases for RAVER2 Gene

  • Ribonucleoprotein, PTB Binding 2 2 3 5
  • Ribonucleoprotein, PTB-Binding 2 2
  • Protein Raver-2 4
  • KIAA1579 4

External Ids for RAVER2 Gene

Previous GeneCards Identifiers for RAVER2 Gene

  • GC01P064916
  • GC01P065210
  • GC01P063319

Summaries for RAVER2 Gene

GeneCards Summary for RAVER2 Gene

RAVER2 (Ribonucleoprotein, PTB Binding 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RAVER1.

UniProtKB/Swiss-Prot for RAVER2 Gene

  • May bind single-stranded nucleic acids.

Additional gene information for RAVER2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAVER2 Gene

Genomics for RAVER2 Gene

GeneHancer (GH) Regulatory Elements for RAVER2 Gene

Promoters and enhancers for RAVER2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I064744 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 561.9 +0.8 828 3.2 ATF1 SIN3A ZNF2 ZNF48 GLIS2 E2F8 ATF7 SP3 REST SMARCA4 RAVER2 GC01P064806
GH01I064959 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 6.1 +218.7 218737 7.8 ARNT ARID4B SIN3A ZNF48 ZNF121 GLIS2 ZNF207 KLF7 ATF7 RUNX3 JAK1 SLC2A3P2 RAVER2 GC01P064945
GH01I064863 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.7 +119.9 119854 2.4 PKNOX1 SMAD1 ARNT IRF4 ZNF766 CBX5 E2F8 ZNF207 ZNF143 JUNB JAK1 RAVER2 GC01P064868 GC01M064851
GH01I064919 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +176.7 176723 3.9 FOXA2 BMI1 ZBTB40 TCF12 ATF7 RCOR1 FOS RUNX3 CEBPB NFIL3 JAK1 AK4 RAVER2 GC01P064919 GC01M064928
GH01I064914 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +171.9 171900 3.9 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 FOS ATF7 RXRA GC01P064919 LOC100130270 JAK1 RAVER2 GC01P064910
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAVER2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAVER2 gene promoter:

Genomic Locations for RAVER2 Gene

Genomic Locations for RAVER2 Gene
chr1:64,744,964-64,833,232
(GRCh38/hg38)
Size:
88,269 bases
Orientation:
Plus strand
chr1:65,210,778-65,298,915
(GRCh37/hg19)

Genomic View for RAVER2 Gene

Genes around RAVER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAVER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAVER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAVER2 Gene

Proteins for RAVER2 Gene

  • Protein details for RAVER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCJ3-RAVR2_HUMAN
    Recommended name:
    Ribonucleoprotein PTB-binding 2
    Protein Accession:
    Q9HCJ3
    Secondary Accessions:
    • Q6P141
    • Q9NPV7

    Protein attributes for RAVER2 Gene

    Size:
    691 amino acids
    Molecular mass:
    74339 Da
    Quaternary structure:
    • Interacts with PTBP1 and RAVER1.
    SequenceCaution:
    • Sequence=BAB13405.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAVER2 Gene

    Alternative splice isoforms for RAVER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAVER2 Gene

Post-translational modifications for RAVER2 Gene

No Post-translational modifications

Other Protein References for RAVER2 Gene

No data available for DME Specific Peptides for RAVER2 Gene

Domains & Families for RAVER2 Gene

Gene Families for RAVER2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAVER2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAVER2: view

No data available for UniProtKB/Swiss-Prot for RAVER2 Gene

Function for RAVER2 Gene

Molecular function for RAVER2 Gene

UniProtKB/Swiss-Prot Function:
May bind single-stranded nucleic acids.

Phenotypes From GWAS Catalog for RAVER2 Gene

Gene Ontology (GO) - Molecular Function for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0003723 RNA binding IEA,HDA 22658674
genes like me logo Genes that share ontologies with RAVER2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAVER2 Gene

Localization for RAVER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAVER2 Gene

Nucleus. Cytoplasm. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAVER2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RAVER2: view

Pathways & Interactions for RAVER2 Gene

SuperPathways for RAVER2 Gene

No Data Available

Interacting Proteins for RAVER2 Gene

Gene Ontology (GO) - Biological Process for RAVER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with RAVER2: view

No data available for Pathways by source and SIGNOR curated interactions for RAVER2 Gene

Drugs & Compounds for RAVER2 Gene

No Compound Related Data Available

Transcripts for RAVER2 Gene

Unigene Clusters for RAVER2 Gene

Ribonucleoprotein, PTB-binding 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAVER2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for RAVER2 Gene

GeneLoc Exon Structure for
RAVER2
ECgene alternative splicing isoforms for
RAVER2

Expression for RAVER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAVER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAVER2 Gene

This gene is overexpressed in Adipocyte (24.0), Pancreas (14.9), Placenta (14.2), and Islet of Langerhans (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAVER2 Gene



Protein tissue co-expression partners for RAVER2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAVER2 Gene:

RAVER2

SOURCE GeneReport for Unigene cluster for RAVER2 Gene:

Hs.591443

Evidence on tissue expression from TISSUES for RAVER2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RAVER2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAVER2 Gene

Orthologs for RAVER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAVER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAVER2 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia RAVER2 33 34
  • 91.36 (n)
cow
(Bos Taurus)
Mammalia RAVER2 33 34
  • 91.32 (n)
mouse
(Mus musculus)
Mammalia Raver2 33 16 34
  • 81.25 (n)
rat
(Rattus norvegicus)
Mammalia Raver2 33
  • 81.25 (n)
oppossum
(Monodelphis domestica)
Mammalia RAVER2 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAVER2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAVER2 33 34
  • 71.76 (n)
lizard
(Anolis carolinensis)
Reptilia RAVER2 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia raver2 33
  • 64.88 (n)
zebrafish
(Danio rerio)
Actinopterygii raver2 33 34
  • 57.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2565 34
  • 32 (a)
OneToMany
Species where no ortholog for RAVER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAVER2 Gene

ENSEMBL:
Gene Tree for RAVER2 (if available)
TreeFam:
Gene Tree for RAVER2 (if available)

Paralogs for RAVER2 Gene

Paralogs for RAVER2 Gene

(1) SIMAP similar genes for RAVER2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RAVER2: view

Variants for RAVER2 Gene

Sequence variations from dbSNP and Humsavar for RAVER2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000072365 -- 64,822,736(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000102834 -- 64,763,603(+) A/C intron_variant
rs1000126455 -- 64,792,831(+) A/G intron_variant
rs1000127039 -- 64,746,850(+) G/A intron_variant
rs1000166174 -- 64,746,525(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAVER2 Gene

Variant ID Type Subtype PubMed ID
esv3577903 CNV loss 25503493

Variation tolerance for RAVER2 Gene

Residual Variation Intolerance Score: 9.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAVER2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAVER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAVER2 Gene

Disorders for RAVER2 Gene

Additional Disease Information for RAVER2

No disorders were found for RAVER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAVER2 Gene

Publications for RAVER2 Gene

  1. Raver2, a new member of the hnRNP family. (PMID: 16051233) Kleinhenz B … Illenberger S (FEBS letters 2005) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for RAVER2 Gene

Sources for RAVER2 Gene

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