Aliases for RAVER1 Gene

Aliases for RAVER1 Gene

  • Ribonucleoprotein, PTB Binding 1 2 3 5
  • Ribonucleoprotein PTB-Binding 1 3 4
  • Protein Raver-1 3 4
  • KIAA1978 2 4
  • Ribonucleoprotein, PTB-Binding 1 2
  • RAVER1 5

External Ids for RAVER1 Gene

Previous GeneCards Identifiers for RAVER1 Gene

  • GC19U990309
  • GC19M010649
  • GC19M010272
  • GC19M010287
  • GC19M010426
  • GC19M010007

Summaries for RAVER1 Gene

GeneCards Summary for RAVER1 Gene

RAVER1 (Ribonucleoprotein, PTB Binding 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RAVER2.

UniProtKB/Swiss-Prot Summary for RAVER1 Gene

  • Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Gene Wiki entry for RAVER1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAVER1 Gene

Genomics for RAVER1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAVER1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAVER1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAVER1

Top Transcription factor binding sites by QIAGEN in the RAVER1 gene promoter:
  • Bach2
  • HEN1
  • Sp1

Genomic Locations for RAVER1 Gene

Latest Assembly
17,427 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
17,318 bases
Minus strand

(GRCh37/hg19 by Ensembl)
17,429 bases
Minus strand

Genomic View for RAVER1 Gene

Genes around RAVER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAVER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAVER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAVER1 Gene

Proteins for RAVER1 Gene

  • Protein details for RAVER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonucleoprotein PTB-binding 1
    Protein Accession:
    Secondary Accessions:
    • A6NMU4
    • Q8IY60
    • Q8TF24

    Protein attributes for RAVER1 Gene

    606 amino acids
    Molecular mass:
    63877 Da
    Quaternary structure:
    • Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1 (By similarity).
    • Sequence=AAH37565.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB85564.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for RAVER1 Gene

    Alternative splice isoforms for RAVER1 Gene


neXtProt entry for RAVER1 Gene

Post-translational modifications for RAVER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAVER1 Gene

No data available for DME Specific Peptides for RAVER1 Gene

Domains & Families for RAVER1 Gene

Gene Families for RAVER1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAVER1 Gene

  • RNA-binding region RNP-1 (RNA recognition motif)

Suggested Antigen Peptide Sequences for RAVER1 Gene

GenScript: Design optimal peptide antigens:
  • Protein raver-1 (RAVR1_HUMAN)
genes like me logo Genes that share domains with RAVER1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RAVER1 Gene

Function for RAVER1 Gene

Molecular function for RAVER1 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).

Phenotypes From GWAS Catalog for RAVER1 Gene

Gene Ontology (GO) - Molecular Function for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA,IBA 21873635
GO:0003723 RNA binding IEA,HDA 22681889
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with RAVER1: view
genes like me logo Genes that share phenotypes with RAVER1: view

Animal Models for RAVER1 Gene

MGI Knock Outs for RAVER1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAVER1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAVER1 Gene

Localization for RAVER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAVER1 Gene

Nucleus. Cytoplasm. Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAVER1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RAVER1: view

Pathways & Interactions for RAVER1 Gene

PathCards logo

SuperPathways for RAVER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAVER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA 21873635
genes like me logo Genes that share ontologies with RAVER1: view

No data available for Pathways by source and SIGNOR curated interactions for RAVER1 Gene

Drugs & Compounds for RAVER1 Gene

No Compound Related Data Available

Transcripts for RAVER1 Gene

mRNA/cDNA for RAVER1 Gene

6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAVER1

Alternative Splicing Database (ASD) splice patterns (SP) for RAVER1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: -
SP5: -

Relevant External Links for RAVER1 Gene

GeneLoc Exon Structure for

Expression for RAVER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAVER1 Gene

Protein differential expression in normal tissues from HIPED for RAVER1 Gene

This gene is overexpressed in Liver (29.9), Peripheral blood mononuclear cells (8.9), Nasal epithelium (8.3), and Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAVER1 Gene

Protein tissue co-expression partners for RAVER1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAVER1

SOURCE GeneReport for Unigene cluster for RAVER1 Gene:


Evidence on tissue expression from TISSUES for RAVER1 Gene

  • Nervous system(4.4)
  • Blood(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RAVER1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAVER1 Gene

Orthologs for RAVER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAVER1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAVER1 30 31
  • 96.76 (n)
(Bos Taurus)
Mammalia RAVER1 30 31
  • 89.53 (n)
(Canis familiaris)
Mammalia RAVER1 30 31
  • 89.14 (n)
(Rattus norvegicus)
Mammalia Raver1 30
  • 85.12 (n)
(Mus musculus)
Mammalia Raver1 30 17 31
  • 84.44 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia raver1 30
  • 62.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30898 30
(Danio rerio)
Actinopterygii raver1 31
  • 49 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2565 31
  • 33 (a)
Species where no ortholog for RAVER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RAVER1 Gene

Gene Tree for RAVER1 (if available)
Gene Tree for RAVER1 (if available)
Evolutionary constrained regions (ECRs) for RAVER1: view image

Paralogs for RAVER1 Gene

Paralogs for RAVER1 Gene

(1) SIMAP similar genes for RAVER1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RAVER1: view

Variants for RAVER1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAVER1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAVER1 Gene

Variant ID Type Subtype PubMed ID
nsv470124 CNV gain 18288195

Variation tolerance for RAVER1 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAVER1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAVER1 Gene

Disorders for RAVER1 Gene

Additional Disease Information for RAVER1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for RAVER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAVER1 Gene

Publications for RAVER1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 41
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

Products for RAVER1 Gene

Sources for RAVER1 Gene