The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. [provided by RefSeq, Jul 2008] See more...

Aliases for RASSF9 Gene

Aliases for RASSF9 Gene

  • Ras Association Domain Family Member 9 2 3 5
  • P-CIP1 2 3 4
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor 2 4
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 9 2 3
  • Ras Association Domain-Containing Protein 9 3 4
  • PAM COOH-Terminal Interactor Protein 1 3 4
  • PAMCI 3 4
  • PCIP1 3 4
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor Protein-1 3
  • RASSF9 5

External Ids for RASSF9 Gene

Previous HGNC Symbols for RASSF9 Gene

  • PAMCI

Previous GeneCards Identifiers for RASSF9 Gene

  • GC12M084722
  • GC12M086198
  • GC12M083254

Summaries for RASSF9 Gene

Entrez Gene Summary for RASSF9 Gene

  • The protein encoded by this gene localizes to perinuclear endosomes. This protein associates with peptidylglycine alpha-amidating monooxygenase, and may be involved with the trafficking of this enzyme through secretory or endosomal pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF9 Gene

RASSF9 (Ras Association Domain Family Member 9) is a Protein Coding gene. Diseases associated with RASSF9 include Isolated Growth Hormone Deficiency, Type Ii. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is RASSF10.

UniProtKB/Swiss-Prot Summary for RASSF9 Gene

Gene Wiki entry for RASSF9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF9 Gene

Genomics for RASSF9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RASSF9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J085834 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +1.1 1147 4.5 ZNF600 ZNF580 ATF2 CEBPA ZNF10 CEBPB FEZF1 ZNF639 MAX EP300 RASSF9 ENSG00000258178 KR153194-035 ALX1
GH12J085625 Enhancer 0.9 Ensembl ENCODE 14.4 +209.7 209708 3 ZNF600 JUND BRCA1 CEBPB ZNF639 ZEB1 EP300 MAFF RFX5 STAT3 RASSF9 HSALNG0092815 HSALNG0092819 HSALNG0092816-001 LINC02820 ALX1
GH12J085590 Enhancer 0.4 Ensembl 24.8 +244.9 244908 1 PRDM6 ZNF26 NANOG ZNF680 RASSF9 piR-36588-102 LOC101059974 LINC02820 ALX1
GH12J085575 Enhancer 0.7 Ensembl ENCODE 12.7 +260.9 260932 1 ZNF654 TRIM22 CTCF ELF1 RAD21 SMC3 ZNF143 PRDM10 ZNF335 ZNF184 RASSF9 LOC101059974 piR-36588-102 LINC02820 ALX1
GH12J085468 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 6.7 +367.1 367145 2 ZNF654 JUND ZNF580 TRIM22 FEZF1 CTCF RAD21 RFX5 SMC3 CBFB LOC107984537 RASSF9 piR-55905-006 lnc-RASSF9-2 LINC02820 ALX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF9

Top Transcription factor binding sites by QIAGEN in the RASSF9 gene promoter:
  • c-Myb
  • CREB
  • deltaCREB
  • En-1
  • Evi-1
  • HNF-3beta
  • NF-E2
  • NF-E2 p45
  • RREB-1
  • Sox5

Genomic Locations for RASSF9 Gene

Latest Assembly
chr12:85,800,703-85,836,409
(GRCh38/hg38)
Size:
35,707 bases
Orientation:
Minus strand

Previous Assembly
chr12:86,194,481-86,230,187
(GRCh37/hg19 by Entrez Gene)
Size:
35,707 bases
Orientation:
Minus strand

chr12:86,198,331-86,230,348
(GRCh37/hg19 by Ensembl)
Size:
32,018 bases
Orientation:
Minus strand

Genomic View for RASSF9 Gene

Genes around RASSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF9 Gene

Proteins for RASSF9 Gene

  • Protein details for RASSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75901-RASF9_HUMAN
    Recommended name:
    Ras association domain-containing protein 9
    Protein Accession:
    O75901
    Secondary Accessions:
    • B3KMQ4
    • Q8N5U8

    Protein attributes for RASSF9 Gene

    Size:
    435 amino acids
    Molecular mass:
    50021 Da
    Quaternary structure:
    • Interacts with PAM.

neXtProt entry for RASSF9 Gene

Post-translational modifications for RASSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASSF9 Gene

Domains & Families for RASSF9 Gene

Gene Families for RASSF9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF9 Gene

InterPro:
Blocks:
  • RA domain

Suggested Antigen Peptide Sequences for RASSF9 Gene

GenScript: Design optimal peptide antigens:
  • Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor (RASF9_HUMAN)
genes like me logo Genes that share domains with RASSF9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF9 Gene

Function for RASSF9 Gene

Molecular function for RASSF9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating vesicuar trafficking in cells.

Phenotypes From GWAS Catalog for RASSF9 Gene

Gene Ontology (GO) - Molecular Function for RASSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9837933
genes like me logo Genes that share ontologies with RASSF9: view
genes like me logo Genes that share phenotypes with RASSF9: view

miRNA for RASSF9 Gene

miRTarBase miRNAs that target RASSF9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF9 Gene

Localization for RASSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF9 Gene

Endosome. Note=Accumulates on perinuclear endosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF9 gene
Compartment Confidence
endosome 5
cytosol 5
extracellular 4
nucleus 3
cytoskeleton 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for RASSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA,IDA 9837933
GO:0005829 cytosol IBA,IDA 9837933
GO:0012510 trans-Golgi network transport vesicle membrane IDA 9837933
GO:0055037 recycling endosome IBA 21873635
GO:0070062 extracellular exosome HDA 18570454
genes like me logo Genes that share ontologies with RASSF9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASSF9 Gene

Pathways & Interactions for RASSF9 Gene

PathCards logo

SuperPathways for RASSF9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting NAS 9837933
GO:0007165 signal transduction IEA --
GO:0016197 endosomal transport NAS 9837933
GO:0046907 intracellular transport IBA 21873635
genes like me logo Genes that share ontologies with RASSF9: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF9 Gene

Drugs & Compounds for RASSF9 Gene

No Compound Related Data Available

Transcripts for RASSF9 Gene

mRNA/cDNA for RASSF9 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF9

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF9 Gene

No ASD Table

Relevant External Links for RASSF9 Gene

GeneLoc Exon Structure for
RASSF9

Expression for RASSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RASSF9 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF9 Gene



Protein tissue co-expression partners for RASSF9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF9

SOURCE GeneReport for Unigene cluster for RASSF9 Gene:

Hs.527881

Evidence on tissue expression from TISSUES for RASSF9 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with RASSF9: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF9 Gene

Orthologs for RASSF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RASSF9 29 30
  • 99.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RASSF9 29 30
  • 91.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RASSF9 29 30
  • 91.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rassf9 29
  • 82.84 (n)
Mouse
(Mus musculus)
Mammalia Rassf9 29 16 30
  • 82.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RASSF9 30
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RASSF9 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RASSF9 29 30
  • 72.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RASSF9 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rassf9 29
  • 59.29 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100150148 29
  • 55.7 (n)
rassf9 30
  • 41 (a)
OneToOne
Species where no ortholog for RASSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RASSF9 Gene

ENSEMBL:
Gene Tree for RASSF9 (if available)
TreeFam:
Gene Tree for RASSF9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF9: view image
Alliance of Genome Resources:
Additional Orthologs for RASSF9

Paralogs for RASSF9 Gene

Paralogs for RASSF9 Gene

genes like me logo Genes that share paralogs with RASSF9: view

Variants for RASSF9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF9 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs7397266 -- p.Ala285Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RASSF9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RASSF9 Gene

Variant ID Type Subtype PubMed ID
dgv1537n100 CNV loss 25217958
dgv1539n100 CNV gain 25217958
esv3892241 CNV gain 25118596
esv3892242 CNV loss 25118596
nsv1049179 CNV gain 25217958

Variation tolerance for RASSF9 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF9
Leiden Open Variation Database (LOVD)
RASSF9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF9 Gene

Disorders for RASSF9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF9 Gene - From: COP

Disorder Aliases PubMed IDs
isolated growth hormone deficiency, type ii
  • ighd2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASSF9

genes like me logo Genes that share disorders with RASSF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF9 Gene

Publications for RASSF9 Gene

  1. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. (PMID: 9837933) Chen L … Milgram SL (The Journal of biological chemistry 1998) 2 3 4 22
  2. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. (PMID: 18272789) Sherwood V … Chalmers AD (Molecular biology of the cell 2008) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. MicroRNA-1254 exerts oncogenic effects by directly targeting RASSF9 in human breast cancer. (PMID: 30132526) Li B … He J (International journal of oncology 2018) 3
  5. Local Adaptation of Sun-Exposure-Dependent Gene Expression Regulation in Human Skin. (PMID: 27760139) Kita R … Fraser HB (PLoS genetics 2016) 3

Products for RASSF9 Gene

Sources for RASSF9 Gene