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Aliases for RASSF7 Gene

Aliases for RASSF7 Gene

  • Ras Association Domain Family Member 7 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 7 2 3
  • HRAS1-Related Cluster Protein 1 3 4
  • C11orf13 3 4
  • HRC1 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 7 3
  • Ras Association Domain-Containing Protein 7 3
  • Chromosome 11 Open Reading Frame 13 2
  • HRAS1-Related Cluster-1 3
  • HRAS1 3

External Ids for RASSF7 Gene

Previous HGNC Symbols for RASSF7 Gene

  • C11orf13

Previous GeneCards Identifiers for RASSF7 Gene

  • GC11P000552
  • GC11P000375

Summaries for RASSF7 Gene

GeneCards Summary for RASSF7 Gene

RASSF7 (Ras Association Domain Family Member 7) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton. An important paralog of this gene is RASSF8.

UniProtKB/Swiss-Prot for RASSF7 Gene

  • Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

Additional gene information for RASSF7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF7 Gene

Genomics for RASSF7 Gene

GeneHancer (GH) Regulatory Elements for RASSF7 Gene

Promoters and enhancers for RASSF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000559 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +3.1 3139 7.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B FOS LMNTD2 RASSF7 GC11M000563 PHRF1 HRAS TMEM80 PKP3 RNH1 PTDSS2 ENSG00000254815
GH11J000555 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.7 -4.5 -4510 0.1 CTCF GATAD2A SP5 MXD4 SIN3A ZNF398 KDM3A GABPA ZGPAT POLR2A RASSF7 ENSG00000254815 LMNTD2 HRAS
GH11J000514 Enhancer 0.6 ENCODE dbSUPER 12.8 -44.6 -44553 1.8 CEBPB CEBPG LOC105376507 RNH1 HRAS ENSG00000254815 RASSF7 LMNTD2 PTDSS2 CEND1 SLC25A22 PIDD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASSF7 gene promoter:
  • NF-1
  • NF-1/L
  • STAT3

Genomic Locations for RASSF7 Gene

Genomic Locations for RASSF7 Gene
chr11:559,776-564,025
(GRCh38/hg38)
Size:
4,250 bases
Orientation:
Plus strand
chr11:560,404-564,025
(GRCh37/hg19)
Size:
3,622 bases
Orientation:
Plus strand

Genomic View for RASSF7 Gene

Genes around RASSF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF7 Gene

Proteins for RASSF7 Gene

  • Protein details for RASSF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02833-RASF7_HUMAN
    Recommended name:
    Ras association domain-containing protein 7
    Protein Accession:
    Q02833
    Secondary Accessions:
    • G5E9N9
    • Q3KP41
    • Q3KP42

    Protein attributes for RASSF7 Gene

    Size:
    373 amino acids
    Molecular mass:
    39945 Da
    Quaternary structure:
    • Interacts with MAP2K7 and GTP-bound NRAS.

    Alternative splice isoforms for RASSF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF7 Gene

Post-translational modifications for RASSF7 Gene

  • Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF7 Gene

Domains & Families for RASSF7 Gene

Gene Families for RASSF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RASSF7 Gene

Suggested Antigen Peptide Sequences for RASSF7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASSF7: view

No data available for UniProtKB/Swiss-Prot for RASSF7 Gene

Function for RASSF7 Gene

Molecular function for RASSF7 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

Gene Ontology (GO) - Molecular Function for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RASSF7: view
genes like me logo Genes that share phenotypes with RASSF7: view

Animal Model Products

CRISPR Products

miRNA for RASSF7 Gene

miRTarBase miRNAs that target RASSF7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF7 Gene

Localization for RASSF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with gamma-tubulin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF7 gene
Compartment Confidence
cytoskeleton 5
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA,IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with RASSF7: view

Pathways & Interactions for RASSF7 Gene

genes like me logo Genes that share pathways with RASSF7: view

Pathways by source for RASSF7 Gene

1 BioSystems pathway for RASSF7 Gene

Interacting Proteins for RASSF7 Gene

Gene Ontology (GO) - Biological Process for RASSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0070507 regulation of microtubule cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with RASSF7: view

No data available for SIGNOR curated interactions for RASSF7 Gene

Drugs & Compounds for RASSF7 Gene

No Compound Related Data Available

Transcripts for RASSF7 Gene

mRNA/cDNA for RASSF7 Gene

Unigene Clusters for RASSF7 Gene

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for RASSF7 Gene

GeneLoc Exon Structure for
RASSF7
ECgene alternative splicing isoforms for
RASSF7

Expression for RASSF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASSF7 Gene

Protein differential expression in normal tissues from HIPED for RASSF7 Gene

This gene is overexpressed in Pancreas (30.9), Placenta (30.8), and Islet of Langerhans (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF7 Gene



Protein tissue co-expression partners for RASSF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASSF7 Gene:

RASSF7

SOURCE GeneReport for Unigene cluster for RASSF7 Gene:

Hs.72925
genes like me logo Genes that share expression patterns with RASSF7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF7 Gene

Orthologs for RASSF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF7 34 33
  • 99.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf7 16 34 33
  • 83.5 (n)
dog
(Canis familiaris)
Mammalia RASSF7 34 33
  • 83.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RASSF7 34 33
  • 81.93 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf7 33
  • 81.68 (n)
oppossum
(Monodelphis domestica)
Mammalia RASSF7 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF7 34 33
  • 61.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASSF7 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf7 33
  • 57.08 (n)
Str.13483 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14379 33
zebrafish
(Danio rerio)
Actinopterygii rassf7b 34
  • 31 (a)
OneToMany
rassf7a 34
  • 31 (a)
OneToMany
RASSF7 (3 of 3) 34
  • 31 (a)
OneToMany
sbcb262 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7475 33
fruit fly
(Drosophila melanogaster)
Insecta RASSF8 34
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K05B2.2 34
  • 17 (a)
OneToMany
Species where no ortholog for RASSF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF7 Gene

ENSEMBL:
Gene Tree for RASSF7 (if available)
TreeFam:
Gene Tree for RASSF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF7: view image

Paralogs for RASSF7 Gene

Paralogs for RASSF7 Gene

(2) SIMAP similar genes for RASSF7 Gene using alignment to 4 proteins:

  • RASF7_HUMAN
  • E9PM39_HUMAN
  • F8W7Q0_HUMAN
  • H0YEI0_HUMAN
genes like me logo Genes that share paralogs with RASSF7: view

Variants for RASSF7 Gene

Sequence variations from dbSNP and Humsavar for RASSF7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000012138 -- 564,435(+) T/C downstream_transcript_variant
rs1000856296 -- 562,111(+) C/T coding_sequence_variant, missense_variant
rs1001244556 -- 564,401(+) C/T downstream_transcript_variant
rs1001296929 -- 564,187(+) C/T downstream_transcript_variant
rs1001576130 -- 559,692(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF7 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for RASSF7 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.26; 81.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF7 Gene

Disorders for RASSF7 Gene

Additional Disease Information for RASSF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RASSF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF7 Gene

Publications for RASSF7 Gene

  1. The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain. (PMID: 1339391) Weitzel JN … Krontiris TG (Genomics 1992) 2 3 4 22 58
  2. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. (PMID: 21278800) Takahashi S … Katada T (Cell death and differentiation 2011) 3 4 58
  3. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. (PMID: 20629633) Recino A … Chalmers AD (The Biochemical journal 2010) 3 4 58
  4. Human longevity and 11p15.5: a study in 1321 centenarians. (PMID: 19367319) Lescai F … Franceschi C (European journal of human genetics : EJHG 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RASSF7 Gene

Sources for RASSF7 Gene

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