This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alt... See more...

Aliases for RASSF6 Gene

Aliases for RASSF6 Gene

  • Ras Association Domain Family Member 6 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 6 2 3
  • Ras Association Domain-Containing Protein 6 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 6 3
  • Putative RAS Binding Protein 3

External Ids for RASSF6 Gene

Previous GeneCards Identifiers for RASSF6 Gene

  • GC04M074680
  • GC04M074842
  • GC04M074907
  • GC04M074905
  • GC04M074803
  • GC04M074437
  • GC04M070250

Summaries for RASSF6 Gene

Entrez Gene Summary for RASSF6 Gene

  • This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RASSF6 Gene

RASSF6 (Ras Association Domain Family Member 6) is a Protein Coding gene. Diseases associated with RASSF6 include Bronchiolitis. Among its related pathways are Hippo signaling pathway and Hippo signaling pathway - multiple species. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot Summary for RASSF6 Gene

  • Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Additional gene information for RASSF6 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF6 Gene

Genomics for RASSF6 Gene

GeneHancer (GH) Regulatory Elements for RASSF6 Gene

Promoters and enhancers for RASSF6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073615 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 507.3 +1.8 1840 7.2 NRF1 USF1 NCOR1 TEAD4 ZIC2 TRIM28 CTBP1 SKI TRIM22 TEAD1 RASSF6 lnc-ANKRD17-2 lnc-AFM-3
GH04J073598 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +20.7 20651 4 EP300 TCF12 POLR2G NCOR1 KDM6A TCF7 TGIF2 CTBP1 SKI TEAD1 RASSF6 MTHFD2L PF4V1 lnc-ANKRD17-2 lnc-AFM-3
GH04J073660 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -42.3 -42270 4.6 CTCF FOS REST RAD21 TRIM22 SMC3 RAD51 NANOG FOSL1 EZH2 CXCL3 CXCL2 CXCL8 RASSF6 MTHFD2L PF4V1 PPBP HSALNG0035158
GH04J073588 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.8 +30.7 30651 2.6 EP300 TRIM28 JUND RELA RCOR1 TRIM22 FOXA2 OSR2 BCL11A TCF12 RASSF6 MTHFD2L ANKRD17 ENSG00000250220 ENSG00000221639 lnc-AFM-3 lnc-ANKRD17-2
GH04J073605 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +12.3 12308 5.9 POLR2G EP300 TCF7 RELA RCOR1 BCL11A TCF12 FOXA2 ZNF384 FOS RASSF6 MTHFD2L lnc-ANKRD17-2 lnc-AFM-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF6

Top Transcription factor binding sites by QIAGEN in the RASSF6 gene promoter:
  • FOXI1
  • HFH-3
  • HTF
  • Nkx6-1
  • RORalpha2

Genomic Locations for RASSF6 Gene

Genomic Locations for RASSF6 Gene
chr4:73,571,550-73,620,631
(GRCh38/hg38)
Size:
49,082 bases
Orientation:
Minus strand
chr4:74,437,267-74,486,348
(GRCh37/hg19)
Size:
49,082 bases
Orientation:
Minus strand

Genomic View for RASSF6 Gene

Genes around RASSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF6 Gene

Proteins for RASSF6 Gene

  • Protein details for RASSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTQ3-RASF6_HUMAN
    Recommended name:
    Ras association domain-containing protein 6
    Protein Accession:
    Q6ZTQ3
    Secondary Accessions:
    • Q68DT2
    • Q6PDA6
    • Q86WG9
    • Q86WH0

    Protein attributes for RASSF6 Gene

    Size:
    369 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    • Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779).
    SequenceCaution:
    • Sequence=AAH58835.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18138.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF6 Gene

Post-translational modifications for RASSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF6 Gene

Domains & Families for RASSF6 Gene

Gene Families for RASSF6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF6 Gene

Suggested Antigen Peptide Sequences for RASSF6 Gene

GenScript: Design optimal peptide antigens:
  • Ras association domain-containing protein 6 (RASF6_HUMAN)
genes like me logo Genes that share domains with RASSF6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF6 Gene

Function for RASSF6 Gene

Molecular function for RASSF6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Phenotypes From GWAS Catalog for RASSF6 Gene

Gene Ontology (GO) - Molecular Function for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF6: view
genes like me logo Genes that share phenotypes with RASSF6: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF6 Gene

Localization for RASSF6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF6 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF6 Gene

Pathways & Interactions for RASSF6 Gene

genes like me logo Genes that share pathways with RASSF6: view

Pathways by source for RASSF6 Gene

SIGNOR curated interactions for RASSF6 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with RASSF6: view

Drugs & Compounds for RASSF6 Gene

No Compound Related Data Available

Transcripts for RASSF6 Gene

mRNA/cDNA for RASSF6 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -

Relevant External Links for RASSF6 Gene

GeneLoc Exon Structure for
RASSF6

Expression for RASSF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF6 Gene

This gene is overexpressed in Stomach (x7.1), Colon - Transverse (x5.3), Bladder (x5.0), Small Intestine - Terminal Ileum (x4.1), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for RASSF6 Gene

This gene is overexpressed in Liver (47.7), Thyroid (12.2), and Cardia (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF6

SOURCE GeneReport for Unigene cluster for RASSF6 Gene:

Hs.529677

mRNA Expression by UniProt/SwissProt for RASSF6 Gene:

Q6ZTQ3-RASF6_HUMAN
Tissue specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.

Evidence on tissue expression from TISSUES for RASSF6 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with RASSF6: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF6 Gene

Orthologs for RASSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF6 31 30
  • 99.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RASSF6 31 30
  • 87.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF6 31 30
  • 86.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf6 17 31 30
  • 81.05 (n)
rat
(Rattus norvegicus)
Mammalia Rassf6 30
  • 80.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASSF6 31
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASSF6 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF6 31 30
  • 66.37 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf6 30
  • 63.86 (n)
Str.15569 30
African clawed frog
(Xenopus laevis)
Amphibia MGC52938 30
zebrafish
(Danio rerio)
Actinopterygii rassf6 31 30
  • 59.19 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rassf 31
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToMany
Species where no ortholog for RASSF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF6 Gene

ENSEMBL:
Gene Tree for RASSF6 (if available)
TreeFam:
Gene Tree for RASSF6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF6: view image

Paralogs for RASSF6 Gene

Paralogs for RASSF6 Gene

(2) SIMAP similar genes for RASSF6 Gene using alignment to 1 proteins:

  • RASF6_HUMAN
genes like me logo Genes that share paralogs with RASSF6: view

Variants for RASSF6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF6 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
727256 Benign: not provided 73,576,478(-) A/T SYNONYMOUS_VARIANT
727257 Likely Benign: not provided 73,611,788(-) A/G MISSENSE_VARIANT,INTRON_VARIANT
rs12507775 - p.Ser163Pro
rs17804499 - p.Ala306Gly

Additional dbSNP identifiers (rs#s) for RASSF6 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASSF6 Gene

Variant ID Type Subtype PubMed ID
esv2676507 CNV deletion 23128226
esv3600997 CNV gain 21293372
esv3600998 CNV loss 21293372
nsv1001725 CNV gain 25217958
nsv1117100 CNV deletion 24896259
nsv292546 CNV deletion 16902084
nsv822617 CNV loss 20364138

Variation tolerance for RASSF6 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF6 Gene

Disorders for RASSF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bronchiolitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASSF6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RASSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF6 Gene

Publications for RASSF6 Gene

  1. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian AD … CF Gene Modifier Study Group (Genes and immunity 2008) 3 41 54
  2. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. (PMID: 17367779) Ikeda M … Hata Y (Experimental cell research 2007) 3 4 54
  3. RASSF6 is a novel member of the RASSF family of tumor suppressors. (PMID: 17404571) Allen NP … Clark GJ (Oncogene 2007) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for RASSF6 Gene

Sources for RASSF6 Gene