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Aliases for RASSF6 Gene

Aliases for RASSF6 Gene

  • Ras Association Domain Family Member 6 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 6 2

External Ids for RASSF6 Gene

Previous GeneCards Identifiers for RASSF6 Gene

  • GC04M074680
  • GC04M074842
  • GC04M074907
  • GC04M074905
  • GC04M074803
  • GC04M074437
  • GC04M070250

Summaries for RASSF6 Gene

Entrez Gene Summary for RASSF6 Gene

  • This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RASSF6 Gene

RASSF6 (Ras Association Domain Family Member 6) is a Protein Coding gene. Diseases associated with RASSF6 include Bronchiolitis. Among its related pathways are Hippo signaling pathway - multiple species and Hippo signaling pathway. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot for RASSF6 Gene

  • Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Additional gene information for RASSF6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF6 Gene

Genomics for RASSF6 Gene

GeneHancer (GH) Regulatory Elements for RASSF6 Gene

Promoters and enhancers for RASSF6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I073615 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.4 +1.8 1840 7.2 PKNOX1 FOXA2 SMAD1 ZNF133 SIN3A FEZF1 ZNF48 TCF12 GLIS2 ZNF143 RASSF6 ENSG00000249970
GH04I073598 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +20.4 20438 3.5 FOXA2 MLX ARID4B SIN3A ZNF48 ETS1 SP5 MIER2 PPARG KAT8 RASSF6 MTHFD2L PF4V1 ENSG00000249970
GH04I073660 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -41.8 -41765 3.3 CTCF ATF1 RB1 JUN TEAD4 RAD21 ZBTB40 YY1 CC2D1A ZNF664 CXCL3 CXCL2 CXCL8 RASSF6 MTHFD2L PF4V1 LOC105377272
GH04I073588 Enhancer 1.1 ENCODE dbSUPER 16.8 +30.7 30651 2.6 HDGF FOXA2 PKNOX1 ATF1 SMAD1 RB1 BMI1 FEZF1 BATF ZNF2 RASSF6 MTHFD2L ANKRD17 ENSG00000250220 ENSG00000221639 ENSG00000249970
GH04I073605 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +12.3 12308 5.9 FOXA2 BATF KLF5 RARA ZNF143 ATF7 IKZF2 RUNX3 ELF1 ZNF592 RASSF6 MTHFD2L ENSG00000249970
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RASSF6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASSF6 gene promoter:

Genomic Locations for RASSF6 Gene

Genomic Locations for RASSF6 Gene
49,082 bases
Minus strand

Genomic View for RASSF6 Gene

Genes around RASSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF6 Gene

Proteins for RASSF6 Gene

  • Protein details for RASSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q68DT2
    • Q6PDA6
    • Q86WG9
    • Q86WH0

    Protein attributes for RASSF6 Gene

    369 amino acids
    Molecular mass:
    43384 Da
    Quaternary structure:
    • Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779).
    • Sequence=AAH58835.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18138.1; Type=Erroneous termination; Positions=148; Note=Translated as Gln.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF6 Gene


neXtProt entry for RASSF6 Gene

Post-translational modifications for RASSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF6 Gene

Domains & Families for RASSF6 Gene

Gene Families for RASSF6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF6 Gene

Suggested Antigen Peptide Sequences for RASSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASSF6: view

No data available for UniProtKB/Swiss-Prot for RASSF6 Gene

Function for RASSF6 Gene

Molecular function for RASSF6 Gene

UniProtKB/Swiss-Prot Function:
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Gene Ontology (GO) - Molecular Function for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF6: view
genes like me logo Genes that share phenotypes with RASSF6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF6 Gene

Localization for RASSF6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF6 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF6 Gene

Pathways & Interactions for RASSF6 Gene

genes like me logo Genes that share pathways with RASSF6: view

Pathways by source for RASSF6 Gene

SIGNOR curated interactions for RASSF6 Gene


Gene Ontology (GO) - Biological Process for RASSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with RASSF6: view

Drugs & Compounds for RASSF6 Gene

No Compound Related Data Available

Transcripts for RASSF6 Gene

Unigene Clusters for RASSF6 Gene

Ras association (RalGDS/AF-6) domain family member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -

Relevant External Links for RASSF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF6 Gene

This gene is overexpressed in Stomach (x7.1), Colon - Transverse (x5.3), Bladder (x5.0), Small Intestine - Terminal Ileum (x4.1), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for RASSF6 Gene

This gene is overexpressed in Liver (47.7), Thyroid (12.2), and Cardia (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASSF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASSF6 Gene:


SOURCE GeneReport for Unigene cluster for RASSF6 Gene:


mRNA Expression by UniProt/SwissProt for RASSF6 Gene:

Tissue specificity: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.

Evidence on tissue expression from TISSUES for RASSF6 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with RASSF6: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF6 Gene

Orthologs for RASSF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASSF6 33 34
  • 99.91 (n)
(Bos Taurus)
Mammalia RASSF6 33 34
  • 87.06 (n)
(Canis familiaris)
Mammalia RASSF6 33 34
  • 86.67 (n)
(Mus musculus)
Mammalia Rassf6 33 16 34
  • 81.05 (n)
(Rattus norvegicus)
Mammalia Rassf6 33
  • 80.16 (n)
(Ornithorhynchus anatinus)
Mammalia RASSF6 34
  • 58 (a)
(Monodelphis domestica)
Mammalia RASSF6 34
  • 51 (a)
(Gallus gallus)
Aves RASSF6 33 34
  • 66.37 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf6 33
  • 63.86 (n)
Str.15569 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52938 33
(Danio rerio)
Actinopterygii rassf6 33 34
  • 59.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
Species where no ortholog for RASSF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF6 Gene

Gene Tree for RASSF6 (if available)
Gene Tree for RASSF6 (if available)

Paralogs for RASSF6 Gene

Paralogs for RASSF6 Gene

(2) SIMAP similar genes for RASSF6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASSF6: view

Variants for RASSF6 Gene

Sequence variations from dbSNP and Humsavar for RASSF6 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000067685 -- 73,599,823(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000077508 -- 73,599,504(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000279750 -- 73,597,888(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000285088 -- 73,611,318(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000312996 -- 73,598,187(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF6 Gene

Variant ID Type Subtype PubMed ID
esv2676507 CNV deletion 23128226
esv3600997 CNV gain 21293372
esv3600998 CNV loss 21293372
nsv1001725 CNV gain 25217958
nsv1117100 CNV deletion 24896259
nsv292546 CNV deletion 16902084
nsv822617 CNV loss 20364138

Variation tolerance for RASSF6 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.47; 88.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF6 Gene

Disorders for RASSF6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASSF6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RASSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF6 Gene

Publications for RASSF6 Gene

  1. Modulation of cystic fibrosis lung disease by variants in interleukin-8. (PMID: 18563170) Hillian AD … CF Gene Modifier Study Group (Genes and immunity 2008) 3 44 58
  2. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. (PMID: 17367779) Ikeda M … Hata Y (Experimental cell research 2007) 3 4 58
  3. RASSF6 is a novel member of the RASSF family of tumor suppressors. (PMID: 17404571) Allen NP … Clark GJ (Oncogene 2007) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RASSF6 Gene

Sources for RASSF6 Gene

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