This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in respo... See more...

Aliases for RASSF5 Gene

Aliases for RASSF5 Gene

  • Ras Association Domain Family Member 5 2 3 5
  • Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues 2 4
  • Ras Association (RalGDS/AF-6) Domain Family Member 5 2 3
  • Ras Association Domain-Containing Protein 5 3 4
  • Novel Ras Effector 1 2 3
  • New Ras Effector 1 3 4
  • NORE1 3 4
  • RAPL 3 4
  • Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue 3
  • Ras Association (RalGDS/AF-6) Domain Family 5 3
  • Ras Effector-Like Protein 3
  • Tumor Suppressor RASSF3 3
  • Rap1-Binding Protein 3
  • NORE1A 3
  • NORE1B 3
  • RASSF3 3
  • Maxp1 3

External Ids for RASSF5 Gene

Previous GeneCards Identifiers for RASSF5 Gene

  • GC01P202391
  • GC01P203324
  • GC01P203764
  • GC01P203069
  • GC01P204747
  • GC01P206680
  • GC01P177379

Summaries for RASSF5 Gene

Entrez Gene Summary for RASSF5 Gene

  • This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF5 Gene

RASSF5 (Ras Association Domain Family Member 5) is a Protein Coding gene. Diseases associated with RASSF5 include Lung Cancer and Myeloproliferative Syndrome, Transient. Among its related pathways are Ras signaling pathway and B Cell Receptor Signaling Pathway (sino). An important paralog of this gene is RASSF1.

UniProtKB/Swiss-Prot Summary for RASSF5 Gene

  • Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Gene Wiki entry for RASSF5 Gene

Additional gene information for RASSF5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF5 Gene

Genomics for RASSF5 Gene

GeneHancer (GH) Regulatory Elements for RASSF5 Gene

Promoters and enhancers for RASSF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206554 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 518 +55.4 55379 16.8 EP300 SIN3A NRF1 USF1 SP1 GTF2E2 SIX5 ZNF10 REST ZBTB11 RASSF5 EIF2D C1orf147 IKBKE MAPKAPK2 ENSG00000279946 piR-48611 lnc-EIF2D-2
GH01J206507 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 507.9 +1.0 971 4.2 CTCF POLR2G NCOR1 GTF2E2 REST POLR2A GABPA EZH2 BCL11A NR2F2 RASSF5 ENSG00000261000 IKBKE RPL7AP20
GH01J206573 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 47 +71.3 71331 10.9 ZBTB40 CTCF NRF1 GTF2E2 EP300 ZBTB10 ZBTB11 AFF1 TARDBP HES1 RASSF5 MAPKAPK2 EIF2D IKBKE C1orf147 DYRK3 IL19 FCMR piR-48611 lnc-EIF2D-2
GH01J206586 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +81.7 81746 6.4 ZNF217 CTCF JUND FOS POLR2A CLOCK REST CUX1 SMC3 CTBP1 RASSF5 EIF2D MAPKAPK2 C1orf147 IKBKE piR-48611 lnc-EIF2D-2 ENSG00000279946
GH01J206684 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.6 +179.0 178971 4.6 ZBTB40 SIN3A NRF1 POLR2G SP1 GTF2E2 PHB2 TEAD4 ZFX ZIC2 MAPKAPK2 RASSF5 DYRK3 FCMR IKBKE ENSG00000224114 lnc-IL10-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF5

Top Transcription factor binding sites by QIAGEN in the RASSF5 gene promoter:
  • Ik-2
  • NF-kappaB1
  • p53

Genomic Locations for RASSF5 Gene

Genomic Locations for RASSF5 Gene
chr1:206,507,530-206,589,448
(GRCh38/hg38)
Size:
81,919 bases
Orientation:
Plus strand
chr1:206,680,879-206,762,616
(GRCh37/hg19)
Size:
81,738 bases
Orientation:
Plus strand

Genomic View for RASSF5 Gene

Genes around RASSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF5 Gene

Proteins for RASSF5 Gene

  • Protein details for RASSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWW0-RASF5_HUMAN
    Recommended name:
    Ras association domain-containing protein 5
    Protein Accession:
    Q8WWW0
    Secondary Accessions:
    • A8K1E6
    • Q5SY32
    • Q8WWV9
    • Q8WXF4
    • Q9BT99

    Protein attributes for RASSF5 Gene

    Size:
    418 amino acids
    Molecular mass:
    47090 Da
    Quaternary structure:
    • Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation.
    SequenceCaution:
    • Sequence=AAH04270.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH04270.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RASSF5 Gene

    Alternative splice isoforms for RASSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF5 Gene

Post-translational modifications for RASSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF5 Gene

No data available for DME Specific Peptides for RASSF5 Gene

Domains & Families for RASSF5 Gene

Gene Families for RASSF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF5 Gene

Blocks:
  • RA domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RASSF5 Gene

GenScript: Design optimal peptide antigens:
  • Regulator for cell adhesion and polarization enriched in lymphoid tissues (RASF5_HUMAN)
genes like me logo Genes that share domains with RASSF5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF5 Gene

Function for RASSF5 Gene

Molecular function for RASSF5 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

Phenotypes From GWAS Catalog for RASSF5 Gene

Gene Ontology (GO) - Molecular Function for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9488663
GO:0017016 Ras GTPase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASSF5: view
genes like me logo Genes that share phenotypes with RASSF5: view

Animal Models for RASSF5 Gene

MGI Knock Outs for RASSF5:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF5 Gene

Localization for RASSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF5 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF5 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
plasma membrane 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with RASSF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASSF5 Gene

Pathways & Interactions for RASSF5 Gene

genes like me logo Genes that share pathways with RASSF5: view

Pathways by source for RASSF5 Gene

2 Sino Biological pathways for RASSF5 Gene
1 Qiagen pathway for RASSF5 Gene
  • Transendothelial Migration of Leukocytes

SIGNOR curated interactions for RASSF5 Gene

Activates:

Gene Ontology (GO) - Biological Process for RASSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF5: view

Drugs & Compounds for RASSF5 Gene

(1) Drugs for RASSF5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Salirasib Investigational Pharma Inhibitor of active Ras protein, Ras inhibitor; also induces autophagy 0

(3) Additional Compounds for RASSF5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(1) ApexBio Compounds for RASSF5 Gene

Compound Action Cas Number
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with RASSF5: view

Drug Products

Transcripts for RASSF5 Gene

mRNA/cDNA for RASSF5 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF5 Gene

No ASD Table

Relevant External Links for RASSF5 Gene

GeneLoc Exon Structure for
RASSF5

Expression for RASSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF5 Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for RASSF5 Gene

This gene is overexpressed in Lymph node (12.9), Tlymphocyte (9.3), Monocytes (9.1), Bone marrow stromal cell (8.1), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASSF5 Gene



Protein tissue co-expression partners for RASSF5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF5

SOURCE GeneReport for Unigene cluster for RASSF5 Gene:

Hs.497579

mRNA Expression by UniProt/SwissProt for RASSF5 Gene:

Q8WWW0-RASF5_HUMAN
Tissue specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.

Evidence on tissue expression from TISSUES for RASSF5 Gene

  • Lymph node(4.4)
  • Nervous system(4.4)
  • Skin(4.2)
  • Blood(2.4)
  • Spleen(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with RASSF5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF5 Gene

Orthologs for RASSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RASSF5 30
  • 87.96 (n)
rat
(Rattus norvegicus)
Mammalia Rassf5 30
  • 86.28 (n)
mouse
(Mus musculus)
Mammalia Rassf5 17 30
  • 84.99 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100150414 30
  • 62.25 (n)
wufj66h02 30
Species where no ortholog for RASSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF5 Gene

ENSEMBL:
Gene Tree for RASSF5 (if available)
TreeFam:
Gene Tree for RASSF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF5: view image

Paralogs for RASSF5 Gene

Paralogs for RASSF5 Gene

(3) SIMAP similar genes for RASSF5 Gene using alignment to 1 proteins:

  • RASF5_HUMAN
genes like me logo Genes that share paralogs with RASSF5: view

Variants for RASSF5 Gene

Additional dbSNP identifiers (rs#s) for RASSF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASSF5 Gene

Variant ID Type Subtype PubMed ID
dgv138e212 CNV loss 25503493
esv2672106 CNV deletion 23128226
nsv160541 CNV deletion 16902084
nsv946614 CNV duplication 23825009

Variation tolerance for RASSF5 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF5 Gene

Human Gene Mutation Database (HGMD)
RASSF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF5 Gene

Disorders for RASSF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RASSF5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
myeloproliferative syndrome, transient
  • mst
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASSF5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RASSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF5 Gene

Publications for RASSF5 Gene

  1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PMID: 11965544) Tommasi S … Pfeifer GP (Oncogene 2002) 2 3 4 23 54
  2. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. (PMID: 15109305) Praskova M … Avruch J (The Biochemical journal 2004) 3 4 23 54
  3. Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. (PMID: 23972470) Ni L … Luo X (Structure (London, England : 1993) 2013) 2 3 54
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for RASSF5 Gene

Sources for RASSF5 Gene