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This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in respo... See more...
Aliases for RASSF5 Gene
Aliases for RASSF5 Gene
- Ras Association Domain Family Member 5 2 3 5
- NORE1 2 3 4
- RAPL 2 3 4
- Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues 2 4
- Ras Association (RalGDS/AF-6) Domain Family Member 5 2 3
- Ras Association Domain-Containing Protein 5 3 4
- Novel Ras Effector 1 2 3
- New Ras Effector 1 3 4
- Maxp1 2 3
External Ids for RASSF5 Gene
- HGNC: 17609
- NCBI Entrez Gene: 83593
- Ensembl: ENSG00000266094
- OMIM®: 607020
- UniProtKB/Swiss-Prot: Q8WWW0
Previous GeneCards Identifiers for RASSF5 Gene
- GC01P202391
- GC01P203324
- GC01P203764
- GC01P203069
- GC01P204747
- GC01P206680
- GC01P177379
Summaries for RASSF5 Gene
-
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RASSF5 Gene
RASSF5 (Ras Association Domain Family Member 5) is a Protein Coding gene. Diseases associated with RASSF5 include Leukocyte Adhesion Deficiency, Type I and Lung Cancer. Among its related pathways are Ras signaling pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. An important paralog of this gene is RASSF1.
UniProtKB/Swiss-Prot Summary for RASSF5 Gene
-
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Additional gene information for RASSF5 Gene
- HGNC (17609)
- NCBI Entrez Gene (83593)
- Ensembl (ENSG00000266094)
- OMIM® (607020)
- UniProtKB/Swiss-Prot (Q8WWW0)
- Open Targets Platform(ENSG00000266094)
- Monarch Initiative
- Alliance of Genome Resources
- Search for RASSF5 at DataMed
- Search for RASSF5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF5 Gene
Genomics for RASSF5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RASSF5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RASSF5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF5
- Top Transcription factor binding sites by QIAGEN in the RASSF5 gene promoter:
-
- Ik-2
- NF-kappaB1
- p53
Genomic Locations for RASSF5 Gene
Latest Assembly
- chr1:206,507,531-206,589,448
- (GRCh38/hg38)
- Size:
- 81,918 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:206,680,864-206,762,780
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 81,917 bases
- Orientation:
- Plus strand
Genomic View for RASSF5 Gene
Genes around RASSF5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by HGNC
- 1q32.1 by Entrez Gene
- 1q32.1 by Ensembl
RASSF5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RASSF5 Gene
Proteins for RASSF5 Gene
-
Protein details for RASSF5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWW0-RASF5_HUMAN
- Recommended name:
- Ras association domain-containing protein 5
- Protein Accession:
- Q8WWW0
- A8K1E6
- Q5SY32
- Q8WWV9
- Q8WXF4
- Q9BT99
Protein attributes for RASSF5 Gene
- Size:
- 418 amino acids
- Molecular mass:
- 47090 Da
- Quaternary structure:
-
- Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS (By similarity). Interacts with KRAS (By similarity). Probably interacts with Ras-like GTPases RRAS, MRAS, RAP1B, RAP2A and RALA (By similarity). Interacts with RRAS2 (PubMed:31130282). Can self-associate (By similarity). Interacts with RSSF1 isoform A (By similarity). The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1 (PubMed:12845325, PubMed:15569673). Binds STK4/MST1, inhibiting STK4/MST1 autoactivation (PubMed:15109305).
- SequenceCaution:
-
- Sequence=AAH04270.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH04270.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH07203.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
Protein Expression for RASSF5 Gene
Post-translational modifications for RASSF5 Gene
Other Protein References for RASSF5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for RASSF5
- Invitrogen Antibodies for RASSF5 (AFLGC-RASSF5)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RASSF5
- Sino Biological Antibodies for RASSF5
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for RASSF5
- Origene Custom Protein Services for RASSF5
-
Abcam proteins for RASSF5
Assay products for research
No data available for DME Specific Peptides for RASSF5 Gene
Domains & Families for RASSF5 Gene
Gene Families for RASSF5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RASSF5 Gene
Suggested Antigen Peptide Sequences for RASSF5 Gene
- GenScript: Design optimal peptide antigens:
-
- Regulator for cell adhesion and polarization enriched in lymphoid tissues (RASF5_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF5 Gene
Function for RASSF5 Gene
Molecular function for RASSF5 Gene
- UniProtKB/Swiss-Prot Function:
- Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
Phenotypes From GWAS Catalog for RASSF5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9488663 |
| GO:0017016 | Ras GTPase binding | IEA | -- |
| GO:0042802 | identical protein binding | IPI | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RASSF5 Gene
- MGI mutant phenotypes for RASSF5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RASSF5:
Animal Models for RASSF5 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RASSF5 - Starting at $85 >
- * RASSF5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RASSF5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASSF5
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASSF5
miRNA for RASSF5 Gene
- miRTarBase miRNAs that target RASSF5
-
- hsa-miR-124-3p (MIRT002619)
- hsa-miR-335-5p (MIRT017885)
- hsa-miR-1-3p (MIRT023792)
- hsa-miR-374b-5p (MIRT036802)
- hsa-miR-193b-3p (MIRT041417)
- hsa-miR-19a-3p (MIRT132676)
- hsa-miR-19b-3p (MIRT132677)
- hsa-miR-15a-5p (MIRT132734)
- hsa-miR-16-5p (MIRT132735)
- hsa-miR-15b-5p (MIRT132744)
- hsa-miR-195-5p (MIRT132746)
- mmu-miR-466a-5p (MIRT577853)
- mmu-miR-466e-5p (MIRT577854)
- mmu-miR-466p-5p (MIRT577855)
- mmu-miR-1198-5p (MIRT577856)
- mmu-miR-1187 (MIRT577857)
- mmu-miR-511-3p (MIRT577858)
- mmu-miR-669f-3p (MIRT577859)
- mmu-miR-669m-3p (MIRT577860)
- mmu-miR-466d-3p (MIRT577861)
- mmu-miR-467g (MIRT577862)
- mmu-miR-466a-3p (MIRT577863)
- mmu-miR-466e-3p (MIRT577864)
- mmu-miR-297b-3p (MIRT577865)
- mmu-miR-410-3p (MIRT577866)
- mmu-miR-344d-3p (MIRT577867)
- mmu-miR-344e-3p (MIRT577868)
- mmu-miR-374b-5p (MIRT577869)
- mmu-miR-369-3p (MIRT577870)
- mmu-miR-374c-5p (MIRT577871)
- mmu-miR-466n-3p (MIRT577872)
- hsa-miR-214-5p (MIRT734113)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASSF5
- Browse OriGene Inhibitory RNA Products For RASSF5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF5
Clone products for research
- Applied Biological Materials (abm): Clones for RASSF5 - Starting at $45 >
- * RASSF5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG222330
- MR222330
- MR222330L3
- MR222330L4
- RC203854
- RC203854L1
- RC203854L2
- RC203854L3
- RC203854L4
- RC215017
- RC215017L1
- RC215017L2
- RC215017L3
- RC215017L4
- RC224073
- RC224073L3
- RC224073L4
- RG203854
- RG215017
- RG224073
- RR210535
- RR210535L3
- RR210535L4
- MR222330L3V
- MR222330L4V
- RC203854L1V
- RC203854L2V
- RC203854L3V
- RC203854L4V
- RC215017L1V
- RC215017L2V
- RC215017L3V
- RC215017L4V
- RC224073L3V
- RC224073L4V
- RR210535L3V
- RR210535L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASSF5
- Addgene plasmids for RASSF5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASSF5
Cell Lines for research
-
Horizon Cell Lines for RASSF5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF5 Gene
Localization for RASSF5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RASSF5 Gene
- Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASSF5 Gene
Pathways & Interactions for RASSF5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ras signaling pathway | ||
| 2 | TCR signaling in naive CD4+ T cells | ||
| 3 | Cellular senescence (KEGG) | ||
| 4 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways | ||
| 5 | Glioma | ||
Pathways by source for RASSF5 Gene
1 Sino Biological pathway for RASSF5 Gene
2 BioSystems pathways for RASSF5 Gene
6 KEGG pathways for RASSF5 Gene
1 Qiagen pathway for RASSF5 Gene
- Transendothelial Migration of Leukocytes
Interacting Proteins for RASSF5 Gene
Selected Interacting proteins:
Q8WWW0-RASF5_HUMAN
ENSP00000462099
for RASSF5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RASSF5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007165 | signal transduction | IEA,IBA | 21873635 |
| GO:0008285 | negative regulation of cell proliferation | IEA | -- |
| GO:0031398 | positive regulation of protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
Drugs & Compounds for RASSF5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Salirasib | Investigational | Pharma | Inhibitor of active Ras protein, Ras inhibitor; also induces autophagy | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| DG(16:0/24:0/0:0) |
|
|
||||
| Diglycerides Group B |
|
257891-89-7 |
|
|||
| Diglycerides Group C |
|
91125-76-7, 29541-66-0, 51621-26-2 |
|
|||
| Diglycerides Group D |
|
|
(1) ApexBio Compounds for RASSF5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Salirasib | Inhibitor of active Ras protein | 162520-00-5 |
Transcripts for RASSF5 Gene
mRNA/cDNA for RASSF5 Gene
- 4 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000577571 3496 nts (view in UCSC)
- ENST00000579436 3799 nts (view in UCSC)
- ENST00000579942 3279 nts (view in UCSC)
- ENST00000580449 1932 nts (view in UCSC)
- ENST00000581503 5586 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RASSF5 - Starting at $85 >
- * RASSF5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RASSF5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASSF5
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASSF5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASSF5
- Browse OriGene Inhibitory RNA Products For RASSF5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF5
Clone products for research
- Applied Biological Materials (abm): Clones for RASSF5 - Starting at $45 >
- * RASSF5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG222330
- MR222330
- MR222330L3
- MR222330L4
- RC203854
- RC203854L1
- RC203854L2
- RC203854L3
- RC203854L4
- RC215017
- RC215017L1
- RC215017L2
- RC215017L3
- RC215017L4
- RC224073
- RC224073L3
- RC224073L4
- RG203854
- RG215017
- RG224073
- RR210535
- RR210535L3
- RR210535L4
- MR222330L3V
- MR222330L4V
- RC203854L1V
- RC203854L2V
- RC203854L3V
- RC203854L4V
- RC215017L1V
- RC215017L2V
- RC215017L3V
- RC215017L4V
- RC224073L3V
- RC224073L4V
- RR210535L3V
- RR210535L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASSF5
- Addgene plasmids for RASSF5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASSF5
Relevant External Links for RASSF5 Gene
- GeneLoc Exon Structure for
- RASSF5
Expression for RASSF5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Brain (Nervous System)
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Bone (Muscoskeletal System)
- Blood (Hematopoietic System)
-
Spleen (Hematopoietic System)
-
Testis (Reproductive System)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for RASSF5 Gene
This gene is overexpressed in Whole Blood (x13.3).
This gene is overexpressed in Lymph node (12.9), Tlymphocyte (9.3), Monocytes (9.1), Bone marrow stromal cell (8.1), and CD8 Tcells (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASSF5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF5
SOURCE GeneReport for Unigene cluster for RASSF5 Gene:
Hs.497579mRNA Expression by UniProt/SwissProt for RASSF5 Gene:
Q8WWW0-RASF5_HUMAN
Tissue specificity:
Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
Evidence on tissue expression from TISSUES for RASSF5 Gene
- Nervous system(4.6)
- Lymph node(4.5)
- Skin(4.4)
- Blood(2.8)
- Spleen(2.8)
- Intestine(2.5)
- Bone marrow(2.5)
- Lung(2.3)
Primer products for research
-
OriGene qPCR primer pairs for RASSF5
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF5 Gene
Orthologs for RASSF5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Cow (Bos Taurus) |
Mammalia | RASSF5 29 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Rassf5 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rassf5 29 16 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100150414 29 |
|
||
| wufj66h02 29 |
|
- Species where no ortholog for RASSF5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for RASSF5 Gene
- ENSEMBL:
- Gene Tree for RASSF5 (if available)
- TreeFam:
- Gene Tree for RASSF5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RASSF5: view image
- Alliance of Genome Resources:
- Additional Orthologs for RASSF5
Paralogs for RASSF5 Gene
Variants for RASSF5 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv138e212 | CNV | loss | 25503493 |
| esv2672106 | CNV | deletion | 23128226 |
| nsv160541 | CNV | deletion | 16902084 |
| nsv946614 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.42;
54.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RASSF5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF5 Gene
Disorders for RASSF5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukocyte adhesion deficiency, type i |
|
|
| lung cancer |
|
|
| myeloproliferative syndrome, transient |
|
|
Search RASSF5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RASSF5
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF5 Gene
Publications for RASSF5 Gene
- RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PMID: 11965544) Tommasi S … Pfeifer GP (Oncogene 2002) 2 3 4 22
- Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. (PMID: 15109305) Praskova M … Avruch J (The Biochemical journal 2004) 3 4 22
- Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. (PMID: 23972470) Ni L … Luo X (Structure (London, England : 1993) 2013) 2 3
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 40
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
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Products for RASSF5 Gene
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