This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in respo...
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Aliases for RASSF5 Gene
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Ras Association Domain Family Member 5
2
3
5
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NORE1
2
3
4
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RAPL
2
3
4
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Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissues
2
4
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Ras Association (RalGDS/AF-6) Domain Family Member 5
2
3
-
Ras Association Domain-Containing Protein 5
3
4
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Novel Ras Effector 1
2
3
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New Ras Effector 1
3
4
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Maxp1
2
3
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Regulator For Cell Adhesion And Polarization Enriched In Lymphoid Tissue
3
-
Ras Association (RalGDS/AF-6) Domain Family 5
3
-
Ras Effector-Like Protein
3
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Tumor Suppressor RASSF3
3
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Rap1-Binding Protein
3
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NORE1A
3
-
NORE1B
3
-
RASSF3
3
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RASSF5
5
External Ids for RASSF5 Gene
Previous GeneCards Identifiers for RASSF5 Gene
- GC01P202391
- GC01P203324
- GC01P203764
- GC01P203069
- GC01P204747
- GC01P206680
- GC01P177379
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This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
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CIViC Summary ,
Tocris Summary ,
PharmGKB "VIP" Summary ,
Rfam classification and
piRNA Summary
for RASSF5 Gene