The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008] See more...

Aliases for RASSF4 Gene

Aliases for RASSF4 Gene

  • Ras Association Domain Family Member 4 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 4 2 3
  • Ras Association Domain-Containing Protein 4 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 4 3
  • Ras Association Domain Family 4 3
  • Tumor Suppressor RASSF4 3
  • AD037 3

External Ids for RASSF4 Gene

Previous GeneCards Identifiers for RASSF4 Gene

  • GC10P045230
  • GC10P044739
  • GC10P044775
  • GC10P045454
  • GC10P041979

Summaries for RASSF4 Gene

Entrez Gene Summary for RASSF4 Gene

  • The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF4 Gene

RASSF4 (Ras Association Domain Family Member 4) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway - multiple species. An important paralog of this gene is RASSF2.

UniProtKB/Swiss-Prot Summary for RASSF4 Gene

  • Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

Additional gene information for RASSF4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF4 Gene

Genomics for RASSF4 Gene

GeneHancer (GH) Regulatory Elements for RASSF4 Gene

Promoters and enhancers for RASSF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF4

Top Transcription factor binding sites by QIAGEN in the RASSF4 gene promoter:
  • AREB6
  • Bach2
  • HNF-1
  • HNF-1A
  • Pax-5
  • RFX1
  • SRF
  • SRF (504 AA)
  • SRY
  • ZID

Genomic Locations for RASSF4 Gene

Genomic Locations for RASSF4 Gene
chr10:44,959,407-44,995,891
(GRCh38/hg38)
Size:
36,485 bases
Orientation:
Plus strand
chr10:45,454,855-45,491,339
(GRCh37/hg19)
Size:
36,485 bases
Orientation:
Plus strand

Genomic View for RASSF4 Gene

Genes around RASSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF4 Gene

Proteins for RASSF4 Gene

  • Protein details for RASSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2L5-RASF4_HUMAN
    Recommended name:
    Ras association domain-containing protein 4
    Protein Accession:
    Q9H2L5
    Secondary Accessions:
    • Q86WH5
    • Q86WH6
    • Q86WH7
    • Q8N5A9
    • Q8TCK6

    Protein attributes for RASSF4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36748 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner.

    Alternative splice isoforms for RASSF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF4 Gene

Post-translational modifications for RASSF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASSF4 Gene

Domains & Families for RASSF4 Gene

Gene Families for RASSF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF4 Gene

Blocks:
  • RA domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RASSF4 Gene

GenScript: Design optimal peptide antigens:
  • Ras association (RalGDS/AF-6) domain family member 4 (Q5T737_HUMAN)
  • Ras association domain-containing protein 4 (RASF4_HUMAN)
genes like me logo Genes that share domains with RASSF4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF4 Gene

Function for RASSF4 Gene

Molecular function for RASSF4 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

Gene Ontology (GO) - Molecular Function for RASSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with RASSF4: view
genes like me logo Genes that share phenotypes with RASSF4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RASSF4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF4 Gene

Localization for RASSF4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF4 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RASSF4 Gene

Pathways & Interactions for RASSF4 Gene

PathCards logo

SuperPathways for RASSF4 Gene

genes like me logo Genes that share pathways with RASSF4: view

Pathways by source for RASSF4 Gene

1 KEGG pathway for RASSF4 Gene

Gene Ontology (GO) - Biological Process for RASSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF4: view

No data available for SIGNOR curated interactions for RASSF4 Gene

Drugs & Compounds for RASSF4 Gene

(1) Drugs for RASSF4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASSF4: view

Transcripts for RASSF4 Gene

mRNA/cDNA for RASSF4 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - - - -
SP15:
SP16: - -
SP17: -
SP18: - - -
SP19:

ExUns: 12c ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ^ 15a · 15b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -
SP16: -
SP17:
SP18: -
SP19: -

Relevant External Links for RASSF4 Gene

GeneLoc Exon Structure for
RASSF4

Expression for RASSF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF4 Gene

This gene is overexpressed in Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for RASSF4 Gene

This gene is overexpressed in Fetal Brain (35.3), Spleen (18.7), and NK cells (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF4 Gene



Protein tissue co-expression partners for RASSF4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF4

SOURCE GeneReport for Unigene cluster for RASSF4 Gene:

Hs.522895

mRNA Expression by UniProt/SwissProt for RASSF4 Gene:

Q9H2L5-RASF4_HUMAN
Tissue specificity: Widely expressed. Frequently down-regulated in tumor cell lines.

Evidence on tissue expression from TISSUES for RASSF4 Gene

  • Lymph node(4.3)
  • Adrenal gland(4.2)
  • Skin(4.1)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with RASSF4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF4 Gene

Orthologs for RASSF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF4 31 30
  • 98.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF4 31 30
  • 87.12 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 86 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RASSF4 31 30
  • 83.77 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rassf4 17 31 30
  • 82.97 (n)
rat
(Rattus norvegicus)
Mammalia Rassf4 30
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia RASSF4 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf4 30
  • 63.38 (n)
zebrafish
(Danio rerio)
Actinopterygii rassf4 31
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000149 30
  • 56.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rassf 31 30
  • 51.53 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
OneToMany
Species where no ortholog for RASSF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF4 Gene

ENSEMBL:
Gene Tree for RASSF4 (if available)
TreeFam:
Gene Tree for RASSF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF4: view image

Paralogs for RASSF4 Gene

Paralogs for RASSF4 Gene

(2) SIMAP similar genes for RASSF4 Gene using alignment to 6 proteins:

  • RASF4_HUMAN
  • G8JLC1_HUMAN
  • Q5T737_HUMAN
  • Q5T739_HUMAN
  • R4GNA4_HUMAN
  • V9GYK1_HUMAN
genes like me logo Genes that share paralogs with RASSF4: view

Variants for RASSF4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF4 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs34692238 - p.His10Tyr
rs870957 - p.Arg88Gly

Additional dbSNP identifiers (rs#s) for RASSF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASSF4 Gene

Variant ID Type Subtype PubMed ID
esv3576560 CNV gain 25503493
esv3578790 CNV loss 25503493
esv3623077 CNV loss 21293372
esv3623079 CNV loss 21293372
esv3623080 CNV gain 21293372
nsv1035235 CNV loss 25217958
nsv526734 CNV loss 19592680
nsv831845 CNV gain 17160897
nsv831846 CNV loss 17160897

Variation tolerance for RASSF4 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF4 Gene

Disorders for RASSF4 Gene

Additional Disease Information for RASSF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RASSF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF4 Gene

Publications for RASSF4 Gene

  1. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan AR … Williams J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 41 54
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  5. RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. (PMID: 15574778) Eckfeld K … Clark GJ (Cancer research 2004) 3 4 54

Products for RASSF4 Gene

Sources for RASSF4 Gene