The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003] See more...

Aliases for RASSF3 Gene

Aliases for RASSF3 Gene

  • Ras Association Domain Family Member 3 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 3 2 3
  • Ras Association Domain-Containing Protein 3 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 3 3
  • RASSF5 3

External Ids for RASSF3 Gene

Previous GeneCards Identifiers for RASSF3 Gene

  • GC12U990170
  • GC12P064721
  • GC12P063290
  • GC12P065004
  • GC12P062056
  • GC12P064610

Summaries for RASSF3 Gene

Entrez Gene Summary for RASSF3 Gene

  • The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM, Jul 2003]

GeneCards Summary for RASSF3 Gene

RASSF3 (Ras Association Domain Family Member 3) is a Protein Coding gene. Diseases associated with RASSF3 include Alternating Esotropia and Growth Hormone Secreting Pituitary Adenoma. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is RASSF5.

Additional gene information for RASSF3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF3 Gene

Genomics for RASSF3 Gene

GeneHancer (GH) Regulatory Elements for RASSF3 Gene

Promoters and enhancers for RASSF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J064607 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 512.1 +103.9 103901 5.9 ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G USF1 GTF2E2 JUND TEAD4 RASSF3 ENSG00000256670 LOC105369804 TBK1 LEMD3 PABPC1P4 ENSG00000255566 ENSG00000256293 C12orf66 GNS
GH12J064505 Enhancer 0.2 Ensembl 500.7 -1.2 -1200 0.4 L13715-008 RASSF3
GH12J064664 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.3 +168.3 168315 21.8 ZBTB40 ZNF217 ZSCAN5C TCF12 USF1 CTCF ZNF639 ZNF10 ZIC2 REST RASSF3 MSRB3 ENSG00000256670 MIR548C ENSG00000223294 LEMD3 GNS C12orf66 TBK1 RF00017-1171
GH12J064618 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.3 +116.6 116624 10.1 ZBTB40 ZNF217 TCF12 USF1 POLR2G JUND FOS EP300 CLOCK ZBTB11 MIR548C MIR548Z TBK1 RASSF3 ENSG00000256293 GNS ENSG00000225195
GH12J064655 Enhancer 1.1 ENCODE dbSUPER 16.4 +150.4 150393 4.6 EP300 ZSCAN5C TCF12 GTF2E2 ZNF10 TCF7 TRIM28 HES1 TGIF2 CTBP1 RASSF3 MIR548C ENSG00000256670 ENSG00000223294 ENSG00000256314 RF00017-1171
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF3

Top Transcription factor binding sites by QIAGEN in the RASSF3 gene promoter:
  • E47
  • FOXI1
  • Hand1
  • HFH-3
  • Msx-1
  • MyoD
  • POU2F1a
  • Sox5
  • Tal-1beta

Genomic Locations for RASSF3 Gene

Genomic Locations for RASSF3 Gene
chr12:64,507,001-64,697,567
(GRCh38/hg38)
Size:
190,567 bases
Orientation:
Plus strand
chr12:65,004,293-65,091,347
(GRCh37/hg19)
Size:
87,055 bases
Orientation:
Plus strand

Genomic View for RASSF3 Gene

Genes around RASSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF3 Gene

Proteins for RASSF3 Gene

  • Protein details for RASSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WH2-RASF3_HUMAN
    Recommended name:
    Ras association domain-containing protein 3
    Protein Accession:
    Q86WH2
    Secondary Accessions:
    • Q86WH1

    Protein attributes for RASSF3 Gene

    Size:
    238 amino acids
    Molecular mass:
    27562 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF3 Gene

Post-translational modifications for RASSF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF3 Gene

No data available for DME Specific Peptides for RASSF3 Gene

Domains & Families for RASSF3 Gene

Gene Families for RASSF3 Gene

Protein Domains for RASSF3 Gene

Suggested Antigen Peptide Sequences for RASSF3 Gene

GenScript: Design optimal peptide antigens:
  • Ras association domain-containing protein 3 (RASF3_HUMAN)
genes like me logo Genes that share domains with RASSF3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF3 Gene

Function for RASSF3 Gene

Phenotypes From GWAS Catalog for RASSF3 Gene

Gene Ontology (GO) - Molecular Function for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20920251
GO:0042802 identical protein binding IPI 20920251
genes like me logo Genes that share ontologies with RASSF3: view
genes like me logo Genes that share phenotypes with RASSF3: view

miRNA for RASSF3 Gene

miRTarBase miRNAs that target RASSF3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF3 Gene

Localization for RASSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Localized to microtubules in vascular endothelial cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 3
nucleus 2
extracellular 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RASSF3: view

Pathways & Interactions for RASSF3 Gene

PathCards logo

SuperPathways for RASSF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with RASSF3: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF3 Gene

Drugs & Compounds for RASSF3 Gene

No Compound Related Data Available

Transcripts for RASSF3 Gene

mRNA/cDNA for RASSF3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for RASSF3 Gene

GeneLoc Exon Structure for
RASSF3

Expression for RASSF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF3 Gene

This gene is overexpressed in Artery - Tibial (x6.7) and Colon - Sigmoid (x4.5).

Protein differential expression in normal tissues from HIPED for RASSF3 Gene

This gene is overexpressed in CD4 Tcells (31.5), CD8 Tcells (26.1), and NK cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASSF3 Gene



Protein tissue co-expression partners for RASSF3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF3

SOURCE GeneReport for Unigene cluster for RASSF3 Gene:

Hs.643605

mRNA Expression by UniProt/SwissProt for RASSF3 Gene:

Q86WH2-RASF3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RASSF3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF3 Gene

Orthologs for RASSF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASSF3 31 30
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RASSF3 31 30
  • 92.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RASSF3 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rassf3 30
  • 88.49 (n)
mouse
(Mus musculus)
Mammalia Rassf3 17 31 30
  • 88.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RASSF3 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASSF3 31 30
  • 79.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASSF3 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf3 30
  • 71.19 (n)
zebrafish
(Danio rerio)
Actinopterygii rassf3 31
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsf-1 31
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for RASSF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASSF3 Gene

ENSEMBL:
Gene Tree for RASSF3 (if available)
TreeFam:
Gene Tree for RASSF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF3: view image

Paralogs for RASSF3 Gene

Paralogs for RASSF3 Gene

(3) SIMAP similar genes for RASSF3 Gene using alignment to 2 proteins:

  • RASF3_HUMAN
  • Q496A9_HUMAN
genes like me logo Genes that share paralogs with RASSF3: view

Variants for RASSF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs74098110 - p.Arg232His

Additional dbSNP identifiers (rs#s) for RASSF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASSF3 Gene

Variant ID Type Subtype PubMed ID
dgv2682n54 CNV gain 21841781
dgv298e199 CNV deletion 23128226
esv2387704 CNV deletion 18987734
esv2446886 CNV deletion 19546169
esv3629775 CNV loss 21293372
esv3629776 CNV loss 21293372
esv3629777 CNV loss 21293372
nsv1110895 OTHER inversion 24896259
nsv1133186 CNV tandem duplication 24896259
nsv438218 CNV loss 16468122
nsv476769 CNV novel sequence insertion 20440878
nsv515833 CNV loss 19592680
nsv524627 CNV loss 19592680
nsv818921 CNV loss 17921354
nsv832443 CNV loss 17160897
nsv832444 CNV loss 17160897

Variation tolerance for RASSF3 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF3 Gene

Disorders for RASSF3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RASSF3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alternating esotropia
growth hormone secreting pituitary adenoma
  • growth hormone producing adenoma of the pituitary
glaucoma, normal tension
  • glaucoma, normal tension, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASSF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RASSF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF3 Gene

Publications for RASSF3 Gene

  1. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. (PMID: 15569673) Fujita H … Mochizuki N (The Journal of biological chemistry 2005) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. (PMID: 11965544) Tommasi S … Pfeifer GP (Oncogene 2002) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for RASSF3 Gene

Sources for RASSF3 Gene