This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008] See more...

Aliases for RASSF2 Gene

Aliases for RASSF2 Gene

  • Ras Association Domain Family Member 2 2 3 5
  • CENP-34 2 3 4
  • Ras Association (RalGDS/AF-6) Domain Family Member 2 2 3
  • Ras Association Domain-Containing Protein 2 3 4
  • Centromere Protein 34 2 3
  • KIAA0168 2 4
  • Ras Association (RalGDS/AF-6) Domain Family 2 3
  • RASFADIN 3
  • RASSF2 5

External Ids for RASSF2 Gene

Previous GeneCards Identifiers for RASSF2 Gene

  • GC20M004748
  • GC20M004755
  • GC20M004708
  • GC20M004760

Summaries for RASSF2 Gene

Entrez Gene Summary for RASSF2 Gene

  • This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF2 Gene

RASSF2 (Ras Association Domain Family Member 2) is a Protein Coding gene. Diseases associated with RASSF2 include Colorectal Cancer. Among its related pathways are Hippo signaling pathway - multiple species. An important paralog of this gene is RASSF4.

UniProtKB/Swiss-Prot Summary for RASSF2 Gene

  • Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Gene Wiki entry for RASSF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF2 Gene

Genomics for RASSF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RASSF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J004820 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 255.4 +0.9 852 5 BCLAF1 SP1 ZNF600 POLR2A ZIC2 ZBTB10 BCL11A CTCF FEZF1 ZNF341 RASSF2 piR-45035-120 PRND
GH20J004808 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 276.5 +11.1 11119 8 BCLAF1 SP1 POLR2A ZIC2 BCL11A CTCF ZNF592 SIN3A TRIM22 BHLHE40 RASSF2 HSALNG0128339 LOC107985392 PRNT IDI1P3 CDS2 SLC23A2 PRND
GH20J004958 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 26.2 -139.1 -139133 11.2 MYC SSRP1 KLF9 CEBPA ATF3 CHD4 YY1 FOXA1 KLF11 TARDBP RASSF2 PCNA IDI1P3 PRNT TMEM230 PRND CDS2 SLC23A2 lnc-TMEM230-5 RF00017-3166
GH20J004828 Enhancer 1 FANTOM5 ENCODE dbSUPER 29.2 -6.0 -5980 2.1 CEBPA CTCF FEZF1 PRDM6 SPI1 MAX REST HLF PKNOX1 ZNF692 HSALNG0128342 RASSF2 CDS2 SLC23A2 HSALNG0128346
GH20J004760 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 +62.6 62580 1.8 ZNF207 ZNF654 ZNF600 CEBPA MXD4 CTCF REST CEBPB KLF11 ZNF592 ENSG00000278595 lnc-PRND-1 PRNT RASSF2 TMEM230 SLC23A2 PRNP RF00017-3164 PRND
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF2

Top Transcription factor binding sites by QIAGEN in the RASSF2 gene promoter:
  • IRF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT4
  • SRY

Genomic Locations for RASSF2 Gene

Latest Assembly
chr20:4,780,023-4,823,668
(GRCh38/hg38)
Size:
43,646 bases
Orientation:
Minus strand

Previous Assembly
chr20:4,760,669-4,804,254
(GRCh37/hg19 by Entrez Gene)
Size:
43,586 bases
Orientation:
Minus strand

chr20:4,760,669-4,804,291
(GRCh37/hg19 by Ensembl)
Size:
43,623 bases
Orientation:
Minus strand

Genomic View for RASSF2 Gene

Genes around RASSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF2 Gene

Proteins for RASSF2 Gene

  • Protein details for RASSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50749-RASF2_HUMAN
    Recommended name:
    Ras association domain-containing protein 2
    Protein Accession:
    P50749
    Secondary Accessions:
    • A6NIX9
    • A8K5Z3
    • Q17S06
    • Q53HD0
    • Q6AHZ2
    • Q8IZA5

    Protein attributes for RASSF2 Gene

    Size:
    326 amino acids
    Molecular mass:
    37790 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.
    SequenceCaution:
    • Sequence=BAA11485.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASSF2 Gene

Post-translational modifications for RASSF2 Gene

Antibodies for research

  • Abcam antibodies for RASSF2
  • Santa Cruz Biotechnology (SCBT) Antibodies for RASSF2

No data available for DME Specific Peptides for RASSF2 Gene

Domains & Families for RASSF2 Gene

Gene Families for RASSF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF2 Gene

InterPro:
Blocks:
  • RA domain

Suggested Antigen Peptide Sequences for RASSF2 Gene

GenScript: Design optimal peptide antigens:
  • Ras association (RalGDS/AF-6) domain family 2 protein isoform 2B (Q8IZA5_HUMAN)
  • Ras association domain-containing protein 2 (RASF2_HUMAN)
genes like me logo Genes that share domains with RASSF2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF2 Gene

Function for RASSF2 Gene

Molecular function for RASSF2 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Phenotypes From GWAS Catalog for RASSF2 Gene

Gene Ontology (GO) - Molecular Function for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IGI 19962960
GO:0005515 protein binding IPI 12732644
genes like me logo Genes that share ontologies with RASSF2: view
genes like me logo Genes that share phenotypes with RASSF2: view

Animal Models for RASSF2 Gene

MGI Knock Outs for RASSF2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF2 Gene

Localization for RASSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF2 Gene

Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF2 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
golgi apparatus 4
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IBA,IDA 19525978
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RASSF2: view

Pathways & Interactions for RASSF2 Gene

PathCards logo

SuperPathways for RASSF2 Gene

genes like me logo Genes that share pathways with RASSF2: view

Pathways by source for RASSF2 Gene

1 KEGG pathway for RASSF2 Gene

Gene Ontology (GO) - Biological Process for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IBA 21873635
genes like me logo Genes that share ontologies with RASSF2: view

No data available for SIGNOR curated interactions for RASSF2 Gene

Drugs & Compounds for RASSF2 Gene

(1) Drugs for RASSF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASSF2: view

Transcripts for RASSF2 Gene

mRNA/cDNA for RASSF2 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF2

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7:
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for RASSF2 Gene

GeneLoc Exon Structure for
RASSF2

Expression for RASSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF2 Gene

This gene is overexpressed in Whole Blood (x11.0), Brain - Spinal cord (cervical c-1) (x9.6), and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for RASSF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.6), Lymph node (10.7), Monocytes (10.1), CD8 Tcells (6.9), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASSF2 Gene



Protein tissue co-expression partners for RASSF2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF2

SOURCE GeneReport for Unigene cluster for RASSF2 Gene:

Hs.631504

mRNA Expression by UniProt/SwissProt for RASSF2 Gene:

P50749-RASF2_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.

Evidence on tissue expression from TISSUES for RASSF2 Gene

  • Nervous system(4.9)
  • Eye(4.9)
  • Bone marrow(4.4)
  • Liver(3.1)
  • Intestine(2.6)
  • Blood(2.6)
  • Kidney(2.6)
  • Lymph node(2.4)
genes like me logo Genes that share expression patterns with RASSF2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF2 Gene

Orthologs for RASSF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RASSF2 29 30
  • 99.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RASSF2 30
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RASSF2 29 30
  • 91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rassf2 29
  • 87.63 (n)
Mouse
(Mus musculus)
Mammalia Rassf2 29 16 30
  • 87.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RASSF2 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RASSF2 29 30
  • 78.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RASSF2 30
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rassf2 29
  • 69.9 (n)
Str.8222 29
Zebrafish
(Danio rerio)
Actinopterygii rassf2a 29 30
  • 66.78 (n)
OneToMany
rassf2b 30
  • 52 (a)
OneToMany
wufa04h12 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG4656 31
  • 35 (a)
Rassf 30
  • 9 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 21 (a)
OneToMany
Species where no ortholog for RASSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RASSF2 Gene

ENSEMBL:
Gene Tree for RASSF2 (if available)
TreeFam:
Gene Tree for RASSF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF2: view image
Alliance of Genome Resources:
Additional Orthologs for RASSF2

Paralogs for RASSF2 Gene

Paralogs for RASSF2 Gene

(2) SIMAP similar genes for RASSF2 Gene using alignment to 2 proteins:

  • RASF2_HUMAN
  • Q8IZA5_HUMAN
genes like me logo Genes that share paralogs with RASSF2: view

Variants for RASSF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF2 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs758816530 A colorectal cancer sample p.Arg144His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RASSF2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RASSF2 Gene

Variant ID Type Subtype PubMed ID
esv1413742 CNV insertion 17803354
esv274965 CNV loss 21479260
esv29645 CNV loss 19812545
esv3383156 CNV insertion 20981092
esv3418342 CNV insertion 20981092
esv3584433 CNV loss 25503493
esv3645074 CNV gain 21293372
esv3893273 CNV loss 25118596
nsv1061866 CNV gain 25217958
nsv526507 CNV loss 19592680
nsv585310 CNV gain 21841781

Variation tolerance for RASSF2 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF2
Leiden Open Variation Database (LOVD)
RASSF2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF2 Gene

Disorders for RASSF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASSF2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASSF2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RASSF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASSF2 Gene

Publications for RASSF2 Gene

  1. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (PMID: 16012945) Akino K … Tokino T (Gastroenterology 2005) 3 4 22
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4
  5. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. (PMID: 19525978) Cooper WN … Latif F (Oncogene 2009) 3 4

Products for RASSF2 Gene

Sources for RASSF2 Gene