Aliases for RASSF10 Gene

Aliases for RASSF10 Gene

  • Ras Association Domain Family Member 10 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 10 2 3
  • Ras Association Domain-Containing Protein 10 3 4
  • Peptidylglycine Alpha-Amidating Monooxygenase COOH-Terminal Interactor-Like 2
  • RASSF10 5

External Ids for RASSF10 Gene

Previous GeneCards Identifiers for RASSF10 Gene

  • GC11P012710

Summaries for RASSF10 Gene

GeneCards Summary for RASSF10 Gene

RASSF10 (Ras Association Domain Family Member 10) is a Protein Coding gene. An important paralog of this gene is RASSF9.

UniProtKB/Swiss-Prot Summary for RASSF10 Gene

Additional gene information for RASSF10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASSF10 Gene

Genomics for RASSF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RASSF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J013007 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 600.7 +1.0 990 6.5 CREB1 GATAD2A TEAD4 TFE3 SOX13 KDM1A RCOR2 BACH1 RELA ZIC2 RASSF10 RASSF10-DT LINC00958 ENSG00000252329 RF00994-166 ARNTL
GH11J013138 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.8 +132.2 132173 5.1 HNRNPL GATAD2A ATF7 TFE3 SOX13 NFKBIZ RCOR2 RBFOX2 RXRB TCF12 RASSF10 ENSG00000255558 ENSG00000255018 ARNTL
GH11J013117 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +109.6 109585 5.4 SOX13 SP1 CEBPB FOS FOSL2 TBP BHLHE40 MAFK JUND SMAD5 lnc-RASSF10-9 RASSF10 LINC00958 ENSG00000255558 ARNTL
GH11J013125 Enhancer 0.7 Ensembl ENCODE 10.7 +117.5 117462 1.6 FOXA1 CEBPB SP1 NR3C1 FOS FOSL2 BHLHE40 MAFK USF2 NFE2L2 RASSF10 ENSG00000255558 lnc-RASSF10-9 ARNTL
GH11J013114 Enhancer 1 Ensembl ENCODE 7.3 +105.6 105584 2.2 GATAD2A RFX1 RCOR2 RXRB REST ZNF24 SOX6 FOXJ2 SCRT2 SOX13 LOC105376558 RASSF10 BTBD10 lnc-RASSF10-9 ENSG00000255558 ARNTL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASSF10

Top Transcription factor binding sites by QIAGEN in the RASSF10 gene promoter:
  • c-Rel
  • CUTL1
  • HSF2
  • Pax-4a
  • POU2F1
  • POU2F1a
  • POU3F1
  • RelA
  • S8
  • Spz1

Genomic Locations for RASSF10 Gene

Genomic Locations for RASSF10 Gene
chr11:13,009,316-13,012,119
(GRCh38/hg38)
Size:
2,804 bases
Orientation:
Plus strand
chr11:13,030,696-13,033,653
(GRCh37/hg19)
Size:
2,958 bases
Orientation:
Plus strand

Genomic View for RASSF10 Gene

Genes around RASSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF10 Gene

Proteins for RASSF10 Gene

  • Protein details for RASSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK89-RASFA_HUMAN
    Recommended name:
    Ras association domain-containing protein 10
    Protein Accession:
    A6NK89

    Protein attributes for RASSF10 Gene

    Size:
    507 amino acids
    Molecular mass:
    56900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASSF10 Gene

Post-translational modifications for RASSF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASSF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASSF10 Gene

Domains & Families for RASSF10 Gene

Gene Families for RASSF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF10 Gene

Suggested Antigen Peptide Sequences for RASSF10 Gene

GenScript: Design optimal peptide antigens:
  • Ras association domain-containing protein 10 (RASFA_HUMAN)
genes like me logo Genes that share domains with RASSF10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASSF10 Gene

Function for RASSF10 Gene

Molecular function for RASSF10 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in regulating embryonic neurogenesis.

Phenotypes From GWAS Catalog for RASSF10 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASSF10 Gene

Localization for RASSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF10 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF10 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
plasma membrane 1
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with RASSF10: view

Pathways & Interactions for RASSF10 Gene

PathCards logo

SuperPathways for RASSF10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development IEA --
GO:0050769 positive regulation of neurogenesis IEA,ISS --
GO:2000179 positive regulation of neural precursor cell proliferation IEA,ISS --
genes like me logo Genes that share ontologies with RASSF10: view

No data available for Pathways by source and SIGNOR curated interactions for RASSF10 Gene

Drugs & Compounds for RASSF10 Gene

No Compound Related Data Available

Transcripts for RASSF10 Gene

mRNA/cDNA for RASSF10 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASSF10

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF10 Gene

No ASD Table

Relevant External Links for RASSF10 Gene

GeneLoc Exon Structure for
RASSF10

Expression for RASSF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF10 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.8), Skin - Sun Exposed (Lower leg) (x8.1), Skin - Not Sun Exposed (Suprapubic) (x7.2), and Stomach (x4.3).

Protein differential expression in normal tissues from HIPED for RASSF10 Gene

This gene is overexpressed in CD4 Tcells (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASSF10 Gene



Protein tissue co-expression partners for RASSF10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASSF10

SOURCE GeneReport for Unigene cluster for RASSF10 Gene:

Hs.134650

mRNA Expression by UniProt/SwissProt for RASSF10 Gene:

A6NK89-RASFA_HUMAN
Tissue specificity: Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas.
genes like me logo Genes that share expression patterns with RASSF10: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF10 Gene

Orthologs for RASSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASSF10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RASSF10 30
  • 99.8 (n)
Dog
(Canis familiaris)
Mammalia RASSF10 30
  • 88.36 (n)
Cow
(Bos Taurus)
Mammalia RASSF10 30
  • 86.85 (n)
Mouse
(Mus musculus)
Mammalia Rassf10 30 17
  • 85.21 (n)
Rat
(Rattus norvegicus)
Mammalia RGD1309847 30
  • 84.32 (n)
Chicken
(Gallus gallus)
Aves LOC100859008 30
  • 73.46 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492205 30
  • 64.11 (n)
Zebrafish
(Danio rerio)
Actinopterygii rassf10a 30
  • 64.66 (n)
Species where no ortholog for RASSF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RASSF10 Gene

ENSEMBL:
Gene Tree for RASSF10 (if available)
TreeFam:
Gene Tree for RASSF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASSF10: view image

Paralogs for RASSF10 Gene

Paralogs for RASSF10 Gene

genes like me logo Genes that share paralogs with RASSF10: view

Variants for RASSF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASSF10 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs4323847 - p.Gln194His

Additional dbSNP identifiers (rs#s) for RASSF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASSF10 Gene

Variant ID Type Subtype PubMed ID
esv3625395 CNV gain 21293372
esv3625402 CNV gain 21293372
nsv951309 CNV deletion 24416366

Additional Variant Information for RASSF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RASSF10 Gene

Disorders for RASSF10 Gene

Additional Disease Information for RASSF10

No disorders were found for RASSF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF10 Gene

Publications for RASSF10 Gene

  1. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. (PMID: 18272789) Sherwood V … Chalmers AD (Molecular biology of the cell 2008) 2 3 4
  2. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. (PMID: 20956940) Hill VK … Latif F (Oncogene 2011) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Predictive value of the serum RASSF10 promoter methylation status in gastric cancer. (PMID: 31119967) Hu Y … Xue W (The Journal of international medical research 2019) 3
  5. Residual methylation of tumor suppressor gene promoters, RASSF6 and RASSF10, as novel biomarkers for minimal residual disease detection in adult acute lymphoblastic leukemia. (PMID: 31486880) Younesian S … Ghaffari SH (Annals of hematology 2019) 3

Products for RASSF10 Gene

Sources for RASSF10 Gene