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Aliases for RASL12 Gene

Aliases for RASL12 Gene

  • RAS Like Family 12 2 3 5
  • Ras Family Member Ris 2 3
  • Ras-Like Protein Ris 3 4
  • RIS 3 4
  • Ras-Like Protein Family Member 12 3
  • RAS-Like, Family 12 2
  • RAS-Like Family 12 2

External Ids for RASL12 Gene

Previous GeneCards Identifiers for RASL12 Gene

  • GC15M063061
  • GC15M063132
  • GC15M065345
  • GC15M042170

Summaries for RASL12 Gene

GeneCards Summary for RASL12 Gene

RASL12 (RAS Like Family 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RERG.

Additional gene information for RASL12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL12 Gene

Genomics for RASL12 Gene

GeneHancer (GH) Regulatory Elements for RASL12 Gene

Promoters and enhancers for RASL12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I065066 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.4 +7.1 7072 6 PKNOX1 NR2F1 ZMYM3 NR2F2 FOSL1 ZFHX2 GLIS1 ZKSCAN8 ZFP36 FOS RASL12 UBAP1L SPG21 SLC51B RBPMS2 PIR51727
GH15I065077 Enhancer 0.8 ENCODE dbSUPER 550.8 -1.4 -1411 0.4 CTCF L3MBTL2 MAX SIN3A RAD21 ZKSCAN8 ZNF143 ZSCAN29 ZBTB33 RASL12 KBTBD13 UBAP1L LOC105370862
GH15I065076 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 0.0 -37 0.1 KBTBD13 RASL12
GH15I065048 Promoter/Enhancer 1.4 Ensembl ENCODE 12 +26.8 26804 1.9 HDAC1 PKNOX1 ATF1 RB1 NEUROD1 SIN3A BMI1 KLF5 ZBTB7B IRF4 ENSG00000277351 SPG21 UBAP1L CSNK1G1 MTFMT KBTBD13 RASL12 ENSG00000259635 ZNF609 MIR1272
GH15I065053 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.1 +21.5 21512 2.4 PKNOX1 ARID4B SIN3A ZNF48 YY1 ARID2 ZNF143 DEK RXRA SP5 UBAP1L SPG21 MTFMT RASL12 KBTBD13 RNU5B-1 RBPMS2 MIR1272 ENSG00000277351 PIR51727
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RASL12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASL12 gene promoter:

Genomic Locations for RASL12 Gene

Genomic Locations for RASL12 Gene
chr15:65,045,582-65,076,690
(GRCh38/hg38)
Size:
31,109 bases
Orientation:
Minus strand
chr15:65,345,675-65,369,028
(GRCh37/hg19)

Genomic View for RASL12 Gene

Genes around RASL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL12 Gene

Proteins for RASL12 Gene

  • Protein details for RASL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYN1-RASLC_HUMAN
    Recommended name:
    Ras-like protein family member 12
    Protein Accession:
    Q9NYN1
    Secondary Accessions:
    • B2RC29
    • B4DJW2
    • B4DU82

    Protein attributes for RASL12 Gene

    Size:
    266 amino acids
    Molecular mass:
    29662 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RASL12 Gene

    Alternative splice isoforms for RASL12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASL12 Gene

Post-translational modifications for RASL12 Gene

No Post-translational modifications

Other Protein References for RASL12 Gene

No data available for DME Specific Peptides for RASL12 Gene

Domains & Families for RASL12 Gene

Gene Families for RASL12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9NYN1

UniProtKB/Swiss-Prot:

RASLC_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL12: view

Function for RASL12 Gene

Gene Ontology (GO) - Molecular Function for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL12: view
genes like me logo Genes that share phenotypes with RASL12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL12 Gene

Localization for RASL12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL12 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RASL12 Gene

Pathways & Interactions for RASL12 Gene

SuperPathways for RASL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASL12: view

No data available for Pathways by source and SIGNOR curated interactions for RASL12 Gene

Drugs & Compounds for RASL12 Gene

No Compound Related Data Available

Transcripts for RASL12 Gene

Unigene Clusters for RASL12 Gene

RAS-like, family 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for RASL12 Gene

GeneLoc Exon Structure for
RASL12
ECgene alternative splicing isoforms for
RASL12

Expression for RASL12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL12 Gene

This gene is overexpressed in Artery - Tibial (x8.8), Artery - Coronary (x4.5), and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for RASL12 Gene

This gene is overexpressed in Frontal cortex (35.4) and Prostate (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RASL12 Gene



NURSA nuclear receptor signaling pathways regulating expression of RASL12 Gene:

RASL12

SOURCE GeneReport for Unigene cluster for RASL12 Gene:

Hs.27018

Evidence on tissue expression from TISSUES for RASL12 Gene

  • Nervous system(4.5)
  • Eye(4.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RASL12: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL12 Gene

Orthologs for RASL12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RASL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL12 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia RASL12 33 34
  • 91.27 (n)
cow
(Bos Taurus)
Mammalia RASL12 33 34
  • 90.35 (n)
mouse
(Mus musculus)
Mammalia Rasl12 33 16 34
  • 88.6 (n)
rat
(Rattus norvegicus)
Mammalia Rasl12 33
  • 88.35 (n)
oppossum
(Monodelphis domestica)
Mammalia RASL12 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASL12 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves RASL12 33 34
  • 75.54 (n)
lizard
(Anolis carolinensis)
Reptilia RASL12 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl12 33
  • 65.78 (n)
zebrafish
(Danio rerio)
Actinopterygii rasl12 33 34
  • 65.33 (n)
zgc63633 33
worm
(Caenorhabditis elegans)
Secernentea Y71F9AR.2 33 34
  • 49.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 34
  • 25 (a)
OneToMany
Species where no ortholog for RASL12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASL12 Gene

ENSEMBL:
Gene Tree for RASL12 (if available)
TreeFam:
Gene Tree for RASL12 (if available)

Paralogs for RASL12 Gene

Paralogs for RASL12 Gene

genes like me logo Genes that share paralogs with RASL12: view

Variants for RASL12 Gene

Sequence variations from dbSNP and Humsavar for RASL12 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs115182478 conflicting-interpretations-of-pathogenicity, benign, not specified, Nemaline myopathy 6 65,077,061(-) G/C upstream_transcript_variant
rs116406369 conflicting-interpretations-of-pathogenicity, likely-benign, benign, not specified, Nemaline Myopathy, Dominant, Nemaline myopathy 6 65,078,178(-) A/G upstream_transcript_variant
rs116623596 conflicting-interpretations-of-pathogenicity, likely-benign, benign, not specified, Nemaline Myopathy, Dominant, Nemaline myopathy 6 65,077,943(-) G/A/C upstream_transcript_variant
rs12901617 benign, Nemaline Myopathy, Dominant 65,078,314(-) T/C upstream_transcript_variant
rs138484272 benign, likely-benign, not specified, Nemaline Myopathy, Dominant, Nemaline myopathy 6 65,076,904(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RASL12 Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565

Variation tolerance for RASL12 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL12 Gene

Disorders for RASL12 Gene

Additional Disease Information for RASL12

No disorders were found for RASL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL12 Gene

Publications for RASL12 Gene

  1. Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. (PMID: 12107412) Wistow G … Peterson K (Molecular vision 2002) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for RASL12 Gene

Sources for RASL12 Gene

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