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Aliases for RASL11A Gene

Aliases for RASL11A Gene

  • RAS Like Family 11 Member A 2 3 5
  • RAS-Like, Family 11, Member A 2
  • RAS-Like Family 11 Member A 2

External Ids for RASL11A Gene

Previous GeneCards Identifiers for RASL11A Gene

  • GC00U914303
  • GC13U900274
  • GC13P026742
  • GC13P027844
  • GC13P008666

Summaries for RASL11A Gene

Entrez Gene Summary for RASL11A Gene

  • RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

GeneCards Summary for RASL11A Gene

RASL11A (RAS Like Family 11 Member A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RASL11B.

UniProtKB/Swiss-Prot for RASL11A Gene

  • Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).

Additional gene information for RASL11A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL11A Gene

Genomics for RASL11A Gene

GeneHancer (GH) Regulatory Elements for RASL11A Gene

Promoters and enhancers for RASL11A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I027270 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 558.4 +1.3 1340 3 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF213 ZNF143 KLF13 RASL11A GC13P027309
GH13I027269 Enhancer 0.4 Ensembl 550.8 -1.0 -1026 0.2 MIER2 REST ZNF214 RASL11A GC13P027267
GH13I027167 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11 -99.6 -99624 5.9 ATF1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 TCF12 GLIS2 USP12 USP12-AS2 SNORA27 SNORD102 RPL21 RASL11A LINC00412 USP12-AS1
GH13I027042 Enhancer 1.2 Ensembl ENCODE dbSUPER 16 -227.3 -227277 1.4 PKNOX1 NFIB MAX SIN3A BACH1 MZF1 RAD21 RFX5 FOSL1 GATA3 GC13P027043 RASL11A RPS20P32
GH13I027053 Enhancer 1.1 Ensembl ENCODE dbSUPER 15.9 -215.8 -215849 2.2 MEIS2 PKNOX1 MAX ZIC2 E4F1 ZFHX2 EGR1 VEZF1 ATF7 FOS LOC105370124 RASL11A LINC00412 RPL21 SNORA27 SNORD102 USP12 GC13P027043
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RASL11A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASL11A gene promoter:

Genomic Locations for RASL11A Gene

Genomic Locations for RASL11A Gene
3,441 bases
Plus strand

Genomic View for RASL11A Gene

Genes around RASL11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL11A Gene

Proteins for RASL11A Gene

  • Protein details for RASL11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-like protein family member 11A
    Protein Accession:
    Secondary Accessions:
    • B2RN97

    Protein attributes for RASL11A Gene

    242 amino acids
    Molecular mass:
    27006 Da
    Quaternary structure:
    • Interacts with UBF/UBTF.

neXtProt entry for RASL11A Gene

Post-translational modifications for RASL11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL11A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL11A Gene

Domains & Families for RASL11A Gene

Gene Families for RASL11A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RASL11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL11A: view

Function for RASL11A Gene

Molecular function for RASL11A Gene

UniProtKB/Swiss-Prot Function:
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Phenotypes From GWAS Catalog for RASL11A Gene

Gene Ontology (GO) - Molecular Function for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL11A: view
genes like me logo Genes that share phenotypes with RASL11A: view

Animal Model Products

miRNA for RASL11A Gene

miRTarBase miRNAs that target RASL11A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL11A Gene

Localization for RASL11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL11A Gene

Nucleus, nucleolus. Note=Associates with rDNA transcription unit throughout the cell cycle. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL11A gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL11A: view

Pathways & Interactions for RASL11A Gene

SuperPathways for RASL11A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0045943 positive regulation of transcription by RNA polymerase I ISS,IEA --
genes like me logo Genes that share ontologies with RASL11A: view

No data available for Pathways by source and SIGNOR curated interactions for RASL11A Gene

Drugs & Compounds for RASL11A Gene

No Compound Related Data Available

Transcripts for RASL11A Gene

mRNA/cDNA for RASL11A Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASL11A Gene

RAS-like, family 11, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL11A Gene

No ASD Table

Relevant External Links for RASL11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASL11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL11A Gene

NURSA nuclear receptor signaling pathways regulating expression of RASL11A Gene:


SOURCE GeneReport for Unigene cluster for RASL11A Gene:


mRNA Expression by UniProt/SwissProt for RASL11A Gene:

Tissue specificity: Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.
genes like me logo Genes that share expression patterns with RASL11A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL11A Gene

Orthologs for RASL11A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL11A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASL11A 33 34
  • 100 (n)
(Canis familiaris)
Mammalia RASL11A 33 34
  • 89.67 (n)
(Bos Taurus)
Mammalia RASL11A 33 34
  • 85.28 (n)
(Mus musculus)
Mammalia Rasl11a 33 16 34
  • 85.12 (n)
(Monodelphis domestica)
Mammalia RASL11A 34
  • 83 (a)
(Rattus norvegicus)
Mammalia Rasl11a 33
  • 82.46 (n)
(Ornithorhynchus anatinus)
Mammalia RASL11A 34
  • 67 (a)
(Gallus gallus)
Aves RASL11A 33 34
  • 72.15 (n)
(Anolis carolinensis)
Reptilia RASL11A 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl11a 33
  • 71.17 (n)
(Danio rerio)
Actinopterygii rasl11a 34
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006025 33
  • 55.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8519 33 34
  • 54.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for RASL11A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL11A Gene

Gene Tree for RASL11A (if available)
Gene Tree for RASL11A (if available)

Paralogs for RASL11A Gene

Paralogs for RASL11A Gene

(21) SIMAP similar genes for RASL11A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RASL11A: view

Variants for RASL11A Gene

Sequence variations from dbSNP and Humsavar for RASL11A Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000477741 -- 27,270,617(+) C/T 5_prime_UTR_variant
rs1001001285 -- 27,268,476(+) C/T upstream_transcript_variant
rs1001033161 -- 27,268,577(+) G/C upstream_transcript_variant
rs1002067881 -- 27,268,583(+) G/A upstream_transcript_variant
rs1002454162 -- 27,270,584(+) C/G 5_prime_UTR_variant

Variation tolerance for RASL11A Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASL11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RASL11A Gene

Disorders for RASL11A Gene

Additional Disease Information for RASL11A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RASL11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL11A Gene

Publications for RASL11A Gene

  1. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. (PMID: 15033445) Louro R … Reis EM (Biochemical and biophysical research communications 2004) 2 3 4 58
  2. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PMID: 21529783) Heath AC … Montgomery GW (Biological psychiatry 2011) 44 58
  3. Chromatin association and regulation of rDNA transcription by the Ras-family protein RasL11a. (PMID: 20168301) Pistoni M … Amati B (The EMBO journal 2010) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 44 58

Products for RASL11A Gene

Sources for RASL11A Gene

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