Aliases for RASL10B Gene

Aliases for RASL10B Gene

  • RAS Like Family 10 Member B 2 3 5
  • Ras-Like Protein Family Member 10B 3 4
  • Ras-Like Protein VTS58635 3 4
  • Ras-Related Protein 17 3 4
  • RRP17 3 4
  • RAS-Like, Family 10, Member B 2
  • Alternative Protein RASL10B 3
  • RAS-Like Family 10 Member B 2
  • VTS58635 3

External Ids for RASL10B Gene

Previous GeneCards Identifiers for RASL10B Gene

  • GC17P034204
  • GC17P031082
  • GC17P034058
  • GC17P030243

Summaries for RASL10B Gene

GeneCards Summary for RASL10B Gene

RASL10B (RAS Like Family 10 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RASL10A.

UniProtKB/Swiss-Prot Summary for RASL10B Gene

  • May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Additional gene information for RASL10B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASL10B Gene

Genomics for RASL10B Gene

GeneHancer (GH) Regulatory Elements for RASL10B Gene

Promoters and enhancers for RASL10B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J035731 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.5 452 1.8 ZBTB6 HLF SP1 SP7 PRDM1 EGR1 KLF14 GLIS2 ZBTB8A PRDM10 RASL10B TAF15 GAS2L2
GH17J035742 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 750.4 +9.8 9752 0.8 CTCF L3MBTL2 GMEB1 MGA USF1 NRF1 BHLHE40 SIN3A POLR2A SMARCA4 RASL10B MMP28 TAF15 NLE1 GAS2L2
GH17J035734 Promoter 0.3 EPDnew 750.6 +3.4 3353 0.1 RASL10B GAS2L2 TAF15
GH17J035730 Promoter 0.3 Ensembl 750.6 -0.7 -748 0.2 RASL10B RPL17P42 TAF15
GH17J035743 Promoter 0.3 EPDnew 750.4 +10.4 10444 0.1 RASL10B MMP28 TAF15 NLE1 GAS2L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASL10B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASL10B gene promoter:
  • ATF
  • CREB
  • deltaCREB
  • FOXD3
  • HNF-3beta
  • ITF-2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • Tal-1beta

Genomic Locations for RASL10B Gene

Genomic Locations for RASL10B Gene
chr17:35,731,649-35,743,525
(GRCh38/hg38)
Size:
11,877 bases
Orientation:
Plus strand
chr17:34,058,668-34,070,540
(GRCh37/hg19)
Size:
11,873 bases
Orientation:
Plus strand

Genomic View for RASL10B Gene

Genes around RASL10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL10B Gene

Proteins for RASL10B Gene

  • Protein details for RASL10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S79-RSLAB_HUMAN
    Recommended name:
    Ras-like protein family member 10B
    Protein Accession:
    Q96S79
    Secondary Accessions:
    • B3KV31

    Protein attributes for RASL10B Gene

    Size:
    203 amino acids
    Molecular mass:
    23229 Da
    Quaternary structure:
    • Interacts with CADPS.

neXtProt entry for RASL10B Gene

Post-translational modifications for RASL10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASL10B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASL10B Gene

Domains & Families for RASL10B Gene

Gene Families for RASL10B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASL10B Gene

Suggested Antigen Peptide Sequences for RASL10B Gene

GenScript: Design optimal peptide antigens:
  • Ras-like protein VTS58635 (RSLAB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96S79

UniProtKB/Swiss-Prot:

RSLAB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL10B: view

Function for RASL10B Gene

Molecular function for RASL10B Gene

UniProtKB/Swiss-Prot Function:
May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Phenotypes From GWAS Catalog for RASL10B Gene

Gene Ontology (GO) - Molecular Function for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL10B: view
genes like me logo Genes that share phenotypes with RASL10B: view

Animal Models for RASL10B Gene

MGI Knock Outs for RASL10B:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASL10B Gene

Localization for RASL10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL10B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL10B gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
cytosol 1
extracellular 0
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL10B: view

Pathways & Interactions for RASL10B Gene

PathCards logo

SuperPathways for RASL10B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide IEA,ISS --
GO:0007165 signal transduction IEA --
GO:0090277 positive regulation of peptide hormone secretion IEA,ISS --
genes like me logo Genes that share ontologies with RASL10B: view

No data available for Pathways by source and SIGNOR curated interactions for RASL10B Gene

Drugs & Compounds for RASL10B Gene

No Compound Related Data Available

Transcripts for RASL10B Gene

mRNA/cDNA for RASL10B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL10B Gene

No ASD Table

Relevant External Links for RASL10B Gene

GeneLoc Exon Structure for
RASL10B
ECgene alternative splicing isoforms for
RASL10B

Expression for RASL10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL10B Gene

mRNA differential expression in normal tissues according to GTEx for RASL10B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.1) and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for RASL10B Gene

This gene is overexpressed in CD8 Tcells (35.9), Blymphocyte (21.7), and Lung (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASL10B Gene



Protein tissue co-expression partners for RASL10B Gene

NURSA nuclear receptor signaling pathways regulating expression of RASL10B Gene:

RASL10B

SOURCE GeneReport for Unigene cluster for RASL10B Gene:

Hs.744994

mRNA Expression by UniProt/SwissProt for RASL10B Gene:

Q96S79-RSLAB_HUMAN
Tissue specificity: Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas.

Evidence on tissue expression from TISSUES for RASL10B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RASL10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL10B Gene

Orthologs for RASL10B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL10B 32
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia RASL10B 32
  • 96.39 (n)
dog
(Canis familiaris)
Mammalia RASL10B 32
  • 95.73 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912246 32
  • 94.25 (n)
mouse
(Mus musculus)
Mammalia Rasl10b 17 32
  • 93.76 (n)
chicken
(Gallus gallus)
Aves RASL10B 32
  • 85.39 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl10b 32
  • 77.18 (n)
zebrafish
(Danio rerio)
Actinopterygii rasl10a 32
  • 63.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14669 32
  • 52.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002563 32
  • 50.17 (n)
Species where no ortholog for RASL10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL10B Gene

ENSEMBL:
Gene Tree for RASL10B (if available)
TreeFam:
Gene Tree for RASL10B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASL10B: view image

Paralogs for RASL10B Gene

(6) SIMAP similar genes for RASL10B Gene using alignment to 2 proteins:

  • RSLAB_HUMAN
  • L8ECL9_HUMAN
genes like me logo Genes that share paralogs with RASL10B: view

Variants for RASL10B Gene

Sequence variations from dbSNP and Humsavar for RASL10B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs781851443 A breast cancer sample 35,735,338(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000820520 -- 35,738,713(+) A/T intron_variant
rs1000851786 -- 35,738,961(+) G/T intron_variant
rs1001258463 -- 35,737,692(+) A/G intron_variant
rs1001416129 -- 35,731,681(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RASL10B Gene

Variant ID Type Subtype PubMed ID
esv3892999 CNV loss 25118596

Variation tolerance for RASL10B Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASL10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL10B Gene

Disorders for RASL10B Gene

Additional Disease Information for RASL10B

No disorders were found for RASL10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL10B Gene

Publications for RASL10B Gene

  1. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. (PMID: 17984325) Rybkin II … Olson EN (The Journal of cell biology 2007) 3 4 56
  2. Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. (PMID: 17028781) Zou H … Cao K (Biotechnology letters 2006) 2 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for RASL10B Gene

Sources for RASL10B Gene